Potential impact of clinical use of noninvasive FFRCT on radiation dose exposure and downstream clinical event rate

2016 ◽  
Vol 40 (5) ◽  
pp. 1055-1060 ◽  
Author(s):  
Nicolas Bilbey ◽  
Philipp Blanke ◽  
Christopher Naoum ◽  
Chesnel Dey Arepalli ◽  
Bjarne Linde Norgaard ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Event Rate ◽  
Clinical Event ◽  
Clinical Use ◽  
Radiation Dose Exposure ◽  
Potential Impact

scholarly journals POTENTIAL IMPACT OF NON-INVASIVE FFRCT ON RADIATION DOSE EXPOSURE AND DOWNSTREAM CLINICAL EVENT RATE

2015 ◽  
Vol 65 (10) ◽  
pp. A1126
Author(s):  
Nicolas Bilbey ◽  
Philipp Blanke ◽  
Chesnal Arepalli ◽  
James Min ◽  
Bjarne Norgaard ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Event Rate ◽  
Clinical Event ◽  
Non Invasive ◽  
Radiation Dose Exposure ◽  
Potential Impact

Vorklinische Untersuchung zur Organverteilung und Strahlenbelastung von Radiojod-Jodlisurid

1991 ◽  
Vol 30 (04) ◽  
pp. 137-140
Author(s):  
H. Flade ◽  
B. Johannsen ◽  
V. Pink ◽  
U. Herold ◽  
R. Harhammer ◽  
...  
Keyword(s):  
Radiation Dose ◽  
The Body ◽  
Organ Distribution ◽  
Clinical Use ◽  
Isolated Organs

The distribution in rats of 125l-iodolisuride was studied. Three rats each were sacrificed at fixed intervals between 5 min and 24 h p. i., and the radioactivity was measured in isolated organs and parts of the body. The organ distribution and biexponential blood disappearance were similar to values for unlabeled lisuride. The radiation dose was estimated for man assuming a 123l label. The resulting doses were comparable to those from other radiopharmaceuticals in clinical use.

scholarly journals Low-Dose Computed Tomography for the Optimization of Radiation Dose Exposure in Patients with Crohn’s Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Richard G. Kavanagh ◽  
John O’Grady ◽  
Brian W. Carey ◽  
Patrick D. McLaughlin ◽  
Siobhan B. O’Neill ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Crohn’S Disease ◽  
Image Quality ◽  
Crohn's Disease ◽  
Radiation Dose ◽  
Ionizing Radiation ◽  
Low Dose ◽  
Radiation Doses ◽  
Radiation Dose Exposure ◽  
Ct Technology

Magnetic resonance imaging (MRI) is the mainstay method for the radiological imaging of the small bowel in patients with inflammatory bowel disease without the use of ionizing radiation. There are circumstances where imaging using ionizing radiation is required, particularly in the acute setting. This usually takes the form of computed tomography (CT). There has been a significant increase in the utilization of computed tomography (CT) for patients with Crohn’s disease as patients are frequently diagnosed at a relatively young age and require repeated imaging. Between seven and eleven percent of patients with IBD are exposed to high cumulative effective radiation doses (CEDs) (>35–75 mSv), mostly patients with Crohn’s disease (Newnham E 2007, Levi Z 2009, Hou JK 2014, Estay C 2015). This is primarily due to the more widespread and repeated use of CT, which accounts for 77% of radiation dose exposure amongst patients with Crohn’s disease (Desmond et al., 2008). Reports of the projected cancer risks from the increasing CT use (Berrington et al., 2007) have led to increased patient awareness regarding the potential health risks from ionizing radiation (Coakley et al., 2011). Our responsibilities as physicians caring for these patients include education regarding radiation risk and, when an investigation that utilizes ionizing radiation is required, to keep radiation doses as low as reasonably achievable: the “ALARA” principle. Recent advances in CT technology have facilitated substantial radiation dose reductions in many clinical settings, and several studies have demonstrated significantly decreased radiation doses in Crohn’s disease patients while maintaining diagnostic image quality. However, there is a balance to be struck between reducing radiation exposure and maintaining satisfactory image quality; if radiation dose is reduced excessively, the resulting CT images can be of poor quality and may be nondiagnostic. In this paper, we summarize the available evidence related to imaging of Crohn’s disease, radiation exposure, and risk, and we report recent advances in low-dose CT technology that have particular relevance.

