Development and clinical trials on anti-inflammatory effect of transdermal patch containing a combination of Kaempferia parviflora and Curcuma longa extracts

Studies have revealed that anti-inflammatory agents could provide beneficial effect in lowering the incidence/progression of neurological diseases. Hence, this study sought to investigate the effect of essential oils from Nigeria ginger and turmeric rhizomes on some cytokines in cadmium induced neurotoxicity. The result revealed that essential oil from ginger and turmeric rhizomes exerts anti-inflammatory effect by preventing alterations of some cytokines/inflammatory biomarkers (IL-6, IL-10 and TNF-Alpha) levels and inhibits both hippocampus and prefrontal cortex acetylcholinesterase (AChE) and adenosine deaminase (ADA) activities (important enzymes relevant in the management/prevention of neurodegenerative diseases) in Cd treated rats. In conclusion, essential oil from ginger and turmeric rhizomes exerts anti-inflammatory properties in Cd induced neurotoxicity. The observed effect could be due to the volatile compounds as revealed by GC-MS analysis.

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Curcuma longa Extract Exerts a Myorelaxant Effect on the Ileum and Colon in a Mouse Experimental Colitis Model, Independent of the Anti-Inflammatory Effect

PLoS ONE ◽

10.1371/journal.pone.0044650 ◽

2012 ◽

Vol 7 (9) ◽

pp. e44650 ◽

Cited By ~ 17

Author(s):

Rita Aldini ◽

Roberta Budriesi ◽

Giulia Roda ◽

Matteo Micucci ◽

Pierfranco Ioan ◽

...

Keyword(s):

Curcuma Longa ◽

Experimental Colitis ◽

Model Independent ◽

Anti Inflammatory ◽

Colitis Model ◽

Inflammatory Effect

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A RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE ANTI-INFLAMMATORY EFFECT OF COMMIPHORA WIGHTII IN COMBINATION WITH CURCUMA LONGA AGAINST DICLOFENAC POTASSIUM IN NON-SPECIFIC KNEE EFFUSION

Journal of Biological and Scientific Opinion ◽

10.7897/2321-6328.03215 ◽

2015 ◽

Vol 3 (2) ◽

pp. 68-72

Author(s):

Narinder Singh ◽

A R Bhattacharya ◽

Akhilesh Mishra

Keyword(s):

Randomized Controlled Trial ◽

Curcuma Longa ◽

Controlled Trial ◽

Commiphora Wightii ◽

Randomized Controlled ◽

Knee Effusion ◽

Anti Inflammatory ◽

Inflammatory Effect

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Efektifitas Anti Inflamasi Formulasi Kunyit (Curcuma Longa), Daun Binahong (Anredera Cordifolia) Dan Daun Sambiloto (Andrographis Paniculata) Terhadap Luka Sayat Pada Kelinci

Interest : Jurnal Ilmu Kesehatan ◽

10.37341/interest.v7i2.46 ◽

2018 ◽

Vol 7 (2) ◽

Author(s):

Kh Endah Widhi Astuti ◽

Sih Rini Handajani

Keyword(s):

Curcuma Longa ◽

Healing Process ◽

Andrographis Paniculata ◽

Control Group ◽

Wound Healing Process ◽

Second Stage Of Labor ◽

Post Test ◽

Treatment Research ◽

Anti Inflammatory ◽

Inflammatory Effect

Background: Perineal lacerations are tears that occur in the perineum because of the second stage of labor. The Javanese people do the purpose of this study is the effectiveness of anti-inflammatory formulation of turmeric (curcuma longa), leaves of Binahong (Anredera cordifolia) and leaves of Sambiloto (Andrographis paniculata) against incisions in rabbits. Method: The method used in this study is the method in this study. This research uses a quantitative method with a type of pure treatment research in the form of pre-post test design. The sample in this study was 10 rabbits per group in 5 groups. Results: There was an anti-inflammatory effect of the turmeric formulation, binahong leaves of bitter leaf (F1, F2 and F3) in the incision wound in rabbits (ρ <0.001). There is an anti-inflammatory effect of turmeric formulation, binahong leaves of bitter leaf on leukocyte levels in rabbit incisions in F1, F2 and F3 compared to the control group (ρ <0.001). Conclusion: Turmeric formula, binahong leaf, bitter leaf (F1, F2 and F3) in the incision in rabbits can improve the wound healing process.

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An Overview of Golden Spice’s (Turmeric) Medicinal Properties for Future Development Potential

Malaysian Journal of Science Health & Technology ◽

10.33102/mjosht.v6i.127 ◽

2021 ◽

Author(s):

Zarini Ismail ◽

Nur Ain Nabila Mazuki

Keyword(s):

