A novel approach towards multivariate optimization of graphite/PbO2 anode synthesis conditions: Insight into its enhanced oxidation ability and physicochemical characteristics
CdTe QD based stripping voltammetry for Vi capsular polysaccharide detection. The technique has provided an insight into the competence of CdTe QD and GNP immuno-conjugates. This is a novel approach to characterize the efficiency of immuno-conjugates of QDs and GNPs.
PurposeIn spite of millions of quasi-formal workers in the European Union (EU), there is still limited understanding of what motivates workers to participate in these detrimental employment schemes, and why certain groups of workers exhibit higher inclination towards it. This article takes a novel approach by putting prospective envelope wage earners in the centre of this analysis.Design/methodology/approachData from the 2019 Special Eurobarometer on undeclared work are used, and two-level random intercept cumulative logit modelling is applied.FindingsOne in seven fully declared EU workers would have nothing against receiving one part of their wages off-the-books. Manual workers and individuals whose job assumes travelling are the most willing to accept such kind of remuneration, and the same applies to workers with low tax morale and those who perceive the risk of being detected and persecuted as very small. On the other hand, women, older individuals, married persons and employees from large enterprises express the smallest inclination towards envelope wages. The environment in which an individual operates also plays a non-negligible role as the quality of the pension system and the strength of social contract were also identified as significant determinants of workers' readiness to accept envelope wages.Originality/valueThis article fills in the gap in the literature by analysing what workers think about wage under-reporting and what factors drive their willingness to accept envelope wages.
Chemo-immunotherapy is central to the treatment of small cell lung cancer (SCLC). Despite modest progress made with the addition of immunotherapy, current cytotoxic regimens display minimal survival benefit and new treatments are needed. Thymidylate synthase (TS) is a well-validated anti-cancer drug target, but conventional TS inhibitors display limited clinical efficacy in refractory or recurrent SCLC. We performed RNA-Seq analysis to identify gene expression changes in SCLC biopsy samples to provide mechanistic insight into the potential utility of targeting pyrimidine biosynthesis to treat SCLC. We identified systematic dysregulation of pyrimidine biosynthesis, including elevated TYMS expression that likely contributes to the lack of efficacy for current TS inhibitors in SCLC. We also identified E2F1-3 upregulation in SCLC as a potential driver of TYMS expression that may contribute to tumor aggressiveness. To test if TS inhibition could be a viable strategy for SCLC treatment, we developed patient-derived organoids (PDOs) from human SCLC biopsy samples and used these to evaluate both conventional fluoropyrimidine drugs (e.g., 5-fluorouracil), platinum-based drugs, and CF10, a novel fluoropyrimidine polymer with enhanced TS inhibition activity. PDOs were relatively resistant to 5-FU and while moderately sensitive to the front-line agent cisplatin, were relatively more sensitive to CF10. Our studies demonstrate dysregulated pyrimidine biosynthesis contributes to drug resistance in SCLC and indicate that a novel approach to target these pathways may improve outcomes.
This study is an examination into the feasibility of a quasi-static approach to evaluating the reaction forces that impact tires. This information could lend valuable insight into efforts to limit overturning and side-slip accidents of vehicles exposed to strong side winds. The performance of the quasi-static approach was evaluated by comparing the calculated tire forces with those created using TruckSim, which is a dynamic vehicle analysis software. Governing equations were formulated for two types of vehicles that are susceptible to the force of wind, vans, and trailers, by considering a force equilibrium, a compatibility condition, and several assumptions. The quasi-static approach for trailers is a novel expansion of the conventional approach to a two-axle vehicle. Proposed enhancements to the quasi-static approach reflect the additional rolling moment of a trailer. The curvature and the cant of a curved road were accounted for via centrifugal forces. Both uniform and turbulent wind conditions were considered in questioning the feasibility of this novel approach.
This paper presents a survey of methods and techniques developed for the solution of the continuous gas-lift optimization problem over the last two decades. These range from isolated single-well analysis all the way to real-time multivariate optimization schemes encompassing all wells in a field. While some methods are clearly limited due to their neglect of treating the effects of inter-dependent wells with common flow lines, other methods are limited due to the efficacy and quality of the solution obtained when dealing with large-scale networks comprising hundreds of difficult to produce wells. The aim of this paper is to provide an insight into the approaches developed and to highlight the challenges that remain.
The physicochemical characteristics (SEM, N2 adsorption, FT-IR, MASNMR) of samples from kinetics (10 min, 20 min, 30 min, 1 h and 3h) of hydrolysis of tetraethyl orthosilicate (TEOS) gives new insight into the synthesis of nanosphere. The particle sizes are increased with time, however, the surface areas decreased. FT-IR investigation reveals the presence of high intensed silanol groups of 960 cm-1 at 10 min, which reduced on progress of the reaction time. This suggests the partial hydrolysis and condensation of alkoxy groups in TEOS. 29Si MASNMR analysis shows the presence three different silica species(Q4, Q3 and Q2) in 10 and 20 min samples. The intensity of Q2 species decreases with time and other species concentration were increased.
Fast degrading and declining land, water availability, biodiversity, environment and other natural resources, together with shrinking farm returns and reduced crop productivity caused by continuous and intensive cultivation of rice-wheat systems, necessitate diversification of farming in Northern India. Integrated farming systems (IFS) involving animals (livestock, fish, etc.) and cropping (cereals, trees, etc.) are recognised as an alternative for preserving ecosystems and enhancing livelihood security. A study was therefore undertaken under Northern Indian conditions to develop IFS models for various sizes of farm and to compare these models with the existing rice-wheat system for sustainability and profitability. The IFS models were developed in single objective (using linear programming) and multi-objective (using compromise programming) frameworks. Multi-objective analysis provides deeper insight into the problem as it caters directly for the multi-faceted needs of the farmers. These parallel methodologies offer a novel approach to modelling IFS to draw different farming scenarios for comparison. The IFS strategies developed show the potential to generate a greater farm income than with existing rice-wheat cropping for all sizes of farm. The study revealed that IFS offer more perspectives for an economically viable and sustainable agriculture for typical farms in Northern India.
Dysregulated Pyrimidine Biosynthesis Contributes to 5-FU Resistance in SCLC Patient-Derived Organoids but Response to a Novel Polymeric Fluoropyrimidine, CF10