Lipomatous metaplasia in ischemic cardiomyopathy: Current knowledge and clinical perspective

2011 ◽  
Vol 146 (1) ◽  
pp. 120-122 ◽  
Author(s):  
Gaetano Nucifora ◽  
Giovanni D. Aquaro ◽  
Pier Giorgio Masci ◽  
Andrea Barison ◽  
Giancarlo Todiere ◽  
...  
Keyword(s):  
Ischemic Cardiomyopathy ◽  
Current Knowledge ◽  
Clinical Perspective ◽  
Lipomatous Metaplasia

Pathophysiology of telangiectasias of the lower legs and its therapeutic implication: A systematic review

2018 ◽  
Vol 33 (4) ◽  
pp. 225-233 ◽  
Author(s):  
P Kern
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Current Knowledge ◽  
Clinical Perspective ◽  
Review Of The Literature ◽  
Venous Plexus ◽  
Treatment Results ◽  
Therapeutic Implications ◽  
Improve Treatment ◽  
Tissue Abnormalities

Objective Telangiectasias of the lower legs are intradermal dilatations of the subpapillary venous plexus, but their pathophysiology and risk factors are still largely unknown. The purpose of this review is to summarize the current knowledge on the pathophysiology and risk factors for telangiectasias. Methods A systematic review of the literature indexed in Medline completed with textbooks and European phlebology journals from the French, Swiss, and German phlebology societies was performed. Results A multitude of risk factors and several pathophysiological hypotheses, such as reflux, arterio-venous micro-shunts, parietal, and connective tissue abnormalities, are described in the literature. The different hypotheses are discussed and put in a clinical perspective, in particular their therapeutic implications for phlebologists. Conclusion In conclusion, pathophysiology and risk factors of telangiectasias are still largely unknown, and a better understanding could improve treatment results and reduce recurrence.

scholarly journals WHAT HAPPENS NEXT? CURRENT KNOWLEDGE AND CLINICAL PERSPECTIVE OF PREGNANCY DENIAL AND CHILDREN’S OUTCOME

2021 ◽  
Vol 33 (2) ◽  
pp. 140-146
Author(s):  
Donatella Kettlewell ◽  
◽  
Maud Dujeu ◽  
Helene Nicolis ◽  
◽  
...  
Keyword(s):  
Current Knowledge ◽  
Clinical Perspective ◽  
Pregnancy Denial

Clinical perspective on pain in multiple sclerosis

2020 ◽  
pp. 135245852095201
Author(s):  
Cigdem Yilmazer ◽  
Ilse Lamers ◽  
Claudio Solaro ◽  
Peter Feys
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Multiple Sclerosis ◽  
Current Knowledge ◽  
Experimental Studies ◽  
Clinical Perspective ◽  
Frequent Symptom ◽  
Topical Review ◽  
Disability Level

Pain is an important and frequent symptom in multiple sclerosis (MS), which leads to a low quality of life, increased disability level, and lack of employment and mental health. Recently, studies have shown increased interest in pain in MS and there is a growing evidence of its prevalence. However, the literature suffers from lack of experimental studies focusing on pain reduction. This topical review summarizes the current knowledge about pain in MS with its definitions, assessments, treatments and rehabilitation within a holistic perspective.

scholarly journals Lipomatous Metaplasia in Ischemic Cardiomyopathy

Circulation ◽  
2007 ◽  
Vol 116 (1) ◽  
Author(s):  
Matthias Schmitt ◽  
Nilesh Samani ◽  
Gerry McCann
Keyword(s):  
Ischemic Cardiomyopathy ◽  
Lipomatous Metaplasia

scholarly journals Head and Neck Lymphomas in HIV Patients: a Clinical Perspective

2017 ◽  
Vol 21 (04) ◽  
pp. 399-407 ◽  
Author(s):  
Natsuki Oishi ◽  
José Bagán ◽  
Karla Javier ◽  
Enrique Zapater
Keyword(s):  
Head And Neck ◽  
Current Knowledge ◽  
Diagnosis And Treatment ◽  
Rapid Progression ◽  
Clinical Perspective ◽  
Hiv Patients ◽  
Benign Condition ◽  
Immunodeficiency Virus ◽  
Epidemiological Changes ◽  
The Many

Introduction Because of the many HIV-related malignancies, the diagnosis and treatment of lymphoma in patients infected with human immunodeficiency virus are challenging. Objective Here, we review current knowledge of the pathogenesis, epidemiology, symptomatology, diagnosis, and treatment of head and neck lymphomas in HIV patients from a clinical perspective. Data Synthesis Although Hodgkin's lymphoma is not an AIDS-defining neoplasm, its prevalence is ten times higher in HIV patients than in the general population. NHL is the second most common malignancy in HIV patients, after Kaposi's sarcoma. In this group of patients, NHL is characterized by rapid progression, frequent extranodal involvement, and a poor outcome. HIV-related salivary gland disease is a benign condition that shares some features with lymphomas and is considered in their differential diagnosis. Conclusion The otolaryngologist may be the first clinician to diagnose head and neck lymphomas. The increasing survival of HIV patients implies clinical and epidemiological changes in the behavior of this disease. Early diagnosis is important to improve the prognosis and avoid the propagation of HIV infection.

