scholarly journals Neuroprotective effect of aqueous extract of xylopia aethiopica seed on lead-induced injury on the hippocampus and cerebral cortex of male wistar rat

IBRO Reports ◽  
2019 ◽  
Vol 7 ◽  
pp. 13-14
Author(s):  
S. George ◽  
P. Filma ◽  
L. David ◽  
C. Orish
Keyword(s):  
Cerebral Cortex ◽  
Aqueous Extract ◽  
Neuroprotective Effect ◽  
Wistar Rat ◽  
Xylopia Aethiopica

scholarly journals Neuroprotective Effect of Xylopia Aethiopica Seed on Lead-Induced Injury on the Cerebral Cortex of Male Wistar Rat

2021 ◽  
Vol 6 (1) ◽  
pp. 7
Author(s):  
Chinna Nneka Orish ◽  
Samuel Sotonye George ◽  
Eberechi Wogu ◽  
Anthoneth Ndidiamaka Ezejiofor
Keyword(s):  
Cerebral Cortex ◽  
Neuroprotective Effect ◽  
Wistar Rat ◽  
Xylopia Aethiopica

scholarly journals Inhibitory Potential of Murraya Koenigii (L.) and Ficus Carica L. Extracts Against Aldose Reductase (ALR), Advanced Glycation End Products (AGEs) Formation and Sorbitol Accumulation

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Shah Asma Farooq ◽  
Randhir Singh
Keyword(s):  
Aqueous Extract ◽  
Microvascular Complications ◽  
Wistar Rat ◽  
Inhibitory Effect ◽  
Significant Inhibition ◽  
Ficus Carica ◽  
Alcoholic Extract ◽  
Murraya Koenigii ◽  
Treatment Of Diabetes ◽  
Inhibitory Potential

Abstract Introduction: Murraya koenigii (L.) and Ficus carica L. are traditionally used plants with significant medicinal and nutritional values. Aim and Objective: The present study was focused on the evaluation of hydro-alcoholic and aqueous extracts of M. koenigii (L.) leaves [MKHA (M. koenigii (L.) hydro-alcoholic extract) and MKAQ (M.koenigii (L.) aqueous extract)] and dried fruits of F. carica L. [FCHA (F. carica L. hydro-alcoholic extract) and FCAQ (F. carica L. aqueous extract)] in the attenuation of markers of microvascular complications associated with diabetes mellitus which can be further used to investigate the pharmacological activity of these plants in treatment of diabetes and its complications. Material and Method: The attenuating effect of the extracts was evaluated by calculating the ALR1 enzyme inhibition in a kidney of Wistar rat, anti-glycation activity in bovine serum albumin (BSA) and erythrocyte sorbitol accumulation inhibition in heparinized human blood. Results: A significant inhibitory effect (IC50 6.47μg/ml,7.26μg/ml,8.93 μg/ml and 9.66μg/ml) was observed with different concentrations of extracts (MKHA, MKAQ, FCHA and FCAQ) respectively, against ALR enzyme. After the 4th week of incubation, the inhibition of AGEs formation by MKHA, MKAQ, FCHA and FCAQ (500μg/ml) was found to be 82.58%, 78.58%, 74.39% and 69.56% respectively. MKHA, MKAQ, FCHA and FCAQ were found to exhibit significant inhibition against the accumulation of sorbitol in RBCs with IC50 188.88 μg/ml, 247.74μg/ml, 291.94μg/ml and 345.34μg/ml, respectively. Conclusion: The administration of different concentrations of MKHA, MKAQ, FCHA and FCAQ significantly attenuated ALR, AGEs and sorbitol accumulation; hence, it can provide a basis for identification and development of new inhibitors of these biomarkers.

scholarly journals Neuroprotective effect of vitamin E supplementation in wistar rat treated with acrylamide

