When I'm 64: A review of instrumental music-making and brain health in later life

2019 ◽  
Vol 123 ◽  
pp. 17-23
Author(s):  
Catherine Jordan
2020 ◽  
Vol 2 (1) ◽  
pp. 585-614
Author(s):  
Caleb E. Finch ◽  
Todd E. Morgan

Brain development is impaired by maternal exposure to airborne toxins from ambient air pollution, cigarette smoke, and lead. Shared postnatal consequences include gray matter deficits and abnormal behaviors as well as elevated blood pressure. These unexpectedly broad convergences have implications for later life brain health because these same airborne toxins accelerate brain aging. Gene-environment interactions are shown for ApoE alleles that influence the risk of Alzheimer disease. The multigenerational trace of these toxins extends before fertilization because egg cells are formed in the grandmaternal uterus. The lineage and sex-specific effects of grandmaternal exposure to lead and cigarettes indicate epigenetic processes of relevance to future generations from our current and recent exposure to airborne toxins.


2021 ◽  
Vol 50 (Supplement_2) ◽  
pp. ii5-ii7
Author(s):  
Q Dercon ◽  
J Nicholas ◽  
S-N James ◽  
J Schott ◽  
M Richards

Abstract Introduction Grip strength is an objective measure of physical function with potential predictive value for health in ageing populations. We aimed to assess whether levels and changes in grip strength from midlife predicted later-life brain health and cognition. Methods 446 participants in an ongoing British birth cohort study, the MRC National Survey of Health and Development (NSHD), had their maximum grip strength measured at ages 53, 60–64, and 69, and underwent neuroimaging as part of its neuroscience sub-study, Insight 46, at 69–71. A group-based trajectory model identified latent groups of individuals in the whole NSHD cohort with below- and above-average grip strength over time, plus a reference group. Trajectory group membership, plus standardised grip strength levels and change from age 53, were each related to MRI-derived measures of whole-brain volume (WBV) and white-matter hyperintensity volume (WMHV), plus several cognitive tests. Models were adjusted for sex, body size, head size (where appropriate), sociodemographics, and behavioural and vascular risk factors. Results Consistently below-average grip strength from midlife was associated with lower WBV and non-verbal reasoning ability at age 69–71 (e.g. low group WBV vs. reference group β = −13.38 cm^3; 95% CI = (−24.12 cm^3, −2.64 cm^3); p = 0.015). There was some accompanying evidence that above-average maximum grip strength showed a positive association with WBV, which was more pronounced in female participants (high group female WBV vs. reference group β = 18.30 cm^3; 95% CI = (1.34 cm^3, 35.29 cm^3); p = 0.034). Steeper than average declines in grip strength between 53 and 69 were additionally weakly associated with an estimated 10% higher WMHV at age 69–71 (β = 1.10, 95% CI = (1.00, 1.22); p = 0.053). Conclusion This study provides preliminary evidence that tests of maximum grip strength may have value in predicting brain health. Future work should assess how these observed differences relate to later-life negative health outcomes, and whether changes in grip strength reflect concurrent changes in brain structure and connectivity.


Stroke ◽  
2022 ◽  
Author(s):  
Saima Hilal ◽  
Carol Brayne

Brain health as expressed in our mental health and occurrence of specific disorders such as dementia and stroke is vitally important to quality of life, functional independence, and risk of institutionalization. Maintaining brain health is, therefore, a societal imperative, and public health challenge, from prevention of acquisition of brain disorders, through protection and risk reduction to supporting those with such disorders through effective societal and system approaches. To identify possible mechanisms that explain the differential effect of potentially modifiable risk factors, and factors that may mitigate risk, a life course approach is needed. This is key to understanding how poor health can accumulate from the earliest life stages. It also allows us to integrate and investigate key material, behavioral, and psychological factors that generate health inequalities within and across communities and societies. This review provides a narrative on how brain health is intimately linked to wider health determinants, thus importance for clinicians and societies alike. There is compelling evidence accumulated from research over decades that socioeconomic status, higher education, and healthy lifestyle extend life and compress major morbidities into later life. Brain health is part of this, but collective action has been limited, partly because of the separation of disciplines and focus on highly reductionist approaches in that clinicians and associated research have focused more on mitigation and early detection of specific diseases. However, clinicians could be part of the drive for better brain health for all society to support life courses that have more protection and less risk. There is evidence of change in such risks for conditions such as stroke and dementia across generations. The evidence points to the importance of starting with parental health and life course inequalities as a central focus.


