UV cell stress induces oxidative cyclization of a protective reagent for DNA damage reduction in skin explants

2019 ◽  
Vol 134 ◽  
pp. 133-138 ◽  
Author(s):  
Jing Liu ◽  
Haizhou Zhu ◽  
Gurdat Premnauth ◽  
Kaylin G. Earnest ◽  
Patricia Hahn ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Cyclization ◽  
Cell Stress ◽  
Damage Reduction ◽  
Skin Explants

Assessment of the Photoprotection Properties of Sunscreens by Chromatographic Measurement of DNA Damage in Skin Explants

2010 ◽  
Vol 87 (1) ◽  
pp. 109-116 ◽  
Author(s):  
Stéphane Mouret ◽  
Patrick Bogdanowicz ◽  
Marie-José Haure ◽  
Nathalie Castex-Rizzi ◽  
Jean Cadet ◽  
...  
Keyword(s):  
Dna Damage ◽  
Skin Explants ◽  
Chromatographic Measurement

Gadd45a regulates hematopoietic stem cell stress responses in mice

Blood ◽  
2014 ◽  
Vol 123 (6) ◽  
pp. 851-862 ◽  
Author(s):  
Yulin Chen ◽  
Xiaoming Ma ◽  
Meimei Zhang ◽  
Xiaomin Wang ◽  
Changxin Wang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Stress Responses ◽  
Cell Stress ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Dna Damage Responses

Key Points Loss of Gadd45a enhances HSC reconstitution on hematopoietic stress. Gadd45a regulates DNA damage responses in HSCs.

scholarly journals Inter-center variation in the efficiency of sperm DNA damage reduction following density gradient centrifugation

2013 ◽  
Vol 05 (07) ◽  
pp. 15-20
Author(s):  
Carmen López-Fernández ◽  
Stephen D. Johnston ◽  
Altea Gosálbez ◽  
Jose Luís Fernández ◽  
Juan G. Álvarez ◽  
...  
Keyword(s):  
Dna Damage ◽  
Density Gradient ◽  
Density Gradient Centrifugation ◽  
Gradient Centrifugation ◽  
Sperm Dna Damage ◽  
Damage Reduction ◽  
Sperm Dna

scholarly journals Clove Buds Affect MCF-7 Breast Cancer Cell Stress/Survival Pathways and Induce Oxidative Stress, DNA Damage, Cell Cycle Arrest, and Apoptosis

Proceedings ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 51
Author(s):  
Martin Kello ◽  
Lenka Varinska ◽  
Matus Coma ◽  
Peter Kubatka ◽  
Klaudia Petrova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Cell Cycle ◽  
Dna Damage ◽  
Cell Stress ◽  
Damage Cell ◽  
Cycle Arrest ◽  
Survival Pathways ◽  
Stress Survival ◽  
Mcf 7

Breast cancer is reportedly the second most diagnosed cancer worldwide. Several recent [...]

Senescence of the Kidney

2019 ◽  
pp. 39-48
Author(s):  
Eoin D. O’Sullivan ◽  
David A. Ferenbach
Keyword(s):  
Chronic Kidney Disease ◽  
Dna Damage ◽  
Kidney Disease ◽  
Growth Arrest ◽  
Cell Stress ◽  
Renal Protection ◽  
Functional Changes ◽  
The Face ◽  
Renal Aging

Senescence is a state of terminal growth arrest, with associated structural and functional changes in the affected cell. Cellular senescence can be induced in embryogenesis and in response to stimuli including aging, DNA damage, and cell stress. There is great interest in the physiological function and pathological role of senescent cells in the progression of the renal aging phenotype and chronic kidney disease. This chapter will explore the incomplete but evolving knowledge of the roles for senescence in the developing, injured, aged, and scarred kidneys. The potential for senescent cells to be targeted to maximize renal protection in the face of aging and injury will also be summarized.

scholarly journals Antigenotoxic properties of anthocyanin-enriched fraction of strawberry (cv. Romina) extract on DNA damage induced by H2O2 in human peripheral blood leukocytes

2021 ◽  
Vol 71 (3) ◽  
pp. 197-206
Author(s):  
Biljana Spremo-Potparević ◽  
Andrea Čabarkapa-Pirković ◽  
Dragana Dekanski ◽  
Dijana Topalović ◽  
Vladan Bajić ◽  
...  
Keyword(s):  
Dna Damage ◽  
Peripheral Blood ◽  
Oxidative Dna Damage ◽  
Human Peripheral Blood ◽  
Antioxidant Properties ◽  
Protective Agent ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Damage Reduction

Strawberry fruit Fragaria × ananassa Duchesne, Rosaceae (cv. Romina), rich in anthocyanin polyphenols, has been demonstrated to have favorable effects on health due to its antioxidant properties. The present study investigated the antigenotoxic potential of anthocyanin enriched fraction of Romina strawberry methanolic extract (ACY) against DNA damage on human peripheral blood leukocytes, induced by hydrogen peroxide in vitro. Five concentrations of the ACY extract were used in all experiments (2.5, 5, 10, 15, 20 µg/ml). The results of the alkaline comet assay showed no genotoxic effect of the ACY. After the pre-exposure of the leukocytes to the ACY, and subsequent incubation with H2O2, a decreased number of DNA damaged cells was recorded in all the tested concentrations, compared to controls. In the posttreatment, there was a concentration-dependent DNA damage reduction, while a statistically significant decrease was achieved with 15 and 20 µg/ml concentrations. The results indicate that ACY is efficient in oxidative DNA damage reduction, and it is more potent as a post-applicative than a protective agent.

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