scholarly journals Somatic-Affective Symptoms of Depression Have a Stronger Association with Insulin Resistance than Cognitive Symptoms

2013 ◽  
Vol 37 ◽  
pp. S45
Author(s):  
Anthony W. Austin ◽  
Jennifer L. Gordon ◽  
Kim L. Lavoie ◽  
André Arsenault ◽  
Kaberi Dasgupta ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cognitive Symptoms ◽  
Symptoms Of Depression ◽  
Affective Symptoms

scholarly journals Theta and gamma activity is linked with affective and cognitive symptoms in Parkinson's disease

2020 ◽  
Author(s):  
Kartik K Iyer ◽  
Tiffany R Au ◽  
Anthony J Angwin ◽  
David A Copland ◽  
Nadeeka N Dissanayaka
Keyword(s):  
Cognitive Impairment ◽  
Gamma Activity ◽  
Oscillatory Activity ◽  
Optimal Dosage ◽  
Temporal Region ◽  
Cognitive Symptoms ◽  
Electrophysiological Response ◽  
Symptoms Of Depression ◽  
Affective Symptoms ◽  
Multivariate Relationship

Background The progression of Parkinsons disease (PD) can often exacerbate symptoms of depression, anxiety, and/or cognitive impairment. In this study, we explore the possibility that multiple brain network responses are associated with symptoms of depression, anxiety and cognitive impairment in PD. This association is likely to provide insights into a single multivariate relationship, where common affective symptoms occurring in PD cohorts are related with alterations to electrophysiological response. Methods 70 PD patients and 21 healthy age-matched controls (HC) participated in a high-density electroencephalography (EEG) study. Functional connectivity differences between PD and HC groups of oscillatory activity at rest and during completion of an emotion-cognition task were examined to identify key brain oscillatory activities. A canonical correlation analysis (CCA) was applied to identify a putative multivariate relationship between connectivity patterns and affective symptoms in PD groups. Results A CCA analysis identified a single mode of co-variation linking theta and gamma connectivity with affective symptoms in PD groups. Increases in frontotemporal gamma, frontal and parietal theta connectivity were related with increased anxiety and cognitive impairment. Decreases in temporal region theta and frontoparietal gamma connectivity were associated with higher depression ratings and PD patient age. Limitations This study only reports on optimal dosage of dopaminergic treatment (on state) in PD and did not investigate at off medication. Conclusions Theta and gamma connectivity during rest and task-states are linked to affective and cognitive symptoms within fronto-temporo-parietal networks, suggesting a potential assessment avenue for understanding brain-behavior associations in PD with electrophysiological task paradigms.

scholarly journals Somatics Symptoms and Depression: A Review

2020 ◽  
pp. 1-8
Author(s):  
M. Herrera-Estrella ◽  
E. Izar ◽  
K. Luna ◽  
M. Cuellar-García
Keyword(s):  
Quality Of Life ◽  
Somatic Complaints ◽  
Emotional Symptoms ◽  
Major Depressive ◽  
Symptoms Of Depression ◽  
Affective Symptoms ◽  
The World ◽  
Receive Treatment ◽  
Specific Symptoms

Aims: The objective of this review has been to highlight the importance of non-specific and painful symptoms of depression since sometimes the person does not notice or is not able to talk about their emotional symptoms. This leads us to refine the search for symptoms that can mask depression and not be treated properly. This is important as it is predicted that by 2020 depression will be the leading cause of disability in the world. Method: We review some articles that relate depression to painful symptoms. Results: Patients with the major depressive disorder may present, as initial complaints, multiple somatic complaints, nonspecific and especially pain, which complicates their diagnosis and sometimes leads them to not receive treatment for depression, complicating its evolution and deteriorating the quality of life. Conclusion: Depression can have many forms of presentation, people can complain of multiple non-specific symptoms, which do not allow a diagnosis of medical disease so it will be necessary to look for affective symptoms, investigate factors that trigger their condition to achieve an adequate diagnosis, provide the indicated medication and allow them a better quality of life. 

