Aqueous Extract of Xylopia Aethiopica Fruits Protects against Carbon Tetrachloride - Induced Hepatotoxicity in Rats

2016 ◽  
Vol 6 (3) ◽  
pp. 860
Author(s):  
Adewale J
Keyword(s):  
Carbon Tetrachloride ◽  
Aqueous Extract ◽  
Xylopia Aethiopica

The preventive effect of aqueous extract of Rosemary (Rosmarinus officinalis) leaves against the nephrotoxicity of carbon tetrachloride in mice

2018 ◽  
Vol 126 (3) ◽  
pp. 201-208
Author(s):  
Houda Hamed ◽  
Salha Boulila ◽  
Ferdaws Ghrab ◽  
Rim Kallel ◽  
Tahia Boudawara ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Aqueous Extract ◽  
Rosmarinus Officinalis ◽  
Preventive Effect

scholarly journals Hepatoprotective Effects of Vernonia amygdalina (Astereaceae) Extract on CCl4-Induced Liver Injury in Broiler Chickens

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3371
Author(s):  
Bemela Mawulom Tokofai ◽  
Kokou Idoh ◽  
Oyegunle Emmanuel Oke ◽  
Amegnona Agbonon
Keyword(s):  
Carbon Tetrachloride ◽  
Aqueous Extract ◽  
Broiler Chickens ◽  
Treated Group ◽  
Hepatoprotective Effect ◽  
Saline Control ◽  
Control Group ◽  
Vernonia Amygdalina ◽  
Hepatocellular Damage ◽  
Randomized Design

The aim of this study was to evaluate the effect of Vernonia amygdalina leaf extract (VALE) on the carbon tetrachloride-induced hepatotoxicity (CCl4) in broiler chickens. A total of 360-day-old broilers were divided into 4 treatments of 90 birds each consisting of 6 replicates of 15 birds each. The treatments were birds offered 1 mL/kg BW saline (control group), 100 mg/kg BW VALE, 1 mL/kg BW CCl4 (CCl4-treated group), and 100 mg/kg BW VALE + 1 mL/kg BW CCl4 (VALE + CCl4 group). Blood samples were collected at 42 days of age and analyzed for the liver enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and selected biochemical parameters. The experiment was laid out in a completely randomized design. The results obtained showed that VALE had the potential to mitigate the adverse effects of CCl4 on protein and lipid metabolism as reflected in the low serum malondialdehyde (MDA) levels, which is a marker of lipid peroxidation. The aqueous extract of Vernonia amygdalina (VA) at a dose of 100 mg/kg body weight showed a moderate hepatoprotective effect by reducing serum AST levels (p < 0.05). The levels of serum AST, ALP, ALT, and GGT were significantly increased in CCl4-treated birds compared to the control group, reflecting carbon tetrachloride-induced liver damage. The VALE + CCl4 group showed a significantly higher amount of ALP compared to birds treated with carbon tetrachloride, suggesting a hepatoprotective effect. To conclude, Vernonia amygdalina aqueous extract can be used to confer protection against hepatotoxicity, which can induce severe hepatocellular damage in birds.

scholarly journals Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats

2009 ◽  
Vol 124 (1) ◽  
pp. 130-136 ◽  
Author(s):  
Xingshen Ye ◽  
Yibin Feng ◽  
Yao Tong ◽  
Kwan-Ming Ng ◽  
SaiWah Tsao ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Aqueous Extract ◽  
Coptidis Rhizoma ◽  
Hepatoprotective Effects

scholarly journals Hepatoprotective effect of aqueous extract of Melothria perpusilla against carbon tetrachloride induced liver injury in albino rats

2017 ◽  
Vol 5 (3) ◽  
pp. 806 ◽  
Author(s):  
Nokul S. Yengkhom ◽  
Ngangom Gunindro ◽  
Sania M. Kholi ◽  
Rakesh S. Moirangthem ◽  
Bharati D. Rajkumari
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Aqueous Extract ◽  
Liquid Paraffin ◽  
Herbal Medicines ◽  
Modern Medicine ◽  
Hepatoprotective Effect ◽  
Albino Rats ◽  
Group Iii ◽  
Group I

Background: In absence of reliable hepatoprotective drug in modern medicine, the traditional herbal medicines have been emphasized. Present study was designed to assess hepatoprotective effect of aqueous extract of Melothria perpusilla (AEMP) against carbon tetrachloride (CCl4) induced liver injury.Methods: Five groups of animals with 6 rats in each were treated for 7 days.  Group I received 1% gum acacia in distilled water (1 ml/200 g p.o.) daily.  Group II, III, IV and V received CCl4 in liquid paraffin (1 ml/kg s.c.) on day 2, 4 and 6. Group III, IV and V were treated respectively with silymarin (100 mg/kg p.o.), AEMP- 200 and 400 mg/kg p.o. daily. On day 8, liver injury was assessed by measuring serum ALT, AST, ALP and bilirubin.Results: ALT, AST, ALP and bilirubin were significantly reduced in groups receiving both CCl4 and AEMP when compared with CCl4 treated group.Conclusions: AEMP produced hepatoprotective effect against CCl4 induced liver injury.

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