scholarly journals A Comparative Study on Effect of Oral Administration of Turmeric and Nutmeg on Memory Boosting and Regaining in Wistar Albino Rats

2013 ◽  
Vol 1 (3) ◽  
pp. 46-52 ◽  
Author(s):  
SS Kumar ◽  
G Jissa ◽  
PV Setty ◽  
JK Mukkadan
Keyword(s):  
Oral Administration ◽  
Animal Studies ◽  
Oral Intake ◽  
Control Group ◽  
Albino Rats ◽  
Diabetes Research ◽  
Physiological Measures ◽  
Medical Sciences ◽  
Turmeric Extract ◽  
Wistar Albino Rats

BACKGROUND AND OBJECTIVES: Although a few drugs are available today for the management of Alzheimer's disease (AD) and many plants and their extracts are extensively employed in animal studies and AD patients, yet no substantial drug or plant extract is able to reverse the AD symptoms adequately. It is tangible that there has been augmenting need for such therapeutic intervention. The present study was undertaken with an objective to compare the memory boosting and regaining effects of oral administration of nutmeg and turmeric which are used commonly as spice in various dishes, as components of teas and soft drinks. MATERIAL AND METHODS: A total of 24 male and female wistar albino rats were used for this study. They were randomly assigned into three groups with 8 rats in each group. The influence of oral intake of nutmeg and turmeric extract on behavioral task performance was studied by using T-maze and radial arm maze and physiological measures relative to a milk control group was investigated. RESULTS: We have observed significant memory boosting and memory regaining effects of nutmeg when administered orally when compared with control group..However, nutmeg is having strong memory regaining effect than turmeric. CONCLUSION: We conclude that nutmeg is having strong memory regaining effect than turmeric. However further pharmacological and biochemical investigations will clearly elucidate the mechanism of action and helpful in projecting these plant extracts as a therapeutic target in diabetes research. DOI: http://dx.doi.org/10.3126/jucms.v1i3.8765   Journal of Universal College of Medical Sciences Vol.1(3) 2013: 46-52

scholarly journals A study on effect of oral administration of cardamom on memory boosting and regaining in wistar albino rats

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Prabha V Setty ◽  
Kumar Sai Sailesh ◽  
Neethu Neethu ◽  
Mukkadan J.K
Keyword(s):  
Oral Administration ◽  
Cholinesterase Activity ◽  
Memory Performance ◽  
Oral Intake ◽  
Control Group ◽  
Albino Rats ◽  
Physiological Measures ◽  
Acetyl Cholinesterase ◽  
Oral Consumption ◽  
Wistar Albino Rats

This study provides further evidence for improvement of memory by oral consumption of cardamom. The present study was undertaken with an objective to study the effects of oral administration of cardamom on memory boosting and regaining. Here we investigate the influence of oral intake of cardamom on behavioral task performance by using T-maze and radial arm maze and physiological measures relative to a milk control group. We have observed significant memory boosting and memory regaining effects of cardamom when administered orally. This effect may be due to facilitation of acetylcholine activity by decreasing acetyl cholinesterase activity of cardamom. Hence we recommend further research in this area by investigating compound metabolism to optimize quantification of memory performance following cardamom consumption

scholarly journals Effect of Oral Administration of Coriander Extract on Memory Boosting & Regaining in Wistar Albino Rats.

KYAMC Journal ◽  
2017 ◽  
Vol 4 (2) ◽  
pp. 398-401
Author(s):  
Mohamed Jasira ◽  
Kumar Sai Sailesh ◽  
JK Mukkadan
Keyword(s):  
Oral Administration ◽  
Task Performance ◽  
Nutritional Value ◽  
Oral Intake ◽  
Radial Arm Maze ◽  
Control Group ◽  
Albino Rats ◽  
Physiological Measures ◽  
The World ◽  
Wistar Albino Rats

Coriander is cultivated throughout the world for its nutritional value. The present study was undertaken with an objective to study the effects of oral administration of coriander on memory boosting and regaining. Here we investigated the influence of oral intake of coriander on behavioural task performance by using T-maze and radial arm maze and physiological measures relative to a milk control group. We have observed significant memory boosting and memory regaining effects of coriander when administered orally. This effect may be due to memory-improving property and anticholinesterase activity of coriander. Hence we recommend that coriander can be used as a remedy in the management of Alzheimer's disease.KYAMC Journal Vol. 4, No.-2, Jan 2014, Page 398-401

scholarly journals A study on comparison of memory boosting and regaining effects of oral administration of peppermint and coriander in wistar albino rats.

