Baseline data of oral and pharyngeal cancer before introducing an oral cancer prevention campaign in Germany

Betel quid (BQ) is a psychostimulant, an addictive substance, and a group 1 carcinogen that exhibits the potential to induce adverse health effects. Approximately, 600 million users chew a variety of BQ. Areca nut (AN) is a necessary ingredient in BQ products. Arecoline is the primary alkaloid in the AN and can be metabolized through the cytochrome P450 (CYP) superfamily by inducing reactive oxygen species (ROS) production. Full-length CYP26B1 is related to the development of oral pharyngeal cancers. We investigated whether a splice variant of CYP26B1 is associated with the occurrence of ROS related oral and pharyngeal cancer. Cytotoxicity assays were used to measure the effects of arecoline on cell viability in a dose-dependent manner.In vitroandin vivostudies were conducted to evaluate the expression of the CYP26B1 splice variant. The CYP26B1 splice variant exhibited lower expression than did full-length CYP26B1 in the human gingival fibroblast-1 and Ca9-22 cell models. Increased expression of the CYP26B1 splice variant was observed in human oral cancer tissue compared with adjacent normal tissue, and increased expression was observed in patients at a late tumor stage. Our results suggested that the CYP26B1 splice variant is associated with the occurrence of BQ-related oral cancer.

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Prevalence of Oral and Pharyngeal Cancers and the Relationship Between Tumour Size and Lymph Node Metastases in Oral Cancer.

10.21203/rs.3.rs-551265/v1 ◽

2021 ◽

Author(s):

Abdullah Omar ◽

Mohammad Rmman ◽

Madiha Al Hafi ◽

Mohammad Sadek Al-Masalmeh ◽

Louei Darjazini Nahas

Keyword(s):

Lymph Node ◽

Oral Cancer ◽

Tumour Size ◽

Nasopharyngeal Cancer ◽

Chief Complaint ◽

Histological Type ◽

Pharyngeal Cancer ◽

Lower Lip ◽

Oral And Pharyngeal Cancer ◽

The Relationship

Abstract Background: the study aimed at studying the incidence and prevalence rates of oral and pharyngeal cancer and their distribution according to gender, tumour size, histological type and chief complaint. We also tackled the relationship between the tumour size and the metastasis to the regional lymph nodes.Materials and Methods: This cohort retrospective study was done in Al-Mouasat hospital from January 2017 to June 2020. The population included patients with oral or pharynx cancer who were admitted to the Ear, Nose, Throat department.Results: The total participants were 96 cases. The median age was 57 year. The most common tumour location was oral tumour 58.3%, and the most common chief complaint about oral tumour was mass by 62.5%. while nasopharynx cases most commonly came with neck mass 68.2%. 50% was the percentage of dysphagia that was the most common complaint. Squamous cell carcinoma (SCC) was the most common histologic type < 90% of the oral, oropharynx, and hypopharynx cases. About the classification of the tumour due to its subsite 33.9% of the oral cases were in lip and especially the lower one. Whereas, oropharynx most frequent tumour site was the tonsil (50%). we found statistical evidence for the relationship between the tumour size (T) and the metastasis to the regional lymph node (N) in oral cancer.Conclusion: Oral and pharyngeal cancer is a very important issue. And according to our paper, the most frequent cancer was oral cancer and especially lower lip tumour. oral cancer presents with mass. whereas, the nasopharyngeal cancer presentation was neck mas. The most common histological type was SCC. And we reached a relationship between the T and N in oral cancer

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Exploratory Research Focusing on Oral Cancer Prevention: Challenges of Dealing With Informational and Cognitive Barriers

Qualitative Health Research ◽

10.1177/1049732318802263 ◽

2018 ◽

Vol 29 (13) ◽

pp. 1930-1941

Author(s):

Eva Baumann ◽

Helmut Scherer ◽

Elena Link ◽

Jörg Wiltfang ◽

Hans-Jürgen Wenz ◽

...

Keyword(s):

Oral Cancer ◽

Cancer Prevention ◽

Information Seeking ◽

Public Health Problem ◽

Computer Assisted ◽

Exploratory Research ◽

Face To Face ◽

Main Challenge ◽

Prevention Campaign ◽

Information Seeking Behaviors

Oral cancer is a considerable public health problem, and a low level of awareness and knowledge about this tumor and its risk factors is prevalent. To gain a profound understanding of risks groups and to identify suitable communication strategies for a prevention campaign in Northern Germany, an exploratory research was realized. In semistructured face-to-face interviews, the participants of the study ( n = 28) described their individual oral cancer-related perceptions and information-seeking behaviors. A computer-assisted qualitative data analysis showed a vague but also deterring picture of cancer combined with restricted attitudes toward the topic and an inactive or even avoiding information behavior. Four underlying cognitive patterns of self-distancing were identified: (a) optimistic bias, (b) fatalism, (c) hedonism, and (d) pragmatism. The main challenge of oral cancer prevention is to deal with the target groups’ informational and cognitive barriers.

