Bioactive compounds of the Ubá mango juices decrease inflammation and hepatic steatosis in obese Wistar rats

2017 ◽  
Vol 32 ◽  
pp. 409-418 ◽  
Author(s):  
Dorina Isabel Gomes Natal ◽  
Kellen Cristina da Cruz Rodrigues ◽  
Maria Eliza de Castro Moreira ◽  
José Humberto de Queiróz ◽  
Laércio dos Anjos Benjamin ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Bioactive Compounds ◽  
Wistar Rats ◽  
Mango Juices

Broccoli extract improves high fat diet-induced obesity, hepatic steatosis and glucose intolerance in Wistar rats

2019 ◽  
Vol 59 ◽  
pp. 319-328 ◽  
Author(s):  
Paula Aranaz ◽  
David Navarro-Herrera ◽  
Ana Romo-Hualde ◽  
María Zabala ◽  
Miguel López-Yoldi ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Glucose Intolerance ◽  
High Fat Diet ◽  
Wistar Rats ◽  
High Fat ◽  
Diet Induced Obesity

Cafeteria diet from birth to adulthood promotes hepatic steatosis and redox imbalance in Wistar rats

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Letícia Fernandes Gomes ◽  
Sibelle Aparecida Madureira Costa ◽  
Arthur Rocha-Gomes ◽  
Amanda Escobar Teixeira ◽  
Alexandre Alves da Silva ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Liver Tissue ◽  
Design Methodology ◽  
Wistar Rats ◽  
Redox State ◽  
Liver Weight ◽  
Cafeteria Diet ◽  
Control Group ◽  
Content Type ◽  
Markers Of Oxidative Stress

Purpose The purpose of this paper is to evaluate the pathological, biochemical and redox state parameters of liver tissue in Wistar rats treated from birth to adulthood (119 days) with cafeteria diet. Design/methodology/approach During the lactation, 6 liters of Wistar rats (dam + 8 pups each) were fed one of two diets: control (CTRL; n = 3) or cafeteria (CAF; n = 3) diets and water ad libitum. After weaning, the males were placed in individual cages, receiving the same diet offered to their respective dams (CTRL or CAF; n = 18) until adulthood. The following parameters were evaluated: absolute and relative liver weight; blood, liver and feces biochemistry; liver histology; and redox state of the liver. Findings When assessing the relative and absolute organ weight, no significant differences were found between the groups. The Cafeteria group exhibited higher values of serum LDL-c (p = 0.008), VLDL-c (p = 0.03) and triglycerides (p = 0.01), as well as several micro and macrovacuoles of fat accumulation, higher hepatic lipid (p = 0.03) and cholesterol (p = 0.0001) levels regarding Control group. Cafeteria group showed greater expression of glutathione-s-transferase (p = 0.03) and superoxide dismutase (p = 0.005) enzymes compared to the control group. In the case of the markers of oxidative stress, there was no difference between the groups. Originality/value A simple and standardized cafeteria diet caused an accumulation of fatty acids in liver tissue, inducing a state of hepatic steatosis besides an increased expression of antioxidant enzymes.

Conjugated linoleic acid does not reduce body fat but decreases hepatic steatosis in adult Wistar rats

2007 ◽  
Vol 18 (10) ◽  
pp. 676-684 ◽  
Author(s):  
Aparna Purushotham ◽  
Gayle E. Shrode ◽  
Angela A. Wendel ◽  
Li-Fen Liu ◽  
Martha A. Belury
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Hepatic Steatosis ◽  
Body Fat ◽  
Wistar Rats

scholarly journals Protective effect of apricot (Prunus armeniacaL.) on hepatic steatosis and damage induced by carbon tetrachloride in Wistar rats

2009 ◽  
Vol 102 (12) ◽  
pp. 1767-1775 ◽  
Author(s):  
Feral Ozturk ◽  
Mehmet Gul ◽  
Burhan Ates ◽  
I. Cetin Ozturk ◽  
Asli Cetin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Hepatic Steatosis ◽  
Wistar Rats ◽  
Liver Steatosis ◽  
Radical Scavenging ◽  
Hepatic Necrosis ◽  
Control Group ◽  
Cytoplasmic Matrix

