Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI

ObjectivesSurveillance colonoscopy is thought to prevent colorectal cancer (CRC) in patients with long-standing colonic IBD, but data regarding the frequency of surveillance and the findings thereof are lacking. Our aim was to determine whether consecutive negative surveillance colonoscopies adequately predict low neoplastic risk.DesignA multicentre, multinational database of patients with long-standing IBD colitis without high-risk features and undergoing regular CRC surveillance was constructed. A ‘negative’ surveillance colonoscopy was predefined as a technically adequate procedure having no postinflammatory polyps, no strictures, no endoscopic disease activity and no evidence of neoplasia; a ‘positive’ colonoscopy was a technically adequate procedure that included at least one of these criteria. The primary endpoint was advanced colorectal neoplasia (aCRN), defined as high-grade dysplasia or CRC.ResultsOf 775 patients with long-standing IBD colitis, 44% (n=340) had >1 negative colonoscopy. Patients with consecutive negative surveillance colonoscopies were compared with those who had at least one positive colonoscopy. Both groups had similar demographics, disease-related characteristics, number of surveillance colonoscopies and time intervals between colonoscopies. No aCRN occurred in those with consecutive negative surveillance, compared with an incidence rate of 0.29 to 0.76/100 patient-years (P=0.02) in those having >1 positive colonoscopy on follow-up of 6.1 (P25–P75: 4.6–8.2) years after the index procedure.ConclusionWithin this large surveillance cohort of patients with colonic IBD and no additional high-risk features, having two consecutive negative colonoscopies predicted a very low risk of aCRN occurrence on follow-up. Our findings suggest that longer surveillance intervals in this selected population may be safe.

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Risk for intravesical recurrence of bladder cancer stratified by the results on two consecutive UroVysion fluorescence in situ hybridization tests: a prospective follow-up study in Japan

International Journal of Clinical Oncology ◽

10.1007/s10147-020-01634-9 ◽

2020 ◽

Vol 25 (6) ◽

pp. 1163-1169

Author(s):

Atsushi Ikeda ◽

Takahiro Kojima ◽

Koji Kawai ◽

Shiro Hinotsu ◽

Naoto Keino ◽

...

Keyword(s):

Bladder Cancer ◽

Positive Result ◽

Recurrence Rates ◽

Follow Up Study ◽

Negative Results ◽

Negative Findings ◽

History Of ◽

Muscle Invasive ◽

Positive Results

Abstract Background A previous comparative study in Japan has demonstrated that the two consecutive UroVysion tests are useful tools to detect the presence of bladder cancer during follow-up after transurethral resection, but they also presented their high rates of false-positive results. Here, we aimed to evaluate the relationship between the UroVysion tests and subsequent intravesical recurrence. Methods In the previous study, patients without bladder cancer during the first analysis showed the same examination set repeated 3 months later as the second analysis. In this follow-up study, 326 patients showed negative findings confirmed on cystoscopy during the second UroVysion test. Recurrence-free survival was assessed using a median follow-up of 27 months. Results In the two consecutive UroVysion tests, 214 patients (65.6%) showed negative UroVysion results in both tests, whereas 91 presented a positive result on either tests and 21 patients presented positive results in both tests. During the follow-up, 40 patients (12.3%) had an intravesical recurrence with non-muscle-invasive bladder cancer. The recurrence rates in patients with negative results in both tests, those with one positive result in either tests, and those with positive results in both tests were 8.4%, 16.5%, and 33.3%, respectively. The multivariate analysis indicated that the history of bladder cancer and the consecutive UroVysion test pattern were independent risk factors for recurrence. Conclusions Our data confirmed the effectiveness of two consecutive UroVysion tests in predicting intravesical recurrence after TURBT. Further prospective studies would help determine an appropriate interval for cystoscopy follow-up.

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Negative Loop Electrosurgical Cone Biopsy Finding Following a Biopsy Diagnosis of High-Grade Squamous Intraepithelial Lesion: Frequency and Clinical Significance

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2011-0494-oa ◽

2012 ◽

Vol 136 (10) ◽

pp. 1259-1261 ◽

Cited By ~ 17

Author(s):

Benjamin L. Witt ◽

Rachel E. Factor ◽

Elke A. Jarboe ◽

Lester J. Layfield

Keyword(s):

