Antidiabetic and antidyslipidemic activities of aqueous leaf extract of Dioscoreophyllum cumminsii (Stapf) Diels in alloxan-induced diabetic rats

2015 ◽  
Vol 166 ◽  
pp. 313-322 ◽  
Author(s):  
H.O.B. Oloyede ◽  
T.O. Bello ◽  
T.O. Ajiboye ◽  
M.O. Salawu
Keyword(s):  
Leaf Extract ◽  
Diabetic Rats ◽  
Aqueous Leaf Extract

scholarly journals Nephroprotective Property of C. chayamansa Aqueous Leaf Extract in Diabetic Rats

2020 ◽  
pp. 72-84
Author(s):  
Jonathan Dingkwoet Dabak ◽  
Rose Titus Kuyambana ◽  
Titilayo Omolara Johnson ◽  
Jonathan Latrwang Dabal
Keyword(s):  
Uric Acid ◽  
Leaf Extract ◽  
Diabetic Rats ◽  
Histopathological Study ◽  
Standard Drug ◽  
Aqueous Leaf Extract ◽  
Group 5 ◽  
Group 2 ◽  
High Doses ◽  
Test Control

Aim: To evaluate the nephroprotective property of Cnidoscolus chayamansa aqueous leaf extract in diabetic rats. Study Design: Rats were randomly divided into five groups with group 1 as the normal control. Diabetic was induced in groups 2-4. Group 2 was used as the test control while groups 3 and 4 were treated with different concentrations of the leaf extract; group 5 was treated with the standard drug, glipizide. Place and Duration of Study: Departments of Biochemistry and Anatomy, University of Jos, Nigeria, between August to November, 2019. Methodology: Fourty (40) male albino Wistar rats were grouped into five groups. The rats were treated for fourteen days and then sacrificed by decapitation after anaesthesia. Blood was collected for biochemical parameters; kidney was excised and stored in formaldehyde until required for histopathological study. Serum urea, creatinine, uric acid, sodium, potassium, chloride and bicarbonate were determined using appropriate methods. Results: The test control had a significant (P < .05) decrease in the concentrations of Na+, Cl- and HCO3- ions; significant (P < .05) increases in serum K+ ion, urea, uric acid and creatinine. Treatments of the test groups with the different doses of the leaf extract and the standard drug increased the concentration of Na+ ion which was not significantly (P < .05) different from the test control. On the other hand, the concentration of Cl- and HCO- ions  were significantly (P < .05) increased; the concentrations of K+, urea, uric acid and creatinine were significantly (P < .05) decreased. The histochemistry of the kidneys revealed that the injury brought about under diabetic condition was ameliorated with the treatments with the low and high doses of the leaf extract, and the standard drug. Conclusion: The results show that the aqueous leaf extract has nephroprotective property.

scholarly journals Comparative Effect of Aspirin, Meloxicam and Terminalia catappa Leaf Extract on Serum Levels of Some Inflammatory Markers in Alloxan Induced Diabetic Rats

2019 ◽  
pp. 1-10
Author(s):  
Ezekiel E. Ben ◽  
Asuquo E. Asuquo ◽  
Daniel U. Owu
Keyword(s):  
Body Weight ◽  
Interleukin 6 ◽  
Leaf Extract ◽  
Serum Levels ◽  
Diabetic Rats ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Terminalia Catappa ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory

Background: The association between diabetes mellitus and inflammation is established but the use of non-steroidal anti-inflammatory drugs is not without some health risk. Aim: The study was aimed at comparing the levels of some inflammatory biomarkers in diabetic rats treated with aqueous leaf extract of Terminalia catappa, non steroidal anti-inflammatory drugs (NSAIDs) and exogenous insulin. Materials and Methods: Thirty six (36) Wistar rats were assigned to 6 groups of 6 animals each. Group 1 and 2 served as normal and diabetic controls and received orally 5ml/kg body weight of distilled water. Group 3 was diabetic treated orally with 130mg/kg body weight of aqueous leaf extract of Terminalia catappa.  And groups 4, 5 and 6 were administered orally with aspirin (30mg/kg), meloxicam (2mg/kg) and 0.75U/kg body weight of insulin subcutaneously. Diabetes was induced with intraperitoneal injection of 150mg/kg body weight of alloxan solution and diabetes confirmed after 72 hours with blood glucose levels ≥200mg/dl. The experiment lasted for 14 days and blood was collected by cardiac puncture for serum analysis of C-reactive protein, Interleukin-6 and Fibrinogen by ELISA method. Results: The results showed significant (P<0.05) increase in serum levels of C-reactive protein, Interleukin-6 and blood fibrinogen in diabetic group compared to control. These inflammatory biomarker were significantly (P<0.05) reduced by the extract, aspirin, meloxicam and insulin.  Conclusion: The reduced levels of C-reactive protein, Interleukin-6 and fibrinogen by aqueous leaf extract of Terminalia catappa was significant compared to aspirin and meloxicam. This may present the extract as a potent anti-inflammatory agent and could complement the function of insulin in diabetes treatment.

scholarly journals Antidiabetic activity of aqueous leaf extract of Atriplex halimus L. (Chenopodiaceae) in streptozotocin–induced diabetic rats

2014 ◽  
Vol 4 (3) ◽  
pp. 181-184 ◽  
Author(s):  
Ilyas Chikhi ◽  
Hocine Allali ◽  
Mohamed El Amine Dib ◽  
Houria Medjdoub ◽  
Boufeldja Tabti
Keyword(s):  
Leaf Extract ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Atriplex Halimus ◽  
Aqueous Leaf Extract

scholarly journals Serum Levels of Some Inflammatory Markers in Alloxan- Induced Diabetic Rats Treated with Aqueous Leaf Extract of Terminalia catappa and Exogenous Insulin

2019 ◽  
pp. 1-9
Author(s):  
Ezekiel E. Ben ◽  
Asuquo E. Asuquo ◽  
D. U. Owu
Keyword(s):  
Body Weight ◽  
Inflammatory Markers ◽  
Leaf Extract ◽  
Serum Levels ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Distilled Water ◽  
Exogenous Insulin ◽  
Terminalia Catappa ◽  
Aqueous Leaf Extract

Background: Inflammation is said to be associated with hyperglycaemia and is implicated in the complications of diabetes. Aim: This study was designed to investigate the level of some inflammatory markers in blood of diabetic rats administered with aqueous leaf extract of Terminalia catappa and exogenous insulin.  Materials and Methods: Thirty five (35) Wistar rats were assigned to 5 groups of 7 animals each. Group 1 served as the control and received 5ml/kg body weight of distilled water and group 2 received orally, 130/kg body weight of aqueous leaf extract of Terminalia catappa. Groups 3 (diabetic only), 4 (diabetic + extract) and 5 (diabetic + insulin) were administered 150 mg/kg body weight of alloxan solution intraperitoneally to induce diabetes and blood glucose levels ≥200 mg/dl after 72 hours were considered diabetic. Then 5 ml/kg bodyweight of distilled water, 130 mg/kg body weight of Terminalia catappa leaf extract was given orally and 0.75U/kg body weight of insulin was administered subcutaneously to respective groups and the experiment lasted for 14 days. Results: The results showed significant (P< 0.05) increase in serum levels of C-reactive protein, Interleukin-6 and blood fibrinogen in diabetic group compared to control. These inflammatory biomarkers significantly (P<0.05) reduced in diabetic group treated with extract and insulin.  Conclusion: Therefore aqueous leaf extract of Terminalia catappa can reduce some inflammatory cytokines and ameliorate inflammation in diabetes similar to exogenous insulin.

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