The present study was planned to investigate the protective effect of 10 % and 20 % apricot-containing feed on carbon tetrachloride (CCl4)-induced hepatic steatosis and damage. Adult male Wistar rats (n42) were divided into six groups of seven each, as follows: control group; CCl4group; CCl4+10 % apricot group; CCl4+20 % apricot group; 10 % apricot group; 20 % apricot group. All apricot groups were fed with 10 % or 20 % apricot-containing feed for 5 months. CCl4injections were applied to the CCl4groups at the dose of 1 mg/kg for 3 d at the end of 5 months. In the CCl4group, vacuolated hepatocytes and hepatic necrosis were seen, especially in the centrilobular area. Hepatocytes showed an oedematous cytoplasmic matrix, large lipid globules and degenerated organelles. The area of liver injury was found significantly decreased with apricot feeding. Malondialdehyde and total glutathione levels and catalase, superoxide dismutase and glutathione peroxidase activities were significantly changed in the CCl4group and indicated increased oxidative stress. Apricot feeding decreased this oxidative stress and ameliorated histological damage. We concluded that apricot feeding had beneficial effects on CCl4-induced liver steatosis and damage probably due to its antioxidant nutrient (β-carotene and vitamin) contents and high radical-scavenging capacity. Dietary intake of apricot can reduce the risk of liver steatosis and damage caused by free radicals.

Chronic maternal calcium and 25-hydroxyvitamin D deficiency in Wistar rats programs abnormal hepatic gene expression leading to hepatic steatosis in female offspring

2017 ◽  
Vol 43 ◽  
pp. 36-46 ◽  
Author(s):  
Sona S. Sharma ◽  
Nivedita M. Jangale ◽  
Abhay M. Harsulkar ◽  
Medha K. Gokhale ◽  
Bimba N. Joshi
Keyword(s):  
Gene Expression ◽  
Hepatic Steatosis ◽  
Wistar Rats ◽  
Female Offspring ◽  
Hepatic Gene Expression ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats

2017 ◽  
Vol 98 (5) ◽  
pp. 1757-1764 ◽  
Author(s):  
Arunaksharan Narayanankutty ◽  
Devika Mukundan Palliyil ◽  
Kezia Kuruvilla ◽  
Achuthan C Raghavamenon
Keyword(s):  
Lipid Metabolism ◽  
Hepatic Steatosis ◽  
Wistar Rats ◽  
Redox Homeostasis ◽  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Male Wistar Rats

Effects of soy isoflavone genistein on lipid profile and hepatic steatosis in high-fat-fed Wistar rats

2019 ◽  
pp. 1
Author(s):  
Deepa Perumal ◽  
Mangaiarkkarasi Adhimoolam ◽  
Erli Ivan ◽  
Meher Rajamohammed
Keyword(s):  
Lipid Profile ◽  
Hepatic Steatosis ◽  
Wistar Rats ◽  
High Fat ◽  
Soy Isoflavone

scholarly journals Reviewing the Benefits of Grazing/Browsing Semiarid Rangeland Feed Resources and the Transference of Bioactivity and Pro-Healthy Properties to Goat Milk and Cheese: Obesity, Insulin Resistance, Inflammation and Hepatic Steatosis Prevention

Animals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2942
Author(s):  
Claudia Delgadillo-Puga ◽  
Mario Cuchillo-Hilario
Keyword(s):  
Insulin Resistance ◽  
Hepatic Steatosis ◽  
Bioactive Compounds ◽  
Goat Milk ◽  
Bioactive Compound ◽  
High Fat ◽  
Total Polyphenol ◽  
Animal Products ◽  
Healthy Activity ◽  
Semiarid Rangeland

