Novel concept of neutron shield for ITER diagnostic Lower Port Integration

2021 ◽  
Vol 169 ◽  
pp. 112427
Author(s):  
Suguru Tanaka ◽  
Takaki Hatae ◽  
Masao Ishikawa ◽  
Takahiro Shimada ◽  
Toshiyuki Maruyama ◽  
...  
Keyword(s):  
Neutron Shield ◽  
Novel Concept

The multicompartment SlideReactor – a novel concept for continuous monitoring of co-cultured cells

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
N Billecke ◽  
S Tröller ◽  
N Raschzok ◽  
MH Morgül ◽  
NN Kammer ◽  
...  
Keyword(s):  
Continuous Monitoring ◽  
Cultured Cells ◽  
Novel Concept

Decision making based on intuitionistic fuzzy preference relations with additive approximate consistency

2020 ◽  
Vol 39 (3) ◽  
pp. 4041-4058
Author(s):  
Fang Liu ◽  
Xu Tan ◽  
Hui Yang ◽  
Hui Zhao
Keyword(s):  
Decision Making ◽  
Decision Makers ◽  
Real Interval ◽  
Preference Relations ◽  
Intuitionistic Fuzzy ◽  
Proposed Model ◽  
Fuzzy Preference Relations ◽  
Novel Concept ◽  
Fuzzy Weights ◽  
Fuzzy Preference

Intuitionistic fuzzy preference relations (IFPRs) have the natural ability to reflect the positive, the negative and the non-determinative judgements of decision makers. A decision making model is proposed by considering the inherent property of IFPRs in this study, where the main novelty comes with the introduction of the concept of additive approximate consistency. First, the consistency definitions of IFPRs are reviewed and the underlying ideas are analyzed. Second, by considering the allocation of the non-determinacy degree of decision makers’ opinions, the novel concept of approximate consistency for IFPRs is proposed. Then the additive approximate consistency of IFPRs is defined and the properties are studied. Third, the priorities of alternatives are derived from IFPRs with additive approximate consistency by considering the effects of the permutations of alternatives and the allocation of the non-determinacy degree. The rankings of alternatives based on real, interval and intuitionistic fuzzy weights are investigated, respectively. Finally, some comparisons are reported by carrying out numerical examples to show the novelty and advantage of the proposed model. It is found that the proposed model can offer various decision schemes due to the allocation of the non-determinacy degree of IFPRs.

Neuromyelitis optica spectrum: novel concept of pathogenesis, diagnosis and treatment of Devic’s disease

2009 ◽  
Vol 150 (46) ◽  
pp. 2101-2109 ◽  
Author(s):  
Péter Csécsei ◽  
Anita Trauninger ◽  
Sámuel Komoly ◽  
Zsolt Illés
Keyword(s):  
Neuromyelitis Optica ◽  
Water Channel ◽  
Diagnostic Procedures ◽  
Diagnosis And Treatment ◽  
Clinical Settings ◽  
Permanent Disability ◽  
Therapeutic Decisions ◽  
Novel Concept ◽  
The Brain

The identification of autoantibodies generated against the brain isoform water channel aquaporin4 in the sera of patients, changed the current diagnostic guidelines and concept of neuromyelitis optica (NMO). In a number of cases, clinical manifestation is spatially limited to myelitis or relapsing optic neuritis creating a diverse. NMO spectrum. Since prevention of relapses provides the only possibility to reduce permanent disability, early diagnosis and treatment is mandatory. In the present study, we discuss the potential role of neuroimaging and laboratory tests in differentiating the NMO spectrum from other diseases, as well as the diagnostic procedures and therapeutic options. We also present clinical cases, to provide examples of different clinical settings, diagnostic procedures and therapeutic decisions.

