Su.2. Porphyromonas Gingivalis, Serum Anti-P. gingivalis Antibodies and C-Reactive Protein Levels in Pregnant Women with Periodontitis

2008 ◽  
Vol 127 ◽  
pp. S124-S125 ◽  
Author(s):  
Alexander Abdelnoor ◽  
Nada Souccar ◽  
Marita Chakhtoura ◽  
Joseph Ghafari
2010 ◽  
Vol 4 (06) ◽  
pp. 362-366 ◽  
Author(s):  
Nada M. Souccar ◽  
Marita Chakhtoura ◽  
Joseph G. Ghafari ◽  
Alexander Michael Abdelnoor

Background: The periodontopathogen Porphyromonas gingivalis (Pg) has been reported as a risk factor for preterm labour. Its pathogenesis and role in pregnancy have not been investigated in Lebanon. Elevated C-reactive protein (CRP) levels in pregnant women with periodontitis also appear to mediate preterm labour. Methodology: The study included 20 pregnant women with periodontitis and 20 with normal periodontium. PCR was done for Pg detection in oral plaque and vaginal samples. Serum CRP levels were determined by ELISA. Results: Pg was detected in the oral plaque of 13 of 20 pregnant subjects with clinical periodontitis (patients) and 2 of 20 controls with a healthy periodontium. Vaginal swabs were all Pg-negative, ruling out systemic infection. Serum CRP levels were elevated in 12 of 20 patients and 8 of 20 controls. None of the participants experienced preterm labour. Conclusions: This is the first report that implicates Pg in Lebanese periodontitis patients. Preliminary results do not indicate a relationship among Pg, periodontitis, CRP levels and preterm labour.


2005 ◽  
Vol 206 (4) ◽  
pp. 341-345 ◽  
Author(s):  
Simin Rota ◽  
Basak Yildirim ◽  
Babür Kaleli ◽  
Hülya Aybek ◽  
Koray Duman ◽  
...  

Author(s):  
C. N. Nwadike ◽  
A. A. Eze ◽  
C. I. Nosiri ◽  
A. S. Ezekwe ◽  
M. T. Anyagwa ◽  
...  

Aims: The present study investigated levels of trace elements, antioxidants, uric acid, C-reactive proteins and estrogen in preeclamptic pregnant women in Owerri, Imo State, Nigeria using patients from Federal Medical Centre (FMC) and specialists Hospital in Owerri, Nigeria. Study Design: A total of 350 pregnant women between the ages of 20-40 years from two known hospitals in Owerri were examined for the study. The examined pregnant women were group into 160 normotensive pregnant women as control and 190 preeclamptic pregnant women. Results and Discussion: Results obtained for serum trace elements revealed significant decrease (p<0.05) in preeclamptic pregnant women against normotensive pregnant women. Antioxidant vitamins C and E; and estrogen significantly decreased (p<0.05) in preeclamptic pregnant women against normotensive pregnant women. Uric acid and C-reactive protein levels increased in preeclamptic pregnant women against normotensive pregnant women. The decrease in trace elements could be linked to development of preeclampsia since some of these trace elements perform antioxidant function. Increased antioxidant activity and lipid peroxidation could be behind the reduced levels of vitamins C and E, and estrogen in preeclamptic pregnant women against normotensive pregnant women. Conclusion: This study has revealed the trace elements, antioxidants, uric acid, C-reactive proteins, and estrogen levels of preeclamptic pregnant women in Owerri, Nigeria. 


2018 ◽  
Vol 2 ◽  
pp. 3-8
Author(s):  
Natalia Bondarenko

The aim of the research was analyze of C-reactive protein levels in serum blood samples during various periods of pregnancy in women, infected with parvovirus B19 and in case of presence of clinical complications. 129 pregnant women, infected with parvovirus B19 infection and 16 women with physiological pregnancy during first, second and third trimesters of pregnancy were examined. Depending on the presence or absence of clinical complications each group of pregnant women (I, II, III) was divided into two subgroups. The concentration of C-reactive protein in blood serum was determined by the method of immunoassay analysis using diagnostic sets of reagents (ELISA kits, USA). Statistical processing of data was carried out using the package of applied programs Microsoft Office Excel 2010 and StatSoft Statistica 6.1. The mean age of pregnant woman in our study was 26±6 years. In the Iand II groups of infected B19 parvovirus pregnant women were identified a significant increasing of C-reactive protein levels compared to controls by 62.5 % and 50.0 % (p<0.05). The largest increasing of C-reactive protein level relative to control values was observed in women with clinical complications in different pregnancy periods (p<0.05). An increase levels of the marker of systemic inflammation the C-reactive protein in the blood testifies to its active participation in the launch of a complex mechanism for the development of labor activity and the occurrence of fetal disorders, which was confirmed in groups of pregnant women with clinical complications in different periods of pregnancy.


VASA ◽  
2015 ◽  
Vol 44 (3) ◽  
pp. 0187-0194 ◽  
Author(s):  
Xiaoni Chang ◽  
Jun Feng ◽  
Litao Ruan ◽  
Jing Shang ◽  
Yanqiu Yang ◽  
...  

Background: Neovascularization is one of the most important risk factors for unstable plaque. This study was designed to correlate plaque thickness, artery stenosis and levels of serum C-reactive protein with the degree of intraplaque enhancement determined by contrast-enhanced ultrasound. Patients and methods: Contrast-enhanced ultrasound was performed on 72 carotid atherosclerotic plaques in 48 patients. Contrast enhancement within the plaque was categorized as grade 1, 2 or 3. Maximum plaque thickness was measured in short-axis view. Carotid artery stenosis was categorized as mild, moderate or severe. Results: Plaque contrast enhancement was not associated with the degree of artery stenosis or with plaque thickness. Serum C-reactive protein levels were positively correlated with the number of new vessels in the plaque. C-reactive protein levels increased in the three groups(Grade 1: 3.72±1.79mg/L; Grade 2: 7.88±4.24 mg/L; Grade 3: 11.02±3.52 mg/L), with significant differences among them (F=10.14, P<0.01), and significant differences between each two groups (P<0.05). Spearman’s rank correlation analysis showed that serum C-reactive protein levels were positively correlated with the degree of carotid plaque enhancement (Rs =0.69, P<0.01). Conclusions: The combination of C-reactive protein levels and intraplaque neovascularization detected by contrast-enhanced ultrasound may allow more accurate evaluation of plaque stability.


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