scholarly journals Structure-based ligand design and discovery of novel tenuazonic acid derivatives with high herbicidal activity

2021 ◽  
Author(s):  
He Wang ◽  
Qin Yao ◽  
Yanjing Guo ◽  
Qian Zhang ◽  
Zhongchang Wang ◽  
...  
Keyword(s):  
Ligand Design ◽  
Herbicidal Activity ◽  
Tenuazonic Acid

Bioassay of the Herbicidal Activity of AAC-Toxin Produced byAlternaria alternataIsolated fromAgeratina adenophora

2010 ◽  
Vol 24 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Sheng Qiang ◽  
Ling Wang ◽  
Ran Wei ◽  
Bing Zhou ◽  
Shiguo Chen ◽  
...  
Keyword(s):  
Field Trials ◽  
Herbicidal Activity ◽  
Tenuazonic Acid ◽  
Fungal Metabolite ◽  
Redroot Pigweed ◽  
Naturally Occurring ◽  
Brown Leaf Spot ◽  
Brown Leaf ◽  
Leaf Necrosis ◽  
Large Crabgrass

Tenuazonic acid (TeA), a naturally occurring product ofAlternaria alternata, a pathogen to croftonweed, was discovered to be a novel natural photosystem II (PSII) inhibitor. However, herbicidal activity of AAC-toxin, a metabolite of this fungus containing TeA as the main active ingredient, has not been evaluated systematically. In this study, we conducted activity-evaluation experiments in the laboratory, greenhouse, and field trials to assess the herbicidal potential of this fungal metabolite. AAC-toxin had high herbicidal activity on all species tested: croftonweed, large crabgrass, barnyardgrass, redroot pigweed, and eclipta. The AAC-toxin caused brown, leaf spot symptoms and leaf necrosis, subsequently killing the seedlings. When AAC-toxin was applied POST at 83 ml ai/ha, more than 95% of large crabgrass, barnyardgrass, and redroot pigweed plants were controlled 2 d after treatment in field trials. It can be concluded that AAC-toxin has broad-spectrum, rapid, and high herbicidal activity similar to that of paraquat and may have the potential to be developed as a microbe-based herbicide.

Influence of Absolute Configuration of Indanofan on Herbicidal Activity

2001 ◽  
Vol 26 (4) ◽  
pp. 383-384 ◽  
Author(s):  
Akemi HOSOKAWA ◽  
Osamu IKEDA ◽  
Chizuko SASAKI ◽  
Yasuko T. OSANO ◽  
Tetsuo JIKIHARA
Keyword(s):  
Absolute Configuration ◽  
Herbicidal Activity

Toxicity, Uptake, and Distribution of Simazine in Canna hybrida `King Humbert': Implications for Phytoremediation

HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 484e-485
Author(s):  
Patrick C. Wilson ◽  
Ted Whitwell ◽  
Steven J. Klaine
Keyword(s):  
Mass Production ◽  
Photosynthetic Efficiency ◽  
Liquid Scintillation ◽  
Herbicidal Activity ◽  
Fresh Mass ◽  
Contaminated Water ◽  
Golf Courses ◽  
Plant Tolerance ◽  
Nutrient Media ◽  
Potential Use

This research focuses on the potential use of Canna hybrida `King Humbert' for removing simazine from contaminated water generated at golf courses and ornamental nurseries. Because of simazine's herbicidal activity, it is important for levels in solution not to exceed plant tolerance levels. Tolerance levels for C. hybrida were determined by dosing plants for 7 d with 0, 0.01, 0.03, 0.1, 0.3, 1.0, or 3.0 mg simazine/L nutrient media. Measurements of 7-d fresh mass production and photosynthetic efficiency (Fv/Fm) were taken. Simazine uptake and distribution within the plant was determined by dosing plants with 2.03 mCi 14C-simazine (0.243 mg/L) for 1, 3, 5, or 7 d. Plant tissues were analyzed by combustion and liquid scintillation counting. Fresh mass production was reduced 66% and 78% for plants exposed to 1.0 and 3.0 mg/L, respectively. Likewise, photosynthetic efficiency was reduced to 66% and 40% of the controls at the same respective concentrations. Plant uptake of simazine accounted for 13%, 34%, 48%, and 65% of the original simazine in the dosing solution after 1-, 3-, 5-, and 7-d exposure, respectively. This simazine was distributed primarily between roots and leaves.

