The interaction between prepregnancy BMI and gestational vitamin D deficiency on the risk of gestational diabetes mellitus subtypes with elevated fasting blood glucose

2020 ◽  
Vol 39 (7) ◽  
pp. 2265-2273 ◽  
Author(s):  
Bule Shao ◽  
Minjia Mo ◽  
Xing Xin ◽  
Wen Jiang ◽  
Jinhua Wu ◽  
...  
2020 ◽  
Vol 6 (5) ◽  
pp. 102-107
Author(s):  
Dr. Kiranmai G. ◽  
◽  
Dr. Bommi Indira ◽  

Background: Diabetes mellitus with the first onset in pregnancy is known as gestational diabetesmellitus (GDM) which is a common complication of pregnancy. Maternal vitamin D status has beenassociated with gestational diabetes mellitus (GDM) but the evidence is inconsistent. Duringpregnancy, this deficiency is even more critical. It appears that vitamin D insufficiency duringpregnancy may be associated with maternal hazards. Methods: This study included 200 pregnantwomen. 100 women already diagnosed with GDM were taken as cases and 100 normal pregnantwomen were taken as control. All the patients included were subjected to detailed history taking.BMI matched in cases and controls. Blood samples were taken from both cases and control ant sentfor Vitamin-D level, HbA1c, fasting blood glucose, and 2hrs postprandial glucose test. Results:Overall 78% of Indian women are vitamin D deficient in the present study. The mean maternalserum vitamin D levels were 9.25±6.07 in GDM cases and in the controls the mean is 18.11±7.86.The difference was statistically significant reflecting that the mean serum vitamin D was decreasedin women with GDM. Vitamin D levels correlated significantly with the fasting blood glucose, thefasting serum insulin, and the HbA1c levels, the P-value in all these correlations were <0.0001.Conclusions: Low maternal serum vitamin d levels were associated with gestational diabetesmellitus. There is a statistically significant negative correlation between glycemic control and vitaminD levels in serum in the whole study population.


2012 ◽  
Vol 19 (04) ◽  
pp. 462-468
Author(s):  
M. IKRAM ◽  
SYED HAIDER HASAN ALAM ◽  
SHAFQAT MUKHTAR ◽  
M. Saeed

Introduction: Gestational diabetes mellitus is common disorder in pregnancy. It is associated with adverse pregnancy outcome. There is no consensus regarding the optimal approach to screening of gestational diabetes mellitus. The present study has tried toobserve the value of fasting blood glucose in screening of gestational diabetes. Objective: To determine the frequency of patients in whomfasting blood glucose and 100gm glucose tolerance show agreement for screening of gestational diabetes mellitus at 24 -28 wks. Studydesign: Comparative cross sectional study. Settings: The study was conducted at Gynecology and Obstetrics department Shaikh ZayedFederal Post Graduate Institute Lahore. Duration of study with dates: 6 months from 12Nov 2010 to 11 May 2011. Material and method: Thestudy included 135 booked patients with positive family history of diabetes mellitus. All patients underwent fasting blood glucose at 24-28 weeksof gestation, regardless of results of fasting blood glucose on next visit they underwent 100g oral glucose tolerance test (OGTT). The agreementbetween fasting blood glucose and 100g oral glucose tolerance test was calculated in frequency and percentages. Results: The mean age ofwomen in studied population was 27.15±3.70.Out of 135 patients 86.7 %( 117) showed agreement between results of fasting blood glucose and100g OGTT while 13.31 %( 18) showed no agreement between both of the tests. Conclusions: Fasting blood glucose is a good screeningoption for gestational diabetes mellitus along with positive history. It provides a simple, cheap and more practical test for screening of gestationaldiabetes mellitus. However diagnostic confirmation with 100g OGTT should be done.


Author(s):  
Ankita Kumari ◽  
Shaila Mitra ◽  
Harish C Tiwari ◽  
Reena Srivastav

Background: Hypovitaminosis D has been associated with a number of adverse pregnancy outcomes, and has been recognised as a public health concern. The objective of this study was to determine the impact of Vitamin D deficiency on maternal complications like gestational diabetes mellitus (GDM) and preeclampsia (PE) among pregnant women.Methods: This was a case control study undertaken at antenatal clinics and indoor of BRD Medical College, Gorakhpur, Uttar Pradesh, India. Two maternal blood samples, one at <20 weeks and other at term along with cord blood at delivery were taken. Patients were classified into preeclampsia (n=60), gestational diabetes mellitus (n=35) and control group (n=180) after abstracting past medical records at delivery. Vitamin D was estimated by 25- Hydroxyvitamin D125 RIA kit and categorized according to ACOG criteria. Statistical analysis was done by using chi square test, binary logistic regression and Pearson’s correlation coefficient to compare between two variables. P<0.05 was considered statistically significant.Results: Out of 275 women included in the study, 78% of women were Vitamin D deficient. Mean serum vitamin D was significantly lower among preeclamptic women 11.53±6.22 ng/ml and GDM women 12.62±6.69 ng/ml as compared to controls 24.25±14.44 ng/ml (median=18.2 ng/ml) (P<0.05). Vitamin D deficiency was significantly higher in pregnant women GDM (94.28% vs 68.3%) and preeclampsia (96.67% vs 68.3%) when compared to uncomplicated group.Conclusions: Maternal vitamin D deficiency is highly prevalent in early pregnancy and is significantly associated with elevated risk for GDM and preeclampsia.