A novel concept for laser strain rate and vorticity measurements

1998 ◽  
Author(s):  
M. Otugen ◽  
Wei-Jen Su ◽  
George Papadopoulos
Keyword(s):  
Strain Rate ◽  
Novel Concept

Methylglyoxal in diabetes: link to treatment, glycaemic control and biomarkers of complications

2014 ◽  
Vol 42 (2) ◽  
pp. 450-456 ◽  
Author(s):  
Paul J. Beisswenger
Keyword(s):  
Glycaemic Control ◽  
Diabetic Complications ◽  
Predictive Biomarkers ◽  
Complication Rates ◽  
Specific Chemical ◽  
End Products ◽  
Carboxymethyl Lysine ◽  
Genetic And Environmental Factors ◽  
Novel Concept ◽  
The Cost

Diabetic complications are major health problems worldwide, with the cost of caring for diabetes rising to US$245 billion in 2012 in the U.S.A. alone. It is widely recognized that non-enzymatic glycation in diabetes is a major cause of damage and dysfunction of key vascular cells. MG (methylglyoxal) is directly toxic to tissues, and is a major precursor of AGEs (advanced glycation end-products). Various propensities to diabetic complications are seen among individuals with diabetes, with accelerated rates occurring in some individuals with modest hyperglycaemia, while others never progress in spite of poor glycaemic control over many years. Since production and detoxification of MG is ultimately controlled by enzymatic mechanisms, both genetic and environmental factors could regulate tissue glycation and potentially account for these variable complication rates. Activation of pathways that determine MG levels occurs in susceptible patients, indicting an important role in pathogenesis. MG leads to formation of specific AGEs, which are likely to predict propensity to diabetic complications. We have shown recently that three specific plasma AGE biomarkers [MG-H1 (MG-derived hydroimidazolones), CEL (Nε-carboxyethyl-lysine) and CML (Nε-carboxymethyl-lysine)] predict biopsy-documented fast DN (diabetic nephropathy) progression. Since two of the predictive biomarkers are MG end-products, these outcomes support a role for MG in the development of DN. Our studies on MG and its end-products have also shown anti-complication effects of the drug metformin, which binds and inactivates MG, thus reducing MG-related AGEs. We have also shown that reducing post-meal glucose decreases MG levels, as well as levels of MG-related AGEs. Our clinical outcome studies have been based on the novel concept that the unique glycation products that we can measure reflect the activity of specific chemical pathways that are selectively activated by hyperglycaemia in patients that are inherently more susceptible to diabetic complications, and can be used to solve other diabetes-related medical questions.

scholarly journals Oral Tranexamic Acid for the Treatment of Melasma

2014 ◽  
Vol 10 (4) ◽  
pp. 40-43 ◽  
Author(s):  
D Karn ◽  
S KC ◽  
A Amatya ◽  
EA Razouria ◽  
M Timalsina
Keyword(s):  
Tranexamic Acid ◽  
Controlled Trial ◽  
Severity Index ◽  
Sustained Improvement ◽  
Treatment Measures ◽  
Group A ◽  
Group B ◽  
Novel Concept ◽  
High Treatment

Background Melasma poses a great challenge as its treatment is unsatisfactory and recurrence is high. Treatment of melasma using tranexamic acid (oral, topical or intralesional) is a novel concept. Objective To compare the efficacy of oral tranexamic acid with routine topical therapies for the treatment of melasma. Methods It is a prospective, interventional, randomized controlled trial conducted among 260 melasma patients. Patients were divided into two groups consisting of 130 patients each. First group (Group A) was given routine treatment measures and oral Tranexamic Acid while second group (Group B) was treated only with routine topical measures. Capsule Tranexamic Acid was prescribed at a dose of 250 mg twice a day for three months and cases were followed for three months. Response was evaluated on the basis of Melasma Assessment Severity Index (MASI). Mean scores between the two groups were then compared. Results Statistically significant decrease in the mean Melasma Assessment Severity Index from baseline to 8 and 12 weeks was observed among group A patients (11.08±2.91 vs 8.95±2.08 at week 8 and vs. 7.84±2.44 at week 12; p<0.05 for both). While among group B patients the decrease in mean score was significant at 8 weeks and insignificant at 12 weeks follow up (11.60±3.40 vs 9.9±2.61 at 8 weeks and vs. 9.26±3 at 12 weeks; p<0.05 for former but p>0.05 for later). Conclusion Addition of oral tranexamic acid provides rapid and sustained improvement in the treatment of melasma. DOI: http://dx.doi.org/10.3126/kumj.v10i4.10993 Kathmandu Univ Med J 2012;10(4):40-43

