Anti-inflammatory action of polyphenols from grape seed extracts in primary human endothenlial cells

2018 ◽  
Vol 124 ◽  
pp. 574
Author(s):  
Ulrike Resch ◽  
Willibald Wonisch ◽  
Franz Tatzber
2020 ◽  
Vol 13 (5) ◽  
pp. 97 ◽  
Author(s):  
Gabriele Carullo ◽  
Fabio Sciubba ◽  
Paolo Governa ◽  
Sarah Mazzotta ◽  
Luca Frattaruolo ◽  
...  

The winemaking process produces a huge number of pomaces that generally are used for energy purposes. Further valuable applications such as health-promoting properties are still under investigation. The seeds of the white berries of Mantonico and Pecorello cv. were extracted in a Soxhlet apparatus, using n-hexane and chloroform as solvents. Extracts were characterized by NMR and GC-MS analyses. They were assayed in vitro as wound healing and anti-inflammatory agents in HaCaT and RAW 264.7 cell lines, respectively. n-hexane Mantonico extract resulted in the most interesting wound healing sample, while n-hexane Pecorello, containing a good number of carotenoids, resulted in a good anti-inflammatory candidate. These preliminary findings underlined the benefit of grape seed extracts valorization due to their health-promoting properties.


Author(s):  
Jessica Borges-Vilches ◽  
Javiera Poblete ◽  
Fernando Gajardo ◽  
Claudio Aguayo ◽  
Katherina Fernández

2018 ◽  
Vol 50 ◽  
pp. 45-52 ◽  
Author(s):  
Zhihan Xu ◽  
Zeying Chu ◽  
Weinan Li ◽  
Tao Sun ◽  
Xiangjun Sun

2017 ◽  
Vol 4 (11 (88)) ◽  
pp. 4-9 ◽  
Author(s):  
Nataliia Bozhko ◽  
Vasyl Tischenko ◽  
Vasil Pasichnyi ◽  
Andriy Marynin ◽  
Maksym Polumbryk

2014 ◽  
Vol 5 ◽  
Author(s):  
Mayssam Khaddam ◽  
Benjamin Salmon ◽  
Dominique Le Denmat ◽  
Leo Tjaderhane ◽  
Suzanne Menashi ◽  
...  

Author(s):  
Gabriel Davidov-Pardo ◽  
Iñigo Arozarena ◽  
Montserrat Navarro ◽  
María R. Marin-Arroyo

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 4001 ◽  
Author(s):  
José Pérez-Navarro ◽  
Guillaume Cazals ◽  
Christine Enjalbal ◽  
Pedro Miguel Izquierdo-Cañas ◽  
Sergio Gómez-Alonso ◽  
...  

Glycosylated flavanols (monoglycosides and diglycosides) in skin and seed extracts of Vitis vinifera grapes grown in Castilla-La Mancha (Spain) were investigated using ultra-high-performance liquid chromatography—tandem mass spectrometry (UHPLC-ESI-QQQ-MS/MS). Six grape varieties (Airén, Tempranillo, the recently identified Albillo Dorado, Montonera del Casar, Moribel, and Tinto Fragoso) were studied over two consecutive years (2016 and 2017). A total of twenty monomeric flavanol monoglycosides, four diglycosylated monomers, and three dimeric flavanol monoglycosides were detected in all grape samples. The diversity observed in the composition of glycosylated flavanol in the grape berries suggests a strong influence of variety and grape tissue (skin or seed). Monomeric flavanol glycosides were more abundant in grape seed extracts, in contrast with monoglycosylated dimeric forms. In addition, the glycosylated flavanol content was related to berry color in grape skins, with higher concentrations measured in black grape varieties.


2020 ◽  
Vol 11 ◽  
Author(s):  
Guangtian Cao ◽  
Xinfu Zeng ◽  
Jinsong Liu ◽  
Feifei Yan ◽  
Zhentian Xiang ◽  
...  

Grape seed is rich in vitamin E, flavonoids, and proanthocyanidins and has the potential to be used as an antibiotic substitute in broilers. We investigated the effects of grape seed proanthocyanidin extract (GSPE) on growth performance, immune responses, cecal microflora, and serum metabolism in early stage broilers. Data indicated that GSPE improved broiler growth performance by strengthening antioxidant capacity, enhancing immune responses, and increasing cecal short chain fatty acids. 16S rRNA sequencing indicated that GSPE changed the predominant cecal microflora and induced the metabolism of amino acids, lipids, and carbohydrates. An UPLC-Q-TOF/MS-based metabolomics analysis identified 23 serum metabolites (mainly related to lipid, amino acid, and alkaloid) were extremely changed by GSPE treatment. The correlations between the changes of cecal microflora and serum metabolites in birds fed with GSPE were analyzed. Hence, GSPE potentially provides active ingredients that may be used as antibiotic substitute and reduces environmental pollution by grape by-products.


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