Elevated C-reactive protein in acute coronary syndrome presentation is an independent predictor of long-term mortality and heart failure

2007 ◽  
Vol 40 (5-6) ◽  
pp. 326-329 ◽  
Author(s):  
Peter A. Kavsak ◽  
Andrew R. MacRae ◽  
Alice M. Newman ◽  
Viliam Lustig ◽  
Glenn E. Palomaki ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Coronary Syndrome ◽  
Independent Predictor ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coronary Syndrome ◽  
Long Term Mortality

scholarly journals Correlation of Hemoglobin & C-Reactive Protein Levels with In-hospital Outcome of Patient with Acute Coronary Syndrome

2020 ◽  
Vol 17 (1) ◽  
pp. 3-8
Author(s):  
Md Mahboob Morshed ◽  
Md Joynul Islam ◽  
Fariha Haseen ◽  
Khandokar Shaheed Hussain ◽  
Muhammad Kamrul Amin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Acute Coronary Syndrome ◽  
Family History ◽  
C Reactive Protein ◽  
Hospital Outcome ◽  
Reactive Protein ◽  
Coronary Syndrome ◽  
History Of ◽  
Study Population

Background: Haemoglobina and CRP level may be related with the in-hospital outcome of acute coronary syndrome patients. Objective: The purpose of the present study was to correlate haemoglobin and CRP level with in-hospital outcome of patient with acute coronary syndrome. Methodology: This cross-sectional study was conducted in the Department of Cardiology at Mymensingh Medical College, Mymensingh, Bangladesh from December 2010 to November 2011 for a period of two (02) years. Patients of ACS who were presented within 12 hours of chest pain were included as study population. Study population were categorized in four groups according to the level of hemoglobin and C-reactive protein. Blood sample was collected for baseline laboratory investigations. Result: The mean age of the population was 52.18±8.88 years. Arrhythmia was more common in Group 1 which was 5(71.4%) cases and 6(46.2%) cases in VT and AF respectively. Arrhythmia was significantly correlated with age, sex, diabetes mellitus & CRP. Death was significantly correlated with age, diabetes mellitus, hypertension & CRP. Heart failure was significantly correlated with family history of IHD, CRP & Hemoglobin. Bleeding was only significantly correlated with CRP. No significant association was revealed between the types of arrhythmia and age, sex, smoking, diabetes, dyslipidaemia, family history of IHD and hypertension (P = 0.087). Only heart failure was strongly and significantly correlated with hemoglobin level (p=0.000). Bleeding (p=0.003), heart failure (p=0.022) and death (p=0.016) were significantly correlated with CRP level. Conclusion: In conclusion there is a correlation of haemoglobin and CRP level with in-hospital outcome of patient with acute coronary syndrome. Journal of Science Foundation 2019;17(1):3-8

Prognostic Factors and Outcomes in Young Patients With Presented of Different Types Acute Coronary Syndrome

Angiology ◽  
2020 ◽  
Vol 71 (10) ◽  
pp. 894-902
Author(s):  
Sabiye Yılmaz ◽  
Kahraman Coşansu
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Acute Coronary Syndrome ◽  
Hospital Mortality ◽  
Young Patients ◽  
Hospital Death ◽  
Coronary Syndrome ◽  
Different Types ◽  
Long Term Mortality

The prevalence of coronary artery disease is increasing in young adults. We evaluated the outcomes of different types of acute coronary syndrome in 917 patients undergoing coronary angiography aged ≤45 years. Male sex, smoking, dyslipidemia were the most important risk factors. ST-elevation myocardial infarction (STEMI; 54.8%) predominated. The STEMI patients had higher risk of hospital mortality (3.6% vs 0.6%; P = .004) and major adverse cardiac and cerebrovascular events (MACCE; 13.8% vs 3.3%; P < .001, hazard ratio [HR], 4.65; 95% CI, 2.45-8.82). Presentation heart rate, blood pressure, heart failure, shock, arrhythmia, ejection fraction (EF), diabetes, contrast-induced nephropathy (CIN), and elevated troponin were associated with hospital mortality and MACCE. But only heart failure (HR, 5.816; 95% CI, 2.254-15.008) and CIN (HR, 6.241; 95% CI, 2.340-16.641) were independent risk factors for hospital MACCE. There was no difference in long-term mortality between the 2 groups, but non-STEMI patients had higher risk for MACCE after 3 years (14.4% vs 9.9%, P = .033). Although shock (HR, 0.814; 95% CI, 0.699-0.930), Killip class ≥2 (HR, 0.121; 95% CI, 0.071-0.170), CIN (HR, 0.323; 95% CI, 0.265-0.380), and EF (HR, 0.917; 95% CI, 0.854-0.984) were independent predictors of hospital death, only EF was the independent predictor of long-term mortality (HR, 0.897; 95% CI, 0.852-0.944).