scholarly journals The Evolving Landscape of the Molecular Epidemiology of Malignant Pleural Mesothelioma

2021 ◽  
Vol 10 (5) ◽  
pp. 1034
Author(s):  
Sara Lettieri ◽  
Chandra Bortolotto ◽  
Francesco Agustoni ◽  
Filippo Lococo ◽  
Andrea Lancia ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Malignant Pleural Mesothelioma ◽  
Strong Association ◽  
Pleural Mesothelioma ◽  
The European Union ◽  
Long Latency ◽  
Substantial Risk ◽  
Novel Biomarkers ◽  
Definition Of ◽  
Novel Concept

Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy that most commonly affects the pleural lining of the lungs. It has a strong association with exposure to biopersistent fibers, mainly asbestos (80% of cases) and—in specific geographic regions—erionite, zeolites, ophiolites, and fluoro-edenite. Individuals with a chronic exposure to asbestos generally have a long latency with no or few symptoms. Then, when patients do become symptomatic, they present with advanced disease and a worse overall survival (about 13/15 months). The fibers from industrial production not only pose a substantial risk to workers, but also to their relatives and to the surrounding community. Modern targeted therapies that have shown benefit in other human tumors have thus far failed in MPM. Overall, MPM has been listed as orphan disease by the European Union. However, molecular high-throughput profiling is currently unveiling novel biomarkers and actionable targets. We here discuss the natural evolution, mainly focusing on the novel concept of molecular epidemiology. The application of innovative endpoints, quantification of genetic damages, and definition of genetic susceptibility are reviewed, with the ultimate goal to point out new tools for screening of exposed subject and for designing more efficient diagnostic and therapeutic strategies.

scholarly journals Controllable and decomposable multidirectional synchronizations

2021 ◽  
Author(s):  
Gábor Bergmann
Keyword(s):  
Systems Engineering ◽  
Large Scale ◽  
Mathematical Framework ◽  
Collaborative Systems ◽  
Consistency Constraints ◽  
Restoration Mechanism ◽  
Common Goals ◽  
Access Privileges ◽  
Novel Concept ◽  
Engineering Projects

AbstractStudying large-scale collaborative systems engineering projects across teams with differing intellectual property clearances, or healthcare solutions where sensitive patient data needs to be partially shared, or similar multi-user information systems over databases, all boils down to a common mathematical framework. Updateable views (lenses) and more generally bidirectional transformations are abstractions to study the challenge of exchanging information between participants with different read access privileges. The view provided to each participant must be different due to access control or other limitations, yet also consistent in a certain sense, to enable collaboration towards common goals. A collaboration system must apply bidirectional synchronization to ensure that after a participant modifies their view, the views of other participants are updated so that they are consistent again. While bidirectional transformations (synchronizations) have been extensively studied, there are new challenges that are unique to the multidirectional case. If complex consistency constraints have to be maintained, synchronizations that work fine in isolation may not compose well. We demonstrate and characterize a failure mode of the emergent behaviour, where a consistency restoration mechanism undoes the work of other participants. On the other end of the spectrum, we study the case where synchronizations work especially well together: we characterize very well-behaved multidirectional transformations, a non-trivial generalization from the bidirectional case. For the former challenge, we introduce a novel concept of controllability, while for the latter one, we propose a novel formal notion of faithful decomposition. Additionally, the paper proposes several novel properties of multidirectional transformations.

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