Vacuum UV pre-treatment coupled with self-generated peroxide stimulation of biomass: An innovative hybrid system for detoxification and mineralization of toxic compounds

This paper describes a pilot plant study on the performance of a hybrid small municipal wastewater treatment system consisting of a jet mixed separator(JMS) and upgraded RBC. The JMS was used as a pre-treatment of the RBC instead of the primary clarifier. The treatment capacity of the system was fixed at 100 m3/d, corresponding to the hydraulic loading to the RBC of 117 L/m2/d. The effluent from the grid chamber at a municipal wastewater treatment plant was fed into the hybrid system. The RBC was operated using the electric power produced by a solar electric generation panel with a surface area of 8 m2 under enough sunlight. In order to reduce the organic loading to the RBC, polyaluminium chloride(PAC) was added to the JMS influent to remove the colloidal and suspended organic particles. At the operational condition where the A1 dosage and hydraulic retention time of the JMS were fixed at 5 g/m3 and 45 min., respectively, the average effluent water quality of hybrid system was as follows: TOC=8 g/m3, Total BOD=8 g/m3, SS=8 g/m3, Turbidity=6 TU, NH4-N=7 g/m3, T-P=0.5 g/m3. In this operating condition, electric power consumption of the RBC for treating unit volume of wastewater is only 0.07 KWH/m3.

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Effect of Duloxetine Pretreatment on 5-HTP and Dexfenfluramine Induced Behaviours in Albino Rats

Biomedical & Pharmacology Journal ◽

10.13005/bpj/1762 ◽

2019 ◽

Vol 12 (3) ◽

pp. 1339-1343

Author(s):

Vandana Milind Thorat ◽

Chitra C Khanwelkar ◽

Somnath Mallikarjun Matule ◽

Pratibha Satish Salve ◽

Smita Ajit Surle-Patil ◽

...

Keyword(s):

Serotonin Transporter ◽

Behavioural Syndrome ◽

Albino Rats ◽

Behavioral Syndrome ◽

Serotonergic Receptors ◽

Central Brain ◽

Pre Treatment ◽

Stimulation Of

Activation of central brain serotonergic receptors viz 5-HT1A and 5-HT2A by serotonin (5-HT) induces the 5-HT behavioural syndrome in rats. 5-HTP and dexfenfluramine produce 5-HT mediated behaviours. We have carried out the experiment with the aim to study the effect of duloxetine pretreatment on 5-hydroxytryptophan and dexfenfluramine induced behaviours in albino rats. Pre-treatment with 20 mg/kg duloxetine, a SNRI was found to potentiate 75 mg/kg 5-HTP mediated behavioural syndrome. However, 5, 10 and 20 mg/kg duloxetine had decreased the intensity of the behavioral syndrome produced by 10 mg/kg dexfenfluramine significantly. Duloxetine at 5, 10 and 20 mg/kg had produced inhibition of serotonin transporter (SERT) and inhibited dexfenfluramine uptake which had significantly antagonised its behavioural syndrome. Duloxetine at 5 and 10 mg/kg did not affect 5-HTP induced behavioral syndrome significantly where as 20 mg/kg duloxetine did significantly potentiate 5-HTP induced behavioral syndrome. This indicates 20 mg/kg dose of duloxetine blocks neuronal reuptake of 5-HT by blocking SERT and effectively increase its concentration to greater level in the synaptic gap which causes synergistic stimulation of the central postsynaptic 5-HT1A and 5-HT2A receptors and potentiation of 5-HTP behavioral syndrome.

