An independent risk factor for cardiovascular diseases in diabetic nephropathy; Homocysteine

2018 ◽  
Vol 120 ◽  
pp. S153-S154
Author(s):  
Emre Avci ◽  
Gizem Uncu ◽  
Gülçin Alp Avci
Keyword(s):  
Risk Factor ◽  
Diabetic Nephropathy ◽  
Cardiovascular Diseases ◽  
Independent Risk Factor

scholarly journals Serum cholesterol acceptor capacity in intrauterine growth restricted fetuses

2017 ◽  
Vol 45 (7) ◽  
Author(s):  
Ulrich Pecks ◽  
Werner Rath ◽  
Dirk O. Bauerschlag ◽  
Nicolai Maass ◽  
Thorsten Orlikowsky ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Intrauterine Growth Restriction ◽  
Cholesterol Efflux ◽  
Independent Risk Factor ◽  
Cholesterol Transport ◽  
Vascular Risk ◽  
Transport Mechanisms ◽  
Intrauterine Growth ◽  
Acceptor Capacity

AbstractAim:Intrauterine growth restriction (IUGR) is an independent risk factor for the development of cardiovascular diseases later in life. The mechanisms whereby slowed intrauterine growth confers vascular risk are not clearly established. In general, a disturbed cholesterol efflux has been linked to atherosclerosis. The capacity of serum to accept cholesterol has been repeatedly evaluated in clinical studies by the use of macrophage-based cholesterol efflux assays and, if disturbed, precedes atherosclerotic diseases years before the clinical diagnosis. We now hypothesized that circulating cholesterol acceptors in IUGR sera specifically interfere with cholesterol transport mechanisms leading to diminished cholesterol efflux.Methods:RAW264.7 cells were used to determine efflux of [Results:Cholesterol efflux was lower in IUGR as compared to controls [controls: mean 7.7% fractional [Conclusions:Reduced cholesterol efflux in IUGR could account for the enhanced risk of developing cardiovascular diseases later in life.

scholarly journals Homocysteinemia as a risk factor of diabetic nephropathy in children and adolescents

2008 ◽  
Vol 14 (4) ◽  
pp. 320-323
Author(s):  
Zh. V. Shutskaya
Keyword(s):  
Risk Factor ◽  
Diabetic Nephropathy ◽  
Children And Adolescents ◽  
Independent Risk Factor ◽  
Diabetes Type ◽  
Diabetes Type 1

This article summarizes data on homocysteinemia and its influence on vascular pathologic changes in patients with different diseases including diabetes type 1 and type 2. The role of homocystein as an independent risk factor for diabetic nephropathy in children and adolescents is discussed. The problem of homocysteinemia treatment is reviewed.

scholarly journals Increase of Homocysteinemia/Hydrogen Sulfide (Hcy/H2S) Ratio Raises Cardiovascular Injuries

2021 ◽  
Vol 7 (2) ◽  
Author(s):  
Cacciapuoti F ◽  
Keyword(s):  
Risk Factor ◽  
Hydrogen Sulfide ◽  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Independent Risk Factor ◽  
The Other ◽  
Negative Consequences ◽  
Methylation Pathway ◽  
Other Hand

Increased Homocysteine Levels (HHcy) is an independent risk factor for atherosclerosis. On the other hand, hydrogen sulfide (H2S) exerts a protection against cardiovascular injuries. On the contrary, accumulating evidences showed that downregulation of defective catabolism of HHcy, with reduced H2S synthesis, is involved in the pathogenesis of a variety of cardiovascular diseases. In that occurrence, the detrimental actions on cardiovascular structures performed by HHcy are added to the negative consequences of reduced H2S (in part unlike each HHcy) on cardiovascular system. Therefore, when the reduced re-methylation pathway of Hcy towards Met (resulting in HHcy) is contemporarily added to the decreased trans-sulfuration pathway (inducing a reduction of H2S synthesis) cardiovascular impairment significantly increases.

scholarly journals Evaluation of factors influencing hypertension among adults of South Karnataka

2019 ◽  
Vol 6 (6) ◽  
pp. 1779
Author(s):  
Darshan Kumar H. S. ◽  
Karthik N. Sasalu ◽  
Suresh S. R.
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Independent Risk Factor ◽  
Age Groups ◽  
Direct Relation ◽  
Medical Sciences ◽  
Positive Correlation ◽  
Factors Influencing ◽  
Stage 1

