scholarly journals Commensal bacterial metabolites may strengthen the effect of anti-IL6 treatment for COVID-19

2021 ◽  
pp. 108870
Author(s):  
Jiezhong Chen ◽  
Luis Vitetta
Keyword(s):  
Bacterial Metabolites

Determination of microbiological activity during the processing of frost damaged sugar beets

2014 ◽  
pp. 228-231 ◽  
Author(s):  
Maciej Wojtczak ◽  
Aneta Antczak-Chrobot ◽  
Edyta Chmal-Fudali ◽  
Agnieszka Papiewska
Keyword(s):  
Sugar Beet ◽  
Microbiological Activity ◽  
Microbiological Contamination ◽  
Sugar Beets ◽  
Bacterial Metabolites ◽  
Kinetics Of

The aim of the study is to evaluate the kinetics of the synthesis of dextran and other bacterial metabolites as markers of microbiological contamination of sugar beet.

scholarly journals Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19

2021 ◽  
Vol 10 (13) ◽  
pp. 2903
Author(s):  
Jiezhong Chen ◽  
Luis Vitetta
Keyword(s):  
Clinical Trials ◽  
Trace Elements ◽  
Gut Microbiota ◽  
Human Health ◽  
Intestinal Microbiota ◽  
Narrative Review ◽  
Bacterial Metabolites ◽  
Gut Dysbiosis ◽  
Prevention And Treatment

The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is associated with severe COVID-19. Therefore, the modulation of gut microbiota and supplementation of commensal bacterial metabolites could reduce the severity of COVID-19. Many approaches have been studied to improve gut microbiota in COVID-19 including probiotics, bacterial metabolites, and prebiotics, as well as nutraceuticals and trace elements. So far, 19 clinical trials for testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are ongoing. In this narrative review, we summarize the effects of various approaches on the prevention and treatment of COVID-19 and discuss associated mechanisms.

scholarly journals Chemical Elicitors Induce Rare Bioactive Secondary Metabolites in Deep-Sea Bacteria under Laboratory Conditions

Metabolites ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 107
Author(s):  
Rafael de Felício ◽  
Patricia Ballone ◽  
Cristina Freitas Bazzano ◽  
Luiz F. G. Alves ◽  
Renata Sigrist ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Natural Product ◽  
Deep Sea ◽  
Chemical Space ◽  
Bacterial Genome ◽  
Vast Number ◽  
Bacterial Metabolites ◽  
Laboratory Conditions ◽  
Deep Sea Bacteria

Bacterial genome sequencing has revealed a vast number of novel biosynthetic gene clusters (BGC) with potential to produce bioactive natural products. However, the biosynthesis of secondary metabolites by bacteria is often silenced under laboratory conditions, limiting the controlled expression of natural products. Here we describe an integrated methodology for the construction and screening of an elicited and pre-fractionated library of marine bacteria. In this pilot study, chemical elicitors were evaluated to mimic the natural environment and to induce the expression of cryptic BGCs in deep-sea bacteria. By integrating high-resolution untargeted metabolomics with cheminformatics analyses, it was possible to visualize, mine, identify and map the chemical and biological space of the elicited bacterial metabolites. The results show that elicited bacterial metabolites correspond to ~45% of the compounds produced under laboratory conditions. In addition, the elicited chemical space is novel (~70% of the elicited compounds) or concentrated in the chemical space of drugs. Fractionation of the crude extracts further evidenced minor compounds (~90% of the collection) and the detection of biological activity. This pilot work pinpoints strategies for constructing and evaluating chemically diverse bacterial natural product libraries towards the identification of novel bacterial metabolites in natural product-based drug discovery pipelines.

scholarly journals The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases

Gut Microbes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1-22
Author(s):  
F. Hosseinkhani ◽  
A. Heinken ◽  
I. Thiele ◽  
P. W. Lindenburg ◽  
A. C. Harms ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Communicable Diseases ◽  
Immune Signaling ◽  
Non Communicable Diseases ◽  
Bacterial Metabolites ◽  
Immune Signaling Pathway ◽  
Human Immune

scholarly journals Colonic bacterial metabolites and human health

2013 ◽  
Vol 16 (3) ◽  
pp. 246-254 ◽  
Author(s):  
Wendy R Russell ◽  
Lesley Hoyles ◽  
Harry J Flint ◽  
Marc-Emmanuel Dumas
Keyword(s):  
Human Health ◽  
Bacterial Metabolites

scholarly journals Phospholipase A2Inhibitors Synthesized by Two Entomopathogenic Bacteria, Xenorhabdus nematophila and Photorhabdus temperata subsp. temperata

2012 ◽  
Vol 78 (11) ◽  
pp. 3816-3823 ◽  
Author(s):  
Samyeol Seo ◽  
Sunghong Lee ◽  
Yongpyo Hong ◽  
Yonggyun Kim
Keyword(s):  
Immune Responses ◽  
Diamondback Moth ◽  
Culture Broth ◽  
Xenorhabdus Nematophila ◽  
Phenoloxidase Activity ◽  
Bacterial Metabolites ◽  
Content Type ◽  
Entomopathogenic Bacteria ◽  
Inhibitory Activities ◽  
Photorhabdus Temperata

ABSTRACTThe entomopathogenic bacteriaXenorhabdus nematophilaandPhotorhabdus temperatasubsp.temperatasuppress insect immune responses by inhibiting the catalytic activity of phospholipase A2(PLA2), which results in preventing biosynthesis of immune-mediating eicosanoids. This study identified PLA2inhibitors derived from culture broths of these two bacteria. BothX. nematophilaandP. temperatasubsp.temperataculture broths possessed significant PLA2-inhibitory activities. Fractionation of these bacterial metabolites in the culture broths using organic solvent and subsequent chromatography purified seven potent PLA2inhibitors, three of which (benzylideneacetone [BZA], proline-tyrosine [PY], and acetylated phenylalanine-glycine-valine [FGV]) were reported in a previous study. Four other compounds (indole, oxindole,cis-cyclo-PY, andp-hydroxyphenyl propionic acid) were identified and shown to significantly inhibit PLA2.X. nematophilaculture broth contained these seven compounds, whileP. temperatasubsp.temperataculture broth contained three compounds (BZA, acetylated FGV, andcis-cyclo-PY). BZA was detected in the largest amount among these PLA2compounds in both bacterial culture broths. All seven bacterial metabolites also showed significant inhibitory activities against immune responses, such as phenoloxidase activity and hemocytic nodulation; BZA was the most potent. Finally, this study characterized these seven compounds for their insecticidal activities against the diamondback moth,Plutella xylostella. Even though these compounds showed relatively low toxicities to larvae, they significantly enhanced the pathogenicity ofBacillus thuringiensis. This study reports bacterial-origin PLA2inhibitors, which would be applicable for developing novel insecticides.

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