Progression of externalizing disorders into anxiety disorders: Longitudinal transitions in the first three decades of life

2022 ◽  
pp. 102533
Author(s):  
Susanne Knappe ◽  
Julia Martini ◽  
Peter Muris ◽  
Hans-Ulrich Wittchen ◽  
Katja Beesdo-Baum
Keyword(s):  
Anxiety Disorders ◽  
Externalizing Disorders

Familial confounding of the association between maternal smoking during pregnancy and internalizing disorders in offspring

2017 ◽  
Vol 47 (8) ◽  
pp. 1417-1426 ◽  
Author(s):  
S. M. Meier ◽  
K. J. Plessen ◽  
F. Verhulst ◽  
O. Mors ◽  
P. B. Mortensen ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Maternal Smoking ◽  
Depressive Disorders ◽  
Cox Regression ◽  
Severe Depression ◽  
Internalizing Disorders ◽  
Externalizing Disorders ◽  
Smoking During Pregnancy ◽  
Increased Risk ◽  
Maternal Smoking During Pregnancy

BackgroundMaternal smoking has consistently been associated with multiple adverse childhood outcomes including externalizing disorders. In contrast the association between maternal smoking during pregnancy (MSDP) and internalizing (anxiety and depressive) disorders in offspring has received less investigation.MethodWe conducted a nationwide cohort study including 957635 individuals born in Denmark between 1991 and 2007. Data on MSDP and diagnoses of depression or anxiety disorders were derived from national registers and patients were followed up from the age of 5 years to the end of 2012. Hazard rate ratios (HRRs) were estimated using stratified Cox regression models. Sibling data were used to disentangle individual- and familial-level effects of MSDP and to control for unmeasured familial confounding.ResultsAt the population level, offspring exposed to MSDP were at increased risk for both severe depression [HRR 1.29, 95% confidence interval (CI) 1.22–1.36] and severe anxiety disorders (HRR 1.26, 95% CI 1.20–1.32) even when controlling for maternal and paternal traits. However, there was no association between MSDP and internalizing disorders when controlling for the mother's propensity for MSDP (depression: HRR 1.11, 95% CI 0.94–1.30; anxiety disorders: HRR 0.94, 95% CI 0.80–1.11) or comparing differentially exposed siblings (depression: HRR 1.18, 95% CI 0.75–1.89; anxiety disorders: HRR 0.87, 95% CI 0.55–1.36).ConclusionsThe results suggest that familial background factors account for the association between MSDP and severe internalizing disorders not the specific exposure to MSDP.

Mental health in Dutch adolescents: a TRAILS report on prevalence, severity, age of onset, continuity and co-morbidity of DSM disorders

2014 ◽  
Vol 45 (2) ◽  
pp. 345-360 ◽  
Author(s):  
J. Ormel ◽  
D. Raven ◽  
F. van Oort ◽  
C. A. Hartman ◽  
S. A. Reijneveld ◽  
...  
Keyword(s):  
Mental Health ◽  
Anxiety Disorders ◽  
Child Behavior Checklist ◽  
Maternal Education ◽  
Age Of Onset ◽  
Externalizing Disorders ◽  
Self Report ◽  
World Health ◽  
Co Morbidity ◽  
Heterotypic Continuity

BackgroundWith psychopathology rising during adolescence and evidence suggesting that adult mental health burden is often due to disorders beginning in youth, it is important to investigate the epidemiology of adolescent mental disorders.MethodWe analysed data gathered at ages 11 (baseline) and 19 years from the population-based Dutch TRacking Adolescents' Individual Lives Survey (TRAILS) study. At baseline we administered the Achenbach measures (Child Behavior Checklist, Youth Self-Report) and at age 19 years the World Health Organization's Composite International Diagnostic Interview version 3.0 (CIDI 3.0) to 1584 youths.ResultsLifetime, 12-month and 30-day prevalences of any CIDI-DSM-IV disorder were 45, 31 and 15%, respectively. Half were severe. Anxiety disorders were the most common but the least severe whereas mood and behaviour disorders were less prevalent but more severe. Disorders persisted, mostly by recurrence in mood disorders and chronicity in anxiety disorders. Median onset age varied substantially across disorders. Having one disorder increased subjects' risk of developing another disorder. We found substantial homotypic and heterotypic continuity. Baseline problems predicted the development of diagnosable disorders in adolescence. Non-intact families and low maternal education predicted externalizing disorders. Most morbidity concentrated in 5–10% of the sample, experiencing 34–55% of all severe lifetime disorders.ConclusionsAt late adolescence, 22% of youths have experienced a severe episode and 23% only mild episodes. This psychopathology is rather persistent, mostly due to recurrence, showing both monotypic and heterotypic continuity, with family context affecting particularly externalizing disorders. High problem levels at age 11 years are modest precursors of incident adolescent disorders. The burden of mental illness concentrates in 5–10% of the adolescent population.

scholarly journals Study-protocol of the COMPARE-Interaction study: The impact of maternal comorbid depression and anxiety disorders in the peripartum period on child development

2021 ◽  
Author(s):  
Anna-Lena Zietlow ◽  
Christian Franz Josef Woll ◽  
Nora Nonnenmacher ◽  
Mitho Müller ◽  
Verena Labonte ◽  
...  
Keyword(s):  
Child Development ◽  
Anxiety Disorders ◽  
Emotional Development ◽  
Depressive Disorders ◽  
Stress Reactivity ◽  
Parental Psychopathology ◽  
Externalizing Disorders ◽  
Comorbid Anxiety ◽  
Maternity Hospitals ◽  
The Impact