Background: Studies have shown that BP is an independent risk factor for CVD. This relationship is independent as well as consistent and continuous. Observations involving more than 1 million individuals have shown that death from both CVD and stroke increases progressively and linearly from BP levels of as low as 115mm systolic and 75 mm diastolic upwards. The increased risks are present in all age groups ranging from 40 to 89 years old. Hence the present study was undertaken to evaluate the factors influencing hypertension among Adults.Methods: In the present study 400 patients both out-patient and in-patients attending Adichuchanagiri Institute of Medical Sciences were evaluated for factors influencing Hypertension and other cardiovascular diseases. The 400 patients were divided into 200 cases who were again divided into categories based on severity of hypertension into stage 1 and stage 2 and duration of <5 years and ≥5 years.Results: A positive correlation was found between the severity of hypertension, the patients who were found to be having stage 2 hypertension had an increase in SUA levels which was statistically significant when compared with those with stage 1 hypertension. Conclusions: With the results based on the study carried out author concluded that there is direct relation between hyperuricemia and hypertension. Also, the study showed that the SUA levels were significantly increased in patients with Stage 2 hypertension as compared with those of stage 1 hypertension, showing that the severity of hypertension also related to the SUA levels.

scholarly journals INNOVATIONS IN DIAGNOSTICS AND TREATMENT OF PATIENTS WITH HYPERTRIGLYCERIDEMIA

2017 ◽  
Vol 2 (1) ◽  
pp. 43-51
Author(s):  
VV V Simerzin ◽  
OV V Fatenkov ◽  
IV V Gagloeva ◽  
MA A Galkina ◽  
YaA A Panisheva ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Risk Stratification ◽  
Independent Risk Factor ◽  
High Level ◽  
Innovative Techniques

This article presents innovative techniques for diagnostics, risk stratification and treatment of patients with hypertriglyceridemia. Hypertriglyceridemia is not only known as an independent risk factor of cardiovascular diseases, but also its high level can become a cause of acute pancreatitis.

scholarly journals Metabolic Syndrome, Chronic Kidney, and Cardiovascular Diseases: Role of Adipokines

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Manfredi Tesauro ◽  
Maria Paola Canale ◽  
Giuseppe Rodia ◽  
Nicola Di Daniele ◽  
Davide Lauro ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Diabetic Nephropathy ◽  
Cardiovascular Diseases ◽  
Cardiovascular Complications ◽  
Renal Physiology ◽  
Glomerular Sclerosis ◽  
The Metabolic Syndrome ◽  
Cardiovascular Morbidity And Mortality ◽  
Secretory Products

Obesity is a chronic disease, whose incidence is alarmingly growing. It is associated with metabolic abnormalities and cardiovascular complications. These complications are clustered in the metabolic syndrome (MetS) leading to high cardiovascular morbidity and mortality. Obesity predisposes to diabetic nephropathy, hypertensive nephrosclerosis, and focal and segmental glomerular sclerosis and represents an independent risk factor for the development and progression of chronic kidney disease (CKD). Albuminuria is a major risk factor for cardiovascular diseases (CVDs). Microalbuminuria has been described as early manifestation of MetS-associated kidney damage and diabetic nephropathy. Obesity and MetS affect renal physiology and metabolism through mechanisms which include altered levels of adipokines such as leptin and adiponectin, oxidative stress, and inflammation. Secretory products of adipose tissue also deeply and negatively influence endothelial function. A better understanding of these interactions will help in designing more effective treatments aimed to protect both renal and cardiovascular systems.

scholarly journals Cardiovascular Diseases among Suiciders: A Population-Based Study in Northern Finland Population

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Arja Mainio ◽  
Helinä Hakko ◽  
Pirkko Räsänen ◽  
Markku Timonen
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Clinical Practice ◽  
Cardiovascular Diseases ◽  
Independent Risk Factor ◽  
Reference Group ◽  
Population Based ◽  
Psychiatric Consultation ◽  
Population Based Study ◽  
Artery Disease

