An Integrated Approach to Discriminate the Quality Markers of Traditional Chinese Medicine Preparation Based on Multi-dimensional Characteristic Network: Shenqi Jiangtang Granule as a case

2021 ◽  
pp. 114277
Author(s):  
Hui Zhang ◽  
Ruoyu Chen ◽  
Cong Xu ◽  
Guimin Zhang ◽  
Yongxia Guan ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Integrated Approach ◽  
Quality Markers ◽  
Dimensional Characteristic ◽  
Traditional Chinese Medicine Preparation ◽  
Characteristic Network

scholarly journals Traditional Chinese Medicine Preparation Combined Therapy May Improve Chemotherapy Efficacy: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Jiaming Wu ◽  
Yun Liu ◽  
Cantu Fang ◽  
Lixian Zhao ◽  
Lizhu Lin ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Randomized Controlled Trials ◽  
Methodological Quality ◽  
Combined Therapy ◽  
Meta Analysis ◽  
Objective Response ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Traditional Chinese Medicine Preparation

Background. Whether traditional Chinese medicine preparation combined therapy can improve the efficacy of chemotherapy is controversial. This meta-analysis evaluates the efficacy of traditional Chinese medicine preparation combined with chemotherapy. Method. Three databases were searched from inception through August 2018. Eligible randomized controlled trials (RCTs) involving the combined treatment of chemotherapy and traditional Chinese medicine preparation compared to chemotherapy alone for treating cancer were retrieved. The methodological quality of the included RCTs was assessed with Cochrane Collaboration’s risk of bias assessment tool. Meta-analysis was adopted to make comprehensive comparisons between the experimental and control groups. Results. Four RCTs were included in this review, comprising 256 subjects. The majority of the RCTs were judged as being of poor methodological quality. Meta-analysis showed that the combination of traditional Chinese medicine preparation and chemotherapy appeared to be more effective than chemotherapy alone, for the treatment of cancer, as assessed by the disease control rate (RR: 1.41, 95% CI: 1.11 to 1.79) and the objective response rate (RR: 2.71, 95% CI: 1.28 to 5.77). There were no statistically significant differences between the groups in terms of bone marrow suppression (RR: 0.88, 95% CI: 0.57 to 1.37) or gastrointestinal reaction (RR: 1.12, 95% CI 0.75 to 1.69). Conclusions. Traditional Chinese medicine preparation combined with chemotherapy may improve objective response rates and disease control rates more than chemotherapy alone. The evidence that combined traditional Chinese medicine preparation can reduce the side effects of chemotherapy is insufficient. More rigorous randomized controlled trials are needed to confirm these conclusions.

scholarly journals A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4/Nuclear Factor-κB

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Chu-Wen Li ◽  
Zhi-Wei Chen ◽  
Xiao-Li Wu ◽  
Zhao-Xiao Ning ◽  
Zu-Qing Su ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Lung Injury ◽  
Therapeutic Drug ◽  
Nuclear Factor ◽  
Protective Effects ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Traditional Chinese Medicine Preparation

A standardized traditional Chinese medicine preparation named Yejuhua capsule (YJH) has been clinically used in treatments of various acute respiratory system diseases with high efficacy and low toxicity. In this study, we were aiming to evaluate potential effects and to elucidate underlying mechanisms of YJH against lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice. Moreover, the chemical analysis and chromatographic fingerprint study were performed for quality evaluation and control of this drug. ALI was induced by intratracheal instillation of LPS (5 mg/kg) into the lung in mice and dexamethasone (5 mg/kg, p.o.) was used as a positive control drug. Results demonstrated that pretreatments with YJH (85, 170, and 340 mg/kg, p.o.) effectively abated LPS-induced histopathologic changes, attenuated the vascular permeability enhancement and edema, inhibited inflammatory cells migrations and protein leakages, suppressed the ability of myeloperoxidase, declined proinflammatory cytokines productions, and downregulated activations of nuclear factor-κB (NF-κB) and expressions of toll-like receptor 4 (TLR4). This study demonstrated that YJH exerted potential protective effects against LPS-induced ALI in mice and supported that YJH was a potential therapeutic drug for ALI in clinic. And its mechanisms were at least partially associated with downregulations of TLR4/NF-κB pathways.

scholarly journals Application of traditional Chinese medicine preparation in targeting drug delivery system

Drug Delivery ◽  
2014 ◽  
Vol 22 (3) ◽  
pp. 258-265 ◽  
Author(s):  
Wei Xu ◽  
Feng J. Xing ◽  
Kai Dong ◽  
Cuiyu You ◽  
Yan Yan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Drug Delivery System ◽  
Delivery System ◽  
Traditional Chinese Medicine Preparation

The integration of traditional Chinese medicine and Western medicine

2003 ◽  
Vol 11 (2) ◽  
pp. 225-235 ◽  
Author(s):  
CHEN KEJI ◽  
XU HAO
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Western Medicine ◽  
Chinese Philosophy ◽  
Medical Science ◽  
Integrated Approach ◽  
The Body ◽  
Theoretical Research ◽  
Human Beings ◽  
The Future

Traditional Chinese Medicine (TCM) is one of the world's oldest medical systems, having a history of several thousands of years. It is a system of healing based upon the Chinese philosophy of the correspondence between nature and human beings. Its theories refer to yin and yang, the Five Elements, zang-fu, channels-collaterals, qi, blood, body fluid, methods of diagnosis, the differentiation of symptom-complexes, etc. TCM has two main features: a holistic point of view and treatment according to a differentiation of syndromes. The therapeutic methods of TCM involve different approaches, such as acupuncture, moxibustion, tuina bodywork, herbal medicine and qi gong, in order to allow the body to heal itself in a natural way. Western medicine was first introduced into China from the middle of the 17th century. During the first two centuries several different views, related to the future of TCM and the relation between TCM and Western medicine, emerged. Some advocated ‘complete westernization’ of Chinese medicine, others were in favour of keeping it intact, whereas again others recommended the ‘digestion and assimilation of TCM and Western medicine’. Nowadays, more and more people realize that each of the two medical traditions has its own merits and advise that the two systems should benefit from each other's strong points. We offer an argument for integrating Western medicine with TCM. In the 20th century China has maintained and developed three kinds of medical science, that is, TCM, Western medicine, and ‘integrated medicine’. Much has been achieved in clinical, experimental and theoretical research. The development of any science can be furthered by cross-fertilization based on absorption and fusion of whatever useful theory and experience. It is our dream that, in the future, diverse modalities – including TCM, Western medicine and possibly other variants – can work in conjunction with each other as part of a unified team rather than in competition. This integrated approach will ultimately lead to safer, faster and more effective health care.

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