Host gene expression profiling in pathogen–host interactions

2006 ◽  
Vol 18 (4) ◽  
pp. 422-429 ◽  
Author(s):  
Hamid Hossain ◽  
Svetlin Tchatalbachev ◽  
Trinad Chakraborty
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Host Gene ◽  
Host Gene Expression ◽  
Host Interactions

Host gene expression profiling of cervical smear is eligible for cancer risk evaluation

2012 ◽  
Vol 66 (4) ◽  
pp. 282-285 ◽  
Author(s):  
Olga Bourmenskaya ◽  
Ekaterina Shubina ◽  
Dmitry Trofimov ◽  
Denis Rebrikov ◽  
Elina Sabdulaeva ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Risk ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Risk Evaluation ◽  
Host Gene ◽  
Host Gene Expression ◽  
Cervical Smear

scholarly journals Host Gene Expression Profiling of Dengue Virus Infection in Cell Lines and Patients

2007 ◽  
Vol 1 (2) ◽  
pp. e86 ◽  
Author(s):  
Joshua Fink ◽  
Feng Gu ◽  
Ling Ling ◽  
Thomas Tolfvenstam ◽  
Farzad Olfat ◽  
...  
Keyword(s):  
Gene Expression ◽  
Virus Infection ◽  
Dengue Virus ◽  
Gene Expression Profiling ◽  
Cell Lines ◽  
Expression Profiling ◽  
Host Gene ◽  
Host Gene Expression ◽  
Dengue Virus Infection

scholarly journals Biological Threat Detection via Host Gene Expression Profiling

2003 ◽  
Vol 49 (7) ◽  
pp. 1045-1049 ◽  
Author(s):  
Baochuan Lin ◽  
Maryanne T Vahey ◽  
Dzung Thach ◽  
David A Stenger ◽  
Joseph J Pancrazio
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Dna Microarrays ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Host Gene ◽  
Threat Detection ◽  
Host Gene Expression ◽  
Detection Techniques

Abstract With the increased threat posed by biological weapons, detection techniques for biothreat pathogens are critically needed to monitor and assess the severity of the illness once exposure has occurred. Current approaches for detecting biological threats are either time-consuming or highly specific but provide little information regarding pathogenicity. Genotyping of pathogens by PCR provides a fast and definitive means for identifying pathogens, but reliance on pathogen genotypic endpoints has several limitations. Current progress in DNA microarrays technology provides an alternative way to address the issues faced by traditional detection systems through host gene expression profiles of peripheral blood cells. We discuss the advantages and critical issues facing the use of host gene expression profiling for biological threat detection.

scholarly journals Analysis of Tumor-Host Interactions by Gene Expression Profiling of Lung Adenocarcinoma Xenografts Identifies Genes Involved in Tumor Formation

2005 ◽  
Vol 3 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Chad J. Creighton ◽  
Jennifer L. Bromberg-White ◽  
David E. Misek ◽  
David J. Monsma ◽  
Frank Brichory ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Adenocarcinoma ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Tumor Formation ◽  
Host Interactions

scholarly journals Expression profiling of snoRNAs in normal hematopoiesis and AML

2018 ◽  
Vol 2 (2) ◽  
pp. 151-163 ◽  
Author(s):  
Wayne A. Warner ◽  
David H. Spencer ◽  
Maria Trissal ◽  
Brian S. White ◽  
Nichole Helton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alternative Splicing ◽  
Differential Expression ◽  
Expression Profiling ◽  
Host Gene ◽  
Host Gene Expression ◽  
Key Points ◽  
Specific Manner

Key Points A subset of snoRNAs is expressed in a developmental- and lineage-specific manner during human hematopoiesis. Neither host gene expression nor alternative splicing accounted for the observed differential expression of snoRNAs in a subset of AML.

scholarly journals Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

2021 ◽  
Vol 7 (6) ◽  
pp. eabe7386 ◽  
Author(s):  
Ke Zhang ◽  
Lisa Miorin ◽  
Tadashi Makio ◽  
Ishmael Dehghan ◽  
Shengyan Gao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nuclear Export ◽  
Messenger Rna ◽  
Mrna Export ◽  
Host Gene ◽  
Nuclear Pore ◽  
Host Gene Expression ◽  
Host Interactions ◽  
Inhibitory Function ◽  
Cellular Mrnas

The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted the need for understanding viral-host interactions involved in mechanisms of virulence. Here, we show that the virulence factor Nsp1 protein of SARS-CoV-2 interacts with the host messenger RNA (mRNA) export receptor heterodimer NXF1-NXT1, which is responsible for nuclear export of cellular mRNAs. Nsp1 prevents proper binding of NXF1 to mRNA export adaptors and NXF1 docking at the nuclear pore complex. As a result, a significant number of cellular mRNAs are retained in the nucleus during infection. Increased levels of NXF1 rescues the Nsp1-mediated mRNA export block and inhibits SARS-CoV-2 infection. Thus, antagonizing the Nsp1 inhibitory function on mRNA export may represent a strategy to restoring proper antiviral host gene expression in infected cells.

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