scholarly journals Mo1664 EXAMINATION OF LEFT-SIDED DIVERTICULOSIS AS A RISK FACTORS FOR DISTAL COLONIC POLYPS

2018 ◽  
Vol 87 (6) ◽  
pp. AB468-AB469
Author(s):  
Shashank Sarvepalli ◽  
Ari Garber ◽  
Awad Jarrar ◽  
John McMichael ◽  
James M. Church ◽  
...  
Keyword(s):  
Risk Factors ◽  
Colonic Polyps

scholarly journals Colorectal cancer: a review

2017 ◽  
Vol 5 (11) ◽  
pp. 4667 ◽  
Author(s):  
Juan José Granados-Romero ◽  
Alan Isaac Valderrama-Treviño ◽  
Ericka Hazzel Contreras-Flores ◽  
Baltazar Barrera-Mera ◽  
Miguel Herrera Enríquez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Protective Factors ◽  
Cause Of Death ◽  
Genetic Factors ◽  
Colonic Polyps ◽  
Diagnostic Methods ◽  
Degree Relative ◽  
Basis Risk ◽  
Intestinal Inflammatory Disease

Colorectal cancer (CCR) is the third most common cancer worldwide in men and women, the second largest cause of death related to cancer, and the main cause of death in gastrointestinal cancer. The risk of developing this cancer is related to bad alimentary habits, smoking, intestinal inflammatory disease, polyps, genetic factors, and aging. Of the patients that are diagnosed with colorectal cancer 90% are older than 50, with a median age of 64 years; however, the disease is more aggressive in patients that are diagnosed at younger ages. According to the American Cancer Association, it was accounted for more than 49,700 deaths in 2015. The goal is to reduce the mortality rate with early diagnosis and treatment. Currently, the survival rate is used to predict a patient’s prognosis. The patient is considered to have a positive familial history if a first-degree relative has been diagnosed with colorectal cancer or colonic polyps before the age of 60, or also if two or more first-degree relatives have been diagnosed with cancer or polyps at any age. There are several methods for detecting colorectal cancer, such as the guaiac test, immunochemical test of stool, DNA stool test, sigmoidoscopy, colonoscopy, and barium enema. The stage in which the cancer is detected determines the prognosis, survival, and treatment of the patient. Provide a review about generalities, genetic basis, risk factors, protective factors, clinical course, diagnostic methods, therapy and survival in colorectal cancer. Conducted research from different databases such as PubMed, Medline, MedScape, on the definition, genetic factors, classification, risk factors, protective factors, diagnostic methods, epidemiology, survival and treatment of colorectal cancer. Articles from 2000 to 2017 were included using the following keywords.

Risk Factors Associated with Incomplete Endoscopic Mucosal Resection of Colonic Polyps

2016 ◽  
Vol 111 ◽  
pp. S78-S79
Author(s):  
Anna Tavakkoli ◽  
Aarti Oza Bedi ◽  
Anoop Prabhu ◽  
Tadd Hiatt ◽  
Michelle Anderson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endoscopic Mucosal Resection ◽  
Colonic Polyps ◽  
Factors Associated ◽  
Mucosal Resection

scholarly journals Colonic Polyps: Treatment

2016 ◽  
Vol 29 (04) ◽  
pp. 306-314 ◽  
Author(s):  
Ankit Sarin ◽  
Emily Huang
Keyword(s):  
Risk Factors ◽  
Colon Cancer ◽  
Cancer Risk ◽  
Endoscopic Submucosal Dissection ◽  
Colonic Polyps ◽  
Excisional Biopsy ◽  
Endoscopic Techniques ◽  
Risks And Benefits ◽  
Pathway Models ◽  
Snare Polypectomy

AbstractColonic polyps are considered to be precursors of colon cancer based on several different molecular pathway models and should be resected with a principle of complete excisional biopsy. Several techniques are available for excisional biopsy, ranging from endoscopic techniques such as snare polypectomy, endoscopic mucosal resection (EMR), and endoscopic submucosal dissection (ESD) to surgical colonic resection and colonic endolaparoscopic surgery (CELS). This article focuses on these modalities with contemporary recommendations for choice of modality based on the size and features of the polyp encountered upon endoscopy. In addition, the morphologically apparent risk factors for polyps harboring invasive malignancy are discussed along with implications for management. Current literature on the comparative risks and benefits of EMR, ESD, CELS, and surgical resection is reviewed, as well as recommendations regarding cancer risk and subsequent surveillance.

Identification of risk factors for neoplastic colonic polyps in young adults with bloody stool in comparison with those without symptom

2018 ◽  
Vol 33 (7) ◽  
pp. 1335-1340 ◽  
Author(s):  
Kuan-Chih Chen ◽  
Chen-Shuan Chung ◽  
Wei-Fan Hsu ◽  
Tien-Yu Huang ◽  
Cheng-Kuan Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Colonic Polyps ◽  
Bloody Stool

Su1694 Incidence and Risk Factors for Advanced Neoplasia After Endoscopic Mucosal Resection of Colonic Polyps

2017 ◽  
Vol 85 (5) ◽  
pp. AB398-AB399
Author(s):  
Amol Agarwal ◽  
Caitlin Colling ◽  
Siddyarth Garimall ◽  
Nuzhat A. Ahmad ◽  
Michael L. Kochman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endoscopic Mucosal Resection ◽  
Colonic Polyps ◽  
Advanced Neoplasia ◽  
Mucosal Resection

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

Sign in / Sign up

Export Citation Format

Share Document