Aspects of the psychological consequences of cannabis use

2017 ◽  
Vol 41 (S1) ◽  
pp. S479-S479
Author(s):  
L. Montes Reula ◽  
A. Portilla Fernández ◽  
H. Saiz García
Keyword(s):  
Bipolar Disorder ◽  
Suicide Attempts ◽  
Age At Onset ◽  
Cannabis Use ◽  
Psychological Consequences ◽  
Course Of Illness ◽  
Adult Age ◽  
Affective Symptoms ◽  
Competing Interest ◽  
The Relationship

Cannabis is seen among general population as an “anti-depressive drug”. Many papers have been published in the field of investigation about the relationship between cannabis use and affective disorders. We pretend to find the aspect of the psychological consequences of cannabis use.MethodsUsing Pubmed and PsychInfo, we conducted a narrative review of the literature on cannabis and psychiatric comorbidity using the keywords cannabis, psychosis, mood, depression, mania, bipolar, and anxiety.ResultsThere is substantial evidence of an association between cannabis use and psychosis. A few reports suggest an association with bipolar disorder while the association with depression and anxiety disorders is mixed.ConclusionsThe present review confirms earlier findings of an association between cannabis use and a lower age at onset. Data shows that cannabis use, beginning in the adolescence and with a frequency higher than once a week, correlates with the development in adult age of affective symptoms and/or disorder, mainly in bipolar disorder, with a moderate relation with Depressive spectrum. Even more, some authors hypothesize that cannabis may play a role in the development of the disorder, that to say, affective disorder would not appear in the absence of cannabis use. The current findings suggest that recent cannabis use is associated with a more severe course of illness in the early phase of BD I.Recent cannabis use was also associated with more lifetime suicide attempts.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Bipolar disorder and co-occurring cannabis use disorders

2017 ◽  
Vol 41 (S1) ◽  
pp. S466-S466
Author(s):  
S. Ben Mustapha ◽  
W. Homri ◽  
L. Jouini ◽  
R. Labbane
Keyword(s):  
Bipolar Disorder ◽  
Suicide Attempts ◽  
Term Treatment ◽  
Cannabis Use ◽  
Family Dynamic ◽  
Long Term Treatment ◽  
Cannabis Use Disorders ◽  
Competing Interest ◽  
Bipolar Patients ◽  
Psychotic Features

AimsAssess the prevalence of cannabis use disorders (CUD) in patients with bipolar disorder, describe the demographic and clinical profile socio bipolar patients with comorbid addictive and assess the implications of this comorbidity on prognosis and evolution of bipolar disorder.MethodsA case-control study, 100 euthymic patients treated for bipolar disorder, recruited in the department of psychiatry C of Razi hospital. Two groups were individualized by the presence or not of cannabis use disorders comorbidity. The two groups were compared for sociodemographic, clinical, therapeutic and historical characteristics.ResultsThe prevalence of CUD was 27.53% (n = 19) in our sample. Comparing bipolar patients according to the presence or absence of CUD, we found the following results with patients with CUD comorbidity: younger, mostly male, a disturbed family dynamic, low educational level, poor socio-economic conditions, more time abroad history, more suicide attempts in history, more criminal record, more psychiatric family history, an earlier onset of the disease, a longer duration of undiagnosed bipolar disorder, more personality disorder, more frequent presence of a triggering factor for bipolar disorder, more psychotic features during mood episodes, more need of antipsychotic long-term treatment.ConclusionsThe frequency of CUD in BD is higher than the prevalence in the general population and CUD is a factor in the evolution and prognosis of bipolar disorder and promotes the development of mood disorders in predisposed patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Rafaela Torres Portugal Leite ◽  
Sarah de Oliveira Nogueira ◽  
João Paulo Rodrigues do Nascimento ◽  
Laisa Soares de Lima ◽  
Taís Bastos da Nóbrega ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Early Onset ◽  
Suicide Attempts ◽  
Age At Onset ◽  
Prognostic Significance ◽  
Manic Episode ◽  
Cannabis Use ◽  
Pubmed Database ◽  
Increased Risk ◽  
Bipolar Patients

Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early onset of BD and for suicide attempts.Materials and Methods. PubMed database was searched for articles using key words “bipolar disorder,” “suicide attempts,” “cannabis,” “marijuana,” “early age at onset,” and “early onset.”Results. The following percentages in bipolar patients were found: suicide attempts 3.6–42%; suicide attempts and substance use 5–60%; suicide attempts and cannabis use 15–42%. An early AAO was associated with cannabis misuse. The mean age of the first manic episode in individuals with and without BD and cannabis use disorder (CUD) was 19.5 and 25.1 years, respectively. The first depressive episode was at 18.5 and 24.4 years, respectively. Individuals misusing cannabis showed increased risk of suicide.Discussion. Cannabis use is associated with increased risk of suicide attempts and with early AAO. However, the effect of cannabis at the AAO and suicide attempts is not clear.