Lipomatous metaplasia in ischemic cardiomyopathy

2009 ◽  
Vol 10 (7) ◽  
pp. 568-569 ◽  
Author(s):  
Gianluca Di Bella ◽  
Michele Gaeta ◽  
Carmelo Anfuso ◽  
Concetta Zito ◽  
Salvatore Patanè ◽  
...  
Keyword(s):  
Ischemic Cardiomyopathy ◽  
Lipomatous Metaplasia

Macroorganisation and flexibility of thylakoid membranes

2019 ◽  
Vol 476 (20) ◽  
pp. 2981-3018 ◽  
Author(s):  
Petar H. Lambrev ◽  
Parveen Akhtar
Keyword(s):  
Light Harvesting ◽  
Current Knowledge ◽  
Three Dimensional ◽  
Photosynthetic Apparatus ◽  
Dynamic Responses ◽  
State Transitions ◽  
Photochemical Quenching ◽  
Light Harvesting Complex ◽  
Complex Ii ◽  
Light Harvesting Complex Ii

Abstract The light reactions of photosynthesis are hosted and regulated by the chloroplast thylakoid membrane (TM) — the central structural component of the photosynthetic apparatus of plants and algae. The two-dimensional and three-dimensional arrangement of the lipid–protein assemblies, aka macroorganisation, and its dynamic responses to the fluctuating physiological environment, aka flexibility, are the subject of this review. An emphasis is given on the information obtainable by spectroscopic approaches, especially circular dichroism (CD). We briefly summarise the current knowledge of the composition and three-dimensional architecture of the granal TMs in plants and the supramolecular organisation of Photosystem II and light-harvesting complex II therein. We next acquaint the non-specialist reader with the fundamentals of CD spectroscopy, recent advances such as anisotropic CD, and applications for studying the structure and macroorganisation of photosynthetic complexes and membranes. Special attention is given to the structural and functional flexibility of light-harvesting complex II in vitro as revealed by CD and fluorescence spectroscopy. We give an account of the dynamic changes in membrane macroorganisation associated with the light-adaptation of the photosynthetic apparatus and the regulation of the excitation energy flow by state transitions and non-photochemical quenching.

The glycomes of Caenorhabditis elegans and other model organisms

2002 ◽  
Vol 69 ◽  
pp. 117-134 ◽  
Author(s):  
Stuart M. Haslam ◽  
David Gems ◽  
Howard R. Morris ◽  
Anne Dell
Keyword(s):  
Caenorhabditis Elegans ◽  
Current Knowledge ◽  
Structural Data ◽  
Model Organisms ◽  
Entire Genome ◽  
C Elegans ◽  
The Face ◽  
Area Of Concern ◽  
Nematode Worm

There is no doubt that the immense amount of information that is being generated by the initial sequencing and secondary interrogation of various genomes will change the face of glycobiological research. However, a major area of concern is that detailed structural knowledge of the ultimate products of genes that are identified as being involved in glycoconjugate biosynthesis is still limited. This is illustrated clearly by the nematode worm Caenorhabditis elegans, which was the first multicellular organism to have its entire genome sequenced. To date, only limited structural data on the glycosylated molecules of this organism have been reported. Our laboratory is addressing this problem by performing detailed MS structural characterization of the N-linked glycans of C. elegans; high-mannose structures dominate, with only minor amounts of complex-type structures. Novel, highly fucosylated truncated structures are also present which are difucosylated on the proximal N-acetylglucosamine of the chitobiose core as well as containing unusual Fucα1–2Gal1–2Man as peripheral structures. The implications of these results in terms of the identification of ligands for genomically predicted lectins and potential glycosyltransferases are discussed in this chapter. Current knowledge on the glycomes of other model organisms such as Dictyostelium discoideum, Saccharomyces cerevisiae and Drosophila melanogaster is also discussed briefly.

Nucleosome dynamics

2006 ◽  
Vol 73 ◽  
pp. 109-119 ◽  
Author(s):  
Chris Stockdale ◽  
Michael Bruno ◽  
Helder Ferreira ◽  
Elisa Garcia-Wilson ◽  
Nicola Wiechens ◽  
...  
Keyword(s):  
High Resolution ◽  
Chromatin Structure ◽  
Current Knowledge ◽  
Dynamic Properties ◽  
Structure And Dynamics ◽  
Nucleosome Dynamics ◽  
Sharp Focus ◽  
Recent Advances ◽  
Insight Into ◽  
Chromatin Structure And Dynamics

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.

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