2018 ◽  
Vol 9 ◽  
Author(s):  
Mansour Amraei ◽  
Safoura Mohamadpour ◽  
Kourosh Sayehmiri ◽  
Seyedeh Fatemeh Mousavi ◽  
Ehsan Shirzadpour ◽  
...  

2013 ◽  
Vol 209 (6) ◽  
pp. 560.e1-560.e8 ◽  
Author(s):  
Geum Joon Cho ◽  
Soon-Cheol Hong ◽  
Min-Jeong Oh ◽  
Hai-Joong Kim

2015 ◽  
Vol 59 (5) ◽  
pp. 448-454 ◽  
Author(s):  
Esra Bahar Gur ◽  
Muammer Karadeniz ◽  
Mine Genc ◽  
Fatma Eskicioglu ◽  
Murat Yalcin ◽  
...  

2021 ◽  
Author(s):  
chun yang ◽  
Jing Wu ◽  
Sheng Ge ◽  
Wenguang Sun

Abstract Background This study was to assess vitamin D nutritional status and risk factors among pregnancy of shanghai in China. Methods A cross-sectional study conducted in the Sixth Affiliated People’s Hospital of Shanghai Jiao Tong University. All pregnancy was measured for plasma vitamin D, total blood cholesterol (TCh), high-density lipoprotein (HDL), low-density lipoprotein (LDL) or very-low-density lipoprotein (VLDL) cholesterol and triglycerides, and completed OGTTs test. Age, height, and weight variables came from their electronic medical records. Criteria for vitamin D status were: <12 ng/ml: severe deficiency; 12–19 ng/ml: deficiency; 20–29 ng/ml: insufficiency; 30–50 ng/ml: normal; and > 50 ng/ml (particularly > 60 ng/ml): possibly leading to adverse effects. Vitamin D was measured from December 2016 to April 2017. Results Our study included 953 pregnant women. The mean vitamin D level of pregnancy was 16.06 (range 10.90 to 20.60) ng/ml,and severe vitamin D deficiency was 31.79%(303); vitamin D deficiency was 40.71 %(388); vitamin D insufficiency was 25.08%(239); normal vitamin D was 2.42%(23). Vitamin D deficiency risk factors were age over 30, parity over 2, overweight, obese, gestational diabetes mellitus, and hyperglycemia. Conclusions It is a high prevalence of vitamin D deficiency of Chinese pregnancy in shanghai. Aging more than 30 years, the parity of more than 2, overweight and obesity, gestational diabetes mellitus and hyperglycemia are risk factors for vitamin D deficiency. Public health strategies should focus on the population of pregnancy in shanghai in China.


2021 ◽  
pp. 787-792
Author(s):  
Zainab k. Hussain ◽  
Jabbar H. Yenzeel ◽  
Hayfa H. Hassani

To study the genetic effect of gestational diabetes mellitus by study IRS1gene expression in female with Gestational diabetes mellitus. It is characterized high level of blood glucose, especially during first trimester then increased during the 2nd and 3rd trimester of the pregnancy period. The blood samples taken from one hundred twenty healthy women and female with gestational diabetes mellitus in 3rd trimester period of pregnancy, level of fasting blood glucose (FBG) also HbA1c% measured to diagnose GDM, in addition to lipid profile (cholesterol, triglyceride, HDL, LDL, and VLDL), molecular study consist of RNA extraction and qRT- PCR for IRS1gene expression determination. The fasting blood glucose mg/dl and HbA1c% level was increased highly significantly (P<0.01) between patients and control (healthy women) in 3rd trimester stage in addition lipid profile included )serum cholesterol, serum triglyceride, LDL and VLDL( (mg/dl) but level of HDL (mg/dl) was decreased highly significantly (P<0.01) between patients and control. The result showed high significant of IRS1 expression gene in control (1.00 ± 0.00) while in patients (0.147 ± 0.02). The low expression of IRS1 gene was connected with gestational diabetes mellitus comparison in control (healthy women) in Iraqi female in third trimester of pregnancy


2021 ◽  
Vol 2 (2) ◽  
pp. 58-63
Author(s):  
Aasia Kanwal ◽  
Asma Salam ◽  
Aisha Bashir

Background: Gestational diabetes mellitus leads to adverse pregnancy outcomes. Objectives: The objective of the study was to explore the relationship of spontaneous abortions with gestational diabetes mellitus in pregnant women from rural and urban Lahore. Methods: This cross-sectional study was conducted at University of Health Sciences, Lahore in 2019. Among 60 pregnant women sampled, 30 had gestational diabetes mellitus (GDM) and 30 were normal pregnant controls. Pregnant women were sampled from different hospitals of rural and urban areas of Lahore. Independent sample t-test was applied for analyzing the data. Chi- square test was used to analyze the categorical variables. Association of fasting blood glucose (FBG) and abortions was checked. Odd ratio and relative risk were calculated. Results: Mean fasting blood sugar levels were significantly higher in GDM group (105 mg/dL) as compared to non-GDM group (80.50 mg/dL) at p<0.001. The proportions of the women with increased number of abortions had significantly higher blood glucose levels (OR 5.091, 95% CI, RR 1.27). Conclusions: Gestational diabetes mellitus is associated with an increased risk of spontaneous abortions.


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