2003 ◽  
Vol 20 (1) ◽  
pp. 45-59 ◽  
Author(s):  
Susan Young

This article reports on a study which investigated the spontaneous instrumental music-making of three- and four-year-olds in typical pre-school educational settings in London, UK. It argues that many prior studies of children's music-making have analysed and evaluated such activity against models drawn from the practices of Western art music and its conventions of analytical theory, and suggests that this approach has certain drawbacks. The study adopted a grounded theory methodology moving through three phases in different nursery classrooms. Each phase was characterised by successive focusing and refinement of methodological tools in response to the emerging findings. Data were collected on videotape which was then repeatedly reviewed, transcribed and categorised. The children's music-making was analysed as relational processes in time and space involving the two-way interplay of child and instrument. Structures in space delineate the child's movement within the spatial potentials and constraints of the instrument design. Structures in time describe how movements and movement ideas were strung together in ever-lengthening portions.


Author(s):  
Iveta Dukaļska

A folk musician is an important carrier of the folk music tradition. Most of the folk musicians are talented representatives of the musicians’ craft, highly appreciated in the 20th century by the countryside society. Music making is a must at different gatherings and family celebrations (birthday parties, weddings, seasonal festivities, etc.), and this secures a high social status for the musician within the culture environment, though this also gives rise to competition among the musicians. Along with the changes within the countryside culture environment at the turn of the 20th and 21st century, also the society’s attitude towards the folk music- making tradition has changed, on the one hand viewing it as some old-fashioned activity of elderly men (the musicians), while on the other it is viewed as an important object of study for the preservation of the tradition, its renewal and reintroduction into the culture environment of the 21st century. The present study traces the development of the notion “kaktu muzikants” (literally ‘corner musician’ – a busker; self-taught, amateur musician) in Latvia from both historical and contemporary perspective, performing the culture semiotic analysis of the symbolic and mythic meanings of corner. In the Latvian culture discourse the designation “kaktu muzikants” has the following semantic aspects: 1) in the macro space – opposition of the periphery and the centre; 2) in the micro space – a special location in the inner space (the location of the musician, while playing at the dance; the „red” corner); 3) the level of professionalism, its expressive belittlement (playing without the musical score). The present study characterises the importance of the “kaktu muzikants” in the Latvian culture in 1930’s-60’s and in the present day – in the context of the traditional instrumental music. This study also uses the field-work method in order to obtain the empiric material. During field-work the data are gathered in direct interviews, deeply or partially structured interviews, where the data are obtained from the original source in the presence of the interviewer; as the result a joint view of the culture environment of the period under study was formed, along with a view of the importance and place of a country musician in the aforementioned culture environment. In the 1930’s-40’s the folk music-making tradition is mostly a local tradition of some secluded culture environment – within the boundaries of a single family, village or parish. The first skills of music making as well as those of singing are acquired within the family, where these are inherited from the members of family belonging to the older generation. Each village and parish has its musicians. Usually within a parish a single group is formed of musicians having gained recognition by the community, with this group playing at all most important events within that community – like the weddings of the better-off families and the most important dances (e.g. the dance after the remembrance event at the local cemetery). All other musicians are peripheral musicians in relation to this main group, usually playing on their own or in duos. The situations when the music is played without a written score are self-explanatory and characteristic of folk - musicians’ technique. Lacking the knowledge of musical score, the folk - musicians mainly base on the auditory or musical memory and the song’s text, the latter taking the place of notes. In cases of purely instrumental pieces playing is based on musical hearing alone. Such a technique provides good opportunities for improvisation, and reveals the creativity of the musician, his sense of music and taste. Lack of knowledge of the musical score unites people for whom music is an important part of their lives, providing them with the experience of public performance and the sense of belonging to the group of musicians, simultaneously positioning themselves as musicians of lower status compared to those graduated from some musical education institution. The division by the level of professionalism into insiders and outsiders in relation to one or the other group of musicians was especially pronounced in 1950’s-60’s, but this division has still been retained. In any music playing situation the musician has a special place within the available space allocated to him, where this space can be either inside a house (a single room), some shed or place chosen for an open air dance as a relative space. According to the data gathered during the interviews conducted in the field, the musician most frequently is seated in the corner, that corner becoming the place of honour and the centre for the musician. The designation “kaktu muzikants” is not only current in the culture environment of the 20th century countryside, but is still retained. In 1920’s-40’s quite frequently the designation “kaktu balle” (local, less important or inferior quality dance-party) is used to indicate that the event is organised by the local community (dance at some farmstead, open air dance at some grove, etc.) as compared to more official events organised and recognised by the state institutions. With this also the designation “kaktu balles muzikants” enters currency, though this has no relation to the level of professionalism of the particular musician, instead his location – the periphery. The modern designation “kaktu muzikants” is actualised particularly in the memories of the folk musicians and their life stories of the period beginning with the 1950’s. In the vocabulary of the younger generation of musicians (meaning by that the early 21st century) “kaktu muzikants” prevails as a designation of a musician aiming at understanding of the folk music-making tradition and/or the ones who have restored a music-making tradition of some of the aforementioned periods or imitate the particular instrument technique of a single individual musician.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Quentin Dercon ◽  
Jennifer M. Nicholas ◽  
Sarah-Naomi James ◽  
Jonathan M. Schott ◽  
Marcus Richards

