A Controlled-Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocation for Drug Delivery

Docetaxel (TXT) is acknowledged as one of the most important chemotherapy agents for gastric cancer (GC). PI3K/AKT signaling is frequently activated in GC, and its inhibitor LY294002 exerts potent antitumor effects. However, the hydrophobicity of TXT and the poor solubility and low bioavailability of LY294002 limit their clinical application. To overcome these shortcomings, we developed poly(lactic acid/glycolic) (PLGA) nanoparticles loaded with TXT and LY294002. PLGA facilitated the accumulation of TXT and LY294002 at the tumor sites. The in vitro functional results showed that PLGA(TXT+LY294002) exhibited controlled-release and resulted in a markedly reduced proliferative capacity and an elevated apoptosis rate. An in vivo orthotopic GC mouse model and xenograft mouse model confirmed the anticancer superiority and tumor-targeting feature of PLGA(TXT+LY294002). Histological analysis indicated that PLGA(TXT+LY294002) was biocompatible and had no toxicity to major organs. Characterized by the combined slow release of TXT and LY294002, this novel PLGA-based TXT/LY294002 drug delivery system provides controlled release and tumor targeting and is safe, shedding light on the future of targeted therapy against GC.

Download Full-text

A Novel pH and Thermo-sensitive N,O-Carboxymethyl Chitosan-graft-Poly(N-isopropylacrylamide) Hydrogel for Controlled Drug Delivery

e-Polymers ◽

10.1515/epoly.2007.7.1.503 ◽

2007 ◽

Vol 7 (1) ◽

Cited By ~ 1

Author(s):

M. Prabaharan ◽

J. F. Mano

Keyword(s):

Phase Transition ◽

Drug Delivery ◽

Controlled Release ◽

Ph Value ◽

Drug Loading ◽

Crosslinking Agent ◽

Weight Ratio ◽

Carboxymethyl Chitosan ◽

Swelling Ratio ◽

Drug Delivery Carrier

Abstract A novel kind of thermo and pH-responsive hydrogels was prepared by reacting N,O-carboxymethyl chitosan (NOCC) with amino-telechelic poly(Nisopropylacrylamide) (PNIPAAm-NH2) as a drug delivery carrier. The hydrogels were characterized by FT-IR and 1H-NMR techniques. The phase transition behavior of the hydrogels was found to be dependent on the NOCC/PNIPAAm-NH2 weight ratio and pH value of the medium. The hydrogels with a higher content of PNIPAAm showed a definite phase transition at 32 °C as it occurs in pure PNIPAAm. For the release study, NOCC-g-PNIPAAm beads were prepared using glutaraldehyde (GA) as a crosslinking agent. The swelling ratio of the beads was higher in pH 2.1 than pH 7.4. Moreover, the swelling ratio of the beads decreased with the increase in PNIPAAm content of the beads. The release profile of NOCCg- PNIPAAm beads showed a slower and controlled release of the entrapped ketoprofen, and found that the release behaviour was influenced by both the pH and temperature of the medium. It is expected that these smart hydrogels may be useful to develop drug delivery systems with improved drug loading capacity and controlled release behaviour.

Download Full-text

Application of Nanotechnology in Biomedicine: A Major Focus on Cancer Therapy

Journal of Nano Research ◽

10.4028/www.scientific.net/jnanor.35.55 ◽

2015 ◽

Vol 35 ◽

pp. 55-66 ◽

Cited By ~ 7

Author(s):

Hadi Zare-Zardini ◽

Farzad Ferdowsian ◽

Hossein Soltaninejad ◽

Adel Ghorani Azam ◽

Safoura Soleymani ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Cancer Detection ◽

Tumor Targeting ◽

Medical Applications ◽

Nano Materials ◽

Major Focus ◽

The Past ◽

New Compounds ◽

Cancer Diseases

Most of mortality worldwide occurs because of cancer diseases. Nanostructures are the new compounds that have become one of the most important technologies for using in different fields over the past two years especially in medicine. In between, nanotechnology has the potential to cancer detection and therapy. This study is a review of prospects in applications of nano-materials for cancer detection and treatment. We have summarized the nano-materials (metal nanospheres, nanorods, nanoshells and nanotubes) in medical applications targeting cancer. We also discuss advances in established nanoparticle technologies such as liposomes, polymer micelles, and functionalization about tumor targeting, controlled release and drug delivery. This paper will discuss the therapeutic applications of different nano-materials with a major focus on their applications for the treatment of cancer. Briefly, the toxicity of conventional nanostructures was also mentioned in this paper.