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The Fos expression in rat brain following electrical stimulation of dura mater surrounding the superior sagittal sinus changed with the pre-treatment of rizatriptan benzoate

Brain Research ◽

10.1016/j.brainres.2010.10.004 ◽

2011 ◽

Vol 1367 ◽

pp. 340-346 ◽

Cited By ~ 10

Author(s):

Xiaolin Wang ◽

Shengyuan Yu ◽

Zhao Dong ◽

Lei Jiang

Keyword(s):

Electrical Stimulation ◽

Rat Brain ◽

Dura Mater ◽

Superior Sagittal Sinus ◽

Rizatriptan Benzoate ◽

Sagittal Sinus ◽

Fos Expression ◽

Pre Treatment ◽

Stimulation Of

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Lowering the inhibition of sugarcane vinasse as a culture medium for oleaginous fungi through oxidative pre‐treatment aiming at the degradation of toxic compounds

Journal of Chemical Technology & Biotechnology ◽

10.1002/jctb.6454 ◽

2020 ◽

Vol 95 (11) ◽

pp. 2943-2950

Author(s):

Cristiano E Rodrigues Reis ◽

Ana KF Carvalho ◽

Heitor BS Bento ◽

Thiago M Alves ◽

Heizir F Castro

Keyword(s):

Culture Medium ◽

Toxic Compounds ◽

Oleaginous Fungi ◽

Pre Treatment ◽

Sugarcane Vinasse

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The Escherichia coli Regulator of Sigma 70 Protein, Rsd, Can Up-Regulate Some Stress-Dependent Promoters by Sequestering Sigma 70

Journal of Bacteriology ◽

10.1128/jb.00019-07 ◽

2007 ◽

Vol 189 (9) ◽

pp. 3489-3495 ◽

Cited By ~ 30

Author(s):

Jennie E. Mitchell ◽

Taku Oshima ◽

Sarah E. Piper ◽

Christine L. Webster ◽

Lars F. Westblade ◽

...

Keyword(s):

Escherichia Coli ◽

Rna Polymerase ◽

Hybrid System ◽

Transcriptome Analysis ◽

Biological Role ◽

Stress Dependent ◽

Sigma 70 ◽

Two Hybrid ◽

Stimulation Of

ABSTRACT The Escherichia coli Rsd protein forms complexes with the RNA polymerase σ70 factor, but its biological role is not understood. Transcriptome analysis shows that overexpression of Rsd causes increased expression from some promoters whose expression depends on the alternative σ38 factor, and this was confirmed by experiments with lac fusions at selected promoters. The LP18 substitution in Rsd increases the Rsd-dependent stimulation of these promoter-lac fusions. Analysis with a bacterial two-hybrid system shows that the LP18 substitution in Rsd increases its interaction with σ70. Our experiments support a model in which the role of Rsd is primarily to sequester σ70, thereby increasing the levels of RNA polymerase containing the alternative σ38 factor.

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Ovine corticotrophin-releasing factor in dogs: dose-response relationships and effects of dexamethasone

Acta Endocrinologica ◽

10.1530/acta.0.1120012 ◽

1986 ◽

Vol 112 (1) ◽

pp. 12-19 ◽

Cited By ~ 8

Author(s):

R.J. Kemppainen ◽

D. V. Filer ◽

J. L. Sartin ◽

R. B. Reed

Keyword(s):