scholarly journals Experimental Affective Symptoms in Panic Disorder Patients

2005 ◽  
Vol 50 (3) ◽  
pp. 175-178 ◽  
Author(s):  
Thea Overbeek ◽  
Koen Schruers ◽  
Ine Docters van Leeuwen ◽  
Tineke Klaassen ◽  
Eric Griez
Keyword(s):  
Carbon Dioxide ◽  
Panic Disorder ◽  
Outcome Measure ◽  
Gas Mixture ◽  
Comorbid Depression ◽  
Major Depressive ◽  
Symptoms Of Depression ◽  
Affective Symptoms ◽  
Challenge Tests ◽  
Panic Symptoms

Objective: To date, carbon dioxide (CO2) challenge tests in panic disorder (PD) patients have focused on anxiety as the sole outcome measure. This study assesses a broader range of symptoms in patients with PD. Method: We administered a gas mixture of 35% CO2 and 65% oxygen (O2) to 25 patients with PD. Nine patients met the criteria for a comorbid major depressive disorder (MDD), and 16 did not. We assessed not only subjects' symptoms of anxiety but also their symptoms of depression and aggression. Results: Baseline ratings did not differ across the 2 subgroups. Postchallenge ratings were higher for PD and MDD patients on all the assessed affective symptoms, except for specific panic symptoms. Conclusion: These findings suggest that, in addition to anxiety, CO2 challenge induces depressive and aggressive symptoms, specifically in PD patients with comorbid depression.

Religious Coping and Cognitive Symptoms of Depression in Elderly Medical Patients

1995 ◽  
Vol 36 (4) ◽  
pp. 369-375 ◽  
Author(s):  
Harold G. Koenig ◽  
Harvey J. Cohen ◽  
Dan G. Blazer ◽  
Harold S. Kudler ◽  
K. Ranga Rama Krishnan ◽  
...  
Keyword(s):  
Religious Coping ◽  
Cognitive Symptoms ◽  
Medical Patients ◽  
Symptoms Of Depression

scholarly journals Variability in Depressive Symptoms of Cognitive Deficit and Cognitive Bias During the First 2 Years After Diagnosis in Australian Men With Prostate Cancer

2014 ◽  
Vol 10 (1) ◽  
pp. 6-13
Author(s):  
Christopher F. Sharpley ◽  
Vicki Bitsika ◽  
David R. H. Christie
Keyword(s):  
Prostate Cancer ◽  
Depressive Symptoms ◽  
Cognitive Bias ◽  
Cognitive Deficit ◽  
Depression Scale ◽  
Severe Depression ◽  
Background Information ◽  
Cognitive Symptoms ◽  
Depression Severity ◽  
Symptoms Of Depression

The incidence and contribution to total depression of the depressive symptoms of cognitive deficit and cognitive bias in prostate cancer (PCa) patients were compared from cohorts sampled during the first 2 years after diagnosis. Survey data were collected from 394 patients with PCa, including background information, treatments, and disease status, plus total scores of depression and scores for subscales of the depressive symptoms of cognitive bias and cognitive deficit via the Zung Self-Rating Depression Scale. The sample was divided into eight 3-monthly time-since-diagnosis cohorts and according to depression severity. Mean scores for the depressive symptoms of cognitive deficit were significantly higher than those for cognitive bias for the whole sample, but the contribution of cognitive bias to total depression was stronger than that for cognitive deficit. When divided according to overall depression severity, patients with clinically significant depression showed reversed patterns of association between the two subsets of cognitive symptoms of depression and total depression compared with those patients who reported less severe depression. Differences in the incidence and contribution of these two different aspects of the cognitive symptoms of depression for patients with more severe depression argue for consideration of them when assessing and diagnosing depression in patients with PCa. Treatment requirements are also different between the two types of cognitive symptoms of depression, and several suggestions for matching treatment to illness via a personalized medicine approach are discussed.