High and low dose atorvastatin effects on high sensivity C-reactive protein in patient with acute coronary syndrome

2017 ◽  
Vol 21 (4) ◽  
pp. 218-224 ◽  
Author(s):  
Ahmadnoor Abdi ◽  
◽  
Shafei Rahimi ◽  
Hossein Farshidi ◽  
Vahid VahdatKhah ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Low Dose ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coronary Syndrome

Brain-derived neurotrophic factor is associated with coronary macrophage infiltrates in patients with acute coronary syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R.A Montone ◽  
M Camilli ◽  
M Russo ◽  
M Del Buono ◽  
F Gurguglione ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Neurotrophic Factor ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
C Reactive Protein ◽  
St Segment Elevation ◽  
Protein Levels ◽  
Reactive Protein ◽  
Coronary Syndrome ◽  
St Segment

Abstract Background Brain-derived neurotrophic factor (BDNF) is a neurotrophine that plays a key role in the regulation of both central and peripheral nervous system. Moreover, BDNF is secreted in multiple tissues and exerts systemic, autocrine, and paracrine effects in the cardiovascular system. Of importance, BDNF expression was enhanced in macrophages and smooth muscle cells in atherosclerotic coronary arteries and may be involved in thrombus formation. Thus, BDNF has been suggested as an important link between inflammation and thrombosis, potentially involved in the pathogenesis of acute coronary syndrome (ACS). Purpose In our study we aimed at assessing serum levels of BDNF in patients with ACS, evaluating differences according to clinical presentation [ST-segment elevation myocardial infarction (STEMI) vs. Non-ST-segment elevation ACS (NSTE-ACS)]. Moreover, we assessed the presence of optical coherence (OCT)-defined macrophage infiltrates (MØI) in the culprit vessel of ACS patients and evaluated their relationship with BDNF levels. Methods ACS patients were prospectively selected. Blood samples were collected at admission and serum levels of BDNF were subsequently assessed. Presence of OCT-defined MØI along the culprit vessel was assessed. Results 166 ACS patients were enrolled [mean age 65.3±11.9 years, 125 (75.3%) male, 109 STEMI, 57 NSTE-ACS]. Serum levels of BDNF were higher among STEMI patients compared with NSTE-ACS [median (IQR) 2.48 pg/mL (1.54–3.34) vs. 2.12 pg/mL (1.34–2.47), p=0.007], while C-reactive protein levels did not differ between the two groups. OCT assessment was performed in 53 patients and MØI were detected in 27 patients. Of importance, patients with MØI in the culprit vessel had higher levels of BDNF compared with patients without MØI [median (IQR) 2.23 pg/mL (1.38–2.53) vs. 1.41 pg/mL (0.93–2.07), p=0.023], while C-reactive protein levels did not differ between the two groups. Of note, at multivariate regression analysis BDNF levels were independent predictor of MØI [OR: 2.20; 95% CI (1.02–4.74), p=0.043]. Conclusions Serum levels of BDNF may reliable identify the presence of local macrophage inflammatory infiltrates in patients with ACS. Moreover, BDNF levels are higher in patients with STEMI compared with NSTE-ACS. Taken together, these data suggest that BDNF may represent an interesting link between local inflammatory activation and enhanced thrombosis in ACS. BDNF serum levels Funding Acknowledgement Type of funding source: None

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