Combined exercise training improves specific domains of cognitive functions and metabolic markers in middle-aged and older adults with type 2 diabetes mellitus

2021 ◽  
Vol 173 ◽  
pp. 108700
Author(s):  
João Gabriel Silveira-Rodrigues ◽  
Washington Pires ◽  
Patrícia Ferreira Gomes ◽  
Pedro Henrique Madureira Ogando ◽  
Bruno Pereira Melo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Type 2 Diabetes Mellitus ◽  
Exercise Training ◽  
Cognitive Functions ◽  
Middle Aged ◽  
Metabolic Markers ◽  
Combined Exercise

Effects of Power Training on Physical Activity, Sitting Time, Disability, and Quality of Life in Older Patients With Type 2 Diabetes During the COVID-19 Confinement

2021 ◽  
pp. 1-9
Author(s):  
Javier Brazo-Sayavera ◽  
Olga López-Torres ◽  
Álvaro Martos-Bermúdez ◽  
Lorena Rodriguez-Garcia ◽  
Marcela González-Gross ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Type 2 Diabetes Mellitus ◽  
Exercise Training ◽  
Muscle Power ◽  
Training Group ◽  
Sitting Time ◽  
Control Group

Background: To evaluate the effectiveness of a multicomponent supervised and unsupervised training program focused on muscle power to counteract the potential changes in sedentary behavior, disability, physical activity (PA), and health-related quality of life (HRQoL) caused by the COVID-19 pandemic domiciliary confinement in prefrail older adults with type 2 diabetes mellitus. Methods: Thirty-five older adults with type 2 diabetes mellitus were assigned to 2 groups according to their frailty status: exercise training group (prefrail or frail; n = 21; 74.7 [4.5] y; 33.3% male) and control group (robust; n = 14; 73.1 [3.9] y; 42.9% male). The exercise training group followed a multicomponent training program focusing on muscle power: supervised (5 wk) and unsupervised (6 wk). The primary outcomes, including PA and sitting time, perceived disability, and HRQoL, were assessed at the baseline and after 11 weeks. Results: At the end of confinement, there were significant decreases in PA in both groups (P < .05). Thus, sitting time increased more in the control group than in the exercise training group (P < .05). The HRQoL measures remained unchanged. Conclusions: Muscle power training before and during mandatory COVID-19 self-isolation in type 2 diabetes mellitus older adults (1) attenuates the COVID-19 domiciliary confinement-related increase in sitting time and (2) slightly decreases the self-reported levels of disability and maintains HRQoL.

scholarly journals Combined exercise training-induced improvements in executive functions are related to baseline plasmatic levels of Brain-Derived Neurotrophic Factor (BDNF) in middle-aged adults and older with Type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
João Gabriel da Silveira-Rodrigues ◽  
Nathálya Gardênia de Holanda Marinho Nogueira ◽  
Larissa Oliveira Faria ◽  
Daniele Sirineu Pereira ◽  
Danusa Dias Soares
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Exercise Training ◽  
Executive Functions ◽  
Cognitive Functions ◽  
Long Term Memory ◽  
Term Memory

Abstract Background: Type 2 Diabetes Mellitus (T2DM) affects many cognitive functions and aerobic plus resistance exercise training, named combined training (CT), by improving metabolic control may mitigate or reverse the cognitive impairment T2DM-related. Brain-derived neurotrophic factor (BDNF) plays a substantial role in cognitive functions. However, the effects of CT on BDNF levels of T2DM subjects are poorly known.Aim: This study analyzed the effects of 8 weeks of CT on circulating BDNF levels and assessed whether plasmatic BDNF levels were related to CT-induced improvements in executive functions and long-term memory of T2DM subjects.Methods: Thirty-five (63 ± 8 years old) T2DM subjects of both sexes entered into CT (n = 17, thrice-weekly during 8 weeks) or control group (CONT, n = 18). Executive functions (measured through Trail making test, Stroop color task, and Digit Span), long-term memory (measured through the simplified version of Taylor Complex Figure Test), and blood samples were evaluated pre- and post-intervention.Results: Pre-CT plasma BDNF levels were positively related to CT-induced improvements on executive functions composite z-score (r = 0.71), inhibitory control (r = 0.58) and cognitive flexibility (r = 0.56), but not to long-term memory. Plasma BDNF levels were not statistically changed (pre-CT: 179 ± 88 pg/ml; post-CT: 148 ± 108 pg/ml; pre-CONT: 163 ± 71 pg/ml; post-CONT: 141 ± 84 pg/ml, p > 0.05).Conclusion: Higher pre-training BDNF levels might be a potentializing factor of the training-induced improvements on executive functions, independently of the training-alterations in resting BDNF levels of T2DM subjects.

scholarly journals Potential of Creatine in Glucose Management and Diabetes

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 570
Author(s):  
Marina Yazigi Solis ◽  
Guilherme Giannini Artioli ◽  
Bruno Gualano
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Exercise Training ◽  
Creatine Supplementation ◽  
Small Scale ◽  
Therapeutic Effects ◽  
Glucose Management

Creatine is one of the most popular supplements worldwide, and it is frequently used by both athletic and non-athletic populations to improve power, strength, muscle mass and performance. A growing body of evidence has been identified potential therapeutic effects of creatine in a wide variety of clinical conditions, such as cancer, muscle dystrophy and neurodegenerative disorders. Evidence has suggested that creatine supplementation alone, and mainly in combination with exercise training, may improve glucose metabolism in health individuals and insulin-resistant individuals, such as in those with type 2 diabetes mellitus. Creatine itself may stimulate insulin secretion in vitro, improve muscle glycogen stores and ameliorate hyperglycemia in animals. In addition, exercise induces numerous metabolic benefits, including increases in insulin-independent muscle glucose uptake and insulin sensitivity. It has been speculated that creatine supplementation combined with exercise training could result in additional improvements in glucose metabolism when compared with each intervention separately. The possible mechanism underlying the effects of combined exercise and creatine supplementation is an enhanced glucose transport into muscle cell by type 4 glucose transporter (GLUT-4) translocation to sarcolemma. Although preliminary findings from small-scale trials involving patients with type 2 diabetes mellitus are promising, the efficacy of creatine for improving glycemic control is yet to be confirmed. In this review, we aim to explore the possible therapeutic role of creatine supplementation on glucose management and as a potential anti-diabetic intervention, summarizing the current knowledge and highlighting the research gaps.

Sign in / Sign up

Export Citation Format

Share Document