Synthesis and therapeutic potential of stimuli-responsive metal-organic frameworks

2020 ◽  
pp. 127233
Author(s):  
Shahla Karimzadeh ◽  
Siamak Javanbakht ◽  
Behzad Baradaran ◽  
Mohammad-Ali Shahbazi ◽  
Mahmoud Hashemzaei ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Metal Organic Frameworks ◽  
Stimuli Responsive ◽  
Metal Organic

scholarly journals Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

2015 ◽  
Vol 6 (3) ◽  
pp. 1640-1644 ◽  
Author(s):  
Li-Li Tan ◽  
Haiwei Li ◽  
Yu-Chen Qiu ◽  
Dai-Xiong Chen ◽  
Xin Wang ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Stimuli Responsive ◽  
Triggered Release ◽  
Metal Organic ◽  
Hybrid Platform ◽  
First Time

Mechanized monodisperse nano metal–organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered release capabilities were constructed for the first time as a new stimuli-responsive theranostic hybrid platform.

Stimuli-responsive structural changes in metal–organic frameworks

2020 ◽  
Vol 56 (66) ◽  
pp. 9416-9432 ◽  
Author(s):  
Zhanning Liu ◽  
Lu Zhang ◽  
Daofeng Sun
Keyword(s):  
Structural Changes ◽  
Metal Organic Frameworks ◽  
Stimuli Responsive ◽  
Feature Article ◽  
Metal Organic ◽  
External Stimuli

This feature article mainly summarizes how the structure of MOFs changes under external stimuli.

Stimuli‐Responsive Luminescent Properties of Tetraphenylethene‐Based Strontium and Cobalt Metal–Organic Frameworks

2020 ◽  
Vol 132 (44) ◽  
pp. 19884-19889
Author(s):  
Xiaolei Guo ◽  
Nansong Zhu ◽  
Shi‐Ping Wang ◽  
Guanghua Li ◽  
Fu‐Quan Bai ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Luminescent Properties ◽  
Cobalt Metal ◽  
Stimuli Responsive ◽  
Metal Organic

Progress of Stimuli-Responsive Nanoscale Metal Organic Frameworks as Controlled Drug Delivery Systems

2020 ◽  
Vol 17 ◽  
Author(s):  
Ailing Feng ◽  
Yanni Wang ◽  
Jinzi Ding ◽  
Rong Xu ◽  
Xiaodong Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Direct Assembly ◽  
Metal Organic ◽  
Organic Framework

Background: Development of controlled drug delivery systems can improve the pharmacokinetic characteristics of drug molecules in the human body, thereby significantly improving the utilization rate of drugs and reducing toxicity and side effects caused by high concentrations of drugs, which can occur when delivery is not controlled. Metal organic frameworks are a new class of very promising crystalline microporous materials, especially when the size is reduced to the nanometer range. Metal organic frameworks exhibit large specific surface areas, tunable compositions, and easy functionalization. In recent years, increasing number of studies have reported the remarkable advances in multifunctional nanoscale metal organic frameworks in drug delivery. Objective: Review the latest research involving advances in stimuli-responsive nanoscale metal organic frameworks as drug delivery systems in controlled-release drugs. Discussion: We first introduce the two main strategies associated with nanoscale metal organic frameworks used in drug loading: direct assembly and post-encapsulation. We next focus on the latest discoveries of nanoscale metal organic framework-based stimulus response systems for drug delivery, including pH, magnetics, light, ion, temperature, and other stimuli, as well as multiple stimulus-responsive drug delivery systems. Finally, we discuss the challenges and future development directions of nanoscale metal organic framework-based controlled drug release.

Stimuli-Responsive DNA-Functionalized Metal-Organic Frameworks (MOFs)

2016 ◽  
Vol 29 (6) ◽  
pp. 1602782 ◽  
Author(s):  
Jason S. Kahn ◽  
Lina Freage ◽  
Natalie Enkin ◽  
Miguel Angel Aleman Garcia ◽  
Itamar Willner
Keyword(s):  
Metal Organic Frameworks ◽  
Stimuli Responsive ◽  
Metal Organic

scholarly journals Metal-Organic Frameworks for Drug Delivery Applications

2021 ◽  
pp. 139-170
Author(s):  
Doaa Ahmed Ghareeb ◽  
Nessma Magdy Nasr
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Metal Organic Frameworks ◽  
Stimuli Responsive ◽  
Surface Areas ◽  
Wide Range ◽  
Metal Organic ◽  
Delivery Vehicles ◽  
Structural Aspects

