Impact of maternal central adiposity on infant anthropometry and perinatal morbidity: A systematic review

Introduction: Cardiometabolic syndrome consists of a cluster of metabolic dysfunctions such as impaired glucose tolerance, insulin resistance, dyslipidemia, central adiposity, and hypertension. According to the latest estimates, globally, nearly 25% of all adults have cardiometabolic syndrome. Both cardiometabolic syndrome and cancer pathophysiology commonly involve inflammation and oxidative stress. The objective of this systematic review was to evaluate existing evidences that support the association between cardiometabolic syndrome and risk of developing cancer. Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Scopus for relevant articles published from the database inception until October 2019. We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines for this review. Using the Oxford Center for Evidence-Based Medicine guidelines individual studies were evaluated. A total of 59 articles were included in this study. Results: Our review showed that cardiometabolic syndrome was associated with increased risk for colorectal, hepatic, endometrial, breast, and bladder cancers. These associations showed variations for sex and geographical locations. For example, the associations were stronger for pancreatic and rectal cancers among women. The strength of these associations was also stronger for sex specific cancers such as breast and endometrial cancers. Studies on European populations showed that these associations were stronger for colorectal cancer among women. However, one study showed that presence of cardiometabolic syndrome contributed protective effects to prostate cancer among American men. In general, strongest associations were found for colorectal cancer among both men and women and hepatic cancer among men. Among cardiometabolic factors, impaired glucose tolerance and central adiposity were the greatest contributors towards increased risk for cancers. Conclusion: Given these results, there should be greater focus on primary prevention to identify and treat cardiometabolic risk factors. In addition, patients with greater cardiometabolic risk factors should be screened earlier and more frequently for cancers. A number of gender and geographical gaps identified in this review could be targeted for improvements as per the goals of 2030 sustainable development initiatives. Future studies should consider cardiometabolic syndrome and cancer together and develop effective interventions for decreasing the incidence and morbidity associated with both the conditions.

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Central Adiposity Is Associated With Increased Risk of Esophageal Inflammation, Metaplasia, and Adenocarcinoma: A Systematic Review and Meta-analysis

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2013.05.009 ◽

2013 ◽

Vol 11 (11) ◽

pp. 1399-1412.e7 ◽

Cited By ~ 182

Author(s):

Siddharth Singh ◽

Anamay N. Sharma ◽

Mohammad Hassan Murad ◽

Navtej S. Buttar ◽

Hashem B. El–Serag ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Central Adiposity ◽

Increased Risk

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Association of Obesity and Covid-19 Severity: The Systematic Review

International Journal Of Medical Science And Clinical Invention ◽

10.18535/ijmsci/v8i11.08 ◽

2021 ◽

Vol 8 (11) ◽

pp. 5802-5807

Author(s):

Daniel Setiawan Nathan ◽

Hoo Yumilia

Keyword(s):

Systematic Review ◽

Animal Studies ◽

Primary Data ◽

Severe Illness ◽

Central Adiposity ◽

Inclusion Criteria ◽

Is Research ◽

Novel Coronavirus ◽

Visceral Adipose ◽

The Relationship

Introduction: Obesity is a common, serious, and costly chronic disease. Having obesity puts people at risk for many other serious chronic diseases and increases the risk of severe illness from COVID-19. This study was designed to collect data on the association between obesity and severity of COVID-19. Methods: This study is a systematic review. We searched for the keywords “coronavirus disease 2019” or “covid-19” or “2019 novel coronavirus” or “2019-ncov” or “novel coronavirus 2019 infection” or “2019-ncov infection” or “severe acute respiratory syndrome coronavirus 2” or “sars-cov-2”) and “obesity” or “overweight” or “body mass index” or “BMI” or “visceral fat” or “excessive fat” or “abdominal fat” or “visceral adipose tissue” or “visceral adiposity” or “central adiposity” or “waist circumference” or “risk factors” or “factor” or “risk factor” or “clinical characteristics” or “clinical features”. The study included in this is research that focuses on the relationship between obesity and severity of COVID-19. The inclusion criteria of the research that will be included are studies that examine the relationship between obesity and severity of COVID-19, with adult subjects (not animal studies), research conducted within the last ten years and using primary data. The purpose of this study was to examine the relationship between obesity and severity of COVID-19. Results: We found several relevant journals or articles related to the relationship between obesity and severity of COVID-19. The search results in the Pubmed journal database; we found one journal that discusses the relationship between obesity and severity of COVID-19. A Google scholar search shows five studies relevant to this study. Conclusion: Obesity in many studies has been associated with the severity of COVID-19. There are several possible pathways that are thought to cause this severity. First, obesity is associated with altered inflammatory performance. Second, obesity is associated with other comorbidities.

