Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species

2019 ◽  
Vol 137 ◽  
pp. 74-86 ◽  
Author(s):  
Xiaoyu Zhang ◽  
Qin Xia ◽  
Rui Wei ◽  
Hongfei Song ◽  
Jiaqi Mi ◽  
...  
Keyword(s):  
Reactive Oxidative Species ◽  
Oxidative Species

A look at photodynamic inactivation as a tool for pests and vector-borne diseases control

2022 ◽  
Vol 19 (2) ◽  
pp. 025601
Author(s):  
Alessandra R Lima ◽  
Lucas D Dias ◽  
Matheus Garbuio ◽  
Natalia M Inada ◽  
Vanderlei S Bagnato
Keyword(s):  
Public Health ◽  
Low Cost ◽  
Reactive Oxidative Species ◽  
Photodynamic Inactivation ◽  
Health Issues ◽  
Vector Borne Diseases ◽  
Control Techniques ◽  
The Past ◽  
Vector Borne ◽  
Oxidative Species

Abstract The control of pests and vector-borne diseases (VDBs) are considered public health issues Worldwide. Among the control techniques and pesticides used so far, photodynamic inactivation (PDI) has been shown as an eco-friendly, low cost, and efficient approach to eliminate pests and VDBs. PDI is characterized using a photosensitizing molecule, light and molecular oxygen (O2) resulting in production of reactive oxidative species which can promote the oxidation of biomolecules on pests and vectors. Herein, we review the past 51 years (1970–2021) regarding the use of photo pesticides, reporting the most important parameters for the protocol applied, the results obtained, and limitations. Moreover, we described the mechanism of action of the PDI, main classes of photopesticides used so far as well as the cell death mechanism resulting from the photodynamic action.

Abstract 14853: Acute Inhibition of Mitochondrial Reactive Oxidative Species Improves Endothelial SK Channel Function Following Cardioplegic Hypoxia/Reperfusion and Diabetes

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Yi Song ◽  
Zhiqi Zhang ◽  
Hang Xing ◽  
Yixin He ◽  
guangbin shi ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Coronary Arteries ◽  
Ischemia Reperfusion ◽  
Mouse Heart ◽  
Reactive Oxidative Species ◽  
Sk Channels ◽  
Sk Channel ◽  
Relaxation Responses ◽  
Oxidative Species ◽  
Coronary Relaxation

Introduction: Cardioplegic-ischemia/reperfusion (CP-I/R) and diabetes mellitus (DM) are correlated with coronary endothelial dysfunction and inactivated small conductance calcium-activated-potassium (SK) channels. Increased reactive oxidative species (ROS), such as mitochondrial ROS (mROS) may contribute to oxidative injury. Thus, we hypothesized that inhibition of mROS may protect coronary SK channels and endothelial function against CP-I/R-induced injury. Objective: A cardioplegic hypoxia and reoxygenation (CP-H/R) model consisting of coronary endothelial cells and small coronary arteries with or without DM were employed for examining whether MT could protect against coronary endothelial and SK channel dysfunction. Methods: Small coronary arteries (<150μm) and endothelial cells (MHECs) were dissected from the mouse heart with non-diabetes (ND) and DM (n=6/group). The microvessels or MHECs were subjected to hypoxia with cardioplegia and re-oxygenated. The microvessels or MHECs were treated with or without MT (10 -5 M) 5-minutes before and during CP-hypoxia. Microvascular vasodilation function was assessed in vitro by administration of vasoconstrictor, then ADP or NS309,respectively. K + currents of MHECs were measured by whole-cell patch clamp. The levels of endothelial mROS was measured by MitoSox TM . Results: CP-H/R significantly attenuated endothelial SK channels activity and the coronary relaxation responses to ADP and NS309 in the ND and DM groups. Treatment with MT enhanced coronary relaxation responses to ADP or NS309 ( p <0.05, Fig 1. A, B), and similar findings were seen in endothelial SK channel currents in both ND and DM MHECs ( p <0.05, Fig 1. C-F). In addition, treating MHECs with MT reduced CP-H/R-induced mROS in ND and DM groups. Conclusions: Administration of MT improves endothelial SK channels activity which may contribute to its enhancement of endothelium-dependent vasorelaxation following CP-H/R.

Anti-inflammatory drugs degradation during LED-UV365 photolysis of free chlorine: roles of reactive oxidative species and formation of disinfection by-products

2020 ◽  
Vol 185 ◽  
pp. 116252 ◽  
Author(s):  
Chaoqun Tan ◽  
Haotian Wu ◽  
Huan He ◽  
Xu Lu ◽  
Haiying Gao ◽  
...  
Keyword(s):  
Free Chlorine ◽  
Reactive Oxidative Species ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Oxidative Species ◽  
By Products

scholarly journals Zn2+ leakage and photo-induced reactive oxidative species do not explain the full toxicity of ZnO core Quantum Dots

2020 ◽  
Vol 396 ◽  
pp. 122616 ◽  
Author(s):  
Xavier Bellanger ◽  
Raphaël Schneider ◽  
Clément Dezanet ◽  
Boussad Arroua ◽  
Lavinia Balan ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Reactive Oxidative Species ◽  
Oxidative Species

αvβ3 Integrin-Mediated Drug Resistance in Human Laryngeal Carcinoma Cells Is Caused by Glutathione-Dependent Elimination of Drug-Induced Reactive Oxidative Species

2008 ◽  
Vol 74 (1) ◽  
pp. 298-306 ◽  
Author(s):  
Anamaria Brozović ◽  
Dragomira Majhen ◽  
Vibor Roje ◽  
Nevenka Mikac ◽  
Sanjica Jakopec ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Laryngeal Carcinoma ◽  
Carcinoma Cells ◽  
Αvβ3 Integrin ◽  
Reactive Oxidative Species ◽  
Drug Induced ◽  
Human Laryngeal Carcinoma ◽  
Oxidative Species