Age at menarche is related to number of previous depressive episodes in patients with bipolar disorder

2016 ◽  
Vol 33 (S1) ◽  
pp. S338-S338 ◽  
Author(s):  
B. Dunjic-Kostic ◽  
M. Pantovic Stefanovic ◽  
M. Lackovic ◽  
A. Damjanovic ◽  
A. Jovanovic ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicide Attempts ◽  
Previous History ◽  
Control Group ◽  
Age At Menarche ◽  
Course Of Illness ◽  
Hormonal Fluctuations ◽  
Healthy Control ◽  
Competing Interest ◽  
Depressive Episodes

IntroductionOestrogen fluctuations may be an important factor in the etiology of bipolar disorder and age at menarche is associated with the clinical course of BD. Moreover, it is associated with traits related to mood.AimsThe aim of our study was to explore the differences in age at menarche between euthymic BD patients and healthy controls, as well as to explore the relationship between age at menarche and lifetime psychopathology within BD.MethodsThe study group consisted of 83 patients diagnosed with BD, compared to the healthy control group (n = 73) and matched according to age, gender, and body mass index (BMI). Lifetime psychopathology has been assessed according to predominant polarity as well as previous history of suicide attempts and psychotic episodes.ResultsAge at menarche in BD patients was similar to that in controls. After covarying for confounders, we observed that age at menarche is negatively related to number of previous depressive episodes in euthymic BD patients, but not other indicators of lifetime psychopathology.ConclusionsBD patients with earlier age at menarche are more likely to present with more depressive episodes in the course of illness. Systemic, longitudinal monitoring of the course of illness, and potential hormonal fluctuations within particular groups of patients are warranted.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Gender Difference Among Admitted Patients with Bipolar Disorder in a Psychiatric Service During a Three-year Period

2017 ◽  
Vol 41 (S1) ◽  
pp. S115-S115
Author(s):  
M. Fernandes ◽  
D. Mota ◽  
A. Olivera ◽  
J. Ribeiro ◽  
S. Silva ◽  
...  
Keyword(s):  
Gender Differences ◽  
Bipolar Disorder ◽  
Suicide Attempts ◽  
Psychiatric Service ◽  
Treatment Options ◽  
Age At Onset ◽  
Men And Women ◽  
Course Of Illness ◽  
Co Morbidity ◽  
Significant Difference

IntroductionGender differences in bipolar disorder are becoming apparent, but have been less studied compared with major depression. The presentation, clinical features, course and evolution of bipolar disorder differ between men and women. Research data on these differences will help determine whether gender is important in influencing illness variables.ObjectivesDetermine whether men and women with bipolar disorder have statistical significant differences in socio-demographic and clinical data.MethodsCharts of all patients with a diagnosis of bipolar disorder admitted in the Coimbra Hospital and Universitary Center over a three-year period (between 2013 and 2015) were reviewed to gather data on socio-demographic, clinical and psychopathological variables to assess differences across genders. Statistical analysis of data with “SPSS21”.ResultsDuring a three-year period, 189 patients were admitted with bipolar disorder, the majority were female patients, with ages between 21 and 84 years old. The authors will analyse if there is any statistical significant difference between gender in the rate of bipolar I or II diagnoses, age at onset, symptom presentation, delay in diagnoses, number of depressive, or manic episodes, hospitalisations, involuntarily admissions, number of suicide attempts, co-morbidity rates, negative life events, family history and treatment options. Sociodemograpic characteristics will also be analysed.ConclusionGender differences in bipolar disorder is a controversial issue in the literature. The importance of gender on the course and outcome in bipolar disorder has been widely acknowledged. The limited data suggest that the prevalence is similar between sexes but that the course of illness may be different.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Alcohol use and bipolar disorder comorbidity: Synthesis and perspectives

2017 ◽  
Vol 41 (S1) ◽  
pp. S470-S470
Author(s):  
A. Dahdouh ◽  
B. Semaoune ◽  
A. Tremey ◽  
L. Samalin ◽  
V. Flaudias ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Alcohol Use ◽  
Dual Diagnosis ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Systematic Screening ◽  
Electronic Search ◽  
Clinical Interest ◽  
Competing Interest ◽  
The Relationship