Objective. Depression has been found to be an independent risk factor with cardiovascular diseases (CVDs) and also associated with increased mortality among these patients. Method. We used a comprehensive database of all suicides (n=2,283) committed in Northern Finland with information on all hospital-treated cardiovascular diseases and psychiatric disorders. Results. Coronary artery disease (CAD) had been present in 7.7% and other cardiovascular diseases (CVDs) in 11.6% of the suiciders. The likelihood of suicide for patients with hospital-treated CAD was estimated to be two-fold compared to the general population while likelihood for suicide was not elevated among those with other CVDs. Males with CAD and females with CAD or any CVD had been hospitalized significantly more often with depression compared to reference group. Conclusions. Suicidality among patients with cardiovascular diseases has been suggested to associate with depression. Psychiatric consultation is highly recommended in clinical practice for cardiac patients with depression or alcohol-related disorders.

scholarly journals Lipid profile: a conduit in the progression from psoriasis to cardiovascular disease

2017 ◽  
Vol 4 (1) ◽  
pp. 173
Author(s):  
Samir Sahu ◽  
Ellora Devi ◽  
Anirban Poddar ◽  
Subhashree Ray
Keyword(s):  
Cardiovascular Disease ◽  
Risk Assessment ◽  
Metabolic Syndrome ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Lipid Profile ◽  
Independent Risk Factor ◽  
Healthy Controls ◽  
Significant Elevation ◽  
Profile Estimation

Background: Psoriasis although a disease of the skin has been reported to be associated with metabolic syndrome. Metabolic syndrome in turn is associated with dyslipidemia which is a independent risk factor for cardiovascular diseases. Our study therefore aims to assess lipid profile in patients with psoriasis with an objective to observe and report any significant deviations in the same as compared to healthy controls.Methods: 25 patients with psoriasis and 25 age, sex matched healthy controls were recruited in this study and lipid profile was estimated using commercially available reagent kit which employs the CHOD-PAP method.Results: Significant elevation in levels of total cholesterol, triglycerides, VLDL and cholesterol/HDL ratio was observed. Elevated although was observed in case of LDL and HDL levels, but it was statistically insignificant.Conclusions: Dyslipidemia was found to be prevalent in psoriasis patients. Dyslipidemia is an independent risk factor for development of cardiovascular disease. Dyslipidemia in psoriasis therefore clearly suggests an inherent predisposition of psoriasis patients to suffer from cardiovascular diseases. A lipid profile estimation in these patients therefore might serve as an important tool for   risk assessment for cardiovascular disease, thereby aiding a timely intervention.

scholarly journals Rheumatoid arthritis as cardiovascular risk factor: an update

2021 ◽  
Vol 30 (4) ◽  
pp. 576-582
Author(s):  
Calin D. Popa
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Risk Management ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Cardiovascular Risk Factor ◽  
Independent Risk Factor ◽  
Daily Practice ◽  
Cardiovascular Risk Management

Rheumatoid arthritis (RA) patients have a 1.5 – 2.5 higher chance to develop cardiovascular diseases (CVD), which in turn represent the most important cause of mortality and the most frequent comorbidity in these patients. Chronic inflammation crucially contributes to that, either as an independent risk factor or as a modulator of traditional cardiovascular (CV) risk factors, such as dyslipidemia and hypertension. The cardiovascular risk management (CVRM) is therefore essential in these patients. The implementation of it in the daily practice is quite challenging and requires a good networking between different specialists (rheumatologist, cardiologist, internist) and the general practitioners (GPs), and may get various forms of organization depending on region and locations.

scholarly journals Aortic stiffness in degenerative aortic stenosis

2021 ◽  
Vol 27 (3) ◽  
pp. 300-308
Author(s):  
K. V. Protasov ◽  
A. S. Makarova ◽  
V. I. Batekha ◽  
Y. V. Zheltovskiy
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Arterial Stiffness ◽  
Aortic Stenosis ◽  
Cardiovascular Events ◽  
Aortic Stiffness ◽  
Independent Risk Factor ◽  
Clinical Relationship ◽  
Relationship Of ◽  
The Relationship

Aortic stenosis (AS) is one of the most common cardiovascular diseases. The prevalence of AS and vascular stiffness are significantly associated with age. Elevated arterial stiffness is an independent risk factor for cardiovascular events. The pathogenetic and clinical relationship of degenerative AS and aortic stiffness is poorly known. This review reflects the current understanding of the relationship between degenerative AS and aortic stiffness. The existing evidence on the effects of surgical and endovascular correction of the defect on aortic stiffness is described. The potential predictors of AS prognosis and outcomes of valve replacement are discussed. Unresolved issues and directions for further research are clarified.

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