Comparison of simple indices for measuring insulin resistance that integrates adipokines in non-diabetic obese postmenopausal women before and after weight loss: A MONET study

2018 ◽  
Vol 44 (2) ◽  
pp. 190-191
Author(s):  
C. Vatier ◽  
S. Fellahi ◽  
A.D. Karelis ◽  
M. Brochu ◽  
E. Doucet ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Postmenopausal Women ◽  
Before And After

scholarly journals The Relationship between Circulating Acetate and Human Insulin Resistance before and after Weight Loss in the DiOGenes Study

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 339
Author(s):  
Manuel A. González Hernández ◽  
Emanuel E. Canfora ◽  
Kenneth Pasmans ◽  
A. Astrup ◽  
W. H. M. Saris ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Insulin Sensitivity ◽  
Positive Association ◽  
Fat Free Mass ◽  
Model Assessment ◽  
Random Factor ◽  
Before And After ◽  
Homeostatic Model Assessment ◽  
Matsuda Index

Microbially-produced acetate has been reported to beneficially affect metabolic health through effects on satiety, energy expenditure, insulin sensitivity, and substrate utilization. Here, we investigate the association between sex-specific concentrations of acetate and insulin sensitivity/resistance indices (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), circulating insulin and Matsuda Index) in the Diet, Obesity and Genes (DiOGenes) Dietary study at baseline and after a low-calorie diet (LCD, 800 kcal/d). In this analysis, 692 subjects (Body Mass Index >27 kg/m2) were included, who underwent an LCD for 8 weeks. Linear mixed models were performed, which were adjusted for mean acetate concentration, center (random factor), age, weight loss, and fat-free mass (FFM). At baseline, no associations between plasma acetate and insulin sensitivity/resistance indices were found. We found a slight positive association between changes in acetate and changes in HOMA-IR (stdβ 0.130, p = 0.033) in women, but not in men (stdβ −0.072, p = 0.310) independently of age, weight loss and FFM. We were not able to confirm previously reported associations between acetate and insulin sensitivity in this large European cohort. The mechanisms behind the sex-specific relationship between LCD-induced changes in acetate and insulin sensitivity require further study.

scholarly journals Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Christian Hellmuth ◽  
Franca Fabiana Kirchberg ◽  
Nina Lass ◽  
Ulrike Harder ◽  
Wolfgang Peissner ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Clinical Markers ◽  
Obese Children ◽  
Intervention Programme ◽  
Before And After ◽  
Branched Chain ◽  
One Year

In obese children, hyperinsulinaemia induces adverse metabolic consequences related to the risk of cardiovascular and other disorders. Branched-chain amino acids (BCAA) and acylcarnitines (Carn), involved in amino acid (AA) degradation, were linked to obesity-associated insulin resistance, but these associations yet have not been studied longitudinally in obese children. We studied 80 obese children before and after a one-year lifestyle intervention programme inducing substantial weight loss >0.5 BMI standard deviation scores in 40 children and no weight loss in another 40 children. At baseline and after the 1-year intervention, we assessed insulin resistance (HOMA index), fasting glucose, HbA1c, 2 h glucose in an oral glucose tolerance test, AA, and Carn. BMI adjusted metabolite levels were associated with clinical markers at baseline and after intervention, and changes with the intervention period were evaluated. Only tyrosine was significantly associated with HOMA (p<0.05) at baseline and end and with change during the intervention (p<0.05). In contrast, ratios depicting BCAA metabolism were negatively associated with HOMA at baseline (p<0.05), but not in the longitudinal profiling. Stratified analysis revealed that the children with substantial weight loss drove this association. We conclude that tyrosine alterations in association with insulin resistance precede alteration in BCAA metabolism. This trial is registered with ClinicalTrials.gov IdentifierNCT00435734.

scholarly journals Association between Abdominal Fat (DXA) and Its Subcomponents (CT Scan) before and after Weight Loss in Obese Postmenopausal Women: A MONET Study

