Experience with Intravenous Plasma-Derived C1-Inhibitor in Pregnant Women with Hereditary Angioedema: A Systematic Literature Review

2020 ◽  
Vol 8 (6) ◽  
pp. 1875-1880.e3
Author(s):  
Joel P. Brooks ◽  
Cristine Radojicic ◽  
Marc A. Riedl ◽  
Scott D. Newcomer ◽  
Aleena Banerji ◽  
...  
2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1402.1-1402
Author(s):  
R. Pinheiro Torres ◽  
M. H. Fernandes Lourenco ◽  
A. Neto ◽  
F. Pimentel Dos Santos ◽  
I. Silva ◽  
...  

Background:Juvenile idiopathic arthritis (JIA), one of the most common chronic diseases in children, can be classified in seven different categories according to its onset presentation. Concerns about pregnancy outcomes play a secondary role in disease approach. However, recent data showed an increased risk of pre-term birth in women with JIA instead the small patient samples analysed.Objectives:In this review, our aim is to describe the current available knowledge on JIA adverse, maternal and fetal, outcomes.Methods:A systematic literature review was conducted since January of 2000 until December 2020, by searching the PubMed and Embase bibliographic databases. The search was limited to articles in English language, presenting a comparator group (healthy individuals or patients without known auto-immune rheumatic diseases) and at least one clinical outcome of interest. Two independent reviewers screened the titles and abstracts followed by a full-text review to assess papers regarding their eligibility.Results:Ten observational studies out of 1560 references, fulfilled the inclusion criteria, of which, 9 were retrospective and 1 prospective. A total of 6.214 women with JIA (with 6.811 pregnancies) and 18.659.513 healthy controls (with 21.339.194 pregnancies) were included in this review.Concerning maternal outcomes, delivery by caesarian section (CS) was more frequent among JIA women (in 4 out of 6 studies). Pre-eclampsia was referred in 3 out of 6 studies and a higher risk of vaginal bleeding and placenta previa in one additional study. No study found an increased risk for gestational diabetes or hypertension in pregnant women with JIA.Regarding fetal outcomes, 8 studies revealed significantly increased of pre-term birth (only in first births in one study) but one study didn’t show any increased risk. Two studies showed a higher risk of small gestational age (SGA) and in another 2, increased risk for low birth weight (LBW). No evidence of increased risk of major congenital malformations.Conclusion:This systematic review suggests an increased risk for pre-eclampsia, preterm birth, delivery by CS, SGA and LBW, among pregnant women with JIA. Conclusions should be carefully interpreted, giving the heterogeneity of studied populations regarding demography, disease type, disease activity, and prescribed medication.Disclosure of Interests:None declared


2013 ◽  
Vol 88 (4) ◽  
pp. 578-584 ◽  
Author(s):  
Amanda Rodrigues Miranda ◽  
Ana Paula Fusel de Ue ◽  
Dominique Vilarinho Sabbag ◽  
Wellington de Jesus Furlani ◽  
Patricia Karla de Souza ◽  
...  

In this article, three cases of hereditary angioedema (HAE) type III (estrogen-dependent or with normal C1 inhibitor) are reported. The HAE was initially described in women of the same family in association with high-leveled estrogenic conditions such as the use of oral contraceptives and pregnancy. There is no change in the C1 inhibitor as happens in other types of hereditary angioedema, and mutations are observed in the encoding gene of the XII factor of coagulation in several patients. The current diagnosis is mainly clinical and treatment consists in the suspension of the triggering factors and control of acute symptoms. A brief review of physiopathology, clinical features, genetic alterations and treatment are also presented.


2018 ◽  
Vol 37 (1) ◽  
pp. 84-103 ◽  
Author(s):  
Rhonda J. Boorman ◽  
Debra K. Creedy ◽  
Jennifer Fenwick ◽  
Olav Muurlink

2020 ◽  
Author(s):  
Álvaro Francisco Lopes Sousa ◽  
Herica Emilia Félix de Carvalho ◽  
Layze Braz de Oliveira ◽  
Guilherme Schneider ◽  
Emerson Lucas Silva Camargo ◽  
...  

AbstractBackgroundLittle is known about how COVID-19 infection affects pregnant women, as well as about the possibility of vertical transmission or that of premature labor. Thus, this study’s objective was to identify existing evidence to directive public policies.MethodSystematic literature review assessing papers published in the most comprehensive databases in the field of health.Results12 papers were eligible. A total of 119 pregnant women aged between 22 and 42 years old and between the 12th and 41st weeks were analyzed; 90 children were born. Most pregnant women acquired the infection in the third trimester of pregnancy, 97.4% were diagnosed before hospitalization based on signs and symptoms. There was no maternal death and no vertical transmission was confirmed.Conclusionspregnant women must be cautious and vigilant because their exposure to the virus, even if at the end of a pregnancy, has important repercussions, especially for the type of labor.


2015 ◽  
Vol 8 ◽  
pp. A127
Author(s):  
Solange Oliveira Rodrigues Valle ◽  
Maria Luiza Oliva Alonso ◽  
Sérgio Duarte Dortas ◽  
Soloni Afra Pires Levy ◽  
Ana Paula Ferracciú Coutinho Millet ◽  
...  

SPIRAKEL ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 88-93
Author(s):  
Yocki Yuanti ◽  
Daniah Daniah ◽  
Nuraini Nuraini ◽  
Cindy Ria Aprilia Putri ◽  
Anastasia Susila Anugrah Ningrum

SARS-CoV-2 is a coronavirus from the Betacoronavirus group. The COVID-19 pandemic can cause psychological effects, including stress, anxiety, and depression. Worry and anxiety during the COVID-19 pandemic in pregnant women can cause them to refrain from taking prenatal care. The purpose of this review is to analyze and review journals related to the anxiety of pregnant women about COVID-19. This research method is Systematic Literature Review by searching for journals using Google Scholar, ProQuest, PubMed, and Garuda databases from 2019 – 2021 and the literature selection process using PRISMA diagrams with a Cross Sectional research design. The results of this study are that at the initial stage, 3.197 articles were collected, then various selections were made so that the final results obtained were 5 articles that were worthy of analysis. The research topics are 3 out of 5 articles reporting mild anxiety during the COVID-19 pandemic and 2 out of 5 articles reporting severe anxiety during COVID-19. The conclusion of this review is that the anxiety of pregnant women during the COVID-19 pandemic varies so that problems related to anxiety can be immediately overcome by Antenatal Care (ANC) visits.


2019 ◽  
Vol 6 ◽  
Author(s):  
Camila Lopes Veronez ◽  
Régis Albuquerque Campos ◽  
Rosemeire Navickas Constantino-Silva ◽  
Priscila Nicolicht ◽  
João Bosco Pesquero ◽  
...  

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