2014 ◽  
Vol 3 (1) ◽  
pp. 13-19
Author(s):  
Sai Sailesh Kumar ◽  
Jasira V k Mohamed ◽  
JK Mukkadan
Keyword(s):  
Oral Administration ◽  
Task Performance ◽  
Wistar Rats ◽  
Memory Performance ◽  
Oral Intake ◽  
Control Group ◽  
Albino Rats ◽  
Physiological Measures ◽  
Behavioral Task ◽  
Wistar Albino Rats

The present study provides further evidence that oral administration of peppermint and coriander extracts are having memory boosting and memory regaining effects. The present study was undertaken to compare memory boosting and regaining effects of oral administration of peppermint and coriander extracts in adult wistar rats. Here we investigate the influence of oral intake of peppermint and coriander extracts on behavioral task performance by using T-maze and radial arm maze and physiological measures relative to a milk control group. When coriandrum and peppermint groups are compared, the memory boosting and regaining effects of peppermint is significant in R-maze, whereas memory boosting and regaining effects of coriandrum is significant in T-maze. We conclude that oral administration of peppermint and coriander extracts are having memory boosting and memory regaining effects. Hence we recommend peppermint and coriander can be used as a remedy in the management of Alzheimer's disease and we also recommend further research in this area by investigating compound metabolism to optimize quantification of memory performance following peppermint and coriander ingestion. CBMJ 2014 January: Vol. 03 No. 01 P: 13-19

scholarly journals Effect of Oral Administration of Ibuprofen on Prothrombin Time, Activated Partial Thromboplastin and Platelet Count in Wistar Albino Rats

2020 ◽  
pp. 45-50
Author(s):  
Jonathan Esima ◽  
Abraham Zorte ◽  
O. Onwuli, Donatus ◽  
Waribo, Helen Anthony
Keyword(s):  
Platelet Count ◽  
Oral Administration ◽  
Prothrombin Time ◽  
Chronic Exposure ◽  
Control Group ◽  
Albino Rats ◽  
Exposure Group ◽  
Group 2 ◽  
Wistar Albino Rats ◽  
Acute And Chronic Exposure

Aim: Ibuprofen is analgesic, antipyretic and anti-inflammatory drug, which is widely used as a cheap over- the counter drug (OTC); however, this drug accompanies anti coagulation/anti platelets effects which sometimes might illicit adverse effects. In this study, we investigated effect of ibuprofen on prothrombin time (PT), activated partial thromboplastin time (aPTT) and platelet count using wistar albino rats. Methods: A total of 21 rats grouped into 3(control, acute and chronic exposure groups, with all consisting of 7 rats each) was used. The acute and chronic exposure group were given 0.7 mg of ibuprofen orally for 1 and 21 days, respectively. Blood sample was collected via cardiac puncture then analyzed. Results: PT was significantly higher in both group 2 and 3 (acute and chronic exposure, respectively) than that of the control. Acute exposure group showed the highest PT rise. A PTT was not significantly different between group 2 and 3 versus the control group. Platelet count was significantly lower in both group 2 and 3than that in the control group (p<0.05). Group 3 (chronic exposure) showed the lowest platelet count. Conclusion: Oral administration of ibuprofen affected coagulation parameters and a longer exposure reduce platelets count. A strictly prescription for this drug may be needed to prevent its indiscriminate use.

scholarly journals Effectiveness of oral administration of peppermint and coriander extracts on cognition in Scopolamine induced rat model of amnesia

2020 ◽  
Vol 11 (3) ◽  
pp. 4222-4226
Author(s):  
Jasira Sirajudheen ◽  
Sai Sailesh Kumar Goothy ◽  
Mukkadan J K
Keyword(s):  
Oral Administration ◽  
Rat Model ◽  
Positive Impact ◽  
Neurological Diseases ◽  
Control Group ◽  
Albino Rats ◽  
Study Results ◽  
Peppermint Extract ◽  
Neuroprotective Actions ◽  
Wistar Albino Rats

