scholarly journals Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine

2017 ◽  
Vol 4 (2) ◽  
pp. 43-63 ◽  
Author(s):  
Cody S. Lee ◽  
Elliot S. Bishop ◽  
Ruyi Zhang ◽  
Xinyi Yu ◽  
Evan M. Farina ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Personalized Medicine ◽  
New Era ◽  
Potential Applications

scholarly journals Personalized Medicine in Cancer

2015 ◽  
Vol 32 (3) ◽  
pp. 153-163
Author(s):  
Md Mizanur Rahman
Keyword(s):  
Personalized Medicine ◽  
Single Gene ◽  
Biomedical Science ◽  
Practical Application ◽  
Molecular Alteration ◽  
New Era ◽  
Patients With Cancer ◽  
The Past ◽  
Molecular Aspects

Current and emerging biomedical science efforts are driven by determining how to improve clini-cal outcomes for patients. High-throughput tech-nology has revolutionized the area of transla-tional research, confirming the high complexity and heterogeneity of common diseases, partic-ularly cancer. Therefore, moving from ‘classic’ single-gene-based molecular investigation to molecular network research might result in dis-covering clinical implications faster and more efficiently .Molecular characterization of tumour cells enables refinement of classifications for many cancers and can sometimes guide treatment. Malignant diseases are no longer classified only by tumour site and histology but are separated into various homogenous molecular subtypes, distinguished by a presumed key molecular alteration. Therapies for patients with cancer have changed gradually over the past decade, moving away from the administration of broadly acting cytotoxic drugs towards the use of more-specific therapies that are targeted to each tumour. To facilitate this shift, tests need to be developed to identify those individuals who require therapy and those who are most likely to benefit from certain therapies. In particular, tests that predict the clinical outcome for patients on the basis of the genes expressed by their tumours are likely to increasingly affect patient management, heralding a new era of personalized medicine. In this review a brief discussion on definition and molecular aspects of personalized medicine and its practical application for the management of common solid cancers are highlighted.J Bangladesh Coll Phys Surg 2014; 32: 153-163

scholarly journals A new Era of Personalized Medicine for Cystic Fibrosis – at Last!

2015 ◽  
Vol 22 (5) ◽  
pp. 257-260 ◽  
Author(s):  
Bradley S Quon ◽  
Pearce G Wilcox
Keyword(s):  
Cystic Fibrosis ◽  
Personalized Medicine ◽  
Late Phase ◽  
Structure And Function ◽  
Clinical Development ◽  
New Era ◽  
High Throughput Drug Screening ◽  
Cftr Protein ◽  
And Function ◽  
Screening Approaches

The gene responsible for cystic fibrosis (CF) was discovered 25 years ago. This breakthrough has enabled a sophisticated understanding of how various mutations lead to specific alterations in the structure and function of the CF transmembrane regulator (CFTR) protein. Until recently, all therapies in CF were focused on ameliorating the downstream consequences of CFTR dysfunction. High-throughput drug screening approaches have yielded compounds that can modify CFTR structure and function, thus targeting the basic defect in CF. The present article describes theCFTRmutational classes, reviews mutation-specific therapies currently in late-phase clinical development, and highlights research opportunities and challenges with personalized medicine in CF.

Green Synthesis of Nanocomposites

2022 ◽  
pp. 77-100
Author(s):  
Meenal D. Patil ◽  
Suprimkumar D. Dhas ◽  
Annasaheb V. Moholkar
Keyword(s):  
Green Synthesis ◽  
Low Cost ◽  
Future Generation ◽  
Research Area ◽  
Future Prospects ◽  
Comprehensive Overview ◽  
New Era ◽  
Methods Of Synthesis ◽  
Potential Applications ◽  
Negative Impacts

Nanotechnology has been a dynamic research area over the past few decades because it assures the resolution to the problems that hamper progress. Currently, a new era of ‘green synthesis' is an emerging multidisciplinary field in nanotechnology which employs reliable, sustainable, low-cost, non-hazardous, and eco-friendly techniques. Green synthesis is considered a vital tool to reduce the negative impacts accompanying the traditional methods of synthesis for NPs commonly employed in industry and laboratory. This chapter unveils a comprehensive overview of the recent research on available green techniques for the synthesis of various nanocomposites in order to solve future generation challenges. This chapter also focuses on the green synthesis of various nanocomposites, synthesis parameters, potential applications, merits/demerits, and future prospects.

scholarly journals Transplacental Gene Delivery (TPGD) as a Noninvasive Tool for Fetal Gene Manipulation in Mice

2019 ◽  
Vol 20 (23) ◽  
pp. 5926 ◽  
Author(s):  
Nakamura ◽  
Watanabe ◽  
Ando ◽  
Ishihara ◽  
Sato
Keyword(s):  
Gene Delivery ◽  
Nucleic Acids ◽  
Myocardial Cells ◽  
Transcription Activator ◽  
Exogenous Dna ◽  
Cell Functions ◽  
Fetal Tissues ◽  
Potential Applications ◽  
Pregnant Mice ◽  
Basic Studies