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Caroline Y. Doyon ◽  
Martin Brochu ◽  
Virginie Messier ◽  
Marie-Ève Lavoie ◽  
May Faraj ◽  
...  
Keyword(s):  
Weight Loss ◽  
Ct Scan ◽  
Postmenopausal Women ◽  
Caloric Restriction ◽  
Subcutaneous Fat ◽  
Abdominal Fat ◽  
Radiation Doses ◽  
Cross Sectional ◽  
Before And After ◽  
Cross Sectional Studies

Introduction. Subcutaneous fat (ScF) and visceral fat (VF) measurements using CT scan are expensive and may imply significant radiation doses. Cross-sectional studies using CT scan showed that ScF and VF are significantly correlated with abdominal fat measured by DXA (AF-DXA). The association has not been studied after a weight loss.Objective. To determine (1) the associations between AF-DXA and ScF and VF before and after weight loss and (2) the associations between their changes.Methods. 137 overweight/obese postmenopausal women were divided in two groups (1-caloric restriction or 2-caloric restriction + resistance training). AF was assessed using DXA and CT scan.Results. Correlations between AF-DXA and ScF (before:r=0.87, after;r=0.87;P<.01) and, AF-DXA and VF (before:r=0.61, after;r=0.69;P<.01) are not different before and after the weight loss. Correlations between delta AF-DXA and delta ScF (r=0.72;P<.01) or delta VF (r=0.51;P<.01) were found.Conclusion. The use of AF-DXA as a surrogate for VF after weight loss is questionable, but may be interesting for ScF.

scholarly journals Dietary Weight Loss and Exercise Effects on Insulin Resistance in Postmenopausal Women

2011 ◽  
Vol 41 (4) ◽  
pp. 366-375 ◽  
Author(s):  
Caitlin Mason ◽  
Karen E. Foster-Schubert ◽  
Ikuyo Imayama ◽  
Angela Kong ◽  
Liren Xiao ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Postmenopausal Women ◽  
Dietary Weight Loss

scholarly journals Markers of inflammation and insulin resistance in dogs before and after weight loss versus lean healthy dogs

2020 ◽  
Vol 40 (4) ◽  
pp. 300-305
Author(s):  
Juliana T. Jeremias ◽  
Thiago H.A. Vendramini ◽  
Roberta B.A. Rodrigues ◽  
Mariana P. Perini ◽  
Vivian Pedrinelli ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Body Fat ◽  
Peptide Yy ◽  
Body Condition Score ◽  
Weight Loss Program ◽  
Control Group ◽  
Low Grade ◽  
Markers Of Inflammation ◽  
Before And After

ABSTRACT: Chronic low-grade inflammation in obesity is characterized by an increased production of pro-inflammatory cytokines that contribute to insulin resistance. For this study body composition, markers of inflammation and of insulin resistance in dogs before and after weight loss were compared to those of lean dogs. Eleven client-owned obese adult dogs underwent a weight loss program with commercial dry food for weight loss and reached an ideal body condition score (BCS) six months after the beginning of the weight loss program. A Control Group of nine dogs with ideal BCS were selected for the comparison. Shapiro-Wilk test was used to test for normality, Mann Whitney were used for non-normally distributes data, and Student t-test was used for normally distributed parameters. In the Obese Group body fat decreased from 41.6% (30.7-58.6) to 29.1% (18.6-46.3) (P<0.01) and dogs maintained lean body mass throughout the weight loss program (P>0.05). Obese dogs presented higher concentration of fructosamine, triglycerides, insulin, IGF-1 and leptin than the Control Group before weight reduction (P<0.05). Serum concentrations of triglycerides, IL-2, IL-6, TNF-α, insulin, leptin and IGF-1 decreased after weight loss (P<0.01), and these concentrations were similar to the Control Group (P>0.05), except for leptin (P<0.001). No alteration on peptide YY was found. Leptin (r=0.60, P=0.01), fructosamine (r=0.44, P=0.02) and triglycerides (r=0.40, P=0.04) concentrations correlated with the reduction of body fat. Weight loss reduced the concentrations of inflammatory and insulin resistance markers and most parameters became similar to dogs that have always been lean, reinforcing the importance of weight loss in small animal practice.

