A smart polymer for drug delivery sensitive to tumor extracellular pH

Polymers have become an integral part of novel drug delivery system. One such successful biodegradable polymer is poly lactic-co-glycolic acid (PLGA) which consists of polyesters of lactic acid and glycolic acid. It is one of the FDA-approved biodegradable polymers which is extensively used for therapeutic purposes in recent times.The aim. To illuminate researchers on the chemistry, novel properties and applications of PLGA in pharmaceutical fields.Materials and methods. Various internet sources like Science Direct, Scopus, Web of Science, PubMed and google scholar were used as the data source. The key words search was carried out for the following words and combinations: PLGA, Novel drug delivery, PLGA Nano particles, biomedical applications of PLGA.Results. Pharmaceutical and biomedical industries are flooded with the use of synthetic and natural polymers. The mechanical and viscoelastic properties of the polymers make them suitable for the temporal and spatial delivery of therapeutic agents for an extended period. Employment of copolymerization techniques lead to the modification of water solubility of the polymers and make them suitable for various applications of drug delivery systems. Biodegradable polymers due to their biocompatibility and biodegradable property have attracted their use in novel drug delivery systems. PLGA is one of them. PLGA is versatile as it can be fabricated into any size, shape, and can be used to encapsulate small molecules, tissue engineering, and bone repair, etc.Conclusion. The sensitivity and biodegradability of PLGA makes it a smart polymer for targeted and sustained delivery of drugs and in various biomedical applications.

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Stimulus-responsive liquids for encapsulation storage and controlled release of drugs from nano-shell capsules

Journal of The Royal Society Interface ◽

10.1098/rsif.2010.0428 ◽

2010 ◽

Vol 8 (56) ◽

pp. 451-456 ◽

Cited By ~ 14

Author(s):

Ming-Wei Chang ◽

Eleanor Stride ◽

Mohan Edirisinghe

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Drug Release ◽

Polymeric Materials ◽

Controlled Drug Release ◽

Ambient Conditions ◽

Smart Polymer ◽

Release Studies ◽

Stimulus Responsive ◽

New Strategy

Drug-delivery systems with a unique capability to respond to a given stimulus can improve therapeutic efficacy. However, development of such systems is currently heavily reliant on responsive polymeric materials and pursuing this singular strategy limits the potential for clinical translation. In this report, with a model system used for drug-release studies, we demonstrate a new strategy: how a temperature-responsive non-toxic, volatile liquid can be encapsulated and stored under ambient conditions and subsequently programmed for controlled drug release without relying on a smart polymer. When the stimulus temperature is reached, controlled encapsulation of different amounts of dye in the capsules is achieved and facilitates subsequent sustained release. With different ratios of the liquid (perfluorohexane): dye in the capsules, enhanced controlled release with real-time response is provided. Hence, our findings offer great potential for drug-delivery applications and provide new generic insights into the development of stimuli drug-release systems.

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Smart polymer composites in drug delivery

Smart Polymer Nanocomposites ◽

10.1016/b978-0-12-819961-9.00009-8 ◽

2021 ◽

pp. 261-294

Author(s):

Aabid Shalla ◽

Mushtaq Bhat

Keyword(s):

Drug Delivery ◽

Polymer Composites ◽

Smart Polymer

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Long-Term Physical Aging Tracked by Advanced Thermal Analysis of Poly(N-Isopropylacrylamide): A Smart Polymer for Drug Delivery System

Molecules ◽

10.3390/molecules25173810 ◽

2020 ◽

Vol 25 (17) ◽

pp. 3810

Author(s):

Anna Czerniecka-Kubicka ◽

Iwona Zarzyka ◽

Marek Pyda

Keyword(s):

Drug Delivery ◽

Thermal Analysis ◽

Heat Capacity ◽

Glass Transition ◽

Physical Aging ◽

Amorphous Polymer ◽

Recovery Process ◽

Scanning Calorimetry ◽

Smart Polymer ◽

Structural Recovery

Poly(N-isopropylacrylamide) (PNIPA), as a smart polymer, can be applied for drug delivery systems. This amorphous polymer can be exposed on a structural recovery process during the storage and transport of medicaments. For the physical aging times up to one year, the structural recovery for PNIPA was studied by advanced thermal analysis. The structural recovery process occurred during the storage of amorphous PNIPA below glass transition and could be monitored by the differential scanning calorimetry (DSC). The enthalpy relaxation (recovery) was observed as overshoot in change heat capacity at the glass transition region in the DSC during heating scan. The physical aging of PNIPA was studied isothermally at 400.15 K and also in the non-isothermal conditions. For the first time, the structural recovery process was analyzed in reference to absolute heat capacity and integral enthalpy in frame of their equilibrium solid and liquid PNIPA.

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Redox Responsive Copolyoxalate Smart Polymers for Inflammation and Other Aging-Associated Diseases

International Journal of Molecular Sciences ◽

10.3390/ijms22115607 ◽

2021 ◽

Vol 22 (11) ◽

pp. 5607

Author(s):

Berwin Singh Swami Vetha ◽

Angela Guma Adam ◽

Azeez Aileru

Keyword(s):

Drug Delivery ◽

Small Molecules ◽

Smart Polymers ◽

Oxygen Species ◽

Systemic Delivery ◽

Delivery Methods ◽

Smart Polymer ◽

Associated Diseases ◽

Redox Responsive ◽

Hydroxybenzyl Alcohol

Polyoxalate (POx) and copolyoxalate (CPOx) smart polymers are topics of interest the field of inflammation. This is due to their drug delivery ability and their potential to target reactive oxygen species (ROS) and to accommodate small molecules such as curcumin, vanilline, and p-Hydroxybenzyl alcohol. Their biocompatibility, ultra-size tunable characteristics and bioimaging features are remarkable. In this review we discuss the genesis and concept of oxylate smart polymer-based particles and a few innovative systemic delivery methods that is designed to counteract the inflammation and other aging-associated diseases (AADs). First, we introduce the ROS and its role in human physiology. Second, we discuss the polymers and methods of incorporating small molecule in oxalate backbone and its drug delivery application. Finally, we revealed some novel proof of concepts which were proven effective in disease models and discussed the challenges of oxylate polymers.

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