Download Full-text

A Matrix-Forming Polymer Combination as a Drug Delivery Platform for Controlled-Release Oral Dosage Forms

10.26226/morressier.57d6b2bdd462b8028d88d157 ◽

2016 ◽

Author(s):

Elsie Melsopp

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Dosage Forms ◽

Oral Dosage ◽

Delivery Platform ◽

Oral Dosage Forms

Download Full-text

Hydrogel-clay Nanocomposites as Carriers for Controlled Release

Current Medicinal Chemistry ◽

10.2174/0929867325666180831151055 ◽

2020 ◽

Vol 27 (6) ◽

pp. 919-954 ◽

Cited By ~ 4

Author(s):

Raluca Ianchis ◽

Claudia Mihaela Ninciuleanu ◽

Ioana Catalina Gifu ◽

Elvira Alexandrescu ◽

Cristina Lavinia Nistor ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Hybrid Materials ◽

Pharmaceutical Formulations ◽

Tree Of Life ◽

Present Review ◽

Clay Nanocomposites ◽

Delivery Platform ◽

Complex Hybrid

The present review aims to summarize the research efforts undertaken in the last few years in the development and testing of hydrogel-clay nanocomposites proposed as carriers for controlled release of diverse drugs. Their advantages, disadvantages and different compositions of polymers/biopolymers with diverse types of clays, as well as their interactions are discussed. Illustrative examples of studies regarding hydrogel-clay nanocomposites are detailed in order to underline the progressive researches on hydrogel-clay-drug pharmaceutical formulations able to respond to a series of demands for the most diverse applications. Brief descriptions of the different techniques used for the characterization of the obtained complex hybrid materials such as: swelling, TGA, DSC, FTIR, XRD, mechanical, SEM, TEM and biology tests, are also included. Enlightened by the presented data, we can suppose that hydrogel-clay nanocomposites will still be a challenging subject of global assiduous researches. We can dare to dream to an efficient drug delivery platform for the treatment of multiple affection concomitantly, these being undoubtedly like ”a tree of life” bearing different kinds of fruits and leaves proper for human healing.

Download Full-text

Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

Current Pharmaceutical Design ◽

10.2174/1381612825666190903154847 ◽

2019 ◽

Vol 25 (37) ◽

pp. 3917-3926

Author(s):

Sajjad Molavipordanjani ◽

Seyed Jalal Hosseinimehr

Keyword(s):

Drug Delivery ◽

Iron Oxide ◽

Medical Imaging ◽

Cancer Diagnosis ◽

Carbon Nanoparticles ◽

Tumor Targeting ◽

Polymeric Nanoparticles ◽

Inorganic Nanoparticles ◽

Active Targeting ◽

Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

Download Full-text

In vitro Lipolysis as a Tool for the Establishment of IVIVC for Lipid-Based Drug Delivery Systems

Current Drug Delivery ◽

10.2174/1567201816666190620115716 ◽

2019 ◽

Vol 16 (8) ◽

pp. 688-697

Author(s):

Ravinder Verma ◽

Deepak Kaushik

Keyword(s):

Drug Delivery ◽

Ph Value ◽

Electron Paramagnetic Resonance Spectroscopy ◽

Rapid Screening ◽

Resonance Spectroscopy ◽

Fed State ◽

In Vitro Lipolysis ◽

Ph Stat

: In vitro lipolysis has emerged as a powerful tool in the development of in vitro in vivo correlation for Lipid-based Drug Delivery System (LbDDS). In vitro lipolysis possesses the ability to mimic the assimilation of LbDDS in the human biological system. The digestion medium for in vitro lipolysis commonly contains an aqueous buffer media, bile salts, phospholipids and sodium chloride. The concentrations of these compounds are defined by the physiological conditions prevailing in the fasted or fed state. The pH of the medium is monitored by a pH-sensitive electrode connected to a computercontrolled pH-stat device capable of maintaining a predefined pH value via titration with sodium hydroxide. Copenhagen, Monash and Jerusalem are used as different models for in vitro lipolysis studies. The most common approach used in evaluating the kinetics of lipolysis of emulsion-based encapsulation systems is the pH-stat titration technique. This is widely used in both the nutritional and the pharmacological research fields as a rapid screening tool. Analytical tools for the assessment of in vitro lipolysis include HPLC, GC, HPTLC, SEM, Cryo TEM, Electron paramagnetic resonance spectroscopy, Raman spectroscopy and Nanoparticle Tracking Analysis (NTA) for the characterization of the lipids and colloidal phases after digestion of lipids. Various researches have been carried out for the establishment of IVIVC by using in vitro lipolysis models. The current publication also presents an updated review of various researches in the field of in vitro lipolysis.

Download Full-text

Versatile Use of Nanosponge in the Pharmaceutical Arena: A Mini-Review

Recent Patents on Nanotechnology ◽

10.2174/1872210514999200901200558 ◽

2020 ◽

Vol 14 (4) ◽

pp. 351-359

Author(s):

Shubham Shrestha ◽

Sankha Bhattacharya

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Porous Structure ◽

Drug Delivery System ◽

Delivery System ◽

Dosage Form ◽

Carrier System ◽

Current Review ◽

Long Time ◽

Preparation Techniques

Drug delivery for a long time has been a major problem in the pharmaceutical field. The development of a new Nano-carrier system called nanosponge has shown the potential to solve the problem. Nanosponge has a porous structure and can entrap the drug in it. It can carry both hydrophilic and hydrophobic drugs. They also provide controlled release of the drugs and can also protect various substances from degradation. Nanosponge can increase the solubility of drugs and can also be formulated into an oral, topical and parenteral dosage form. The current review explores different preparation techniques, characterization parameters, as well as various applications of nanosponge. Various patents related to nanosponge drug delivery system have been discussed in this study.

Download Full-text