2012 ◽  
Vol 19 (1) ◽  
pp. 1 ◽  
Author(s):  
Nitin Kurkure ◽  
Vandana Hedaoo ◽  
Santosh Rahangadale ◽  
Baijnath Prajapati ◽  
ArunG Bhandarkar
Keyword(s):  
Vitamin E ◽  
Neuroprotective Effect ◽  
Wistar Rat ◽  
Vitamin E Supplementation

scholarly journals In Vitro Antioxidant Activity of Purple Grape Juice (Vitis Labrusca) against Temozolamide Treatment in Rat Brains

Beverages ◽  
2018 ◽  
Vol 4 (4) ◽  
pp. 99
Author(s):  
Tatiane Gabardo ◽  
Marina Rocha Frusciante ◽  
Jessica Pereira Marinho ◽  
Manuela dos Santos ◽  
Ana Abujamra ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Protein Oxidation ◽  
Neuroprotective Effect ◽  
Grape Juice ◽  
Thiobarbituric Acid ◽  
Redox Balance ◽  
Sod Activity ◽  
The Central Nervous System ◽  
In Vitro Antioxidant Activity

Considering that grape juice has high levels of phenolic compounds that produce beneficial physiological effects, important for the maintenance of redox balance, the aim of this study was to evaluate the in vitro neuroprotective effect of purple grape juice on the oxidative damage caused by temozolomide (TMZ) in the cerebral cortex, hippocampus, and cerebellum of Wistar rats. In pre-incubation, TMZ increased thiobarbituric acid reactive substances (TBARS) in the cerebral cortex and cerebellum, enhanced protein oxidation in all tissues studied, increased superoxide dismutase (SOD) activity in the hippocampus, decreased SOD activity in the cerebellum, and enhanced catalase (CAT) activity in the cerebral cortex and cerebellum. In co-incubation, there was enhanced protein oxidation in the cerebral cortex and cerebellum, decreased SOD activity in the cerebellum, inhibition of CAT activity in the hippocampus, and increased CAT activity in the cerebellum. Purple grape juice improved these oxidative alterations. Therefore, the intake of grape juice might have a protective effect against diseases that affect the oxidative status of the central nervous system.

scholarly journals Evaluation of antiulcerogenic activity of aqueous extract of Brassica oleracea var. capitata (cabbage) on Wistar rat gastric ulceration

2011 ◽  
Vol 48 (4) ◽  
pp. 276-282 ◽  
Author(s):  
Camilo Amaro de Carvalho ◽  
Kenner Moraes Fernandes ◽  
Sérgio Luiz Pinto Matta ◽  
Marcelo Barreto da Silva ◽  
Leandro Licursi de Oliveira ◽  
...  
Keyword(s):  
Body Weight ◽  
Acetylsalicylic Acid ◽  
Brassica Oleracea ◽  
Aqueous Extract ◽  
Western Europe ◽  
Wistar Rat ◽  
Significant Inhibition ◽  
Gastric Ulcers ◽  
Chemical Agent ◽  
Antiulcerogenic Activity

CONTEXT: The cabbage (Brassica oleraceae var. capitata) is an herbaceous and leafy plant which belongs to the Brassicaceae family, native to coastal southern and Western Europe. Used in cooking for its nutritional value also has known anti-inflammatory activity. OBJECTIVE We studied the antiulcerogenic activity of aqueous extract of Brassica oleracea var. capitata (AEB) in order to validate ethnobotanical claims regarding the plant use in the gastric disorders. METHOD: Acute gastric ulcers were induced in rats by the oral administration of acetylsalicylic acid. The gastroprotective potential of the AEB (0.250, 0.500 and 1.000 mg.kg-1/body weight) was compared with omeprazole (20 mg.kg-1/body weight). RESULTS: The stomach analysis indicated that treatment with AEB inhibited the gastric damage. The gastroprotective activity as evidenced by its significant inhibition in the formation of ulcers induced by chemical agent with a maximum of 99.44% curation (250 mg.kg-1 body weight) in acetylsalicylic acid-induced ulcers. CONCLUSIONS: The AEB demonstrated good antiulcerogenic activities which justify the inclusion of this plant in the management of gastric disorders. Further experiments are underway to determine which antiulcer mechanisms involved in gastroprotection.