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The Relation Between Cortisol and Anthropometric Measurements Throughout Lifespan: A Systematic Review and Meta-Analysis

Journal of the Endocrine Society ◽

10.1210/jendso/bvab048.057 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. A30-A30

Author(s):

Eline S van der Valk ◽

Ozair Abawi ◽

Mostafa Mohseni ◽

Amir Abdelmoumen ◽

Vincent L Wester ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Correlation Coefficients ◽

Population Based ◽

Population Characteristics ◽

Central Adiposity ◽

Cross Sectional ◽

Random Effects Models ◽

Outcome Information

Abstract Introduction: Recently, cross-sectional studies report associations between long-term glucocorticoid levels in scalp hair (HairGC) and obesity. However, there is a wide variation in studied outcomes and associations, possibly caused by differences in population characteristics, e.g. age, sex, dispersion of adiposity, and used laboratory methods. The aim of this systematic review and meta-analysis was to investigate the relation between HairGC and anthropometrics and to explore possible moderators of this association. Methods: We searched the Medline, Embase, Cochrane, Web of Science, Scopus, Cinahl, PsycInfo, and Google Scholar databases for articles that relate HairGC to measures of adiposity (date 11-16-2020). Primary outcomes were correlations between hair cortisol (HairF) and cortisone (HairE), and anthropometrics: BMI, waist circumference (WC) and waist-hip-ratio (WHR). Authors were contacted to provide missing outcome information. Pooled correlation coefficients were calculated using random effects models. Assessment of heterogeneity was performed using the I2 statistic. Exploratory moderator analyses were performed with subgroup analyses and meta-regression. This systematic review was performed in accordance to the PRISMA guidelines. Results: Our systematic search identified 150 cohorts, comprising a total of 37,107 unique individuals, of which 15,033 sampled from population-based cohorts. For BMI, the pooled correlation for HairF was 0.121 (95% CI 0.083–0.158, n=26,941; I2 94.2%, p<0.001) and for HairE 0.108 (95% CI 0.047–0.167, n=7,250; I2 52%, p<0.01). For WC, the pooled correlation for HairF was 0.111 (95% CI 0.058–0.164, n=10,290; I2 63%, p<0.01) and for HairE 0.200 (95% CI 0.137–0.264, n=2,198; I2 0%, p=0.42). For WHR, the pooled correlation for HairF was 0.102 (95% CI 0.040–0.163, n=6,865; I2 27%, p=0.14) and for HairE 0.261 (95% CI 0.195–0.330, n=1,314; I2 0%, p=0.40). A higher percentage of male participants was related to stronger correlations with WC (p<0.001), but not with BMI and WHR. Mean age, mean BMI, and mean HairGC levels of the cohorts did not significantly moderate the pooled correlations, neither did the used laboratory techniques (immunoassays vs mass spectrometry-based assays). Conclusion: This unique, large meta-analysis demonstrates that long-term endogenous glucocorticoids as assessed by HairGC show small but consistent correlations to measures of obesity, despite a large heterogeneity between the included cohorts. The strongest associations were found between HairE and WC and between HairE and WHR. This suggests that glucocorticoid levels in the high-normal range, especially cortisone, may contribute to or reflect the state of specifically central adiposity, even within the general population.

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Effects of Nutritional Education Interventions on Metabolic Risk in Children and Adolescents: A Systematic Review of Controlled Trials

Nutrients ◽

10.3390/nu12010031 ◽

2019 ◽

Vol 12 (1) ◽

pp. 31

Author(s):

Rosaura Leis ◽

Carmela de Lamas ◽

María-José de Castro ◽

Rosaura Picáns ◽

Mercedes Gil-Campos ◽

...