scholarly journals Strategy of IFCC standardization and use of cardiac markers in acute coronary syndromes

2003 ◽  
Vol 22 (4) ◽  
pp. 303-309 ◽  
Author(s):  
Svetlana Ignjatovic
Keyword(s):  
Cardiac Troponin ◽  
Acute Coronary Syndromes ◽  
Clinical Chemistry ◽  
Clinical Event ◽  
Control Group ◽  
Clinical Use ◽  
Cardiac Damage ◽  
Creatine Kinase Mb ◽  
Coronary Syndromes ◽  
Definition Of

Although the use of troponin to diagnose acute myocardial infarction (AMI) has been previously proposed, the Committee on Standardization of Markers of Cardiac Damage (C-SMCD) of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) made a recommendation in 1999 to expand on the enzyme diagnostic criteria for AMI to include cardiac-specific proteins. In September 2000, a joint committee of the European Society of Cardiology and the American College of Cardiology (ESC/ACC) published a new definition of AMI that for first time officially included troponin. According to these criteria, as the best biochemical indicator for detecting myocardial necrosis is "a concentration of cardiac troponin exceeding the decision limit (defined as the 99th percentile of a reference control group) on at least one occasion during the first 24 hours after the onset of clinical event". The use of creatine kinase MB (CK-MB), measured by mass assays, is still considered as an acceptable alternative only if cardiac troponin assays are not available. It is very important to standardize the clinical use of troponin in diagnosis and management of acute coronary syndromes and to clearly define decision thresholds. Two strategies have competed as the most appropriate for the use of new markers. The first relies on the use of a combination of two markers - a rapid rising marker such as myoglobin, and a marker that takes longer to rise but is more specific, such as cardiac troponin - to enable detection of AMI in patients who present early and late after symptom onset. In the second strategy, only measurement of cardiac troponin is suggested. One of the most important problems in the practical use of the cardiac-specific troponin is the right definition of decision limits. As diagnostic cut-off for clinical use, the IFCC C-SMCD recommends for troponin assays a total imprecision, expressed as coefficient of variation (CV), of <10% at the 99th percentile of a reference control group. For troponin assays that cannot presently meet the 10% CV at the 99th percentile value, a predetermined higher concentration that meets this imprecision goal should be used as cut-off for AMI until the goal of a 10% CV can be achieved at the 99th percentile. It is very important that clinically relevant biomarker, such as cardiac troponin, on which critical decisions will rest, can be measured with highly reliable and standardized methods. There are problems in assay standardization, imprecision interference, and of pre-analytical variability. Cardiac troponin is currently the most sensitive and specific biochemical marker of myocardial damage and is the best marker for diagnosis, risk stratification, and guidance of therapy in acute coronary syndromes.

Clinical Use of CT Colonography for Colorectal Cancer Screening in Military Training Facilities and Potential Impact on HEDIS Measures

2013 ◽  
Vol 10 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Brooks D. Cash ◽  
Kathryn Stamps ◽  
Elizabeth G. McFarland ◽  
Andrew R. Spiegel ◽  
Sally W. Wade
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Ct Colonography ◽  
Military Training ◽  
Clinical Use ◽  
Potential Impact

Radiation dose exposure during cardiac and peripheral arteries catheterisation

2006 ◽  
Vol 113 (2) ◽  
pp. 283-284 ◽  
Author(s):  
D. Kocinaj ◽  
A. Cioppa ◽  
G. Ambrosini ◽  
T. Tesorio ◽  
L. Salemme ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Peripheral Arteries ◽  
Radiation Dose Exposure

scholarly journals CRT-300.05 Impact of Table Height on Radiation Dose Exposure for the Female Interventional Cardiologist

2020 ◽  
Vol 13 (4) ◽  
pp. S37
Author(s):  
Logan S. Schwarzman ◽  
David S. Tofovic ◽  
Mladen I. Vidovich
Keyword(s):  
Radiation Dose ◽  
Interventional Cardiologist ◽  
Radiation Dose Exposure
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