Cognitive symptoms in mayor depression: A study with vortioxetina

2017 ◽  
Vol 41 (S1) ◽  
pp. S538-S538
Author(s):  
O. Porta Olivares ◽  
M. Juncal Ruiz ◽  
B. Fernández Abascal Puente ◽  
M. Gómez Revuelta ◽  
M. Pérez Herrera ◽  
...  
Keyword(s):  
Major Depression ◽  
Short Term Memory ◽  
Cognitive Symptoms ◽  
Therapeutic Tool ◽  
Short Term ◽  
Symptoms Of Depression ◽  
Hearing Test ◽  
Previously Treated ◽  
Competing Interest ◽  
Significant Factors

IntroductionThe major depression is associated with decreased cognitive functions in a range of areas, including attention, memory and executive functions. The cognitive symptoms of depression can have a profound effect on the ability of patients to keep out the tasks of daily living, and are significant factors that affect the ability to function both interpersonal and occupational level.AimsVortioxetina have a multimodal action acting on various serotonin receptors in addition to inhibiting serotonin reuptake. Vortioxetina, is a new therapeutic tool seems to have shown efficacy in the treatment of cognitive symptoms of depression.MethodsTo evaluate this action we have evaluated the cognitive decline in patients with major depression before receiving treatment vortioxetina (whether state or not previously treated with other antidepressants) and at 2, 6 and 12 months after starting treatment with the drug. For that, we’ve used the Verbal Hearing Test King (RAVLT), which evaluates the auditory verbal short-term memory, the learning rate, the retention of information, and the differences between learning and recovery, and testing Digit substitution by symbols (DSST) that perform quick detection of brain dysfunctions by a conventional task.ResultsThe results of this study are still under analysis.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Association Between Affective-Cognitive Symptoms of Depression and Exacerbation of Crohn’s Disease

2016 ◽  
Vol 111 (6) ◽  
pp. 864-870 ◽  
Author(s):  
Lawrence S Gaines ◽  
James C Slaughter ◽  
Sara N Horst ◽  
David A Schwartz ◽  
Dawn B Beaulieu ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Cognitive Symptoms ◽  
Symptoms Of Depression

scholarly journals Intersections between copper, β-arrestin-1, calcium, FBXW7, CD17, insulin resistance and atherogenicity mediate depression and anxiety due to type 2 diabetes mellitus: a nomothetic network approach.

2021 ◽  
Author(s):  
Hussein K Al-Hakeim ◽  
Shaymaa Al-Hamami ◽  
Ghoufran Jawad ◽  
Michael Maes
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Rating Scales ◽  
Serum Levels ◽  
Depression And Anxiety ◽  
Affective Symptoms ◽  
Copper Zinc

Background: Type 2 diabetes mellitus (T2DM) is frequently accompanied by affective disorders with a prevalence of comorbid depression of around 25%. Nevertheless, the biomarkers of affective symptoms including depression and anxiety due to T2DM are not well established. Aims: This study was conducted to delineate the serum biomarkers predicting affective symptoms due to T2DM above and beyond the effects of insulin resistance and atherogenicity. Methods: The present study delineated the effects of serum levels of copper, zinc, β-arrestin-1, FBXW7, lactosylceramide (LacCer), serotonin, albumin, calcium, magnesium, IR and atherogenicity on severity of depression and anxiety in 58 men with T2DM and 30 healthy male controls. Severity of affective symptoms was assessed using the Hamilton Depression and Anxiety rating scales. Results: We found that 61.7% of the variance in affective symptoms was explained by the multivariate regression on copper, β-arrestin-1, calcium, and insulin resistance coupled with atherogenicity, while 44.4% of the variance in the latter was explained by copper, β-arrestin-1, LacCer (all positively) and calcium and FBXW7 (both negatively). Copper and LacCer (positive) and calcium and BXW7 (inverse) had significant specific indirect effects on affective symptoms which were mediated by insulin resistance and atherogenicity. Copper, β-arrestin-1, and calcium were associated with affective symptoms above and beyond the effects of insulin resistance and atherogenicity. Discussion: T2DM and affective symptoms share common pathways namely increased atherogenicity, insulin resistance, copper, and β-arrestin-1, and lowered calcium, whereas copper, β-arrestin-1, calcium, LacCer, and FBXW7 may modulate depression and anxiety symptoms by affecting T2DM.

Sign in / Sign up

Export Citation Format

Share Document