Clinical Significance ◽

Low Grade ◽

High Grade ◽

Biopsy Finding ◽

Squamous Intraepithelial Lesion ◽

Positive Biopsy ◽

Biopsy Diagnosis ◽

Negative Findings ◽

Intraepithelial Lesion

Context.—Loop electrosurgical excision procedure (LEEP) is a therapeutic option following biopsy diagnosis of high-grade squamous intraepithelial lesion (HSIL). Most LEEPs will confirm the HSIL biopsy diagnosis but a number of them will not. Such negative findings suggest the possibility of an incorrect biopsy diagnosis, removal of the lesion by biopsy, or insufficient LEEP sampling. Objective.—To determine the frequency of negative LEEP findings following HSIL biopsies and better understand the clinical significance of negative LEEP findings. Design.—The Department of Pathology's records were searched for all patients undergoing LEEP excision who had prior cervical biopsies and subsequent clinical follow-up. Results.—Three hundred seventy-eight women were found who had index biopsies, subsequent LEEPs, and clinical follow-up averaging 25.8 months. Three hundred six women had HSIL on biopsy with 223 (73%) showing HSIL on LEEP. Seventy-three (24%) LEEPs in women with HSIL index biopsy results yielded negative findings or disclosed low-grade squamous intraepithelial lesion (LSIL). Twenty-nine of 223 patients (13%) with an HSIL result both on biopsies and LEEPs had HSIL on biopsy and/or excisional clinical follow-up. Seven of 73 patients (10%) with positive (HSIL) biopsy results but negative LEEP findings or LSIL had HSIL on biopsy and/or excisional follow-up. Conclusions.—Twenty-four percent of patients with HSIL on biopsy had negative findings or LSIL on LEEP. There is no statistical difference in development of HSIL after LEEP for those with positive biopsy and positive LEEP results (13%) versus positive biopsy and negative LEEP results (10%). The occurrence of a negative LEEP finding following a positive biopsy finding was frequent (24%) and does not portend a different clinical follow-up from a positive biopsy and positive LEEP result.

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Cognition in pregnancy and motherhood: prospective cohort study

The British Journal of Psychiatry ◽

10.1192/bjp.bp.109.068635 ◽

2010 ◽

Vol 196 (2) ◽

pp. 126-132 ◽

Cited By ~ 41

Author(s):

Helen Christensen ◽

Liana S. Leach ◽

Andrew Mackinnon

Keyword(s):

Cohort Study ◽

Prospective Cohort ◽

Late Pregnancy ◽

Cognitive Change ◽

Biased Sampling ◽

Cognitive Deterioration ◽

Negative Findings ◽

In Pregnancy

BackgroundResearch has reported that pregnant women and mothers become forgetful. However, in these studies, women are not recruited prior to pregnancy, samples are not representative and studies are underpowered.AimsThe current study sought to determine whether pregnancy and motherhood are associated with brief or long-term cognitive deterioration using a representative sample and measuring cognition during and before the onset of pregnancy and motherhood.MethodWomen aged 20–24 years were recruited prospectively and assessed in 1999, 2003 and 2007. Seventy-six women were pregnant at follow-up assessments, 188 became mothers between study waves and 542 remained nulliparous.ResultsNo significant differences in cognitive change were found as a function of pregnancy or motherhood, although late pregnancy was associated with deterioration on one of four tests of memory and cognition.ConclusionsThe hypothesis that pregnancy and motherhood are associated with persistent cognitive deterioration was not supported. Previous negative findings may be a result of biased sampling.

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Prevalence of iodine- and thyroglobulin negative findings in differentiated thyroid cancer

Nuklearmedizin ◽

10.1055/s-0038-1623879 ◽

2001 ◽

Vol 40 (05) ◽

pp. 143-147 ◽

Cited By ~ 5

Author(s):

S. Klutmann ◽

L. Jenicke ◽

M. Geiss-Tönshoff ◽

J. Mester ◽

M. Clausen ◽

...

Keyword(s):

Thyroid Cancer ◽

Differentiated Thyroid Cancer ◽

Progressive Disease ◽

Recurrent Disease ◽

University Hospital ◽

Follicular Thyroid Cancer ◽

Negative Findings ◽

Additional Imaging ◽

Iodine Scan

Summary Aim: The prevalence of iodine- and thyroglobulin-nega-tive findings was evaluated in all patients with differentiated thyroid cancer (DTC) treated from 1961 until 1998 at the Department of Nuclear Medicine, University Hospital Hamburg-Eppendorf. Methods: A total of 490 patients with papillary thyroid cancer (PCA) and 242 patients with follicular thyroid cancer (FCA) were analyzed retrospectively. Patients were divided into four groups: 1: no recurrence, 2: recurrent disease, 3: primary metas-tatic/progressive disease and 4: inconclusive follow-up. Results of iodine scan, serum-TG, and additional imaging modalities as well as histology were compared in all patients. Results: 21/490 (4,3%) of patients with PCA and 16/242 (6,6%) with FCA suffered from recurrent disease. 62/490 (12,7%) of patients with PCA and 59/242 (24,4%) with FCA had primary metastatic/progressive disease. 12/21 patients with PCA and 12/16 with FCA showing up with recurrent disease had a negative iodinescan. 11/21 of patients with PCA and 4/16 with FCA and tumor recurrence had negative serum-TG levels. 14/62 patients with PCA and 14/59 with FCA presenting with primary metastatic/ progressive disease had negative iodinescan. 14/62 patients with PCA and 6/59 with FCA had negative serum-TG. Conclusion: The prevalence of iodine-negative recurrent"/metastatic disease is in accordance to the literature, whereas the prevalence of TG-negative recurrent/metastatic was noted higher than reported previously. Thus, the commonly used follow-up scheme of DTC is confirmed. However, iodine scan should be regularly performed in patients with high risk of recurrence.