ObjectiveAlcohol use disorders and bipolar disorder commonly co-occur and both are associated with more pejorative outcomes, thus constituting a major public health problem. We undertook this synthetic review to provide an update on this issue in order to clarify the nature of the relationship between the two disorders, improve clinical outcomes, prevent complications and therefore optimize management of patients.MethodsWe conducted an electronic search by keywords in databases MEDLINE, EMBASE, PsychINFO, published in English and French from January1985 to December 2015.ResultsThe AUD prevalence is important among BD patients in whom the effects of alcohol are more severe. However, in terms of screening, it appears that the comorbidity is not systematically sought. The concept of co-occurrence finds its clinical interest in the development of specific screening and therapeutic strategies. To date, there are only few recommendations about the management of dual diagnosis and the majority of them support “integrated” approaches.ConclusionsRecommendations should emphasize this strong co-occurrence and promote systematic screening and offered integrated cares.Disclosure of interestThe authors have not supplied their declaration of competing interest.

The Relationship Between Smoking and Suicidal Behavior, Comorbidity, and Course of Illness in Bipolar Disorder

2006 ◽  
Vol 67 (12) ◽  
pp. 1907-1911 ◽  
Author(s):  
Michael J. Ostacher ◽  
Andrew A. Nierenberg ◽  
Roy H. Perlis ◽  
Polina Eidelman ◽  
David J. Borrelli ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Behavior ◽  
Course Of Illness ◽  
The Relationship

Effects of cannabis use on age at onset in schizophrenia and bipolar disorder

2011 ◽  
Vol 126 (1-3) ◽  
pp. 270-276 ◽  
Author(s):  
Marc De Hert ◽  
Martien Wampers ◽  
Tihana Jendricko ◽  
Tomislav Franic ◽  
Domagoj Vidovic ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Age At Onset ◽  
Cannabis Use

scholarly journals The Relationship between Bipolar Disorder and Cannabis Use in Daily Life: An Experience Sampling Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0118916 ◽  
Author(s):  
Elizabeth Tyler ◽  
Steven Jones ◽  
Nancy Black ◽  
Lesley-Anne Carter ◽  
Christine Barrowclough
Keyword(s):  
Bipolar Disorder ◽  
Daily Life ◽  
Experience Sampling ◽  
Cannabis Use ◽  
The Relationship

Indications of a dose–response relationship between cannabis use and age at onset in bipolar disorder

2014 ◽  
Vol 215 (1) ◽  
pp. 101-104 ◽  
Author(s):  
Trine Vik Lagerberg ◽  
Levi Røstad Kvitland ◽  
Sofie R. Aminoff ◽  
Monica Aas ◽  
Petter Andreas Ringen ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Dose Response ◽  
Age At Onset ◽  
Cannabis Use ◽  
Response Relationship ◽  
Dose Response Relationship

C-reactive protein levels are related to suicidality in euthymic patients with bipolar disorder

2016 ◽  
Vol 33 (S1) ◽  
pp. S337-S337
Author(s):  
M. Pantovic Stefanovic ◽  
B. Dunjic-Kostic ◽  
M. Lackovic ◽  
A. Damjanovic ◽  
A. Jovanovic ◽  
...  
Keyword(s):  
Suicide Attempts ◽  
Previous History ◽  
Control Group ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Course Of Illness ◽  
Protein Levels ◽  
Reactive Protein ◽  
History Of ◽  
Competing Interest

IntroductionImmune alterations are believed to be an important part in etiopathogenesis of affective disorders. However, it is not clear if the altered immune mediators are related to distinct disorders or particular psychopathology.AimsThe aim of our study was to explore the differences in C-reactive protein levels (CRP) between euthymic BD patients and healthy controls, as well as to explore the relationship between CRP and lifetime presented psychopathology within BD.MethodsThe study group consisted of 83 patients diagnosed with BD, compared to the healthy control group (n = 73) and matched according to age, gender, and body mass index (BMI). Lifetime psychopathology has been assessed according to predominant polarity as well as previous history of suicide attempts and psychotic episodes.ResultsThe CRP levels were significantly higher in BD patients when compared to healthy controls. After covarying for confounders, we observed that CRP levels, in euthymic BD patients, were related to number of previous suicide attempts, but not other indicators of lifetime psychopathology.ConclusionsBD patients per se, and particularly those with more suicide attempts, are more likely to present with proinflammatory state, even when in remission. Previous history of suicide attempts could bear specifically vulnerable endophenotype within BD. Systemic, longitudinal monitoring of the course of illness, and potential inflammatory mediators that underlie its systemic nature is warranted.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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