scholarly journals Neuroprotective Effect of Green Synthesized Iron Oxide Nanoparticles Using Aqueous Extract of Convolvulus Pluricaulis Plant in The Management of Alzheimer’s Disease

2017 ◽  
Vol 9 (5) ◽  
Author(s):  
Lakshmi Pravallika Poka ◽  
Krishna Mohan G. ◽  
Venkateswara Rao K. ◽  
Shanker K.
Keyword(s):  
Iron Oxide ◽  
Learning And Memory ◽  
Iron Oxide Nanoparticles ◽  
Aqueous Extract ◽  
Elevated Plus Maze ◽  
Neuroprotective Effect ◽  
Oxide Nanoparticles ◽  
Whole Plant ◽  
Plus Maze ◽  
Convolvulus Pluricaulis

To evaluate the neuroprotective effect of green synthesized iron oxide nanoparticles using aqueous extract of whole plant of Convolvulus pluricaulis (CPIO) in scopolamine induced amnesia model. CPIO were orally tested at the dose of 100 mg/kg, 200 mg/kg and 400 mg/kg for neuroprotective effect in scopolamine induced amnesia mice. In addition, neurobehavioral studies were carried out using elevated plus maze, Morris water maze to evaluate learning and memory in mice in normal and scopolamine induced amnesia mice. CPIO 400 mg/kg showed a significant improvement in learning and memory in the normal and scopolamine induced amnesia mice in exteroceptive models. Significant differences were observed in lipid peroxidation, catalase and acetylcholinesterase by 400 mg/kg of CPIO treated amnesic animals, when compared with untreated and scopolamine group animals. The highest dose of CPIO exhibited significant neuroprotective effect in normal and scopolamine induced amnesia mice. They also showed significant improvement in learning and memory in exteroceptive and interoceptive models and so might be of value in Alzheimer’s treatment.

scholarly journals Acute and subacute toxicity assessment of an aqueous extract of Crotalaria retusa (Fabaceae) in Swiss mice and Wistar rats

2021 ◽  
Vol 11 (6) ◽  
pp. 94-100
Author(s):  
Lane Adrien GOH BI ◽  
Noel Kouame TOTO ◽  
Ouga Stanislas ZAHOUI ◽  
Yomalan KASSI ◽  
Semi Anthelme NENE Bi ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Aqueous Extract ◽  
Wistar Rat ◽  
Toxicity Assessment ◽  
Female Rats ◽  
Male And Female ◽  
Subacute Toxicity ◽  
Swiss Mice ◽  
Aerial Parts ◽  
Male And Female Rats

The present study is a contribution to the enhancement of Ivorian traditional medicine, by carrying out bio-tolerance tests of an aqueous extract of the aerial parts of Crotalaria retusa (EACr) in mice and rats according to the guidelines of the Organization for Economic Co-operation and Development (OECD) 423 and 407, respectively. The doses of 2000 and 5000 mg/kg of body weight (BW) of the extract were used for acute toxicity. For subacute toxicity which lasted 28 days, doses of 500, 1000, and 2000 mg/kg BW have been used. The administration of the single doses of 2000 and 5000 mg/kg BW of EACr did not provoke death in female mice in the acute toxicity setting. For subacute toxicity in rats (male and female), the administration of repetitive doses of 500, 1000, and 2000 mg/kg BW of EACr over a period of 28 days did not cause death in these animals. In females, these doses caused weight loss and a decrease in platelets. The extract reduced the activity of AST in both sexes of rats. The findings also showed that this extract would possess a nephroprotective property in male and female rats. Keywords: Crotalaria retusa, Acute and subacute toxicities, Wistar rat, Swiss mice

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