Dose Response ◽

Plasma Cortisol ◽

Peak Plasma ◽

Cortisol Response ◽

Corticotrophin Releasing Factor ◽

Pre Treatment ◽

The Relationship ◽

Dose Dependent ◽

Response Area ◽

Stimulation Of

Abstract. Dose-response relationships between iv bolus injections (0, 0.1, 1 or 10 μg/kg) of synthetic ovine corticotropin-releasing factor (oCRF) and plasma immunoreactive (i) ACTH and cortisol concentrations were examined in healthy, conscious dogs. All doses of oCRF resulted in elevated plasma iACTH and cortisol levels over those of the controls. Maximum (or Peak) plasma iACTH concentrations were generally observed 20–30 min after oCRF and the magnitude of these peaks was a linear function (P<0.001) of the logarithm of the oCRF dose. The time of peak cortisol concentrations was more variable but the peak cortisol level was also linearly related (P< 0.001) to the logarithm of the oCRF dose. An estimate for the response areas for both hormones demonstrated a quadratic (P < 0.05) relationship with the logarithm of the oCRF dose. The relationship between oCRF and the iACTH response suggested a progressively greater response at increasing oCRF doses while a maximally effective oCRF dose was predicted in the cortisol response area relationship. Graded (0, 0.01, 0.1 or 1 mg/kg) bolus doses of dexamethasone produced a dose-dependent (P < 0.03) decline in baseline plasma iACTH levels and a non-dosedependent suppression in baseline plasma cortisol. Pre-treatment with 0.001 mg dexamethasone/kg 4 or 8 h before injection of 1 μg oCRF/kg did not alter the plasma iACTH or cortisol response; however, 0.1 mg dexarhethasone/kg administered at these times totally abolished the responses to oCRF. An intermediate dose (0.01 mg/kg) of dexamethasone inhibited the plasma iACTH response by an average of 79% (P<0.01) when administered 4 h before oCRF, but did not significantly alter this response when given 8 h prior to oCRF. The plasma cortisol response to oCRF was inhibited (P < 0.01) when 0.01 mg dexamethasone/kg was given as a 4 h, but not as a 8 h, pre-treatment. Iv administration of oCRF produces a profound, dose-dependent stimulation of the pituitary-adrenocortical axis of dogs and should prove useful in studies of this system.

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An Inhibition Study of the Effect of Azo Dyes on Bioactivity of Biofilms

Water Science & Technology ◽

10.2166/wst.1994.0363 ◽

1994 ◽

Vol 29 (7) ◽

pp. 365-372 ◽

Cited By ~ 6

Author(s):

Yun-Chang Fu ◽

Hongshen Jiang ◽

Paul Bishop

Keyword(s):

Energy Source ◽

Carbon Source ◽

Respiration Rate ◽

Azo Dyes ◽

The Other ◽

Inhibition Study ◽

Toxic Compounds ◽

Low Concentration ◽

Primary Substrate ◽

Stimulation Of

An inhibition study showed that toxic compounds caused two responses when present at low concentration. One is stimulation of the biomass by simply serving as an energy source; this caused an increase in the total respiration rate. The other is inhibition of the reaction. AR14 was more toxic than AO7 for biofilm from reactors fed with a primary substrate. However, AO7 demonstrated inhibition for biofilm from reactors fed with AR14 and primary substrate, and AR14 could serve as a carbon source for the same film.

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Potentiation of prostaglandin E2-induced release of LH by the prostaglandin analogue, 7-oxa-13-prostynoic acid

Acta Endocrinologica ◽

10.1530/acta.0.0970297 ◽

1981 ◽

Vol 97 (3) ◽

pp. 297-304

Author(s):

Jørgen Warberg

Keyword(s):

Binding Site ◽

Hormone Secretion ◽

Male Rats ◽

Stimulatory Action ◽

Minimal Effective Dose ◽

Lh Release ◽

Pre Treatment ◽

Intraventricular Infusion ◽

The Brain ◽

Stimulation Of

Abstract. The prostaglandin (PG) analogue 7-oxa-13-prostynoic acid (7-OPA) was infused into a lateral ventricle of the brain of adult male rats and the effect of the analogue on a subsequent stimulation of LH release by intraventricular infusion of PG's was determined. Pre-treatment of the animals with 44–132 μg of 7-OPA potentiated the stimulatory effect of 2 μg PGE2 on the release of LH but the analogue alone had no effect on the hormone secretion. The minimal effective dose of PGE2 was determined to be within the range 0.01–0.05 μg and it was found that priming with 132 μg of 7-OPA caused a formerly sub-threshold dose (0.01 μg) of PGE2 to become an effective stimulus for the release of LH. In contrast to its potentiating effect on PGE2-induced LH release 7-OPA did not alter the stimulatory action of PGF2α (2 μg) on the secretion of LH. 7-OPA had no effect on LRH-induced release of LH indicating that the PG analogue acts at a suprapituitary site to enhance PGE2-induced LH release. The potentiating effect of 7-OPA may be exerted at a binding site for PGE2 in the brain and the results suggest the existence of a different binding site for PGF2α. The possibility also exists that 7-OPA inhibit metabolic inactivation of PGE2.

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