Novel cosmetic formulations containing a biosurfactant from Lactobacillus paracasei

The current study investigates the capacity of a lipolytic Lactobacillus paracasei postbiotic as a possible regulator for lipid metabolism by targeting metabolic syndrome as a possibly safer anti-obesity and Anti-dyslipidemia agent replacing atorvastatin (ATOR) and other drugs with proven or suspected health hazards. The high DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS [2,2′-azino-bis (3-ethyl benzothiazoline-6-sulphonic acid)] scavenging activity and high activities of antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-px) of the Lactobacillus paracasei postbiotic (cell-free extract), coupled with considerable lipolytic activity, may support its action against metabolic syndrome. Lactobacillus paracasei isolate was obtained from an Egyptian cheese sample, identified and used for preparing the postbiotic. The postbiotic was characterized and administered to high-fat diet (HFD) albino rats (100 and 200 mg kg−1) for nine weeks, as compared to atorvastatin (ATOR; 10 mg kg−1). The postbiotic could correct the disruption in lipid metabolism and antioxidant enzymes in HFD rats more effectively than ATOR. The two levels of the postbiotic (100 and 200 mg kg−1) reduced total serum lipids by 29% and 34% and serum triglyceride by 32–45% of the positive control level, compared to only 25% and 35% in ATOR’s case, respectively. Both ATOR and the postbiotic (200 mg kg−1) equally decreased total serum cholesterol by about 40% and 39%, while equally raising HDL levels by 28% and 30% of the positive control. The postbiotic counteracted HFD-induced body weight increases more effectively than ATOR without affecting liver and kidney functions or liver histopathology, at the optimal dose of each. The postbiotic is a safer substitute for ATOR in treating metabolic syndrome.

Download Full-text

Effect of co-encapsulation using a calcium alginate matrix and fructooligosaccharides with gelatin coating on the survival of Lactobacillus paracasei cells

Brazilian Journal of Microbiology ◽

10.1007/s42770-021-00484-5 ◽

2021 ◽

Author(s):

Rosetânia Correia Neves da Conceição ◽

Rayssa Dias Batista ◽

Fernanda Munhoz dos Anjos Leal Zimmer ◽

Ianna Kelly Martins Trindade ◽

Alex Fernando de Almeida ◽

...

Keyword(s):

Calcium Alginate ◽

Lactobacillus Paracasei ◽

Gelatin Coating ◽

Alginate Matrix

Download Full-text

Selenium nanoparticles, from Lactobacillus paracasei HM1 capable of antagonizing animal pathogenic fungi, as a new source from human breast milk

Saudi Journal of Biological Sciences ◽

10.1016/j.sjbs.2021.07.059 ◽

2021 ◽

Author(s):

Mohamed T. El-Saadony ◽

Ahmed M. Saad ◽

Taha F. Taha ◽

Azhar A. Najjar ◽

Nidal M. Zabermawi ◽

...

Keyword(s):

Breast Milk ◽

Pathogenic Fungi ◽

Lactobacillus Paracasei ◽

Selenium Nanoparticles ◽

Human Breast Milk ◽

Human Breast

Download Full-text

Transformation of Inferior Tomato into Preservative: Fermentation by Multi-Bacteriocin Producing Lactobacillus paracasei WX322

Foods ◽

10.3390/foods10061278 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1278

Author(s):

Rong Zhu ◽

Xiaoqing Liu ◽

Xiaofen Li ◽

Kaifang Zeng ◽

Lanhua Yi

Keyword(s):

Antibacterial Activity ◽

Value Added ◽

Soft Rot ◽

Bacteriocin Production ◽

Lactobacillus Paracasei ◽

Tomato Juice ◽

Vegetable Waste ◽

The Third ◽

Innovative Method ◽

Great Damage

Loss and waste of postharvest vegetables are the main challenges facing the world’s vegetable supply. In this study, an innovative method of value-added transformation was provided: production of bacteriocin from vegetable waste, and then its application to preservation of vegetables. Antibacterial activity to soft rot pathogen Pectobacterium cartovorum (Pcb BZA12) indicated that tomato performed best in the nutrition supply for bacteriocin production among 12 tested vegetables. Moreover, the antibacterial activity was from Lactobacillus paracasei WX322, not components of vegetables. During a fermentation period of 10 days in tomato juice, L. paracasei WX322 grew well and antibacterial activity reached the maximum on the tenth day. Thermostability and proteinase sensitivity of the bacteriocin from tomato juice were the same with that from Man-Rogosa-Sharpe broth. Scanning electron microscope images indicated that the bacteriocin from tomato juice caused great damage to Pcb BZA12. At the same time, the bacteriocin from tomato juice significantly reduced the rotten rate of Chinese cabbage from 100% ± 0% to 20% ± 8.16% on the third day during storage. The rotten rate decrease of cucumber, tomato, and green bean was 100% ± 0% to 0% ± 0%, 70% ± 14.14% to 13.33% ± 9.43%, and 76.67% ± 4.71% to 26.67% ± 4.71%, respectively. Bacteriocin treatment did not reduce the rotten rate of balsam pear, but alleviated its symptoms.

