Correlation between the rate of weight loss and changes in body composition in obese postmenopausal women after 5 weeks: a pilot study

Approximately 25% of weight lost during restrictive diets (without exercise) is lean body mass (LBM). No study has yet investigated the impact of the rate of weight loss (RWL) on LBM and fat mass (FM). The purpose of this study was to investigate the relationships between the RWL and body composition in older obese women. Twenty obese postmenopausal women aged between 51 and 74 years enrolled in a 5 week dietary weight loss intervention. Subjects were characterized according to their RWL (low RWL < 0.74 kg·week–1 (n = 9) vs. high RWL ≥ 0.74 kg·week–1 (n = 11)). Total and trunk FM and LBM (by dual-energy X-ray absorptiometry) were measured before and after weight loss. A significant correlation was observed between the RWL (kg·week–1) and changes in LBM (kg·week–1) (r = 0.75; p = 0.0002). However, no association was observed with changes in FM (kg·week–1) (r = 0.40; p = 0.08). Both groups showed a similar decrease in FM (low RWL, –2.7 ± 0.9 kg,; high RWL, –3.2 ± 0.8 kg; p = 0.38), whereas losses in LBM were significantly higher in the high RWL than in the low RWL group (–1.6 ± 1.2 kg vs. –0.4 ± 1.1 kg; p = 0.05). An RWL > 0.74 kg·week–1 was associated with a greater loss of LBM, but had no extra benefits on FM after a 5 week weight loss program. Current guidelines, which recommend RWL up to 0.91 kg·week–1, might not be optimal to prevent decreases in LBM in postmenopausal women when no exercise is added.

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American Urogynecologic Society Systematic Review: The Impact of Weight Loss Intervention on Lower Urinary Tract Symptoms and Urinary Incontinence in Overweight and Obese Women: Erratum

Female Pelvic Medicine & Reconstructive Surgery ◽

10.1097/spv.0000000000000907 ◽

2020 ◽

Vol 26 (7) ◽

pp. 466-466

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Urinary Incontinence ◽

Lower Urinary Tract ◽

Weight Loss Intervention ◽

Obese Women ◽

Urinary Tract Symptoms ◽

The Impact ◽

American Urogynecologic Society ◽

Lower Urinary

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Appetite Control Might not Be Improved after Weight Loss in Adolescents with Obesity, Despite Non-Persistent Metabolic Syndrome

Nutrients ◽

10.3390/nu12123885 ◽

2020 ◽

Vol 12 (12) ◽

pp. 3885

Author(s):

Valérie Julian ◽

Laurie Isacco ◽

Marwa Khammassi ◽

Alicia Fillon ◽

Maud Miguet ◽

...

Keyword(s):

Metabolic Syndrome ◽

Weight Loss ◽

Body Composition ◽

Energy Intake ◽

Weight Loss Intervention ◽

Appetite Control ◽

Post Intervention ◽

The Metabolic Syndrome ◽

Daily Energy ◽

Before And After

The aim of this study was to evaluate the effect of a multidisciplinary weight loss intervention on energy intake and appetite sensations in adolescents with obesity, depending on the initial diagnosis or persistence of the metabolic syndrome. Ninety-two adolescents with obesity (12–15 years) followed a 16-week multidisciplinary weight loss intervention. Anthropometric and body composition characteristics, metabolic profile, ad libitum daily energy intake, and appetite sensations were assessed before and after the intervention. The presence of metabolic syndrome (MS) was determined at baseline (MS vs. non-MS) and after the program (persistent vs. non-persistent). While the intervention was effective in inducing weight loss (body weight T0: 87.1 ± 14.9 vs. T1: 81.2 ± 13.0 kg; p < 0.001) and body composition improvements in both adolescents with and without MS, energy intake (p = 0.07), hunger (p = 0.008), and prospective food consumption (p = 0.03) increased, while fullness decreased (p = 0.04) in both groups. Energy intake and appetite were not improved in non-persistent MS after the program and remained significantly higher among non-persistent adolescents compared with initially non-MS adolescents. To conclude, appetite control seems impaired in obese adolescents, irrespective of being affected by MS or not, whereas the treatment of MS in this population might fail to effectively preclude the adolescents from potential post-intervention compensatory food intake and subsequent weight regain.

