Transcriptional activity of genes encoding Transforming Growth Factor β and its receptors in peripheral blood mononuclear cells from patients with acute coronary syndromes

2006 ◽  
Vol 111 (2) ◽  
pp. 275-279 ◽  
Author(s):  
Jozefa Dabek ◽  
Urszula Mazurek ◽  
Zbigniew Gasior ◽  
Tadeusz Wilczok ◽  
Andrzej Kulach ◽  
...  
Keyword(s):  
Growth Factor ◽  
Acute Coronary Syndromes ◽  
Transcriptional Activity ◽  
Mononuclear Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Genes Encoding ◽  
Coronary Syndromes

scholarly journals Transforming Growth Factor β1 Production by CD4+ CD25+ Regulatory T Cells in Peripheral Blood Mononuclear Cells from Healthy Subjects Stimulated with Leishmania guyanensis

2005 ◽  
Vol 73 (9) ◽  
pp. 5908-5914 ◽  
Author(s):  
A. Kariminia ◽  
E. Bourreau ◽  
H. Pascalis ◽  
P. Couppié ◽  
D. Sainte-Marie ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Healthy Subjects ◽  
Mononuclear Cells ◽  
Transforming Growth Factor ◽  
Suppressive Activity ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Leishmania Guyanensis ◽  
Tgf Β1

ABSTRACT Transforming growth factor β (TGF-β) has been shown to be a central immunomodulator used by leishmaniae to escape effective mechanisms of protection in human and murine infections with these parasites. However, all the information is derived from studies of established infection, while little is known about TGF-β production in response to Leishmania stimulation in healthy subjects. In this study, TGF-β1 production was demonstrated in peripheral blood mononuclear cells from healthy subjects never exposed to leishmaniae in response to live Leishmania guyanensis, and the TGF-β1-producing cells were described as a distinct subpopulation of CD4+ CD25+ regulatory T cells. The suppressive properties of CD4+ CD25+ T cells were demonstrated in vitro by their inhibition of production of interleukin 2 (IL-2) and IL-10 by CD4+ CD25− T cells in the presence of either anti-CD3 or L. guyanensis. Although neutralization of TGF-β1 did not reverse the suppressive activity of CD4+ CD25+ T cells activated by anti-CD3, it reversed the suppressive activity of CD4+ CD25+ T cells activated by L. guyanensis. Altogether our data demonstrated that TGF-β1 is involved in the suppressive activity of L. guyanensis-stimulated CD4+ CD25+ T cells from healthy controls.

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