P.0577 Variation in P2RX7 interacts with childhood traumas and negative life events influencing current depressive symptoms but not lifetime depression

2021 ◽  
Vol 53 ◽  
pp. S422-S423
Author(s):  
Z. Kristof ◽  
N. Eszlari ◽  
S. Sutori ◽  
Z. Gal ◽  
D. Torok ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Life Events ◽  
Negative Life Events ◽  
Childhood Traumas

The associations between family characteristics and depressive symptoms in older adults: a community-based survey in rural China

2012 ◽  
Vol 24 (8) ◽  
pp. 1226-1234 ◽  
Author(s):  
Yanhong Gong ◽  
Xiaopiao Wen ◽  
Chaoping Guan ◽  
Zhiqing Wang ◽  
Yuan Liang
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Life Events ◽  
Rural China ◽  
Economic Status ◽  
Negative Life Events ◽  
Family Members ◽  
Family Characteristics ◽  
Negative Life Event ◽  
The Past

ABSTRACTBackground: The aim of the current study was to investigate the associations between family characteristics and depressive symptoms, and provide new evidence and recommendations for prevention and intervention in the depressive symptoms of older adults.Methods: The study was a cross-sectional survey conducted door-to-door, utilizing a sample of 1,317 individuals aged 60 years and above in rural China. The five family characteristic variables recorded were: living with spouse, living with descendant, support of family members, self-reported family economic status in the previous year, and family-related negative life events that occurred anytime in the past with a continuous psychological effect during the past 12 months. Gender, age, years of schooling, and self-rated physical health status were taken as potential confounders. Univariable and multivariable logistic regression models were used to examine independent effects on depressive symptoms.Results: In addition to the potential confounders, only family-related negative life events, support of family members, and self-reported family economic status had significant effects on depressive symptoms in older adults. Experiencing a family-related negative life event was the most significant variable (OR = 11.70, 95% CI: 7.72–17.73), the second was support of family members (OR = 6.93, 95% CI: 3.26–14.70), while family economic status was less important than support of family members (OR = 2.38, 95% CI: 1.08–5.25).Conclusion: This study, from the perspective of family characteristics on depressive symptoms in older adults, showed a strong correlation between being exposed to harmful family environments and depressive symptoms among the elderly. Efforts to address family risk factors and strengthen family cohesiveness deserve a higher priority, given the importance of these factors, compared with other efforts such as promoting economic development.

Ethnic Variables and Negative Life Events as Predictors of Depressive Symptoms and Suicidal Behaviors in Latino College Students

2016 ◽  
Vol 38 (2) ◽  
pp. 206-221 ◽  
Author(s):  
Edward C. Chang ◽  
Elizabeth A. Yu ◽  
Tina Yu ◽  
Emma R. Kahle ◽  
Viviana Hernandez ◽  
...  
Keyword(s):  
College Students ◽  
Depressive Symptoms ◽  
Life Events ◽  
Negative Life Events ◽  
Latino College Students ◽  
Suicidal Behaviors

scholarly journals Negative Life Events, Social Ties, and Depressive Symptoms for Older Adults in China

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 580-580
Author(s):  
Hangqing Ruan ◽  
Feinian Chen
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Life Events ◽  
Social Relations ◽  
Stressful Life Events ◽  
Social Ties ◽  
Negative Life Events ◽  
Old Age Support ◽  
Social Survey ◽  
Different Types

Abstract Negative life events are considered important risk factors of depression among older adults. An overwhelming amount of literature suggests that individuals with the most supportive social relations tend to make a better recovery from stressful life events. As for which types of ties matter the most, whether being family, relatives, friends or the broader community, existing literature is much less consistent and has documented varying effects across different contexts. This study is set in China, which traditionally relies on family systems and filial obligations for old-age support. Using two waves of data from China Longitudinal Aging Social Survey, we examine the protective effect of different types of social relations on depressive symptoms, including those who are living in the household, children who live close by or far away, as well as their ties with family, relatives, and friends.

scholarly journals Every Night and Every Morn: Effect of Variation in CLOCK Gene on Depression Depends on Exposure to Early and Recent Stress