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Effects of weight loss intervention on body composition and blood pressure among overweight and obese women: findings from the MyBFF@home study

BMC Women s Health ◽

10.1186/s12905-018-0592-2 ◽

2018 ◽

Vol 18 (S1) ◽

Cited By ~ 1

Author(s):

Mansor Fazliana ◽

Ahmad Zamri Liyana ◽

Azahadi Omar ◽

Rashidah Ambak ◽

Noor Safiza Mohamad Nor ◽

...

Keyword(s):

Blood Pressure ◽

Weight Loss ◽

Body Composition ◽

Weight Loss Intervention ◽

Obese Women ◽

Home Study

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Evaluation of insulin sensitivity with a new lipid-based index in non-diabetic postmenopausal overweight and obese women before and after a weight loss intervention

Acta Endocrinologica ◽

10.1530/eje-09-0091 ◽

2009 ◽

Vol 161 (1) ◽

pp. 51-56 ◽

Cited By ~ 15

Author(s):

Barbara Antuna-Puente ◽

Emmanuel Disse ◽

May Faraj ◽

Marie-Eve Lavoie ◽

Martine Laville ◽

...

Keyword(s):

Weight Loss ◽

Insulin Sensitivity ◽

Weight Loss Program ◽

Model Assessment ◽

Weight Loss Intervention ◽

Obese Women ◽

Insulin Resistant ◽

Significant Difference ◽

Before And After ◽

Post Menopausal

ObjectiveTo evaluate the validity of a new lipid-based index (Disse index) in assessing insulin sensitivity (IS) compared with the hyperinsulinemic-euglycemic (HIEG) clamp in overweight and obese, non-diabetic, postmenopausal women, before and after a weight loss intervention.Research design and methodsAssociation between Disse index and the HIEG clamp was evaluated in 86 non-diabetic postmenopausal overweight and obese women before and after weight loss. Percentage changes (%Δ) were calculated for several fasting indices and compared with %Δ of HIEG clamp.ResultsWe observed a strong correlation between Disse index and HIEG clamp (r=0.69, P<0.001). This association was higher than those of homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI), and McAuley indices while no significant difference was observed with Revised-QUICKI. Percent change of Disse index (pre- versus post-weight loss program) was significantly correlated with %Δ of HIEG clamp (r=0.34, P<0.01). This correlation was similar to those observed for the other indices tested.ConclusionsWe validated the reliability of Disse index in assessing IS in non-diabetic post-menopausal overweight and obese women, before and after weight loss intervention. Disse index may be useful not only for insulin resistant diagnostics in this type of population, but also for the IS follow-up after a weight-loss program and weight stabilization. The presence of lipid elements in this fasting index improves the estimation of IS in overweight and obese non-diabetic post-menopausal women and could add more information about peripheral IS.

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Effect of Energy Restriction on Eating Behavior Traits and Psychobehavioral Factors in the Low Satiety Phenotype

Nutrients ◽

10.3390/nu11020245 ◽

2019 ◽

Vol 11 (2) ◽

pp. 245 ◽

Cited By ~ 5

Author(s):

Vicky Drapeau ◽

Raphaëlle Jacob ◽

Shirin Panahi ◽

Angelo Tremblay

Keyword(s):