BIOCHEMICAL MECHANISMS BY WHICH REACTIVE OXIDATIVE SPECIES MODULATE CALCIUM SENSITIVITY IN AIRWAY SMOOTH MUSCLE

1998 ◽  
Vol 89 (Supplement) ◽  
pp. 1397A
Author(s):  
Robert Lorenz ◽  
David O. Warner ◽  
Keith A. Jones
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Calcium Sensitivity ◽  
Reactive Oxidative Species ◽  
Biochemical Mechanisms ◽  
Oxidative Species

Epigallocathechin-3 gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways

2006 ◽  
Vol 40 (10) ◽  
pp. 1756-1775 ◽  
Author(s):  
Hong-Liang Li ◽  
Yue Huang ◽  
Chan-Na Zhang ◽  
Guang Liu ◽  
Yu-Sheng Wei ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Signal Pathways ◽  
Reactive Oxidative Species ◽  
Oxidative Species

scholarly journals l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility

2020 ◽  
Vol 1 (1) ◽  
pp. 67-81
Author(s):  
Shen Chuen Khaw ◽  
Zhen Zhe Wong ◽  
Richard Anderson ◽  
Sarah Martins da Silva
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Sperm Motility ◽  
Pregnancy Rates ◽  
The Body ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Reactive Oxidative Species ◽  
Idiopathic Male Infertility ◽  
Oxidative Species

Fifteen percent of couples are globally estimated to be infertile, with up to half of these cases attributed to male infertility. Reactive oxidative species (ROS) are known to damage sperm leading to impaired quantity and quality. Although not routinely assessed, oxidative stress is a common underlying pathology in infertile men. Antioxidants have been shown to improve semen analysis parameters by reducing ROS and facilitating repair of damage caused by oxidative stress, but it remains unclear whether they improve fertility. Carnitines are naturally occurring antioxidants in mammals and are normally abundant in the epididymal luminal fluid of men. We conducted a systematic review and meta-analysis to evaluate the safety and efficacy of carnitine supplementation for idiopathic male infertility. We searched ClinicalKey, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, MEDLINE, PubMed and ScienceDirect for relevant studies published from 1 January 2000 to 30 April 2020. Of the articles retrieved, only eight randomised controlled trials were identified and included. Analysis showed that carnitines significantly improve total sperm motility, progressive sperm motility and sperm morphology, but without effect on sperm concentration. There was no demonstrable effect on clinical pregnancy rate in the five studies that included that outcome, although patient numbers were limited. Therefore, the use of carnitines in male infertility appears to improve some sperm parameters but without evidence of an increase in the chance of natural conception. Lay summary Although male infertility affects 1:15 men, there is no obvious reason in the vast majority of cases. Reactive oxidative species (ROS) are highly active molecules containing oxygen and are natural byproducts of normal metabolism. However, high concentrations of ROS have been shown to damage sperm, which negatively impacts a couple’s ability to conceive. Carnitines are natural antioxidants found in the body that counterbalance the damaging effects of ROS. We conducted a comprehensive review of published studies to assess whether carnitine supplements are safe and effective in improving sperm quality and pregnancy rates. Our analysis shows that carnitines improve sperm swimming and production of normal-shaped sperm cells but do not affect sperm count or pregnancy rates, although there are only a few studies and scientific evidence is limited. Whilst it is possible that carnitines may benefit male infertility, more evidence is required regarding chances of pregnancy after carnitine therapy.

scholarly journals Photocatalytic Inactivation of Viruses Using Graphitic Carbon Nitride-Based Photocatalysts: Virucidal Performance and Mechanism

Catalysts ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1448
Author(s):  
Vasudha Hasija ◽  
Shilpa Patial ◽  
Pardeep Singh ◽  
Van-Huy Nguyen ◽  
Quyet Van Le ◽  
...  
Keyword(s):  
Carbon Nitride ◽  
Graphitic Carbon ◽  
Graphitic Carbon Nitride ◽  
Inactivation Kinetics ◽  
Reactive Oxidative Species ◽  
Operational Parameters ◽  
Viral Inactivation ◽  
Sustainable Solutions ◽  
Capsid Shell ◽  
Oxidative Species

The prevalence of lethal viral infections necessitates the innovation of novel disinfection techniques for contaminated surfaces, air, and wastewater as significant transmission media of disease. The instigated research has led to the development of photocatalysis as an effective renewable solar-driven technology relying on the reactive oxidative species, mainly hydroxyl (OH●) and superoxide (O2●−) radicals, for rupturing the capsid shell of the virus and loss of pathogenicity. Metal-free graphitic carbon nitride (g-C3N4), which possesses a visible light active bandgap structure, low toxicity, and high thermal stability, has recently attracted attention for viral inactivation. In addition, g-C3N4-based photocatalysts have also experienced a renaissance in many domains, including environment, energy conversion, and biomedical applications. Herein, we discuss the three aspects of the antiviral mechanism, intending to highlight the advantages of photocatalysis over traditional viral disinfection techniques. The sole agenda of the review is to summarize the significant research on g-C3N4-based photocatalysts for viral inactivation by reactive oxidative species generation. An evaluation of the photocatalysis operational parameters affecting viral inactivation kinetics is presented. An overview of the prevailing challenges and sustainable solutions is presented to fill in the existing knowledge gaps. Given the merits of graphitic carbon nitride and the heterogeneous photocatalytic viral inactivation mechanism, we hope that further research will contribute to preventing the ongoing Coronavirus pandemic and future calamities.

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