Metal-organic frameworks (MOFs) are based on metals and organic linkers; they possess large surface areas, suitable pore size and shape, wide range of chemical composition, and functionalized pore surface, which enable them for possible applications as delivery vehicles for therapeutic agents. The challenges include not only the development of new solids but also continuous improvements in the formulation and processing of the materials, including modifying the morphology and shape of the frameworks to fit the proposed applications of drug delivery. This chapter discussed enormous MOF-based stimuli responsive drug delivery systems, and considerable achievements have been made as a new avenue for drug delivery, their structural aspects, their applications in the controlled release of the drugs, and future view for development of drug controlled release researches using MOFs. Among the properties that must be developed and approved are the materials' toxicology, stability, their reproducibility of manufacture of MOFs in body's liquid, and pharmacokinetics of drug-loaded MOFs.

scholarly journals Frustrated Flexibility in Metal-Organic Frameworks

2020 ◽  
Author(s):  
Roman Pallach ◽  
Julian Keupp ◽  
Kai Terlinden ◽  
Louis Frentzel-Beyme ◽  
Marvin Kloß ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Stimuli Responsive ◽  
Dispersion Energy ◽  
Materials Research ◽  
Geometrical Constraints ◽  
Metal Organic ◽  
Flexible Metal ◽  
Reversible Loss ◽  
Alkoxy Groups ◽  
Global And Local

<div><div><div><p>Stimuli-responsive flexible metal-organic frameworks (MOFs) remain at the forefront of porous materials research due to their enormous potential for various technological applications. Here, we introduce the concept of frustrated flexibility in MOFs, which arises from an incompatibility of intra-framework dispersion forces with the geometrical constraints of the inorganic building units. Controlled by appropriate linker functionalization with dispersion energy donating alkoxy groups, this approach results in a series of MOFs exhibiting a new type of guest- and temperature-responsive structural flexibility characterized by reversible loss and recovery of crystalline order under full retention of framework connectivity and topology. The stimuli-dependent phase change of the frustrated MOFs involves non-correlated deformations of their inorganic building unit, as probed by a combination of global and local structure techniques together with computer simulations. Frustrated flexibility may be a common phenomenon in MOF structures, which are commonly regarded as rigid, and thus may be of crucial importance for the performance of these materials in various applications.</p></div></div></div>

Recent Advances in Metal-Organic Frameworks as Anticancer Drug Delivery Systems: A Review.

2021 ◽  
Vol 21 ◽  
Author(s):  
Abdollah Karami ◽  
Omnia Mohamed ◽  
Ahmed Ahmed ◽  
Ghaleb A. Husseini ◽  
Rana Sabouni
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Metal Organic Frameworks ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery ◽  
Advantages And Disadvantages ◽  
Metal Organic

Background: Metal-organic frameworks (MOFs), as attractive hybrid crystalline porous materials, are increasingly being investigated in biomedical applications owing to their exceptional properties, including high porosity, ultrahigh surface areas, tailorable composition and structure, and tunability and surface functionality. Of interest in this review is the design and development of MOFbased drug delivery systems (DDSs) that have excellent biocompatibility, good stability under physiological conditions, high drug loading capacity, and controlled/targeted drug release. Objective: This review highlights the latest advances in MOFs as anticancer drug delivery systems (DDSs) along with insights on their design, fabrication, and performance under different stimuli that are either internal or external. The synthesis methods of MOFs, along with their advantages and disadvantages, are briefly discussed. The emergence of multifunctional MOF-based theranostic platforms is also discussed. Finally, the future challenges facing the developments of MOFs in the field of drug delivery are discussed. Methods: The review was prepared by carrying out a comprehensive literature survey using relevant work published in various scientific databases. Results: Novel MOFs in biomedical applications, especially in drug delivery, have shown great potentials. MOF-based DDSs can be classified into normal (non-controllable) DDSs, stimuli-responsive DDSs, and theranostic platforms. The normal DDSs are pristine MOFs loaded with MOFs and offer little to no control over the drug delivery. Stimuli-responsive DDSs offer better spatiotemporal control over the drug release by responding to either endogenous (pH, redox, ions, ATP) or exogenous stimuli (light, magnetism, US, pressure, temperature). The theranostic platforms combine stimuli-responsive drug delivery with diagnostic imaging functionality, paving the road for imaging-guided drug delivery. Conclusion: This review presented a summary of the various methods utilized in MOF synthesis along with the advantages and disadvantages of each method. Furthermore, the review highlighted and discussed the latest developments in the field of MOF-based DDSs and theranostic platforms. The review is focused on the characteristics of MOF-based DDSs, the encapsulation of different anticancer drugs as well as their stimuli-responsive release.

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