Weight Loss ◽

Eating Behavior ◽

Energy Restriction ◽

Energy Deficit ◽

Weight Loss Intervention ◽

Before And After ◽

Median Split ◽

Similar Weight ◽

The Impact ◽

Satiety Responsiveness

Studies have shown that individuals with low satiety efficiency may be more susceptible to weight gain, but little is known about the effect of weight loss intervention outcomes in these individuals. This study aimed to evaluate the impact of an energy-restricted weight loss intervention on eating behavior traits and psychobehavioral factors in individuals differing in their satiety responsiveness. A pooled cohort of individuals who were overweight or obese (n = 100; aged 39 ± 9 years) participating in a 12- to 15-week weight loss program targeting an energy deficit of 500–700 kcal/day were included in this study. Satiety responsiveness was determined by a median split of the mean satiety quotient based on appetite sensations measured in response to a test meal at baseline (low satiety responsiveness (LSR) vs. high satiety responsiveness (HSR)). Anthropometric variables, eating behavior traits, psychobehavioral factors, and ad libitum energy intake were assessed before and after the intervention. Although similar weight loss was observed between the LSR and HSR groups (−3.5 ± 3.2 vs. –3.8 ± 2.8 kg, p = 0.64) in response to an energy-restricted weight loss intervention, changes in eating behavior traits were different between groups. Individuals with LSR had a higher increase in cognitive restraint (+5.5 ± 4.1 vs. +3.5 ± 3.5, p = 0.02) and some of its subscales and a lower decrease in situational susceptibility to disinhibition (−0.6 ± 1.1 vs. −1.2 ± 1.3, p = 0.02) in response to the intervention compared to the HSR group. In conclusion, energy-restricted weight loss intervention seems to trigger undesirable changes in some eating behavior traits in individuals more vulnerable to overeating, which could increase their susceptibility to weight regain.

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We-P11:157 Body composition, plasma adipocytokins, and cardiovascular risk factors before and after weight loss in overweight and obese women

Atherosclerosis Supplements ◽

10.1016/s1567-5688(06)81511-4 ◽

2006 ◽

Vol 7 (3) ◽

pp. 380

Author(s):

I. Demonty ◽

S. Santosa ◽

A.H. Lichtenstein ◽

K. Cianflone ◽

P.J.H. Jones

Keyword(s):

Risk Factors ◽

Weight Loss ◽

Body Composition ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Obese Women ◽

Before And After

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Effect of Adherence to Physical Exercise on Cardiometabolic Profile in Postmenopausal Women

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18020656 ◽

2021 ◽

Vol 18 (2) ◽

pp. 656

Author(s):

Valentina Bucciarelli ◽

Francesco Bianco ◽

Francesco Mucedola ◽

Andrea Di Blasio ◽

Pascal Izzicupo ◽

...

Keyword(s):

Physical Exercise ◽

Diastolic Function ◽

Postmenopausal Women ◽

Serum Glucose ◽

Moderate Intensity ◽

Adherence Rate ◽

Before And After ◽

Estrogen Depletion ◽

The Impact ◽

Cardiometabolic Profile

Background: Menopause is associated with negative cardiovascular adaptations related to estrogen depletion, which could be counteracted by physical exercise (PhE). However, the impact of total adherence-rate (TA) to PhE and sedentary time (SedT) on cardiometabolic profile in this population has not been elucidated. Methods: For 13-weeks, 43 women (57.1 ± 4.7 years) participated in a 4-days-a-week moderate-intensity walking training. They underwent laboratory, anthropometric and echocardiographic assessment, before and after training (T0–T1). Spontaneous physical activity (PhA) was assessed with a portable multisensory device. The sample was divided according to TA to PhE program: <70% (n = 17) and ≥70% (n = 26). Results: TA ≥ 70% group experienced a significant T1 improvement of relative wall thickness (RWT), diastolic function, VO2max, cortisol, cortisol/dehydroandrostenedione-sulphate ratio and serum glucose. After adjusting for SedT and 10-min bouts of spontaneous moderate-to-vigorous PhA, TA ≥ 70% showed the most significant absolute change of RWT and diastolic function, body mass index, weight and cortisol. TA ≥ 70% was major predictor of RWT and cortisol improvement. Conclusions: In a group of untrained, postmenopausal women, a high TA to a 13-weeks aerobic PhE program confers a better improvement in cardiometabolic profile, regardless of SedT and PhA levels.