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Outcome of 5-Year Follow-Up in Men with Negative Findings on Initial Biparametric MRI

SSRN Electronic Journal ◽

10.2139/ssrn.3900935 ◽

2021 ◽

Author(s):

Karen-Cecilie Kortenbach ◽

Lars Boesen ◽

Vibeke Løgager ◽

Henrik S. Thomsen

Keyword(s):

Negative Findings

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Treatment of patients with Schistosomiasis mansoni: a double blind clinical trial comparing praziquantel with oxamniquine

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46651986000300007 ◽

1986 ◽

Vol 28 (3) ◽

pp. 174-180 ◽

Cited By ~ 15

Author(s):

Luiz Caetano da Silva ◽

José Murilo R. Zeitune ◽

Lucia Maria F. Rosa-Eid ◽

Dirce Mary C. Lima ◽

Rita H. Antonelli ◽

...

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Statistical Significance ◽

Double Blind ◽

Chemical Structures ◽

Double Blind Clinical Trial ◽

Negative Findings ◽

Rectal Biopsies ◽

Cure Rates

A double-blind clinical trial involving 120 patients with chronic schistosomiasis was carried out to compare the tolerability and efficacy of praziquantel and oxamniquine. The patients were randomly allocated into two groups. One was treated with praziquantel, 55 mg/kg of body weight CBWT), and the other one with oxamniquine, 15mg/kg bwt, administered in a single oral dose. The diagnosis and the parasitological follow-up was based on stool examinations by quantitative Kato-Katz method and on rectal biopsies. Side-effects — mainly dizziness, sleepness, abdominal distress, headache, nausea and diarrhea — were observed in 87% of the cases. Their incidence, intensity and duration were similar for both drugs but abdominal pain was significantly more frequent after praziquantel intake and severe dizziness was more commonly reported after oxamniquine. A significant increase of alanine-aminotransferase and y-glutamyltransferase was found with the latter drug and of total bilirubin with the former one. A total of 48 patients treated with praziquantel and 46 with oxamniquine completed with negative findings the required three post-treatment parasitological controls — three slides of each stool sample on the first, third and sixth month. The achieved cure rates were 79.2% and 84.8%, respectively, a difference without statistical significance. The non-cured cases showed a mean reduction in the number of eggs per gram of feces of 93.5% after praziquantel and of 84.1% after oxamniquine. This diference also was not significant. Five patients retreated with praziquantel were cured but only one out of three treated a second time with oxamniquine. These findings show that both drugs — despite their different chemical structures, pharmacological properties and mechanisms-of-action — induce similar side-effects as well as a comparable therapeutical efficacy, in agreement with the results reported from analogous investigations.

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Ten-year follow-up of ovarian cancer patients after second-look laparotomy with negative findings

Obstetrics and Gynecology ◽

10.1016/s0029-7844(98)00334-2 ◽

1999 ◽

Vol 93 (1) ◽

pp. 21-24 ◽

Cited By ~ 63

Author(s):

S Rubin

Keyword(s):

Ovarian Cancer ◽

Cancer Patients ◽

Second Look ◽

Negative Findings

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Delayed hemorrhage from the tissue of an occluded arteriovenous malformation after stereotactic radiosurgery: report of 3 cases

Journal of Neurosurgery ◽

10.3171/2016.4.jns152320 ◽

2016 ◽

Vol 126 (6) ◽

pp. 1899-1904 ◽

Cited By ~ 3

Author(s):

Conor Grady ◽

Omar Tanweer ◽

David Zagzag ◽

Jafar J. Jafar ◽

Paul P. Huang ◽

...

Keyword(s):

Stereotactic Radiosurgery ◽

Case Series ◽

Imaging Findings ◽

Cerebral Arteriovenous Malformations ◽

Conventional Angiography ◽

Delayed Hemorrhage ◽

Negative Findings ◽

Angiographic Evidence ◽

Risk Of Hemorrhage

Stereotactic radiosurgery is widely used to treat cerebral arteriovenous malformations (AVMs), with the goal of complete angiographic obliteration. A number of case series have challenged the assumption that absence of residual AVM on follow-up angiograms is consistent with elimination of the risk of hemorrhage. The authors describe 3 cases in which patients who had angiographic evidence of AVM occlusion presented with late hemorrhage in the area of their prior lesions. They compare the radiographic, angiographic, and histological features of these patients with those previously described in the literature.Delayed hemorrhage from the tissue of occluded AVMs has been reported as early as 4 and as late as 11 years after initial stereotactic radiosurgery. In all cases for which data are available, hemorrhage occurred in the area of persistent imaging findings despite negative findings on conventional angiography. The hemorrhagic lesions that were resected demonstrated a number of distinct histological findings.While rare, delayed hemorrhage from the tissue of occluded AVMs may occur from a number of distinct, angiographically occult postirradiation changes. The hemorrhages in the authors' 3 cases were symptomatic and localized. The correlation of histological and imaging findings in delayed hemorrhage from occluded AVMs is an area requiring further investigation.

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