Therapeutic Agent ◽

Curcuma Longa ◽

Alternative Source ◽

Traditional Medicines ◽

The Family ◽

The World ◽

Medicinal Properties ◽

Therapeutic Properties ◽

Anti Inflammatory ◽

Inflammatory Effect

Traditional medicines that are derived mainly from herbaceous plants are widely used for years in many regions of the world. Currently, the world is facing the emergence of resistant microorganisms due to the overuse and misuse of antibiotics and the lack of new drug development. In consequence, the discovery of natural phytochemicals that are safe, cheap, non-toxic, and readily available would be an acceptable alternative source. Turmeric, scientifically known as Curcuma longa, in the family of Zingiberaceae (ginger) is well known for its diverse therapeutic properties. The medicinal properties of turmeric include antioxidant, anti-inflammatory, anti-microbial, anti-carcinogenic, cardioprotective, gastroprotective, hepatoprotective, and many more. Numerous studies have shown that curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), which is the most active compound of turmeric, plays a significant role as a therapeutic agent. The present article provides a brief overview of the plethora of research regarding the medicinal properties of golden spice (turmeric), specifically of curcumin's role in the treatment of various illnesses. Interestingly, turmeric might play a role in protecting COVID-19 patients against the development of lung injury caused by cytokine storms. Hence, this warrants further scientific research to monitor the anti-inflammatory effect of turmeric on SARS-CoV-2.

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Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients

International Immunopharmacology ◽

10.1016/j.intimp.2010.04.021 ◽

2010 ◽

Vol 10 (7) ◽

pp. 815-818 ◽

Cited By ~ 57

Author(s):

Chuchart Koosirirat ◽

Sukanya Linpisarn ◽

Don Changsom ◽

Kriangkrai Chawansuntati ◽

Jiraprapa Wipasa

Keyword(s):

Helicobacter Pylori ◽

Curcuma Longa ◽

Anti Inflammatory ◽

Inflammatory Effect

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Anti inflammatory effect of rhizome of Curcuma longa. Linn, in Albino rats by the method of Carrageenin induced paw oedema

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20180032 ◽

2018 ◽

Vol 7 (2) ◽

pp. 229 ◽

Cited By ~ 1

Author(s):

Jayan Pariyani Savaringal ◽

Lally M. S.

Keyword(s):

Curcuma Longa ◽

Ethanolic Extract ◽

Inflammatory Activity ◽

Albino Rats ◽

Standard Drug ◽

Medical College ◽

Inflammatory Conditions ◽

Anti Inflammatory ◽

Animal House ◽

Inflammatory Effect

Background: Curcuma longa or turmeric is a popular Ayurvedic herb, traditionally used for various inflammatory conditions including rheumatoid arthritis and spondylitis. Turmeric which containing phytochemical ingredient curcumin is used in India for centuries as a topical anti inflammatory agent. Many of the currently used anti inflammatory agents like NSAID’s and glucocorticoids have many undesirable adverse effects, especially when they are used for long period. In the present study, Curcuma longa, a plant belonging to the Zingiberaceae family was chosen for investigating its anti-inflammatory effects.Methods: The rhizomes of Curcuma longa were collected locally. The extract was prepared by soxlet extraction with 50% ethanol. Albino rats of Wistar strain (170-250grams) obtained from the animal house of medical college Thiruvananthapuram were used. Aspirin was purchased from sigma Labs, Mumbai. Anti-inflammatory effect of the extract was done in rats by the method of Carrageenin induced paw oedema.Results: The ethanolic extract of Curcuma longa inhibited the development of oedema at the end of 3 hours. The anti-inflammatory activity exhibited by the extract was dose dependent and statistically significant at dose levels of 1000-mg/kg and comparable to that of standard drug used Aspirin.Conclusions: The present study with extract of Curcuma longa revealed that it has significant anti-inflammatory activity.

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Assessment of the effect of calcium on the anti-inflammatory activity of etoricoxib in albino rats

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20212078 ◽

2021 ◽

Vol 10 (6) ◽

pp. 683

Author(s):

Sonali Naringrekar ◽

Jayesh Mamtora

Keyword(s):

Clinical Trials ◽

Calcium Gluconate ◽

Laboratory Animal ◽

Inflammatory Activity ◽

Albino Rats ◽

Human Dose ◽

Cox 2 ◽

Anti Inflammatory ◽

Inflammatory Action ◽

Inflammatory Effect

Background: It would be worthwhile to investigate if it is possible to obtain an anti-inflammatory effect with a lower dose of etoricoxib after it has been combined with calcium, the effect of which is equivalent to higher dose of etoricoxib. Hence the aim was to study effect of calcium and calcium gluconate on the anti-inflammatory activity of etoricoxib.Methods: Animals were distributed in five groups each group containing six rats. Experiments were conducted between 9:00 to 16:00 hours. All animal procedures were performed in accordance with the recommendations for proper care and use of laboratory animal .The doses of drugs employed in the study were based upon the human dose after conversion to that of rat.Results: The results of present study indicate that calcium gluconate (50 mg/kg) combined with etoricoxib (5 mg/kg) possesses significant anti-inflammatory property both in acute and subacute models of inflammation which was comparable to that of etoricoxib (8 mg/kg).Conclusions: From the present study it is concluded that calcium gluconate (50 mg/kg) possesses an anti-inflammatory activity. Lower dose of etoricoxib (5 mg/kg) if combined with calcium gluconate (50 mg/kg) can produce significant anti-inflammatory effect. The advantages of such combined preparations are obviously a reduction in the dose of etoricoxib that could still produce significant anti-inflammatory action and a possible protection against COX -2 inhibitor induced prothrombotic events. It is worthwhile to evaluate such preparations through clinical trials.

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