Introduction:To date, there are only few studies which compare the consequences of peripartum maternal depressive disorders (PD) versus depressive with comorbid anxiety disorders (PDCA) for infant and child development. As comorbidity is associated with greater impairment and symptom severity related to the primary diagnosis, comorbidity in mothers might raise their offspring’s risk of developing internalizing or externalizing disorders even more than has been noted in conjunction with PD alone.Methods and analysis:This study aims to analyse the impact of parental psychopathology, particularly peripartum depression in mothers with and without comorbid anxiety disorders according to DSM-5, on child cognitive and socio-emotional development. Maternal/paternal psychopathology, mother/father-infant-interaction, and child development are assessed at four measurement points over the first 2 years (T1: 3–4 months postpartum, T2: 12 months postpartum, T3: 18 months postpartum, and T4: 24 months postpartum). The mediating role of mother/father-infant-interaction and infant stress reactivity in the relationship between PD/PDCA and infant cognitive and socio-emotional development will be analysed.In the ongoing study N=174 families (n=58 mothers with PD, n=58 mothers with PDCA, and n=58 healthy controls) will be recruited in inpatient and outpatient centres as well as maternity hospitals in Munich and Heidelberg.

Test-Retest Reliability of a Self-Report Questionnaire for DSM-IV and ICD-10 Personality Disorders

2000 ◽  
Vol 16 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Hans Ottosson ◽  
Martin Grann ◽  
Gunnar Kullgren
Keyword(s):  
Personality Disorder ◽  
Anxiety Disorders ◽  
Personality Disorders ◽  
Clinical Sample ◽  
Self Report ◽  
Anxiety State ◽  
Short Term ◽  
Retest Reliability ◽  
Axis I ◽  
Test Retest Reliability

Summary: Short-term stability or test-retest reliability of self-reported personality traits is likely to be biased if the respondent is affected by a depressive or anxiety state. However, in some studies, DSM-oriented self-reported instruments have proved to be reasonably stable in the short term, regardless of co-occurring depressive or anxiety disorders. In the present study, we examined the short-term test-retest reliability of a new self-report questionnaire for personality disorder diagnosis (DIP-Q) on a clinical sample of 30 individuals, having either a depressive, an anxiety, or no axis-I disorder. Test-retest scorings from subjects with depressive disorders were mostly unstable, with a significant change in fulfilled criteria between entry and retest for three out of ten personality disorders: borderline, avoidant and obsessive-compulsive personality disorder. Scorings from subjects with anxiety disorders were unstable only for cluster C and dependent personality disorder items. In the absence of co-morbid depressive or anxiety disorders, mean dimensional scores of DIP-Q showed no significant differences between entry and retest. Overall, the effect from state on trait scorings was moderate, and it is concluded that test-retest reliability for DIP-Q is acceptable.

Effects of an Anxiety-Specific Psychometric Factor on Fear Conditioning and Fear Generalization

2017 ◽  
Vol 225 (3) ◽  
pp. 200-213 ◽  
Author(s):  
Christian Baumann ◽  
Miriam A. Schiele ◽  
Martin J. Herrmann ◽  
Tina B. Lonsdorf ◽  
Peter Zwanzger ◽  
...  
Keyword(s):  
Risk Factor ◽  
Anxiety Disorders ◽  
Fear Conditioning ◽  
Longitudinal Design ◽  
Principal Component ◽  
Anxiety And Depression ◽  
Specific Factor ◽  
High Anxious ◽  
Two Factors ◽  
Fear Generalization

Abstract. Conditioning and generalization of fear are assumed to play central roles in the pathogenesis of anxiety disorders. Here we investigate the influence of a psychometric anxiety-specific factor on these two processes, thus try to identify a potential risk factor for the development of anxiety disorders. To this end, 126 healthy participants were examined with questionnaires assessing symptoms of anxiety and depression and with a fear conditioning and generalization paradigm. A principal component analysis of the questionnaire data identified two factors representing the constructs anxiety and depression. Variations in fear conditioning and fear generalization were solely associated with the anxiety factor characterized by anxiety sensitivity and agoraphobic cognitions; high-anxious individuals exhibited stronger fear responses (arousal) during conditioning and stronger generalization effects for valence and UCS-expectancy ratings. Thus, the revealed psychometric factor “anxiety” was associated with enhanced fear generalization, an assumed risk factor for anxiety disorders. These results ask for replication with a longitudinal design allowing to examine their predictive validity.

Effects of Psychotherapy on Brain Activation Patterns in Anxiety Disorders

2016 ◽  
Vol 224 (2) ◽  
pp. 62-70 ◽  
Author(s):  
Thomas Straube
Keyword(s):  
Anxiety Disorders ◽  
Neuronal Plasticity ◽  
Functional Neuroimaging ◽  
State Of The Art ◽  
Methodological Issues ◽  
Future Directions ◽  
Activation Patterns ◽  
New Learning ◽  
Analytical Strategies ◽  
Sample Characteristics

Abstract. Psychotherapy is an effective treatment for most mental disorders, including anxiety disorders. Successful psychotherapy implies new learning experiences and therefore neural alterations. With the increasing availability of functional neuroimaging methods, it has become possible to investigate psychotherapeutically induced neuronal plasticity across the whole brain in controlled studies. However, the detectable effects strongly depend on neuroscientific methods, experimental paradigms, analytical strategies, and sample characteristics. This article summarizes the state of the art, discusses current theoretical and methodological issues, and suggests future directions of the research on the neurobiology of psychotherapy in anxiety disorders.

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