Keyword(s):

Systematic Review ◽

Metabolic Syndrome ◽

Children And Adolescents ◽

Educational Interventions ◽

Public Health Issue ◽

Global Public Health ◽

Central Adiposity ◽

Nutritional Education ◽

Randomized Controlled Studies ◽

Education Interventions

Childhood obesity is a global public health issue and is linked to metabolic syndrome, which increases the risk of comorbidities such as type 2 diabetes, cardiovascular diseases and cancer. Social, economic and cultural factors influence changes in nutrition and lifestyle characterized by poorer diets and reduced physical activity. This systematic review summarizes the evidence for nutritional education interventions to improve metabolic risks in children and adolescents. Systematic searches of the databases Medline (via PubMed) and Scopus were conducted following PRISMA guidelines. The risk of bias for each study was assessed following the methodology of the Cochrane Collaboration. Ten case-controlled and randomized controlled studies testing nutritional educational interventions targeting children and adolescents from the general population were eligible for inclusion. The sample size was 3915 and the age range was 7–20 years. The duration of intervention ranged from 12 weeks to 20 years. All the studies that provided data on abdominal obesity reported differences in favour of the intervention. However, data on the effects on the remaining components of metabolic syndrome remain inconclusive. These results support the role of nutritional education interventions as a strategy to reduce central adiposity and its possible unhealthy consequences in children and adolescents.

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Outcomes of pregnancy and delivery large fetus

Journal of obstetrics and women s diseases ◽

10.17816/jowd65636-44 ◽

2016 ◽

Vol 65 (6) ◽

pp. 36-44

Author(s):

Marina N Mochalova ◽

Yulia N Ponomareva ◽

Andrey A Mudrov ◽

Viktor A Mudrov

Keyword(s):

Systematic Review ◽

Perinatal Outcomes ◽

Birth Trauma ◽

Morbidity And Mortality ◽

Perinatal Morbidity ◽

Pregnancy And Delivery ◽

Adverse Perinatal Outcomes

In spite of large number of studies on the issue of delivery pregnant with large fetus, avowed tactics of pregnancy and delivery does not exist. High rates of mother’s birth trauma and adverse perinatal outcomes during delivery large fetus are great medical and social problem.The aim of the study was to investigate the course of pregnancy and delivery, and perinatal outcomes during delivery large fetus.Materials: literary data of foreign and domestic authors in the period from 1991 to 2016.Methods: a systematic review and synthesis of the literature data.Conclusion: It is necessary to determine an optimum tactics of pregnancy and delivery large fetus that will reduce significantly perinatal morbidity and mortality.

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Measurement matters: A systematic review of waist measurement sites for determining central adiposity

Collegian Journal of the Royal College of Nursing Australia ◽

10.1016/j.colegn.2016.08.009 ◽

2017 ◽

Vol 24 (5) ◽

pp. 513-523 ◽

Cited By ~ 4

Author(s):

Wendan Shi ◽

Lis Neubeck ◽

Robyn Gallagher

Keyword(s):

Systematic Review ◽

Central Adiposity

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Possibilities of diagnosis fetal macrosomia at present stage

Journal of obstetrics and women s diseases ◽

10.17816/jowd65575-81 ◽

2016 ◽

Vol 65 (5) ◽

pp. 75-81

Author(s):

Marina N Mochalova ◽

Yulia N Ponomareva ◽

Andrey A Mudrov ◽

Viktor A Mudrov

Keyword(s):

Systematic Review ◽

Optimal Algorithm ◽

Birth Trauma ◽

Fetal Macrosomia ◽

Perinatal Morbidity ◽

Present Stage ◽

Pregnancy And Childbirth ◽

Perinatal Pathology ◽

Priority Task ◽

The World

Presently, reduction of perinatal morbidity and mortality is a priority task of medical obstetrics in the world. An important role in the structure of perinatal pathology is taken to labor of macrosomic fetus. High rates of asphyxia (9,2-34,2 %), birth trauma (10,9-24%) during childbirth of large fetus are great medical and social problem.The aim of the study was to define possibilities of diagnosis fetal macrosomia at present stage of science’s development.Materials: literary data of foreign and domestic authors in the period from 1992 to 2016.Methods: a systematic review and synthesis of the literature data.Conclusion. It is necessary to determine an optimal algorithm for the diagnosis of fetal’s macrosomia, which will optimize the tactics of pregnancy and childbirth.

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