Polymeric nanoparticles of (-)-epigallocatechin gallate: A new formulation for the treatment of ocular diseases

2017 ◽  
Vol 259 ◽  
pp. e7
Author(s):  
Amanda Cano ◽  
Elena Sánchez-López ◽  
Marta Espina ◽  
M. Antonia Egea ◽  
M. Luisa García
Keyword(s):  
Polymeric Nanoparticles ◽  
Epigallocatechin Gallate ◽  
Ocular Diseases ◽  
New Formulation

scholarly journals Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Sean Swetledge ◽  
Jangwook P. Jung ◽  
Renee Carter ◽  
Cristina Sabliov
Keyword(s):  
Polymeric Nanoparticles ◽  
Drug Stability ◽  
Administration Route ◽  
Ocular Diseases ◽  
Ocular Penetration ◽  
Disease Therapy ◽  
Tissue Targeting ◽  
Administration Method ◽  
Potential Impact ◽  
Specific Tissue

Abstract Advantages of polymeric nanoparticles as drug delivery systems include controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. Nanoparticle properties such as hydrophobicity, size, and charge, mucoadhesion, and surface ligands, as well as administration route and suspension media affect their ability to overcome ocular barriers and distribute in the eye, and must be carefully designed for specific target tissues and ocular diseases. This review seeks to discuss the available literature on the biodistribution of polymeric nanoparticles and discuss the effects of nanoparticle composition and administration method on their ocular penetration, distribution, elimination, toxicity, and efficacy, with potential impact on clinical applications.

Miniaturised preparation of polymeric nanoparticles using droplet manipulation on open surfaces

2019 ◽  
Vol 14 (13) ◽  
pp. 1312-1316 ◽  
Author(s):  
Alsaeed M. Abualsayed ◽  
Sara A. Abouelmagd ◽  
Mohamed Abdelgawad
Keyword(s):  
Polymeric Nanoparticles ◽  
Droplet Manipulation

Adult’s Total Parenteral Nutrition: Initiative and Implementation of Standardized Formulation in Saudi Arabia

2018 ◽  
Vol 4 (3) ◽  
pp. 483-487
Author(s):  
Yousef Ahmed Alomi ◽  
Hussam Saad Almalki ◽  
Aisha Omar Fallatah ◽  
Awatif Faraj Alshammari ◽  
Nahedh Rashed Alotaibi
Keyword(s):  
Saudi Arabia ◽  
Parenteral Nutrition ◽  
Pharmacy Practice ◽  
International Standards ◽  
Kingdom Of Saudi Arabia ◽  
Parental Nutrition ◽  
International Regulations ◽  
One Year ◽  
New Formulation ◽  
New System

The general administration of pharmaceutical care started potential pharmacy practice program. The program is part of accreditation professional’s process of national and international regulations. The adult’s parenteral nutrition was one of the critical programs. The most healthcare professionals are not familiar with the new system. The new initiatives system adult’s standardized concentration formulation of total parental nutrition as complementary to the previous one. The new formulation consisted of all parental nutrition requirements based on national and international standards. The new system can be converted as computerized physician orders. The new initiatives may implement as project management model over one year or less than that’s. The new system prevents nutrition-related problems, and medication errors, and improve clinical outcomes of the adults’ population in the Kingdom of Saudi Arabia.

L'esperienza clinica con Levometadone nel trattamento del disturbo da uso di oppiacei

MISSION ◽  
2019 ◽  
pp. 54-57
Author(s):  
Marco Riglietta ◽  
Paolo Donadoni ◽  
Grazia Carbone ◽  
Caterina Pisoni ◽  
Franca Colombi ◽  
...  
Keyword(s):  
Adverse Events ◽  
Real Life ◽  
Opioid Use Disorder ◽  
Racemic Mixture ◽  
Opioid Use ◽  
The Real ◽  
New Formulation

In Italy, at the end of the 1970s, methadone hydrochloride was introduced for the treatment of opioid use disorder, in the form of a racemic mixture consisting of levomethadone and dextromethadone.In 2015 Levometadone was introduced, a new formulation marketed in Italy for the treatment of opioid use disorder in 2015.The article aims to bring the experience of an Italian Addiction Centre back to the use of this new formulation in the "real life" analyzing the efficacy, the trend of adverse events and pharmacological iterations in a context in which the treated population often uses besides the opiates, cocaine and alcohol, are burdened by a relevant physical and psychic comorbidity and frequently have a prescribed polypharmacy.

Search for Compounds Suppressing Intestinal α-Glucosidase Expression in Caco-2 Cells

2019 ◽  
Vol 2 (2) ◽  
pp. 96-101
Author(s):  
Kota Noda ◽  
Eisuke Kato ◽  
Jun Kawabata
Keyword(s):  
Blood Glucose ◽  
Intestinal Tract ◽  
Cell Model ◽  
Epigallocatechin Gallate ◽  
Calluna Vulgaris ◽  
Active Principle ◽  
Intestinal Epithelial ◽  
Mrna Expression Level ◽  
Epicatechin Gallate ◽  
Control Post

Diabetes is a chronic disease characterized by elevated blood glucose level.Reducing carbohydrate absorption from the intestinal tract is an effective strategy to control post-meal blood glucose level. Inhibition of intestinal α-glucosidase, involved in digestion of carbohydrates, is known as an approach to accomplish this. On the other hand, reduction of α-glucosidase amount is expected to work in the similar manner. However, none of the previousstudy pursues this approach. A convenient assay was developed to evaluate α-glucosidase amount employing Caco-2 cells, the intestinal epithelial cell model reported to express α-glucosidase. Sixty plants were screened and two candidate plants, Calluna vulgaris and Perilla frutescens var. crispa were found to reduce α-glucosidase expression. C. vulgaris extract was subjected to activity guided isolation. Proanthocyanidin was identified as the active principle which was analyzed by thiol decomposition to reveal the components as a mixture ofcatechin, epicatechin, epigallocatechin, and A type procyanidin dimer. The proanthocyanidin suppressed about 30% of α-glucosidase amount evaluated through convenient assay, and suppressed bulk of mRNA expression level of sucrase-isomaltase (SI) at 0.125 mg/mL. Several flavan-3-ol monomers were also tested, and epicatechin gallate and epigallocatechin gallate were found to suppress α-glucosidase amount significantly.

TRADISI AKADEMIK DALAM KHALAQAH TAFSI>R (Orientasi Semantik al-Qur’an Klasik alam Diskursus Hermeneutik)

2016 ◽  
Vol 1 (1) ◽  
pp. 93
Author(s):  
Syamsul Wathani
Keyword(s):  
New Formulation

This article discusses Qur’anic semantic within hermeneutic discourse. The classical interpretation of the Qur’an (I-IV H) are set to be the sobject matter to be discussed within the framework of hermeneutic. By doing so, the article is expected to contribute to give a new formulation about the classical interpretation discourse on the Qur’an. Besides, the article is also expected to discover the new theory about Qur’anic hermeneutic which operated in the sphere of text. The classical Qur’anic semantic has shown the contestation which not only dit it appear in the sphere of meaning (dilalah), but more deeply in played a dialecticsof language between oral notion (al-Qur’an/kalam) and the recipient (khitab al-Qur’an).

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