Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses

Toll-like receptors (TLRs) are key pathogen sensing receptors that respond to diverse microbial ligands, and trigger both innate and adaptive immune responses to infection. Since their discovery, a growing body of evidence has pointed to an important role for TLRs in retroviral infection and pathogenesis. These data suggest that multiple TLRs contribute to the anti-retroviral response, and that TLR engagement by retroviruses can have complex and divergent outcomes for infection. Despite this progress, numerous questions remain about the role of TLRs in retroviral infection. In this review, I summarize existing evidence for TLR-retrovirus interactions and the functional roles these receptors play in immunity and pathogenesis, with particular focus on human immunodeficiency virus (HIV).

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CD8+lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury

Experimental Dermatology ◽

10.1111/exd.13436 ◽

2017 ◽

Vol 27 (1) ◽

pp. 71-79 ◽

Cited By ~ 2

Author(s):

Rituparna Chakraborty ◽

Janin Chandra ◽

Shuai Cui ◽

Lynn Tolley ◽

Matthew A. Cooper ◽

...

Keyword(s):

Dendritic Cells ◽

Immune Responses ◽

Inflammasome Activation ◽

Adaptive Immune Responses ◽

Skin Injury ◽

Adaptive Immune

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Dendritic Cells in Innate and Adaptive Immune Responses against Influenza Virus

Viruses ◽

10.3390/v1031022 ◽

2009 ◽

Vol 1 (3) ◽

pp. 1022-1034 ◽

Cited By ~ 12

Author(s):

Artur Summerfield ◽

Kenneth McCullough

Keyword(s):

Dendritic Cells ◽

Influenza Virus ◽

Immune Responses ◽

Adaptive Immune Responses ◽

Adaptive Immune

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IN LABORATORY GENERATION AND MATURATION OF HUMAN MONOCYTE-DERIVED DENDRITIC CELLS FOR CANCER IMMUNOTHERAPY

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2020.v12s4.40104 ◽

2020 ◽

pp. 46-52

Author(s):

KANCHAN K. MISHRA ◽

SUMIT BHARADVA ◽

MEGHNAD G. JOSHI ◽

ARVIND GULBAKE

Keyword(s):

Dendritic Cells ◽

Immune Responses ◽

Gradient Centrifugation ◽

Critical Role ◽

Human Monocyte ◽

Blood Monocytes ◽

Adaptive Immune ◽

Immunodeficiency Virus ◽

Adaptive Immune Systems

Dendritic cells (DCs) play a critical role in the regulation of adaptive immune responses, furthermore they act as a bridge between the innate and the adaptive immune systems they have been ideal candidates for cell-based immunotherapy of cancers and infections in humans. The first reported trial using DCs in 1995, since they have been used in trials all over the world for several of indications, including cancer and human immunodeficiency virus infection. Generally, for in vitro experiments or for DCs vaccination monocyte-derived dendritic cells (moDCs) were generated from purified monocytes that isolated from peripheral blood by density gradient centrifugation. A variety of methods can be used for enrichment of monocytes for generation of clinical-grade DCs. Herein we summarized up to date understanding of systems and inputs used in procedures to differentiate DCs from blood monocytes in vitro.

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Dendritic Cells/Macrophages-Targeting Feature of Ebola Glycoprotein and its Potential as Immunological Facilitator for Antiviral Vaccine Approach

Microorganisms ◽

10.3390/microorganisms7100402 ◽

2019 ◽

Vol 7 (10) ◽

pp. 402

Author(s):

Titus Abiola Olukitibi ◽

Zhujun Ao ◽

Mona Mahmoudi ◽

Gary A. Kobinger ◽

Xiaojian Yao

Keyword(s):

Dendritic Cells ◽

Immune Responses ◽

Ebola Virus ◽

Vaccine Development ◽

Adaptive Immune Responses ◽

Adaptive Immune ◽

Immunological Approach ◽

Vaccine Approach ◽

Acquired Immune Responses ◽

Diverse Virus

In the prevention of epidemic and pandemic viral infection, the use of the antiviral vaccine has been the most successful biotechnological and biomedical approach. In recent times, vaccine development studies have focused on recruiting and targeting immunogens to dendritic cells (DCs) and macrophages to induce innate and adaptive immune responses. Interestingly, Ebola virus (EBOV) glycoprotein (GP) has a strong binding affinity with DCs and macrophages. Shreds of evidence have also shown that the interaction between EBOV GP with DCs and macrophages leads to massive recruitment of DCs and macrophages capable of regulating innate and adaptive immune responses. Therefore, studies for the development of vaccine can utilize the affinity between EBOV GP and DCs/macrophages as a novel immunological approach to induce both innate and acquired immune responses. In this review, we will discuss the unique features of EBOV GP to target the DC, and its potential to elicit strong immune responses while targeting DCs/macrophages. This review hopes to suggest and stimulate thoughts of developing a stronger and effective DC-targeting vaccine for diverse virus infection using EBOV GP.