Transplacental gene delivery (TPGD) is a technique for delivering nucleic acids to fetal tissues via tail-vein injections in pregnant mice. After transplacental transport, administered nucleic acids enter fetal circulation and are distributed among fetal tissues. TPGD was established in 1995 by Tsukamoto et al., and its mechanisms, and potential applications have been further characterized since. Recently, discoveries of sequence specific nucleases, such as zinc-finger nuclease (ZFN), transcription activator-like effector nucleases (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9 nuclease (Cas9) (CRISPR/Cas9), have revolutionized genome editing. In 2019, we demonstrated that intravenous injection of plasmid DNA containing CRISPR/Cas9 produced indels in fetal myocardial cells, which are comparatively amenable to transfection with exogenous DNA. In the future, this unique technique will allow manipulation of fetal cell functions in basic studies of fetal gene therapy. In this review, we describe developments of TPGD and discuss their applications to the manipulation of fetal cells.

Nanotechnology for Gene Delivery to the Eye

2009 ◽  
Vol 03 (01) ◽  
pp. 7 ◽  
Author(s):  
Swita R Singh ◽  
Uday B Kompella ◽  
◽  
Keyword(s):  
Gene Delivery ◽  
Enzymatic Degradation ◽  
Viral Vectors ◽  
Viral Vector ◽  
Target Cells ◽  
Loading Capacity ◽  
Adeno Associated Virus ◽  
Complementary Dna ◽  
Privileged Status ◽  
Potential Applications

The relatively immune-privileged status of the eye makes it an interesting target for gene delivery. Gene delivery to the eye using viral vectors via subretinal and intravitreal injections has been extensively investigated. Recently, the safety of recombinant adeno-associated virus vector expressing RPE65 complementary DNA (cDNA) in a limited clinical trial of three patients has also been reported. Nanotechnology-based non-viral vectors offer the advantages of safety and flexibility in terms of loading capacity and delivery system design compared with viral vectors. An ideal non-viral vector should be non-toxic, efficiently taken up into the target cells and conducive to gene expression, and should protect the gene against enzymatic degradation. Multiple kinds of nanotechnology-based non-viral vectors have been investigated for potential applications for gene delivery to the eye, namely nanoplexes, dendrimers, micelles, nanoparticles and liposomes. This article summarises and discusses key advances in the application of nanotechnology for gene delivery to the eye.

scholarly journals Personalized Medicine in Screening for Malignant Disease: A Review of Methods and Applications

2013 ◽  
Vol 8 ◽  
pp. BMI.S11153 ◽  
Author(s):  
F. Schmalfuss ◽  
P.L. Kolominsky-Rabas
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Colorectal Cancer ◽  
Personalized Medicine ◽  
Literature Search ◽  
Malignant Disease ◽  
Decisive Role ◽  
Routine Clinical Practice ◽  
Cancer Breast ◽  
Potential Applications

Personalized medicine (PM) is currently a hot topic in the professional world. It is often called the medicine of the future and has already achieved resounding success in the area of targeted therapy. Nevertheless, integration of the concepts of PM into routine clinical practice is slow. This review is intended to give an overview of current and potential applications of PM in oncology. PM could soon play a decisive role, especially in screening. The relevance of PM in screening was examined in the case of four common cancers (colorectal cancer, lung cancer, breast cancer, and prostate cancer). A literature search was performed. This showed that biomarkers in particular play a crucial role in screening. In summary, it can be emphasized that there are already numerous known promising biomarkers in malignant disease. This results in several possibilities for individualizing and revolutionizing screening.

Shape changing and self-reconfiguring robots

2015 ◽  
Vol 42 (4) ◽  
pp. 290-295 ◽  
Author(s):  
Robert Bogue
Keyword(s):  
Early Stage ◽  
Modular Robots ◽  
Content Type ◽  
New Era ◽  
Technological Advances ◽  
True Shape ◽  
Recent Developments ◽  
Potential Applications ◽  
Practical Reality ◽  
Selection Of

Purpose – This article aims to provide details of recent developments in robots that can change shape and self-reconfigure. Design/methodology/approach – Following an introduction, this article first describes some recent developments in shape-changing materials and then considers a selection of shape-changing robots. It then discusses self-reconfiguring robots and describes a unique self-unfolding robot. Finally, concluding comments are drawn. Findings – This article shows that research into true shape-changing robots is still at an early stage and several very different strategies are being studied. Novel materials are expected to play a key role in many designs and potential applications include search and rescue, health care and surveillance. Self-reconfiguring modular robots are at a more advanced stage and while many can reconfigure to adopt varying shapes and gaits, the ability to accomplish differing tasks in manufacturing is still some way in the future. Overall, the various classes of shape-changing robots being studied represent a move towards a new era in robotic capabilities, but despite many recent technological advances, considerable further work is required before these become a practical reality. Originality/value – This article provides an insight into recent technological advances in shape-changing and self-reconfiguring robots.

New Era of Personalized Medicine: A 10‐Year Anniversary

2009 ◽  
Vol 14 (5) ◽  
pp. 557-558 ◽  
Author(s):  
Jan Trøst Jørgensen
Keyword(s):  
Personalized Medicine ◽  
New Era
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