Aqueous extract of Digitaria exilis grains ameliorate diabetes in streptozotocin-induced diabetic male Wistar rats

SummaryIntroduction: The liver is involved in the metabolism of xenobiotics and their metabolites and it is vulnerable to oxidative damage. Hyperglycaemia is highly implicated in the progression of diabetes mellitus, and adversely affects the liver. Though, conventional hypoglycaemic drugs may be effective in reducing blood glucose, they do not appear to be effective in attenuating the progression of diabetes and its complications.Objective: This study evaluated the ameliorative effects of Anchomanes difformis on hyperglycaemia and hepatic injuries in type 2 diabetes.Methods: Type 2 diabetes was induced in male Wistar rats with a single intraperitoneal injection of streptozotocin (40 mg/kg BW) after two weeks of fructose (10%) administration. Aqueous extract of A. difformis (200 and 400 mg/kg BW) and glibenclamide (5 mg/kg BW) were administered orally for six weeks. Blood glucose concentrations were measured. Serum levels of liver dysfunction markers (ALT, AST, and ALP), total cholesterol, triglycerides, HDL- and LDL-cholesterol were investigated. Total protein, albumin, and globulin were also assessed. Antioxidant parameters: ORAC, GSH, GSSG, SOD, CAT and FRAP were evaluated in the liver while ORAC, FRAP and lipid peroxidation were determined in the serum. Histological examination of the liver tissue was carried out.Results: Treatment with aqueous extract of A. difformis significantly (p<0.05) reduced blood glucose and reversed steatosis in the diabetic-treated rats. The antioxidant status of diabetic-treated rats was significantly (p<0.05) improved. Serum levels of liver dysfunction markers were significantly (p<0.05) reduced in diabetic-treated rats.Conclusion: The findings in this study revealed that 400 mg/kgBW Anchomanes difformis was more effective than 200 mg/kg BW in ameliorating diabetes-induced hepatopathy, however, both doses of Anchomanes difformis demonstrated more antidiabetic ability than glibenclamide. Anchomanes difformis may be a novel and potential therapeutic agent in the management of diabetes and resulted hepatic injuries.

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Lead intoxication and beneficial effect of administering the aqueous extract of Artemisia absinthium on lipid metabolism and hypertension in male Wistar rats

10.38150/sajeb.11(2).p199-209 ◽

2021 ◽

Keyword(s):

Lipid Metabolism ◽

Beneficial Effect ◽

Aqueous Extract ◽

Wistar Rats ◽

Lead Intoxication ◽

Artemisia Absinthium ◽

Male Wistar Rats

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The Consequence of Aqueous Extract of Tobacco Leaves (Nicotiana tabacum. L) on Feed Intake, Body Mass, and Hematological Indices of Male Wistar Rats fed under Equal Environmental Conditions

Journal of the American College of Nutrition ◽

10.1080/07315724.2020.1788471 ◽

2020 ◽

pp. 1-14 ◽

Cited By ~ 1

Author(s):

Felix Atawal Andong ◽

Elijah Sunday Okwuonu ◽

Temitope Dadewura Melefa ◽

Charles Obinwanne Okoye ◽

Augustine Okorie Nkemakolam ◽

...

Keyword(s):

Nicotiana Tabacum ◽

Body Mass ◽

Aqueous Extract ◽

Feed Intake ◽

Environmental Conditions ◽

Wistar Rats ◽

Tobacco Leaves ◽

Hematological Indices ◽

Nicotiana Tabacum L ◽

Male Wistar Rats

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The protective effects of aqueous extract of Carica papaya seeds in paracetamol induced nephrotoxicity in male wistar rats

African Health Sciences ◽

10.4314/ahs.v15i2.37 ◽

2015 ◽

Vol 15 (2) ◽

pp. 598 ◽

Cited By ~ 14

Author(s):

N Madinah ◽

M Nozmo ◽

I Ezekiel

Keyword(s):

Aqueous Extract ◽

Wistar Rats ◽

Carica Papaya ◽

Protective Effects ◽

Male Wistar Rats ◽

Papaya Seeds

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Studies on the toxicological effect of the aqueous extract of the fresh, dried and boiled berries of Solanum aculeastrum Dunal in male Wistar rats

Human & Experimental Toxicology ◽

10.1177/0960327109354545 ◽

2009 ◽

Vol 28 (12) ◽

pp. 765-775 ◽

Cited By ~ 11

Author(s):

OM Aboyade ◽

MT Yakubu ◽

DS Grierson ◽

AJ Afolayan

Keyword(s):

Body Weight ◽

Aqueous Extract ◽

Wistar Rats ◽

Haemoglobin Concentration ◽

Weight Ratio ◽

The Body ◽

Corpuscular Haemoglobin ◽

Toxicological Effect ◽

Male Wistar Rats ◽

Mean Corpuscular Haemoglobin

The toxicological effect of the aqueous extract of fresh, dried and boiled berries of Solanum aculeastrum Dunal at 1, 10 and 25 mg/kg body weight was investigated in male Wistar rats for 28 days. The parameters used were the body weight of the animals and absolute weights of the organs, haematological parameters, renal and liver functional endpoints. The animals gained appreciable weight and showed no signs of clinical toxicity. The dried (DB), boiled dried (BDB), fresh (FB) and boiled fresh berry (BFB) extracts reduced (p < .05) the heart-, liver-and spleen-body weight ratio of the animals whereas that of the lung was not altered. The kidney and testes-body weight ratios were specifically altered by the different extract. All these were not accompanied by any histomorphological changes. The extracts did not alter (p > .05) the levels of RBC, Hb, PCV and albumin of the animals. The platelets were decreased by the DB and FB whereas BFB increased this parameter. The FB and BFB at all the doses also reduced the mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) of the animals. With the exception of the FB where the creatinine and chloride levels decreased, other extracts did not alter the level of these kidney parameters. Only FB increased the levels of uric acid and urea. All the extract decreased the serum alanine aminotransferase (ALT) of the animal. The levels of total protein, globulin, total and conjugated bilirubin were not altered by DB and BDB whereas these indices were increased by FB and BFB. The DB and BDB increased the serum alkaline phosphatase (ALP) activity whereas FB decreased the activity of the enzyme. In contrast, DB and BDB decreased the serum aspartate aminotransferase (AST) activity of the animals whereas FB and BFB increased the activity of the enzyme. The FB and BFB also increased the levels of potassium, magnesium and phosphorus of the animals. Overall, the alterations in the biochemical parameters by the various extracts of S. aculeastrum berries at these doses indicated that the normal functioning of these organs may be adversely affected. However, drying and boiling might reduce the toxic effect of the berries.

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