Class A GPCRs: Structure, Function, Modeling and Structure-based Ligand Design

2017 ◽  
Vol 23 (29) ◽  
Author(s):  
Xiaojing Cong ◽  
Jeremie Topin ◽  
Jerome Golebiowski
Keyword(s):  
Structure Function ◽  
Ligand Design ◽  
Class A

Preliminary Screening of Isolated Mycoherbicidal Fungi for the Management of Noxious Weed Xanthiumstrumarium

2019 ◽  
Vol 6 (02) ◽  
Author(s):  
AJAY KUMAR SINGH ◽  
AKHILESH KUMAR PANDEY
Keyword(s):  
Culture Filtrate ◽  
Photosynthetic Pigment ◽  
Phytopathogenic Fungi ◽  
Herbicidal Activity ◽  
Preliminary Screening ◽  
Detached Leaf ◽  
Noxious Weed ◽  
Complete Collapse

Natural phytotoxins of fungi are great source for the discovery of new herbicide and its offer a benign and eco-friendly alternative to manage weed. Thus, this study aimed to select potential fungi with potent herbicidal activity for control ofweeds. In the present study, various phytopathogenic fungi were isolated from infected tissues of various weeds and evaluated againstXanthium strumarium, a problematic monocotyledonous weed of open lands, agriculture, horticulture and forests. Herbicidal potential of Cell Free Culture Filtrate (CFCF) of strains ofPhoma herbarum (FGCCW#18, FGCCW#43) Fusariummonilifromecoded as FGCCW#35 and Fusarium roseum coded as FGCCW#55againstXanthium strumariumwere evaluated by seedling and shoot cut bioassays. Maximum mortalities of shoots, seedlings and phytotoxic damage were obtainedfrom28 day sold cell free culture filtrate (CFCF) of FGCCW#18 at 100% concentration. Significant reduction in biological contents i.e. photosynthetic pigment and protein was observed in the host weed on treatment with the CFCF as determined by detached leaf bioassay. Phytotoxic damage such as severe wilting, chlorosis, necrosis and complete collapse of the entire parts of the weed were also noticed due to CFCF application.

scholarly journals Discovery, characterization and functional improvement of kumamonamide as a novel plant growth inhibitor that disturbs plant microtubules

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takashi Ishida ◽  
Haruna Yoshimura ◽  
Masatsugu Takekawa ◽  
Takumi Higaki ◽  
Takashi Ideue ◽  
...  
Keyword(s):  
Plant Growth ◽  
Human Life ◽  
Growth Inhibitor ◽  
Herbicidal Activity ◽  
Functional Improvement ◽  
Microtubule Inhibitors ◽  
Plant Microtubules ◽  
Plant Growth Inhibitor ◽  
Derivatives Of ◽  
Synthetic Intermediate

AbstractThe discovery and useful application of natural products can help improve human life. Chemicals that inhibit plant growth are broadly utilized as herbicides to control weeds. As various types of herbicides are required, the identification of compounds with novel modes of action is desirable. In the present study, we discovered a novelN-alkoxypyrrole compound, kumamonamide fromStreptomyces werraensisMK493-CF1 and established a total synthesis procedure. Resulted in the bioactivity assays, we found that kumamonamic acid, a synthetic intermediate of kumamonamide, is a potential plant growth inhibitor. Further, we developed various derivatives of kumamonamic acid, including a kumamonamic acid nonyloxy derivative (KAND), which displayed high herbicidal activity without adverse effects on HeLa cell growth. We also detected that kumamonamic acid derivatives disturb plant microtubules; and additionally, that KAND affected actin filaments and induced cell death. These multifaceted effects differ from those of known microtubule inhibitors, suggesting a novel mode of action of kumamonamic acid, which represents an important lead for the development of new herbicides.

scholarly journals Engineering the Interface between Inorganic Nanoparticles and Biological Systems through Ligand Design

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1001
Author(s):  
Rui Huang ◽  
David C. Luther ◽  
Xianzhi Zhang ◽  
Aarohi Gupta ◽  
Samantha A. Tufts ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Molecular Design ◽  
Biological Systems ◽  
Ligand Design ◽  
Inorganic Nanoparticles ◽  
Organic Ligands ◽  
Biological Applications ◽  
Wide Range ◽  
Insight Into

Nanoparticles (NPs) provide multipurpose platforms for a wide range of biological applications. These applications are enabled through molecular design of surface coverages, modulating NP interactions with biosystems. In this review, we highlight approaches to functionalize nanoparticles with ”small” organic ligands (Mw < 1000), providing insight into how organic synthesis can be used to engineer NPs for nanobiology and nanomedicine.

Synthesis, herbicidal activity study and molecular docking of novel pyrimidine thiourea

2020 ◽  
pp. 104766
Author(s):  
Jia-hui Li ◽  
Yan Wang ◽  
Yun-peng Wu ◽  
Ran-hong Li ◽  
Shuang Liang ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Herbicidal Activity
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