2021 ◽  
Vol 12 ◽  
Author(s):  
Dorka Gyorik ◽  
Nora Eszlari ◽  
Zsofia Gal ◽  
Dora Torok ◽  
Daniel Baksa ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Linkage Disequilibrium ◽  
Life Events ◽  
Negative Life Events ◽  
Population Sample ◽  
Brief Symptom Inventory ◽  
Additive Models ◽  
Outcome Variable ◽  
Childhood Adversities ◽  
Increased Risk

The role of circadian dysregulation is increasingly acknowledged in the background of depressive symptoms, and is also a promising treatment target. Similarly, stress shows a complex relationship with the circadian system. The CLOCK gene, encoding a key element in circadian regulation has been implicated in previous candidate variant studies in depression with contradictory findings, and only a few such studies considered the interacting effects of stress. We investigated the effect of CLOCK variation with a linkage-disequilibrium-based clumping method, in interaction with childhood adversities and recent negative life events, on two phenotypes of depression, lifetime depression and current depressive symptoms in a general population sample.Methods: Participants in NewMood study completed questionnaires assessing childhood adversities and recent negative life events, the Brief Symptom Inventory to assess current depressive symptoms, provided data on lifetime depression, and were genotyped for 1054 SNPs in the CLOCK gene, 370 of which survived quality control and were entered into linear and logistic regression models with current depressive symptoms and lifetime depression as the outcome variable, and childhood adversities or recent life events as interaction variables followed by a linkage disequilibrium-based clumping process to identify clumps of SNPs with a significant main or interaction effect.Results: No significant clumps with a main effect were found. In interaction with recent life events a significant clump containing 94 SNPs with top SNP rs6825994 for dominant and rs6850524 for additive models on current depression was identified, while in interaction with childhood adversities on current depressive symptoms, two clumps, both containing 9 SNPs were found with top SNPs rs6828454 and rs711533.Conclusion: Our findings suggest that CLOCK contributes to depressive symptoms, but via mediating the effects of early adversities and recent stressors. Given the increasing burden on circadian rhythmicity in the modern lifestyle and our expanding insight into the contribution of circadian disruption in depression especially as a possible mediator of stress, our results may pave the way for identifying those who would be at an increased risk for depressogenic effects of circadian dysregulation in association with stress as well as new molecular targets for intervention in stress-related psychopathologies in mood disorders.

Serotonergic influence on depressive symptoms and trait anxiety is mediated by negative life events and frontal activation in children and adolescents

2019 ◽  
Vol 29 (5) ◽  
pp. 691-706 ◽  
Author(s):  
Katharina Kneer ◽  
Julia Reinhard ◽  
Christiane Ziegler ◽  
Anna Slyschak ◽  
Miriam Schiele ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Children And Adolescents ◽  
Life Events ◽  
Trait Anxiety ◽  
Negative Life Events

scholarly journals Disentangling the causal inter-relationship between negative life events and depressive symptoms in women: a longitudinal twin study

2012 ◽  
Vol 42 (9) ◽  
pp. 1801-1814 ◽  
Author(s):  
M. Wichers ◽  
H. H. Maes ◽  
N. Jacobs ◽  
C. Derom ◽  
E. Thiery ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Life Events ◽  
Longitudinal Design ◽  
Negative Life Events ◽  
Model Fitting ◽  
Negative Life Event ◽  
Life Event ◽  
Specific Effects ◽  
Best Fitting ◽  
Longitudinal Twin Study

BackgroundNegative life events are strongly associated with the development of depression. However, the etiologic relationship between life events and depression is complex. Evidence suggests that life events can cause depression, and depression increases the risk for life events. Additionally, third factors influencing both phenotypes may be involved. In this work we sought to disentangle these relationships using a genetically informative longitudinal design.MethodAdult female twins (n=536, including 281 twin pairs) were followed up for measurements of negative life event exposure and depressive symptoms. Four follow-ups were completed, each approximately 3 months apart. Model fitting was carried out using the Mx program.ResultsThe best-fitting model included causal paths from life events to depressive symptoms for genetic and shared environmental risk factors, whereas paths from depressive symptoms to life events were apparent for shared environmental factors. Shared latent influence on both phenotypes was found for individual-specific effects.ConclusionsLife events and depressive symptoms have complex inter-relationships that differ across sources of variance. The results of the model, if replicated, indicate that reducing life event exposure would reduce depressive symptoms and that lowering depressive symptoms would decrease the occurrence of negative life events.

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