Protocol design for the evaluation of chronic antioxidant supplementation on oxidative stress and cognition status in post COVID-19 patients

Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.

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Effect of antioxidant supplementation on urine and blood markers of oxidative stress during extended moderate-altitude training

Wilderness and Environmental Medicine ◽

10.1580/1080-6032(1999)010[0066:eoasou]2.3.co;2 ◽

1999 ◽

Vol 10 (2) ◽

pp. 66-74 ◽

Cited By ~ 35

Author(s):

Jeffrey M. Pfeiffer ◽

Eldon W. Askew ◽

Donald E. Roberts ◽

Steven M. Wood ◽

Joan E. Benson ◽

...

Keyword(s):

Oxidative Stress ◽

Altitude Training ◽

Moderate Altitude ◽

Antioxidant Supplementation ◽

Markers Of Oxidative Stress

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Oxidative Stress and Antioxidant Supplementation in the Management of Diabetic Cardiovascular Disease

Journal of Investigative Medicine ◽

10.1136/jim-52-01-23 ◽

2004 ◽

Vol 52 (1) ◽

pp. 24-32 ◽

Cited By ~ 23

Author(s):

Sonia Vega-López ◽

Sridevi Devaraj ◽

Ishwarlal Jialal

Keyword(s):

Oxidative Stress ◽

Cardiovascular Disease ◽

Antioxidant Supplementation

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Oxidative stress and outcome of antioxidant supplementation in patients with polycystic ovarian syndrome (PCOS)

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20181892 ◽

2018 ◽

Vol 7 (5) ◽

pp. 1667 ◽

Cited By ~ 5

Author(s):

Abubakar A. Panti ◽

Constance E. Shehu ◽

Yusuf Saidu ◽

Karima A. Tunau ◽

Emmanuel I. Nwobodo ◽

...

Keyword(s):

Oxidative Stress ◽

Antioxidant Enzymes ◽

Serum Levels ◽

Clinical Pregnancy ◽

Oxidative Stress Marker ◽

Randomised Control Trial ◽

Antioxidant Supplementation ◽

Control Groups ◽

Stress Marker ◽

And Control

Background: PCOS is a condition with significant decrease in antioxidant with an increased risk of oxidative stress. Antioxidant supplementation has been shown to improve insulin sensitivity in PCOS and may improve outcome of management of PCOS. Objectives of this study were to determine the oxidative stress level of PCOS patients, to assess the effect of antioxidant supplementation on the outcome of management of PCOS and to compare with a control group.Methods: The study was a single blind randomised control trial involving 200 patients with PCOS. The study was conducted at Usmanu Danfodiyo University Teaching Hospital Sokoto. They were randomly divided into intervention and control groups and base line serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals were determined. Antioxidant supplementation and placebo were given to the intervention and control groups respectively. All the patients had ovulation induction with clomiphene citrate and were followed up for 6 months. Outcome measures were clinical pregnancy or menstrual regularisation. Level of significance was <0.05.Results: There was statistical significance in the serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals between the two groups (post intervention). Glutathione peroxidase (p = 0.001), superoxide dismutase (p = 0.0001), catalase (p= 0.0369), melondialdehyde (p= 0.007), Vitamin A, Vitamin C, Vitamin E (p = 0.0001), zinc and copper (p = 0.0001). The clinical pregnancy outcomes were 22 (22%) versus 2 (2%); live births 18 (18%) versus 2 (2%) and menstrual regularisation 48 (48%) versus 46 (46%) in the intervention and control groups respectively.Conclusions: Antioxidant supplementation in this study significantly affected pregnancy rate in patients with PCOS. Larger studies are suggested to revisit the conclusion of the Cochrane review that antioxidants supplementation had no significant role in female infertility.

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Oxidative stress index as a novel biochemical marker in tuberculosis; with therapeutic benefit of antioxidant supplementation

BMC Infectious Diseases ◽

10.1186/1471-2334-12-s1-p66 ◽

2012 ◽

Vol 12 (S1) ◽

Cited By ~ 2

Author(s):

Suresh Babu Kondaveeti ◽

Vamseedhar Annam ◽

DR Suresh

Keyword(s):

Oxidative Stress ◽

Biochemical Marker ◽

Therapeutic Benefit ◽

Stress Index ◽

Antioxidant Supplementation ◽

Oxidative Stress Index

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Role of Anti-oxidants in the Treatment of Vitiligo

Nepal Journal of Dermatology Venereology & Leprology ◽

10.3126/njdvl.v17i1.23132 ◽

2019 ◽

Vol 17 (1) ◽

pp. 49-57

Author(s):

Amit Kumar ◽

Sudha Agrawal ◽

Tapan Kumar Dhali ◽

Shankar Kumr Majhi

Keyword(s):

Oxidative Stress ◽

Placebo Group ◽

Vitamin E ◽

Primary Outcome ◽

Antioxidant Supplementation ◽

Significant Difference ◽

Anti Oxidant ◽

And Oxidative Stress

Introduction: The role of free radicals and oxidative damage in the pathophysiology of vitiligo has been documented in recent studies. Antioxidant supplementation has been reported to be useful in the treatment of vitiligo. Objective: To evaluate the role of oral antioxidants supplementation therapy in the treatment of vitiligo by assessing the onset of repigmentation and oxidative stress. Materials and Methods: A total of 80 cases of vitiligo randomized into two groups: antioxidant and placebo comprising 40 patients each and were followed up for 8 weeks for the assessment of onset of repigmentation of vitiliginous lesions as primary outcome. The activities of Malondialdehyde (MDA), Vitamin C, and Vitamin E in serum and of Catalase (CAT) in erythrocytes of patients at baseline and at end of eight weeks were also assessed by using the spectrophotometric assay. Results: The onset of repigmentation was noted significantly earlier among the anti-oxidant group as compared to the placebo group (p=0.015). At the baseline, between the two groups, no significant difference was found in the different biochemical parameters. However, at the end of 2 months the level of MDA (p<0.001) was found to be significantly lower and that of Vitamin E (p<0.001) and CAT (p=0.005) was significantly higher among the anti-oxidants group as compared to the placebo group. Conclusion: Antioxidant supplementation carried a better response in terms of early onset of repigmentation and significant decrease in the oxidative stress, in the short follow up of two months.

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