Herbs and spices have been shown to be very effective in the management of the neurological disorders. They have neuroprotective actions that prevent the deterioration of the memory and other cognitive functions in the neurological diseases. Peppermint (menthe×piperita, also known as M. balsamea wild) is a hybrid mint, a cross between water mint and spearmint. Peppermint consists of several medicinal components and research was testified safety of consumption of the peppermint. The study compared the memory-boosting and regaining effects of oral administration of peppermint and coriander extracts. 36 male and female Wistar albino rats were assigned into three groups randomly that is control, coriander and peppermint groups, respectively. A control group (n=6) received neither peppermint nor coriander administered (milk was administered). Peppermint group (n=6) received peppermint extract. Coriander group (n=6) received coriander extract. Amnesia rat model was prepared by the administration of as intraperitoneal injection of scopolamine. The R-maze and T-maze tasks was conducted as mentioned in the literature. Mean trials of acquisition is significantly less (P<0.01) in the peppermint group. The number of mean trials of retention is significantly less (P<0.01) in the peppermint group. The mean trials for retention of the coriander group is significantly (P<0.05) less than the peppermint group. The study results support a positive impact of coriander and peppermint on cognition. The study recommends further detailed studies to support the administration of these extracts in the management of neurological diseases that deteriorates cognition.

Effect of Propolis-Supplemented Diet on Body Composition and Endocrine Function of Adipose Tissue

2020 ◽  
Vol 19 (2) ◽  
pp. 217-221
Author(s):  
Maria Jesús Lisbona-González ◽  
Candela Reyes-Botella ◽  
Esther Muñoz-Soto ◽  
Maria Victoria Olmedo-Gaya, ◽  
Jorge Moreno-Fernandez ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Body Composition ◽  
Adipose Tissue ◽  
Endocrine Function ◽  
Control Group ◽  
Albino Rats ◽  
Standard Diet ◽  
Reduced Body ◽  
Esterified Fatty Acids ◽  
Wistar Albino Rats

Adipose tissue is an endocrine organ and has central role in interaction with other organs or tissues while propolis can induce lipolysis. Therefore, the aim of this study is to provide detailed information about adipose tissue homeostasis modifications and body composition during propolis supplement consumption. Twenty male Wistar albino rats (8 weeks) were divided into two groups of 10 animals each and fed for 90 days with two different types of diets: standard for the control group (diet C) and standard diet + 2% propolis (diet P). Thyroid hormones did not show differences, while ghrelin and adiponectin decreased in the group that was fed propolis. Insulin, leptin, and non-esterified fatty acids also increased along with reduced body weight and fat, in addition to increased lean mass when propolis was in the diet. We conclude that propolis could decrease ghrelin and adiponectin but increase non-esterified fatty acids and insulin secretion, which improves body composition.

scholarly journals Biochemical Studies on Phenylhydrazine Induced Experimental Anemic Albino Rats

2015 ◽  
Vol 3 (1) ◽  
pp. 41-47
Author(s):  
Nirjala Laxmi Madhikarmi ◽  
Kora Rudraiah Siddalinga Murthy
Keyword(s):  
Lipid Peroxidation ◽  
Lipid Hydroperoxide ◽  
Thiobarbituric Acid ◽  
Albino Rats ◽  
Enzymatic Antioxidants ◽  
Medical Sciences ◽  
Thiobarbituric Acid Reactive Substances ◽  
Biochemical Studies ◽  
Healthy Control ◽  
Wistar Albino Rats

INTRODUCTION: The present study evaluated the modulatory effects of diphenylhydrazine induced experimental wistar albino rats and also to assess various biochemical parameters in whole blood and red blood cell lysate.MATERIALAND METHODS: Twenty male albino rats weighing 180-200 gm were selected for the study and divided in two groups; ten phenylhydrazine dihydrochloride (PHZ) induced anemia and ten healthy control. Thiobarbituric acid reactive substances and lipid hydroperoxide were measured as lipid peroxidation parameter. The antioxidant vitamins A, C and E and enzymatic antioxidants; catalase, glutathione peroxidase and superoxide dismutase were also assessed.RESULTS: Phenylhydrazine induced anemic rats showed a significant increase in the lipid peroxidation and decrease in the antioxidants as compared to healthy rats.CONCLUSION: The study concludes that phenylhydrazine induced experimental anemic albino rats showed increased oxidative stress than compared with healthy albino rats.Journal of Universal College of Medical Sciences Vol. 3, No. 1, 2015: 41-47 

Hypolipidemic effect of prepared Polyherbal formulations in Wistar albino rats

2021 ◽  
pp. 4314-4320
Author(s):  
Ranjan Kumar Giri ◽  
Sunil Kumar Kanungo ◽  
Saroj Kumar Patro ◽  
Minaketan Sahoo ◽  
Dibya Sundar Panda
Keyword(s):  
Elevated Serum ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Control Group ◽  
Albino Rats ◽  
Histopathological Study ◽  
Oral Glucose ◽  
Hypolipidemic Effect ◽  
Standard Drug ◽  
Wistar Albino Rats