Correlation between the rate of weight loss and changes in body composition in obese postmenopausal women after 5 weeks: a pilot study

2008 ◽  
Vol 33 (2) ◽  
pp. 347-355 ◽  
Author(s):  
Hélène Arguin ◽  
Danielle R. Bouchard ◽  
Mélissa Labonté ◽  
André Carpentier ◽  
Jean-Luc Ardilouze ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Postmenopausal Women ◽  
Weight Loss Intervention ◽  
Obese Women ◽  
X Ray ◽  
Before And After ◽  
The Impact ◽  
Current Guidelines ◽  
Similar Decrease

Approximately 25% of weight lost during restrictive diets (without exercise) is lean body mass (LBM). No study has yet investigated the impact of the rate of weight loss (RWL) on LBM and fat mass (FM). The purpose of this study was to investigate the relationships between the RWL and body composition in older obese women. Twenty obese postmenopausal women aged between 51 and 74 years enrolled in a 5 week dietary weight loss intervention. Subjects were characterized according to their RWL (low RWL < 0.74 kg·week–1 (n = 9) vs. high RWL ≥ 0.74 kg·week–1 (n = 11)). Total and trunk FM and LBM (by dual-energy X-ray absorptiometry) were measured before and after weight loss. A significant correlation was observed between the RWL (kg·week–1) and changes in LBM (kg·week–1) (r = 0.75; p = 0.0002). However, no association was observed with changes in FM (kg·week–1) (r = 0.40; p = 0.08). Both groups showed a similar decrease in FM (low RWL, –2.7 ± 0.9 kg,; high RWL, –3.2 ± 0.8 kg; p = 0.38), whereas losses in LBM were significantly higher in the high RWL than in the low RWL group (–1.6 ± 1.2 kg vs. –0.4 ± 1.1 kg; p = 0.05). An RWL > 0.74 kg·week–1 was associated with a greater loss of LBM, but had no extra benefits on FM after a 5 week weight loss program. Current guidelines, which recommend RWL up to 0.91 kg·week–1, might not be optimal to prevent decreases in LBM in postmenopausal women when no exercise is added.

scholarly journals Obesity is associated with increased basal and postprandial β-cell insulin secretion even in the absence of insulin resistance

2020 ◽  
Author(s):  
Ada Admin ◽  
Stephan van Vliet ◽  
Han-Chow E. Koh ◽  
Bruce W. Patterson ◽  
Mihoko Yoshino ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Glucose Production ◽  
Compensatory Response ◽  
Insulin Kinetics ◽  
Positron Emission ◽  
Glucose Ingestion ◽  
Before And After

We tested the hypothesis that obesity, independent of insulin resistance, is associated with increased insulin secretion. We compared insulin kinetics before and after glucose ingestion in lean healthy people and people with obesity who were matched on multi-organ insulin sensitivity (inhibition of adipose tissue lipolysis and glucose production and stimulation of muscle glucose uptake), assessed by using a two-stage hyperinsulinemic-euglycemic pancreatic clamp procedure in conjunction with glucose and palmitate tracer infusions and positron emission tomography. We also evaluated the effect of diet-induced weight loss on insulin secretion in people with obesity who did not improve insulin sensitivity despite marked (~20%) weight loss. Basal and postprandial insulin secretion rates were more than 50% greater in people with obesity than lean people even though insulin sensitivity was not different between groups. Weight loss in people with obesity decreased insulin secretion by 35% even though insulin sensitivity did not change. These results demonstrate that increased insulin secretion in people with obesity is associated with excess adiposity itself and is not simply a compensatory response to insulin resistance. These findings have important implications regarding the pathogenesis of diabetes, because hyperinsulinemia causes insulin resistance and insulin hypersecretion is an independent risk factor for developing diabetes.