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The Impact of Bariatric Surgery on Menstrual Abnormalities—a Cross-Sectional Study

Obesity Surgery ◽

10.1007/s11695-020-04840-6 ◽

2020 ◽

Vol 30 (11) ◽

pp. 4505-4509

Author(s):

Anna Różańska-Walędziak ◽

Paweł Bartnik ◽

Joanna Kacperczyk-Bartnik ◽

Krzysztof Czajkowski ◽

Maciej Walędziak

Keyword(s):

Bariatric Surgery ◽

Menstrual Cycle ◽

Cross Sectional Study ◽

Reproductive Age ◽

Obese Women ◽

Sectional Study ◽

Cross Sectional ◽

Contraception Use ◽

Before And After ◽

The Impact

Abstract Introduction Obesity is associated with hyperestrogenism along with other hormonal abnormalities affecting the menstrual cycle. The most effective and decisive method of obesity treatment is bariatric surgery. The aim of this study was to analyze the impact of bariatric surgery on menstrual cycle, the incidence of menstrual abnormalities, hyperandrogenism manifestation, and contraception use. Materials and Methods It was a cross-sectional study of 515 pre-menopausal women who had undergone bariatric surgery between 1999 and 2017 in a bariatric center. Data was collected via anonymous questionnaire, and the questions covered a 1-year period before the surgery and the last year before questionnaire completion. Results Before the surgery, 38.6% of the patients reported irregular menstruations in comparison with 25.0% after bariatric surgery (RR = 0.65; 95%CI 0.53–0.79). The mean number of menstruations per year did not differ before and after surgery (10.2 ± 3.9 vs 10.4 ± 3.3; p < .45). There were no statistically significant differences in terms of prolonged menstruations, acne, and hirsutism prevalence. A total of 14.4% of patients before surgery reported estrogen-based contraception use in comparison with 15.0% after the surgery (p < .95). There were no significant differences in the frequency of OC use (11.0% before surgery vs 13.6% 12 months after the surgery vs 11.5% at the moment of survey administration; p < 0.46). Conclusion Bariatric surgery improves the regularity of the menstrual cycle in obese women in reproductive age. The lack of any changes in the combined hormonal contraception (CHC) use, especially OC, before and after bariatric surgery may be a result of a possibly low level of contraception counseling.

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Uric acid is associated with adiposity factors, especially with fat mass reduction during weight loss in obese children and adolescents

Nutrition & Metabolism ◽

10.1186/s12986-020-00500-9 ◽

2020 ◽

Vol 17 (1) ◽

Author(s):

Yang Niu ◽

Xue-lin Zhao ◽

Hui-juan Ruan ◽

Xiao-meng Mao ◽

Qing-ya Tang

Keyword(s):

Weight Loss ◽

Body Composition ◽

Uric Acid ◽

Children And Adolescents ◽

Body Fat ◽

Fat Mass ◽

Dietary Control ◽

Obese Children ◽

Fat Percentage ◽

Before And After

Abstract Background Current adult studies suggest that uric acid (UA) is associated with body fat, but the relationship in obese children is unclear. Thus, we aim to evaluate the association between uric acid and body composition of obese children. Methods A total of 79 obese children were included in this study, and 52 children (34 boys and 18 girls) underwent a 6-week weight loss camp, including 34 boys and 18 girls. Six-week weight-loss interventions were performed on all participants through aerobic exercise and appropriate dietary control. Laboratory tests and body composition were collected before and after the intervention. Results Before the intervention, correlation analysis demonstrated that uric acid was positively correlated with height, weight, body mass index (BMI), waist circumference, hip circumference, fat mass (FM), and free fat mass (FFM) with adjusting for age and gender (P < 0.05). After 6 weeks of intervention, the participants gained 3.12 ± 0.85 cm in height, body fat percentage decreased by 7.23 ± 1.97%, and lost 10.30 ± 2.83 kg in weight. Univariate and multivariate analysis indicated that uric acid at baseline was associated with FM reduction during weight loss (P < 0.05). Conclusions This study is the first report that uric acid is associated with BMI and FM, and may play an important role in the reduction of FM during weight loss in obese children and adolescents. The interaction between UA and adiposity factors and its underlying mechanisms need to be further explored. Trial registration This study was registered in Clinical Trials.gov (NCT03490448) and approved by the Ethics Committee of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.

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