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Quentin Dercon ◽  
Jennifer M. Nicholas ◽  
Sarah-Naomi James ◽  
Jonathan M. Schott ◽  
Marcus Richards

Abstract Background Grip strength is an indicator of physical function with potential predictive value for health in ageing populations. We assessed whether trends in grip strength from midlife predicted later-life brain health and cognition. Methods 446 participants in an ongoing British birth cohort study, the National Survey of Health and Development (NSHD), had their maximum grip strength measured at ages 53, 60–64, and 69, and subsequently underwent neuroimaging as part of a neuroscience sub-study, referred to as “Insight 46”, at age 69–71. A group-based trajectory model identified latent groups of individuals in the whole NSHD cohort with below- or above-average grip strength over time, plus a reference group. Group assignment, plus standardised grip strength levels and change from midlife were each related to measures of whole-brain volume (WBV) and white matter hyperintensity volume (WMHV), plus several cognitive tests. Models were adjusted for sex, body size, head size (where appropriate), sociodemographics, and behavioural and vascular risk factors. Results Lower grip strength from midlife was associated with smaller WBV and lower matrix reasoning scores at age 69–71, with findings consistent between analysis of individual time points and analysis of trajectory groups. There was little evidence of an association between grip strength and other cognitive test scores. Although greater declines in grip strength showed a weak association with higher WMHV at age 69–71, trends in the opposite direction were seen at individual time points with higher grip strength at ages 60–64, and 69 associated with higher WMHV. Conclusions This study provides preliminary evidence that maximum grip strength may have value in predicting brain health. Future work should assess to what extent age-related declines in grip strength from midlife reflect concurrent changes in brain structure.


2021 ◽  
Author(s):  
◽  
Kathleen Gerrard

<p>The Livre d’Airs et de Simphonies meslés de quelques fragmens d’Opéra de la Composition de P. Gillier (Book of Airs and Instrumental Pieces mixed with some operatic fragments composed by Pierre Gillier) was published in Paris in 1697. Its contents are dedicated to the twenty-three year-old Philippe duc de Chartres (son of Philippe I duc d’Orléans, only brother of Louis XIV). Of the life of Pierre Gillier (1665- died after 1713), we know only that he possessed an haute-contre voice, and was employed as a chamber musician in the households of Philippe I duc d’Orléans and of his son, Philippe II. The Parisian courts of the Dauphin, and of Philippe I supported the secular arts that Louis XIV (self-exiled at Versailles), had rejected. There was an insatiable appetite for amateur music making in late seventeenthcentury France, notably in the broader societal context of airs: the salons. Composers generally wrote individual airs (of the serious and drinking types), complete operas, or theatre works. In such a context, Gillier’s publication is unique: his declared aim was to assemble a collection of serious songs linked together tonally in suites with instrumental pieces by means of their keys, for chamber music performance. As a precursor to the arrival in France of the multi-movement sonata and cantata, Gillier’s grouping together of instrumental and vocal movements to make larger musical entities has exceptional interest. His procedure has close links with theatrical practice. The thesis includes a critical edition of Gillier's complete collection made from the copy preserved in the Bibliothèque Nationale de France as F-Pn/ Rés. Vm7 305. The edition is prefaced by a study of performance practices in vocal and instrumental music in late seventeenth-century France.</p>


2019 ◽  
Vol 41 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Simon Spichak ◽  
Timothy G. Dinan ◽  
John F. Cryan

How does the immune system impact brain development? The exciting and somewhat unexpected relationship between the immune system and the brain has become one of the most fascinating topics in neuroscience. Even though the immune system was initially implicated in resolving viral and bacterial threats, it is now becoming more evident that it also plays a role in processes in the brain, both under healthy and pathological conditions. This novel role of the immune system in brain health has been implicated in various psychopathologies where neurodevelopment, stress and mood are central. In particular, its role in healthy brain development is becoming more evident, and understanding neuroimmune communication is becoming crucial in treating neurodevelopmental and mood disorders in later life. In the brain, glia function as part of the innate immune system and are programmed to respond to pathogens and physical injury. They also play an important role in neuronal development and pruning. These cells communicate with and respond to chemical signals, such as cytokines and chemokines, which can then initiate or downregulate inflammatory responses. Finally, the trillions of microbes residing in the gut can also stimulate cytokine and chemokine responses in the periphery and play an important role in both immunity and brain development.


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