scholarly journals Adipose Tissue Inflammation is Not Related to Adipose Insulin Resistance in Humans

2021 ◽  
Author(s):  
Ana Elena Espinosa De Ycaza ◽  
Esben Søndergaard ◽  
Maria Morgan-Bathke ◽  
Kelli Lytle ◽  
Danae A. Delivanis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Strong Predictor ◽  
Normal Weight ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Fat Cell ◽  
Before And After

The role of adipose tissue (AT) inflammation on AT function in humans is unclear. We tested whether AT macrophage (ATM) content, cytokine gene expression and senescent cell burden (markers of AT inflammation) predict AT insulin resistance measured as the insulin concentration that suppresses lipolysis by 50% (IC<sub>50</sub>). We studied 86 volunteers with normal weight or obesity at baseline, and a subgroup of 25 volunteers with obesity before and after weight loss. There was a strong, positive relationship between IC<sub>50 </sub>and abdominal subcutaneous and femoral fat cell size (FCS). The positive, univariate relationships between IC<sub>50 </sub>and abdominal AT inflammatory markers: CD68, CD14, CD206 ATM/100 adipocytes, senescent cells, IL-6 and TNF-α mRNA were not significant after adjustment for FCS. A 10% weight loss significantly reduced IC<sub>50</sub>, however, there was no reduction in adipose ATM content, senescent cells or cytokine gene expression. Our study suggests that commonly used markers of AT inflammation are not causally linked to AT insulin resistance, whereas FCS is a strong predictor of AT insulin resistance with respect to lipolysis.

The effects of weight loss on adipokines and markers of inflammation in dogs

2011 ◽  
Vol 106 (S1) ◽  
pp. S11-S14 ◽  
Author(s):  
Joseph J. Wakshlag ◽  
Angela M. Struble ◽  
Corri B. Levine ◽  
Jennifer J. Bushey ◽  
Dorothy P. Laflamme ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Chronic Inflammation ◽  
Interquartile Range ◽  
Serum Samples ◽  
Monocyte Chemoattractant Protein 1 ◽  
Markers Of Inflammation ◽  
Hmw Adiponectin ◽  
Total Adiponectin ◽  
Before And After

Evidence suggests that adipose tissue-derived adipokines induce mild inflammation and may play a role in insulin resistance associated with diabetes. The present study was designed to examine a series of adipokines and markers of inflammation in dogs before and after a successful weight loss. The study included fasting serum samples from twenty-five dogs before and after a weight-loss programme. Serum C-reactive protein (CRP) and monocyte chemoattractant protein-1 (MCP-1) were measured as indicators of chronic inflammation, while serum adipokines including total adiponectin, high-molecular-weight (HMW) adiponectin, resistin and leptin were also examined. Medians for CRP (before, 10·0 (interquartile range 5·4–15·0) μg/ml; after, 5·6 (interquartile range 3·8–7·0) μg/ml) and MCP-1 (before, 212 (interquartile range 157–288) ng/ml; after, 185 (interquartile range 143–215) ng/ml) decreased significantly after weight loss. Medians for resistin showed a mild, yet significant reduction (before, 67·1 (interquartile range 44·4–88·5) pg/ml; after, 60·5 (interquartile range 32·3–67·1) pg/ml), while leptin showed a dramatic decrease after weight loss (before, 18·9 (interquartile range 10·8–35·4) ng/ml; after, 6·6 (interquartile range 3·9–10·2) ng/ml). Serum total adiponectin and HMW adiponectin were unchanged on all analyses performed. These data suggest that weight loss can decrease chronic inflammation; however, the clinical implications of this decrease are not well elucidated in dogs. Surprisingly, there was no increase in total or HMW serum adiponectin after weight loss, as observed previously in human subjects. The lack of change in total and HMW adiponectin might explain why insulin resistance and type 2 diabetes are less prevalent in obese dogs when compared with humans and cats.

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