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The Epidemiological Trend of Oral Carcinoma in Eastern Europe

Revista de Chimie ◽

10.37358/rc.19.8.7456 ◽

2019 ◽

Vol 70 (8) ◽

pp. 2917-2922

Author(s):

Ramona Camelia Rumel ◽

Laura Cristina Rusu ◽

Pusa Nela Gaje ◽

Ramona Amina Popovici ◽

Marius Raica

Keyword(s):

Oral Cancer ◽

World Health ◽

Pharyngeal Cancer ◽

East Europe ◽

Epidemiological Trend ◽

Incidence And Mortality ◽

Oral And Pharyngeal Cancer ◽

Specific Mortality ◽

Health Organization ◽

Very High

Oral and pharyngeal cancer is estimated by World Health Organization (WHO) to be the eighth most common cancer worldwide with signi�cant regional variation with increasing and decreasing incidence trend. The aim of the study was to evaluate the oral cancer epidemiological trend, incidence and mortality in Central and East Europe (CEE), and to compare the incidence of oral cancer with other regions from the world. The analyzed data was from NORDCAN and GLOBOCAN, using ASR (age- standardize rate) incidence and mortality overall and by sexes. The incidence of oral and pharyngeal cancer is higher in CEE than the global incidence. This is in accord with specific mortality from oral and pharyngeal cancer that is higher in CEE than the regions other submitted to the current evaluation. The incidence of oral cancer is very high at man, especially in Hungary, which is the most affected from oral cancer from CEE.

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Lesões bucais diagnosticadas na campanha de prevenção do câncer bucal no município de Fernandópolis/SP no ano de 2019 / Oral lesions diagnosed in the oral cancer prevention campaign in the city of Fernandópolis/SP in 2019

Brazilian Journal of Health Review ◽

10.34119/bjhrv4n4-115 ◽

2021 ◽

Vol 4 (4) ◽

pp. 15843-15850

Author(s):

Luana Ferreira Oliveira ◽

Caroline Liberato Marchiolli ◽

Maria Eduarda de Freitas Santana Oliveira ◽

Renan Lemos Da Silva ◽

Vitória Parmejane De Oliveira ◽

...

Keyword(s):

Oral Cancer ◽

Cancer Prevention ◽

Oral Lesions ◽

Prevention Campaign ◽

The City

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Oral lesions diagnosed during an oral cancer prevention campaign in Fernandópolis, Brazil, 2018 / Lesões orais durante campanha de prevenção do câncer bucal em Fernandópolis, Brasil, 2018

Brazilian Journal of Development ◽

10.34117/bjdv7n8-113 ◽

2021 ◽

Vol 7 (8) ◽

pp. 77421-77429

Author(s):

Maria Eduarda de Freitas Santana Oliveira ◽

Caroline Liberato Marchiolli ◽

Luana Ferreira Oliveira ◽

Renan Lemos Da Silva ◽

Vitoria Parmejane De Oliveira ◽

...

Keyword(s):

Oral Cancer ◽

Cancer Prevention ◽

Oral Lesions ◽

Prevention Campaign

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Dentists and oral cancer prevention in the UK: opinions, attitudes and practices to screening for mucosal lesions and to counselling patients on tobacco and alcohol use: baseline data from 1991

Oral Diseases ◽

10.1111/j.1601-0825.1999.tb00057.x ◽

2008 ◽

Vol 5 (1) ◽

pp. 10-14 ◽

Cited By ~ 70

Author(s):

KAAS Warnakulasuriya ◽

NW Johnson

Keyword(s):

Alcohol Use ◽

Oral Cancer ◽

Cancer Prevention ◽

Baseline Data ◽

Attitudes And Practices ◽

Mucosal Lesions ◽

The Uk

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Early detection of oral cancer in Portugal: The experience of UMEMD.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e13039 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e13039-e13039

Author(s):

Fernanda Estevinho ◽

Margarida Gouveia ◽

Marta Costa ◽

Sara Moura ◽

João Sérgio Neves ◽

...

Keyword(s):

Oral Cancer ◽

Early Diagnosis ◽

Cancer Diagnosis ◽

Pharyngeal Cancer ◽

Cancer History ◽

Oral Cancers ◽

The North ◽

Oral And Pharyngeal Cancer ◽

The University ◽

Suspicious Lesions

e13039 Background: Oral and pharyngeal cancer is the 11th most common malignancy worldwide. Although the oral cavity is a potentially accessible site for examination, up to 50% of oral cancers are detected at advanced stage. The Mobile Unit of Stomatology and Dental Medicine (UMEMD) of the Portuguese League Against Cancer (LPCC) and of the Portuguese Association of Hospital Dental Medicine (APMDH) has developed oral cancer early diagnosis consultations. This consultations were performed by a team of 50 doctors specialized in oral cancer diagnosis. Once a month the team of UMEMD went to a different region of the North of Portugal. Early oral cancer diagnosis consultations were also performed twice a week at the Portuguese League Against Cancer at Oporto.We present the experience of UMEMD in the early diagnosis consultation of oral cancer, since its foundation in August 2012 until the end of 2016. Methods: We performed a retrospective evaluation of medical records of patients observed in the early diagnosis consultation of oral cancer of UMEMD between August 2012 and December 2016. We assessed the demographic characteristics, risk factors, cancer history, likely diagnosis and the referral of patients. Results: 6,231 new patients were observed; median age of patients was 63 years-old [1;102], 93 patients were younger than 18 years-old. There was information about smoking habits of the majority of patients n = 4,521(72.6%): 597(9.6%) were smokers and 653(10.5%) former smokers. 228 (3.6%) patients had previous cancer. We detected: 963 lesions (15.5%); the majority of the lesions were at the tongue n = 263 (4.2%).The patients with suspicious lesions (n = 638; 10.2%) were referred to: Portuguese Institute of Oncology of Oporto: n = 146 (2.3%); Faculty of Dental Medicine of the University of Oporto: n = 353 (5.7%); Physicians at other hospitals: n = 139 (2.2%). Conclusions: Consultations for oral cancer early diagnosis performed by an experienced team has enabled the detection of suspicious lesions in 10.2% of the patients. Cooperation with other institutions, through protocols, allowed the referral and early treatment of these patients.

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