scholarly journals Blood stream infections by carbapenem resistant bacteria: critical perspectives from Indian tertiary care hospita

2019 ◽  
Vol 79 ◽  
pp. 40
Author(s):  
R. Gupta ◽  
M. Zabiuddin Ahad ◽  
A. Udupa ◽  
M. Varma ◽  
C. Mukhopadhyay ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Blood Stream ◽  
Resistant Bacteria ◽  
Blood Stream Infections ◽  
Carbapenem Resistant ◽  
Critical Perspectives

scholarly journals Erratum: Salmonella blood stream infections in a tertiary care setting in Ghana

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Appiah-Korang Labi ◽  
Noah Obeng-Nkrumah ◽  
Naa Addison ◽  
Eric S. Donkor
Keyword(s):  
Care Setting ◽  
Tertiary Care ◽  
Blood Stream ◽  
Blood Stream Infections ◽  
Tertiary Care Setting

Prevalence and antibiogram of non-fermenting Gram-negative bacilli in blood stream infections: Study in a tertiary care centre, Western Uttar Pradesh, India

2021 ◽  
pp. 004947552097929
Author(s):  
Tarana Sarwat ◽  
Mariyah Yousuf ◽  
Ambreen S Khan ◽  
Dalip K Kakru ◽  
Renu Dutta
Keyword(s):  
Burkholderia Cepacia ◽  
Tertiary Care ◽  
Uttar Pradesh ◽  
Blood Stream ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Acinetobacter Baumanii ◽  
Blood Stream Infections ◽  
Antibiotic Susceptibility Pattern ◽  
Gram Negative

Non-fermenting Gram-negative bacilli (NFGNB) are emerging as important cause of blood stream infections. We aimed to determine the prevalence and antibiotic susceptibility pattern of NFGNB isolated from blood of patients with sepsis. We found, in 176 patients, the most common to be Pseudomonas aeruginosa (74) and Acinetobacter baumanii complex (39) followed by Stenotrophomonas maltophilia (16), Sphingomonas paucimobilis (6), Burkholderia cepacia (5) and Ochrobactrum anthropic (1). Generally, organisms showed a good sensitivity towards colistin, carbapenems and fluoroquinolones, whereas cephalosporins were ineffective.

scholarly journals 1591. Antibiotic Utilization Trends in Veterans Affairs (VA) Patients with Carbapenem Resistant Enterobacteriaceae (CRE) Infections

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S792-S792
Author(s):  
Alfredo Traversa ◽  
Linda Poggensee ◽  
Geneva M Wilson ◽  
Katie J Suda ◽  
Charlesnika T Evans ◽  
...  
Keyword(s):  
Treatment Options ◽  
Blood Stream ◽  
Chi Square ◽  
Blood Stream Infections ◽  
Exact Test ◽  
Carbapenem Resistant ◽  
Extended Spectrum ◽  
New Antibiotics ◽  
Chi Square Test ◽  
Carbapenem Resistant Enterobacteriaceae

Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE) are classified as an “urgent threat” to public health. Historically, colistin and tigecycline had been considered the drugs of choice for CRE infections, while other agents such as aminoglycosides and carbapenems had been used as adjunctive therapy. However, the FDA approval of ceftazidime-avibactam in 2015, meropenem-vaborbactam in 2017, and plazomicin in 2018 has expanded treatment options. Our purpose was to assess trends in CRE treatment for “new” antibiotics (ceftazidime-avibactam, meropenem-vaborbactam, plazomicin) as compared with other antibiotics with CRE activity. Methods This was a retrospective cohort study describing treatment of CRE blood stream infections (BSI) across 134 VA facilities from 2012-2018. Patients were censored at their first positive blood culture with CRE. Categorical data was assessed with a Fisher’s exact test or chi-square test. Trends test and logistic regression were used to describe changes in CRE treatment over time. Results 724 patients with positive blood cultures for CRE were identified during the study period. Most patients were male (94%), white (32%) or Hispanic (38%), and the mean age was 71.5+11.9. Of those patients that received antibiotics (N=697), 53.4% carbapenems, 40.3% received aminoglycosides, 39.3% received polymyxins, 32.9% penicillins, 32.6% extended spectrum cephalosporins, 26.1% fluoroquinolones, 11.6% ceftazidime/avibactam, and 0.4% ceftolazone/tazobactam. Over the study period, there was decreased utilization of aminoglycosides (P < 0.0026) and colistin (P< 0.002) and increases in extended spectrum cephalosporins (P < 0.001) and ceftazidime/avibactam (P < 0.001). Conclusion Utilization of “older” agents such as aminoglycosides and polymyxins for the treatment of CRE blood stream infections is decreasing in the VA. Treating CRE with ceftazidime/avibactam, a newly approved antibiotic, and extended spectrum cephalosporins are increasing. Disclosures All Authors: No reported disclosures

Epidemiology of blood stream infections in pediatric patients at a Tertiary Care Cancer Centre

2014 ◽  
Vol 51 (4) ◽  
pp. 438 ◽  
Author(s):  
B Arora ◽  
N Thacker ◽  
N Pereira ◽  
SD Banavali ◽  
G Narula ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Tertiary Care ◽  
Blood Stream ◽  
Blood Stream Infections ◽  
Cancer Centre

scholarly journals Bacteriological profile of blood stream infections among febrile patients attending a tertiary care centre of Western Nepal

2013 ◽  
Vol 4 (3) ◽  
pp. 92-98 ◽  
Author(s):  
Dharm Raj Bhatta ◽  
Abhishek Gaur ◽  
HS Supram
Keyword(s):  
Tertiary Care ◽  
Blood Stream ◽  
Care Centre ◽  
Salmonella Spp ◽  
Tertiary Care Centre ◽  
Coagulase Negative Staphylococci ◽  
Cross Sectional ◽  
Blood Stream Infections ◽  
Acinetobacter Species ◽  
Study Results

Background Blood stream infections (BSI) are significant cause of morbidity and mortality in the world. This study was conducted to determine the common bacterial agents associated with BSI with their antimicrobial susceptibility patterns in a tertiary care centre in the Western region of Nepal. Method This cross-sectional study was conducted for a period of two years from May 2010 to May 2012. All patients with fever (temperature ≥ 38°C) were included in the study. Results A total of 4,145 patients with febrile illness were included in this study, bacterial agents were isolated in 251 (6%) cases. Common bacterial isolates were Salmonella spp., Klebsiella pneumoniae, Escherichia coli, Pseudomonas species, Acinetobacter species, Staphylococcus aureus and Coagulase negative Staphylococci. Paratyphoid fever (Caused by S. Paratyphi A) is more common than typhoid fever. The members of Enterobacteriaceae were found to be resistant to ampicillin and cefazolin. Majority of the nonfermenters were found to be sensitive to most antibiotics. Gentamicin and Ciprofloxacin were sensitive to majority of gram positive bacteria. Conclusion Gram-negative bacteria were the predominant causes of BSIs. The occurrence of drug resistance among the isolated bacteria is of great concern. Imipenem showed 100% sensitivity against Pseudomonas aeruginosa indicating lack or low level of MBL activity. DOI: http://dx.doi.org/10.3126/ajms.v4i3.8165 Asian Journal of Medical Sciences 4(2013) 92-98

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