scholarly journals Multiblock metabolomics: An approach to elucidate whole-body metabolism with multiblock principal component analysis

Author(s):  
Kazuhiro Tanabe ◽  
Chihiro Hayashi ◽  
Tomoko Katahira ◽  
Katsuhiko Sasaki ◽  
Ko Igami
2021 ◽  
Vol 11 ◽  
Author(s):  
Inge Werner ◽  
Nicolai Szelenczy ◽  
Felix Wachholz ◽  
Peter Federolf

This study compared whole body kinematics of the clean movement when lifting three different loads, implementing two data analysis approaches based on principal component analysis (PCA). Nine weightlifters were equipped with 39 markers and their motion captured with 8 Vicon cameras at 100 Hz. Lifts of 60, 85, and 95% of the one repetition maximum were analyzed. The first PCA (PCAtrial) analyzed variance among time-normed waveforms compiled from subjects and trials; the second PCA (PCAposture) analyzed postural positions compiled over time, subjects and trials. Load effects were identified through repeated measures ANOVAs with Bonferroni-corrected post-hocs and through Cousineau-Morey confidence intervals. PCAtrial scores differed in the first (p < 0.016, ηp2 = 0.694) and fifth (p < 0.006, ηp2 = 0.768) principal component, suggesting that increased barbell load produced higher initial elevation, lower squat position, wider feet position after squatting, and less inclined arms. PCAposture revealed significant timing differences in all components. We conclude, first, barbell load affects specific aspects of the movement pattern of the clean; second, the PCAtrial approach is better suited for detecting deviations from a mean motion trajectory and its results are easier to interpret; the PCAposture approach reveals coordination patterns and facilitates comparisons of postural speeds and accelerations.


2010 ◽  
Vol 49 (02) ◽  
pp. 161-167
Author(s):  
R. Simoliuniene ◽  
M. Tamosiunas ◽  
V. Saferis ◽  
A. Vainoras ◽  
L. Gargasas ◽  
...  

Summary Background: Cardiac output is controlled by the autonomic nervous system by changing the heart rate and/or the contractions of the heart muscle in response to the hemodynamic needs of the whole body. Malfunction of these mechanisms causes the postural orthostatic tachycardia syndrome and/or the chronic fatigue syndrome. Evaluation of functionality and efficiency of the control mechanisms could give valuable diagnostic information in the early stages of dysfunction of the heart control systems and help to monitor the healing process in rehabilitation period after interventions. Objectives: In this study we demonstrate how P-wave changes evoked by an ortho-static test could be quantitatively evaluated by using the method based on the principal component analysis. Methods: ECG signals were recorded during an orthostatic test performed according to the typical protocol in three groups of volunteer subjects representing healthy young and older persons, part of which had transient periods of supraventricular arrhythmias. Quantitative evaluation of P-wave morphology changes was performed by means of principal component analysis-based method. Results: Principal component-based estimates showed certain variety of P-wave shape during orthostatic test, what revealed a possibility to evaluate the properties of para-sympathetic heart control. Conclusions: Quantitative evaluation of ECG P-wave changes evoked by an orthostatic test by using a newly developed method provides a quantitative estimate for functionality and efficiency of the heart rate control mechanisms. The method could be used in eHealth systems.


2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Linpei Jia ◽  
Weiguang Zhang ◽  
Rufu Jia ◽  
Hongliang Zhang ◽  
Xiangmei Chen

The biological age (BA) equation is a prediction model that utilizes an algorithm to combine various biological markers of ageing. Different from traditional concepts, the BA equation does not emphasize the importance of a golden index but focuses on using indices of vital organs to represent the senescence of whole body. This model has been used to assess the ageing process in a more precise way and may predict possible diseases better as compared with the chronological age (CA). The principal component analysis (PCA) is applied as one of the common and frequently used methods in the construction of the BA formula. Compared with other methods, PCA has its own study procedures and features. Herein we summarize the up-to-date knowledge about the BA formula construction and discuss the influential factors, so as to give an overview of BA estimate by PCA, including composition of samples, choices of test items, and selection of ageing biomarkers. We also discussed the advantages and disadvantages of PCA with reference to the construction mechanism, accuracy, and practicability of several common methods in the construction of the BA formula.


VASA ◽  
2012 ◽  
Vol 41 (5) ◽  
pp. 333-342 ◽  
Author(s):  
Kirchberger ◽  
Finger ◽  
Müller-Bühl

Background: The Intermittent Claudication Questionnaire (ICQ) is a short questionnaire for the assessment of health-related quality of life (HRQOL) in patients with intermittent claudication (IC). The objective of this study was to translate the ICQ into German and to investigate the psychometric properties of the German ICQ version in patients with IC. Patients and methods: The original English version was translated using a forward-backward method. The resulting German version was reviewed by the author of the original version and an experienced clinician. Finally, it was tested for clarity with 5 German patients with IC. A sample of 81 patients were administered the German ICQ. The sample consisted of 58.0 % male patients with a median age of 71 years and a median IC duration of 36 months. Test of feasibility included completeness of questionnaires, completion time, and ratings of clarity, length and relevance. Reliability was assessed through a retest in 13 patients at 14 days, and analysis of Cronbach’s alpha for internal consistency. Construct validity was investigated using principal component analysis. Concurrent validity was assessed by correlating the ICQ scores with the Short Form 36 Health Survey (SF-36) as well as clinical measures. Results: The ICQ was completely filled in by 73 subjects (90.1 %) with an average completion time of 6.3 minutes. Cronbach’s alpha coefficient reached 0.75. Intra-class correlation for test-retest reliability was r = 0.88. Principal component analysis resulted in a 3 factor solution. The first factor explained 51.5 of the total variation and all items had loadings of at least 0.65 on it. The ICQ was significantly associated with the SF-36 and treadmill-walking distances whereas no association was found for resting ABPI. Conclusions: The German version of the ICQ demonstrated good feasibility, satisfactory reliability and good validity. Responsiveness should be investigated in further validation studies.


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