The rangeland is an ecological resource that provides multiple benefits for environment and agriculture. Grazing/browsing on rangelands is a useful and inexpensive means to produce food derived from animal products. The aim of this study was to review the benefits of producing milk and cheese under this system in terms of bioactivity and the health benefits of their consumption in model animals. To conduct this review, we particularly considered the experiments that our research group carried out along the last fifteen years at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán in Mexico. Firstly, we examined the forages consumed by goats on the rangelands in terms of plant bioactive compound occurrence and their concentration. Further, goat milk and cheese coming from (1) grazing animals, (2) animals managed indoors, and from (3) animals managed indoor supplemented with rich plant bioactive compounds, were analyzed. Milk was discussed to modulate the negative effects of high-fat diets in mice. Forages consumed by goats on the rangelands showed a close correlation between antioxidant activity assessed by the DPPH+ radical with total flavonoid and total polyphenol contents (TPC). Milk concentration of PUFA, MUFA, and n-3 fatty acids from grazing goats (4.7%, 25.2%, and 0.94% of FAME) was higher than milk from goats fed indoor diets (ID). Similar results were shown in cheese. TPC was higher in cheese manufactured with milk from grazing goats (300 mg of GAE/kg of cheese) when compared to cheese from milk goats fed ID (60 mg of GAE/of cheese). Acacia pods are a semiarid rangeland feed resource that transfers pro-healthy activity, inhibited in vitro lipid peroxidation (inhibition of TBARS formation) and diminished the damage induced by reactive oxygen species (ROS). Additionally, in vivo assessment revealed that Acacia species increased free radical scavenging (DPPH), oxygen radical absorbance capacity, and anti-inflammatory activity. The results highlight that grazing/browsing practices are superior to indoor feeding in order to promote the transference of bioactive compounds from vegetation to animal tissue, and finally to animal products. Grazing management represents a better option than indoor feeding to enhance bioactivity of milk and cheese. Supplementation with rich-bioactive compound forages increased total polyphenol, hydroxycinnamic acids, and flavonoid concentrations in milk and cheese. The consumption of goat milk prevents obesity, insulin resistance, inflammation, and hepatic steatosis while on a high-fat diet induced obesity in mice.

scholarly journals Acute and Chronic Anti-inflammatory effect of Bryophyllum pinnatum Leaf Extract on Wistar Rats

2021 ◽  
pp. 6-14
Author(s):  
Emmanuel Ikechukwu Onwubuya ◽  
Henrietta Aritetsoma Ogbunugafor ◽  
Chike Samuel Okafor ◽  
Afees Adebayo Oladejo
Keyword(s):  
Bioactive Compounds ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Inflammatory Activity ◽  
Dependent Manner ◽  
Flame Ionization ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Inflammatory Effect ◽  
Bryophyllum Pinnatum

Bryophyllum pinnatum (Lam.) Oken (Crassulaceae) is used traditionally to treat many ailments. This study investigated the anti-inflammatory effect of hydro-ethanol leaf extract of Bryophyllum pinnatum on Wistar rats using acute and chronic models and also evaluates the bioactive compounds of the leaf extract. The phytochemical constituents of the plant extract were quantitatively determined by Gas Chromatography-Flame Ionization Detector (GC-FID) and acute anti-inflammatory activity was carried out with the aid of plethysmometer while chronic anti-inflammatory activity was investigated using cotton pellet. Results showed that the leaf extract of B. pinnatum was rich in kaempferol (7.006 ±0.02 μg/g), sapogenin (3.372 ±0.02 μg/g), rutin (1.837 ±0.01 μg/g) and lunamarine (1.359 ±0.01 μg/g). The findings showed that the plant had considerable anti-inflammatory effects in a dose dependent manner, returning edema in carragenean-induced and cotton pellet induced granuloma in Wistar rats to normal within 120 minutes and 7 days respectively. The findings of this work have shown that the leaf of B. pinnatum was rich in bioactive compounds which could be synthesized to produce new plant based product to fight inflammatory disorders with fewer side effects.

Ubá mango juices intake decreases adiposity and inflammation in high-fat diet-induced obese Wistar rats

Nutrition ◽  
2016 ◽  
Vol 32 (9) ◽  
pp. 1011-1018 ◽  
Author(s):  
Dorina Isabel Gomes Natal ◽  
Maria Eliza de Castro Moreira ◽  
Mariana Soares Milião ◽  
Laércio dos Anjos Benjamin ◽  
Maria Inês de Souza Dantas ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
High Fat ◽  
Mango Juices
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