scholarly journals Association of lower circulating Spexin levels with higher body mass indices and glucose metabolic profiles in adult subjects in Egypt

2021 ◽  
pp. 200137
Author(s):  
Eman Salah Albeltagy ◽  
Nashwa Mohamed Abd Elbaky
Keyword(s):  
Body Mass ◽  
Metabolic Profiles

Changes in Body Mass and Metabolic Profiles in Patients with First-Episode Schizophrenia Treated for 12 Months with A First-Generation Antipsychotic

2015 ◽  
Vol 30 (2) ◽  
pp. 277-283 ◽  
Author(s):  
B. Chiliza ◽  
L. Asmal ◽  
P. Oosthuizen ◽  
E. van Niekerk ◽  
R. Erasmus ◽  
...  
Keyword(s):  
Body Mass ◽  
First Generation ◽  
Fasting Blood Glucose ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Metabolic Profiles ◽  
Second Generation Antipsychotics ◽  
Developing Communities ◽  
Long Acting ◽  
First Episode Schizophrenia

AbstractObjectives:To assess changes in body mass and metabolic profiles in patients with first-episode schizophrenia receiving standardised, assured treatment and to identify predictors and moderators of the effects.Methods:We investigated the changes in body mass, fasting blood glucose and lipids in 107 largely antipsychotic naïve, first-episode schizophrenia patients who were treated according to a standard algorithm with long-acting injectable flupenthixol decanoate over 12 months.Results:Eighty-three (78%) participants completed the 12 months of treatment, and 104 (97%) received 100% of the prescribed injections during their participation. There were significant increases in BMI (P < .0001), waist circumference (P = 0.0006) and triglycerides (P = 0.03) and decrease in HDL (P = 0.005), while systolic (P = 0.7) and diastolic blood pressure (P = 0.8), LDL (P = 0.1), cholesterol (P = 0.3), and glucose (P = 0.9) values did not change over time. The triglyceride: HDL ratio increased by 91%. Change in BMI was only correlated with change in triglycerides (P = .008). The only significant predictor of BMI increase was non-substance abuse (P = .002).Conclusions:The risks of weight gain and metabolic syndrome associated with antipsychotic treatment in first-episode schizophrenia are not restricted to second generation antipsychotics. This is a global problem, and developing communities may be particularly susceptible.

scholarly journals Association between sedentary behavior and anthropometric and metabolic profiles among adolescents

2013 ◽  
Vol 19 (4) ◽  
pp. 753-762 ◽  
Author(s):  
Roseane de Fátima Guimarães ◽  
Michael Pereira da Silva ◽  
Oldemar Mazzardo ◽  
Rafael Vieira Martins ◽  
Wagner de Campos
Keyword(s):  
Public Schools ◽  
Sedentary Behavior ◽  
Body Mass ◽  
Screen Time ◽  
Personal Information ◽  
Binary Logistic Regression ◽  
The Body ◽  
Activity Level ◽  
Metabolic Profiles ◽  
Metabolic Variables

The purpose of this study was to establish the association between sedentary behavior and the anthropometric and metabolic profiles within a sample group of 572 adolescents from public schools in the city of Curitiba, State of Paraná, Brazil. Approximately 8 ml of blood was drawn to measure total cholesterol (TC), LDL-c, HDL-c, triglycerides, and glucose. Stature and body mass were measured to calculate the body mass index. Information about the subjects' socioeconomic status, physical activity level, sedentary behavior, eating frequency, as well as personal information was obtained through questionnaires. Descriptive statistics, measures of central tendency and percentage score, and Binary Logistic Regression were used to obtain the odds ratio with a CI of 95% and p<0.05. Half of the girls had TC levels classified as borderline or altered, and total screen time presented a significant association between the metabolic variables analyzed in the study. We conclude that girls had TC levels less favorable than that of the boys and that screen time is associated with some metabolic variables.

scholarly journals Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European birth cohorts

2017 ◽  
Author(s):  
Diana L. Santos Ferreira ◽  
Dylan M. Williams ◽  
Antti J. Kangas ◽  
Pasi Soininen ◽  
Mika Ala-Korpela ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Multiple Testing ◽  
Metabolic Profile ◽  
Negative Control ◽  
Maternal Body Mass Index ◽  
Metabolic Profiles ◽  
Birth Cohorts ◽  
Two Stage ◽  
Maternal Bmi