Lipid lowering effect of polyherbal formulations using eight different plants was evaluated in triton and diet induced hyperlipidemic models of wistar albino rats. Formulations such as Tablet, Syrup and Suspension inhibited the elevation in serum cholesterol and triglyceride levels on Triton WR 1339 administration rats. The formulations at the same dose level significantly attenuated the elevated serum total cholesterol and triglycerides with an increase in high-density lipoprotein cholesterol in high-fat diet-induced hyperlipidemic rats. The standard drug Niacin showed slightly better effects. The treatment with herbal formulations produced 30-35 percentage improvement in oral glucose tolerance. Similarly all the formulations also reduced the elevated C-reactive protein which is a marker of Hyperlipidemia. In histopathological study it was found that treatment of polyherbal formulation significantly reduced the plaque size in aorta compared with HFD treated control group. The outcome of the study reveals the lipid lowering activity of polyherbal formulations in dyslipidaemic conditions by interfering with the biosynthesis of cholesterol and utilization of lipids.

Effects of erdosteine on cyclosporin-A-induced nephrotoxicity

2011 ◽  
Vol 31 (6) ◽  
pp. 565-573 ◽  
Author(s):  
M Tutanc ◽  
V Arica ◽  
N Yılmaz ◽  
A Nacar ◽  
I Zararsiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cyclosporin A ◽  
Protective Role ◽  
Control Group ◽  
Albino Rats ◽  
Protective Mechanism ◽  
Antioxidant Parameters ◽  
Group 2 ◽  
Wistar Albino Rats

Aim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a potential responsible mechanism. Therefore, we aimed to investigate the protective role of erdosteine against CsA-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Materials and methods: Wistar albino rats were randomly separated into four groups. Group 1 rats treated with sodium chloride served as the control, group 2 rats were treated with CsA, group 3 with CsA plus erdosteine, and group 4 with erdosteine alone. Animals were killed and blood samples were analyzed for blood urea nitrogen (BUN), serum creatinine (Cr), uric acid (UA), total protein (TP), and albumin (ALB) levels. Kidney sections were analyzed for malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as for histopathological changes. Results: In the CsA group, MDA, GSH-Px, BUN, and Cr levels were increased. The TP and ALB levels were decreased. These changes had been improved by erdosteine administration. Other biochemical parameters did not show any significant change. Conclusion: These results indicate that erdosteine produces a protective mechanism against CsA-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.

scholarly journals Evaluation of antidiabetic activity of fruit of Coriandrum sativum. Linn methanolic extract in Streptozocin induced diabetic wistar Albino rats

2017 ◽  
Vol 7 (1) ◽  
pp. 121
Author(s):  
Ahmed S. K. ◽  
Chakrapani Cheekavolu ◽  
Sampath D. ◽  
Sunil M.
Keyword(s):  
Research Study ◽  
Diabetes Management ◽  
Methanolic Extract ◽  
Coriandrum Sativum ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Citrate Buffer ◽  
Standard Drug ◽  
Wistar Albino Rats

Background: Diabetes prevalence is estimated to increase annually. Numerous people use traditional medicine, such as India also considered as the diabetic capital in the world. Diabetes is a metabolic disorder characterized by disturbances in lipid, carbohydrate and protein metabolism. The present study to evaluate the antidiabetic potential of coriandrum sativum. linn fruits methanolic extract in streptozocin induced diabetic wistar albino rats model.Methods: Diabetes induction in wistar albino rats by administration of streptozocin (50mg/kg, i.p.) in citrate buffer. 30 wistar albino rats were divided into 5 groups (A, B, C, D, E). Group A: served as normal control, whereas Group B: diabetic control, Group C, D methanolic coriandrum sativum Linn. fruits extract (CSFME) at a dose of 100, 200mg/kg orally, Group E was given standard drug Glibenclamide (0.5mg/kg) orally. All groups are administered for the period of 14 consecutive days and blood sugar levels was measured at regular intervals up to end of the study.Results: This present research study confirms that the test drug compound CSFME has sustained oral hypoglycaemic activity and statistically significant (p ≤0.05) and which is comparable with standard drug Glibenclamide.Conclusions: This research study confirms that the CSFME has antidiabetic activity against streptozocin induced wistar diabetic albino rats. It could be a novel antidiabetic agent and also a dietary adjunct in the type 2 diabetes management and its complication. Further studies are necessary required to confirm the antidiabetic activity of individual phytochemical compounds of Coriandrum sativum.

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