Download Full-text

Synthesis of Biobased Phloretin Analogues: An Access to Antioxidant and Anti-Tyrosinase Compounds for Cosmetic Applications

Antioxidants ◽

10.3390/antiox10040512 ◽

2021 ◽

Vol 10 (4) ◽

pp. 512

Author(s):

Laurène Minsat ◽

Cédric Peyrot ◽

Fanny Brunissen ◽

Jean-Hugues Renault ◽

Florent Allais

Keyword(s):

Natural Products ◽

Consumer Demand ◽

Radical Scavenging ◽

Green Process ◽

Direct Extraction ◽

Low Concentration ◽

Cosmetic Formulations ◽

Valuable Compounds ◽

The Stability

The current cosmetic and nutraceutical markets are characterized by a strong consumer demand for a return to natural products that are less harmful to both the consumers and the environment than current petrosourced products. Phloretin, a natural dihydrochalcone (DHC) found in apple, has been widely studied for many years and identified as a strong antioxidant and anti-tyrosinase ingredient for cosmetic formulations. Its low concentration in apples does not allow it to be obtained by direct extraction from biomass in large quantities to meet market volumes and prices. Moreover, its remarkable structure prevents its synthesis through a green process. To overcome these issues, the synthesis of phloretin analogs appears as an alternative to access valuable compounds that are potentially more active than phloretin itself. Under such considerations, 12 chalcones (CHs) and 12 dihydrochalcones (DHCs) were synthesized through a green Claisen–Schmidt condensation using bio-based reagents. In order to evaluate the potential of these molecules, radical scavenging DPPH and anti-tyrosinase tests have been conducted. Moreover, the UV filtering properties and the stability of these analogs towards UV-radiations have been evaluated. Some molecules showed competitive antioxidant and anti-tyrosinase activities regarding phloretin. Two compounds in particular showed EC50 lower than phloretin, one chalcone and one dihydrochalcone.

Download Full-text

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

Molecules ◽

10.3390/molecules26154429 ◽

2021 ◽

Vol 26 (15) ◽

pp. 4429

Author(s):

Anca Maria Juncan ◽

Dana Georgiana Moisă ◽

Antonello Santini ◽

Claudiu Morgovan ◽

Luca-Liviu Rus ◽

...

Keyword(s):

Hyaluronic Acid ◽

Glucuronic Acid ◽

Biological Effects ◽

Biological Processes ◽

Cosmetic Products ◽

Aesthetic Medicine ◽

Cosmetic Formulations ◽

Other Substances ◽

Bioactive Ingredients ◽

Brand Portfolio

This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used in skin regeneration, with moisturizing and anti-ageing effects. HA molecular weight influences its penetration into the skin and its biological activity. Considering that, nowadays, hyaluronic acid has a wide use and a multitude of applications (in ophthalmology, arthrology, pneumology, rhinology, aesthetic medicine, oncology, nutrition, and cosmetics), the present study describes the main aspects related to its use in cosmetology. The biological effect of HA on the skin level and its potential adverse effects are discussed. Some available cosmetic products containing HA have been identified from the brand portfolio of most known manufacturers and their composition was evaluated. Further, additional biological effects due to the other active ingredients (plant extracts, vitamins, amino acids, peptides, proteins, saccharides, probiotics, etc.) are presented, as well as a description of their possible toxic effects.

Download Full-text

Purification and characterization of a novel bacteriocin from Lactobacillus paracasei ZFM54

LWT ◽

10.1016/j.lwt.2021.111125 ◽

2021 ◽

Vol 143 ◽

pp. 111125 ◽

Cited By ~ 1

Author(s):

Pengxin Ye ◽

Jiawen Wang ◽

Manman Liu ◽

Ping Li ◽

Qing Gu

Keyword(s):

Lactobacillus Paracasei ◽

Purification And Characterization

Download Full-text