AbstractBackgroundA high proportion of women start pregnancy overweight/obese. According to the developmental overnutrition hypothesis, this could lead offspring to have metabolic disruption throughout their lives, and, thus perpetuate the obesity epidemic across generations. Concerns about this hypothesis are influencing antenatal care. However, it is unknown whether maternal pregnancy adiposity is associated with long-term risk of adverse metabolic profiles in offspring, and if so, whether this association is causal, via intrauterine mechanisms, or explained by shared familial (genetic, lifestyle, socioeconomic) characteristics. We aimed to determine if associations between maternal body mass index (BMI) with offspring systemic metabolite profile are causal via intrauterine mechanisms or familial factors.Methods and FindingsWe used one and two-stage individual participant data (IPD) metaanalysis, and a negative-control (paternal BMI) to examine the association between maternal prepregnancy BMI and offspring serum metabolome from three European birth cohorts (offspring age at metabolite assessment 16, 17 and 31 years). Circulating metabolites were quantified by high-throughput nuclear magnetic resonance metabolomics. Results from one-stage IPD meta-analysis (N=5327 to 5377 mother-father-offspring trios) showed that increasing maternal and paternal BMI was associated with an adverse cardio-metabolic profile in offspring. We observed strong positive associations with VLDL-lipoproteins, VLDL-C, VLDL-triglycerides, VLDL-diameter, branched/aromatic amino acids, glycoprotein acetyls, and triglycerides, and strong negative associations with HDL-lipoprotein, HDL-diameter, HDL-C, HDL2-C and HDL3-C (all P<0.003). Stronger magnitudes of associations were present for maternal compared with paternal BMI across these associations, however there was no strong statistical evidence for heterogeneity between them (all bootstrap P >0.003, equivalent to 0.05 after accounting for multiple testing). Results were similar in each individual cohort, and in the two-stage analysis. Offspring BMI showed similar patterns of crosssectional association with metabolic profiles as for parental pre-pregnancy BMI associations, but with greater magnitudes. Adjustment of the parent BMI-offspring metabolite associations for offspring BMI suggested the parental associations were largely due to the association of parental BMI measures with offspring BMI.ConclusionOur findings suggest that maternal BMI-offspring metabolome associations are likely to be largely due to shared genetic or familial lifestyle confounding, rather than intrauterine programming mechanisms. They do not support the introduction of measures to reduce maternal BMI in order to prevent adverse offspring cardio-metabolic health.

Poster #T45 CHANGES IN BODY MASS AND METABOLIC PROFILES OVER 12 MONTHS IN PATIENTS WITH FIRST-EPISODE SCHIZOPHRENIA WITH ASSURED ANTIPSYCHOTIC ADHERENCE

2014 ◽  
Vol 153 ◽  
pp. S305
Author(s):  
Bonginkosi Chiliza ◽  
Laila Asmal ◽  
Piet Oosthuizen ◽  
Yvette van Niekerk ◽  
Rajiv Erasmus ◽  
...  
Keyword(s):  
Body Mass ◽  
First Episode ◽  
Metabolic Profiles ◽  
First Episode Schizophrenia

Abstract P208: Changes in metabolic profiles among evacuees after the Great East Japan Earthquake: the Fukushima Health Management Survey

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Tetsuya Ohira ◽  
Mitsuaki Hosoya ◽  
Seiji Yasumura ◽  
Hiroaki Sato ◽  
Hitoshi Suzuki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Great East Japan Earthquake ◽  
Metabolic Profiles ◽  
Before And After ◽  
Prevalence Of Obesity ◽  
Obesity Hypertension

Background: The Great East Japan Earthquake occurred on 11 March 2011 in Japan. To this day, over 140,000 people have been forced to evacuate their homes due to a nuclear accident, which occurred at the Fukushima Daiichi Nuclear Power Plant. Hypothesis: We assessed the hypothesis that prevalence of obesity, hypertension, dyslipidemia, and diabetes mellitus was increased among evacuees after the disaster, compared with that before the disaster. Methods: A prospective study of Japanese subjects aged 40-90 years was undertaken using data collected from 32,949 participants (14,963 men and 17,986 women) in general health checkups conducted in 12 communities, including the evacuation zone specified by the government, between 2008 and 2010. Height, body weight, blood pressure, and blood test such as glucose, hemoglobin A1c (HbA1c), and lipid panel were examined. Follow-up examination was conducted between 2011 and 2012 (at least of 6-month after the disaster). The participants were divided into two groups: evacuees and non-evacuees. Changes in metabolic profiles among the evacuees and non-evacuees were compared between before and after the disaster. Results: 22,117 participants (10,170 men and 11,947 women, follow-up rate: 67%) received follow-up examination after the disaster, and an average follow up was 1.5-years. Mean levels of body weight were significantly increased in the both evacuee and non-evacuee groups after the disaster, and changes in body weight and body mass index were greater in the evacuee group than those in the non-evacuee group; +1.3kg versus +0.3kg, p<0.001, and +0.60kg/m 2 versus +0.13kg/m 2 , p<0.001. In the evacuee group, prevalence of obesity, hypertension, dyslipidemia, and diabetes mellitus was increased after the disaster. Respective prevalence before and after the disaster were 31.8% and 39.4% for obesity (body mass index>=25.0kg/m 2 ), 54.2% and 60.2% for hypertension, 41.2% and 53.9% for dyslipidemia, and 10.2% and 11.9% for diabetes mellitus, while, in the non-evacuee group, those were 28.3% and 30.3%, 54.7% and 60.0%, 42.6% and 49.4%, and 8.5% and 9.9%. Conclusions: Prevalence of obesity, hypertension, dyslipidemia, and diabetes mellitus may be increased among residents, especially evacuees, in the evacuation zone of Fukushima prefecture after the Great East Japan Earthquake.

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