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Toxic adjuvants alter the function and phenotype of dendritic cells to initiate adaptive immune responses induced by oralHelicobacter pylorivaccines

Helicobacter ◽

10.1111/hel.12536 ◽

2018 ◽

Vol 23 (6) ◽

Cited By ~ 6

Author(s):

Shuanghui Luo ◽

Wei Liu ◽

Zhiqin Zeng ◽

Feng Ye ◽

Chupeng Hu ◽

...

Keyword(s):

Dendritic Cells ◽

Immune Responses ◽

Adaptive Immune Responses ◽

Adaptive Immune

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Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance

mBio ◽

10.1128/mbio.02790-19 ◽

2019 ◽

Vol 10 (6) ◽

Cited By ~ 3

Author(s):

Carol L. Vinton ◽

Samuel J. Magaziner ◽

Kimberly A. Dowd ◽

Shelly J. Robertson ◽

Emerito Amaro-Carambot ◽

...

Keyword(s):

Immune Responses ◽

Zika Virus ◽

Neutralizing Antibodies ◽

Rhesus Macaques ◽

Type I Interferons ◽

Type I ◽

Adaptive Immune Responses ◽

Zikv Infection ◽

Adaptive Immune ◽

Immunodeficiency Virus

ABSTRACT Flaviviruses are controlled by adaptive immune responses but are exquisitely sensitive to interferon-stimulated genes (ISGs). How coinfections, particularly simian immunodeficiency viruses (SIVs), that induce robust ISG signatures influence flavivirus clearance and pathogenesis is unclear. Here, we studied how Zika virus (ZIKV) infection is modulated in SIV-infected nonhuman primates. We measured ZIKV replication, cellular ZIKV RNA levels, and immune responses in non-SIV-infected and SIV-infected rhesus macaques (RMs), which we infected with ZIKV. Coinfected animals had a 1- to 2-day delay in peak ZIKV viremia, which was 30% of that in non-SIV-infected animals. However, ZIKV viremia was significantly prolonged in SIV-positive (SIV+) RMs. ISG levels at the time of ZIKV infection were predictive for lower ZIKV viremia in the SIV+ RMs, while prolonged ZIKV viremia was associated with muted and delayed adaptive responses in SIV+ RMs. IMPORTANCE Immunocompromised individuals often become symptomatic with infections which are normally fairly asymptomatic in healthy individuals. The particular mechanisms that underlie susceptibility to coinfections in human immunodeficiency virus (HIV)-infected individuals are multifaceted. ZIKV and other flaviviruses are sensitive to neutralizing antibodies, whose production can be limited in HIV-infected individuals but are also sensitive to type I interferons, which are expressed at high levels in HIV-infected individuals. Data in this study highlight how individual components of the innate and adaptive immune responses which become perturbed in HIV-infected individuals influence ZIKV infection.

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Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis

Genes ◽

10.3390/genes11030323 ◽

2020 ◽

Vol 11 (3) ◽

pp. 323 ◽

Cited By ~ 1

Author(s):

Guoying Wang ◽

Xianghui Li ◽

Lei Zhang ◽

Abualgasim Elgaili Abdalla ◽

Tieshan Teng ◽

...

Keyword(s):

Immune Response ◽

Dendritic Cells ◽

Immune Responses ◽

Critical Role ◽

Innate Immune ◽

Adaptive Immune Responses ◽

Adaptive Immune ◽

Th2 Responses ◽

Novel Strategy

Dendritic cells (DCs) play a critical role in the immune system which sense pathogens and present their antigens to prime the adaptive immune responses. As the progression of sepsis occurs, DCs are capable of orchestrating the aberrant innate immune response by sustaining the Th1/Th2 responses that are essential for host survival. Hence, an in-depth understanding of the characteristics of DCs would have a beneficial effect in overcoming the obstacle occurring in sepsis. This paper focuses on the role of DCs in the progression of sepsis and we also discuss the reverse sepsis-induced immunosuppression through manipulating the DC function. In addition, we highlight some potent immunotherapies that could be used as a novel strategy in the early treatment of sepsis.

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