scholarly journals Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours

2012 ◽  
Vol 48 (17) ◽  
pp. 3215-3222 ◽  
Author(s):  
Antoine Italiano ◽  
Junwei Chen ◽  
Lei Zhang ◽  
Mihai Hajdu ◽  
Samuel Singer ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signalling Pathway ◽  
Gastrointestinal Stromal Tumours ◽  
Insulin Growth Factor ◽  
Growth Factor Signalling ◽  
Growth Factor Signalling Pathway

scholarly journals Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Ji Eun Kim ◽  
Clare Stones ◽  
Wayne R Joseph ◽  
Euphemia Leung ◽  
Graeme J Finlay ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Lines ◽  
Melanoma Cell ◽  
Signalling Pathway ◽  
Growth Factor Signalling ◽  
Melanoma Cell Lines ◽  
Growth Factor Signalling Pathway

scholarly journals Activation of the epidermal growth factor signalling pathway by tissue plasminogen activator in pancreas cancer cells

Gut ◽  
2007 ◽  
Vol 56 (9) ◽  
pp. 1266-1274 ◽  
Author(s):  
M. Hurtado ◽  
J. J. Lozano ◽  
E. Castellanos ◽  
L. A Lopez-Fernandez ◽  
K. Harshman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Cells ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Pancreas Cancer ◽  
Tissue Plasminogen ◽  
Growth Factor Signalling ◽  
Epidermal Growth ◽  
Growth Factor Signalling Pathway

Transmembrane signalling pathways initiating cell growth in fibroblasts

1988 ◽  
Vol 320 (1199) ◽  
pp. 427-436 ◽  
Keyword(s):  
Growth Factor ◽  
Cell Line ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Growth Arrest ◽  
Chinese Hamster ◽  
Signalling Pathways ◽  
Fibroblastic Cell ◽  
Growth Factor Signalling ◽  
Growth Factor Signalling Pathway

The mechanisms of growth factor action were studied in a fibroblastic cell line capable of reversible growth arrest in G0-G1. This cell line, derived from Chinese hamster lung, can be stimulated to divide by a limited set of purified growth factors, including EGF, FGF, PDGF, x-thrombin (THR), serotonin (5-HT) and insulin. THR and 5-HT stimulate, via a G-protein (G p ), a polyphosphoinositide-specific phospholipase C (PtdIns(4,5)P 2 -PLC). In contrast, the mitogens EGF, FGF, PDGF, and insulin do not stimulate PtdIns(4,5)P 2 -PLC, unless this pathway has been preactivated by THR or AIF 4 . Finally, from the specific inhibitory action of pertussis toxin on THR- and 5-HT-induced DNA synthesis, and from the exploitation of the 5-HT pharmacological tools, we conclude that: (i) there are at least two distinct Gproteins involved in signalling growth: G p , coupling receptors to PtdIns(4,5)P 2 -PLC, and G 1 coupling receptors negatively to adenylyl cyclase and probably to other unknown effector(s); (ii) activation of receptor-tyrosine kinases provides an alternate growth factor signalling pathway, independent of G p - and G i -mediated actions; and (iii) tyrosine kinases positively ‘cross-communicate ’ with the inositol-lipid pathway (phosphorylation of G p , PLC, Ptdlns kinases...?).

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