Associations of urinary dichloroacetic acid and trichloroacetic acid exposure with platelet indices: Exploring the mediating role of blood pressure in the general population

In the current study, we had two aims. First, we investigated the associations between eating psychopathology, situational interpersonal difficulties, and dispositional interpersonal difficulties among athletes and nonathletes. Second, we examined the mediating role of self-critical perfectionism, self-esteem, and depression in these associations. A total of 152 athletes and 147 nonathletes completed self-report instruments pertaining to relationship quality with significant others, as well as social anxiety, loneliness, self-critical perfectionism, self-esteem, depression, and eating psychopathology. Social anxiety and loneliness were found to be the only significant independent predictors of eating psychopathology among both athletes and nonathletes. However, such associations were indirectly mediated through depression for athletes and through self-critical perfectionism, self-esteem, and depression for nonathletes. The findings of this study suggest that the psychosocial mechanisms involved in the eating psychopathology of athletes are relatively similar to that of nonathletes. Thus, it can be tentatively proposed that treatments and interventions that target reducing interpersonal conflicts currently available for the general population should also be offered to athletes.

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The role of mouse intestinal microflora in the metabolism of trichloroethylene, an in vivo study

Human & Experimental Toxicology ◽

10.1177/096032719701601101 ◽

1997 ◽

Vol 16 (11) ◽

pp. 629-635 ◽

Cited By ~ 7

Author(s):

AP Moghaddam ◽

R. Abbas ◽

JW Fisher ◽

JC Lipscomb

Keyword(s):

Trichloroacetic Acid ◽

Liver Tumors ◽

Dichloroacetic Acid ◽

Gut Microflora ◽

Acid Produce ◽

Different Content ◽

The Impact

1 Both trichloroethylene and its metabolite, dichloroa cetic acid, produce liver tumors peroxisome prolifera tion and other adverse cellular alterations in rodents. 2 The hepatic mechanism by which dichloroacetic acid is formed is not conclusively demonstrated, but pharmacokinetic models have successfully associated its formation with trichloroacetic acid as immediate precursor. 3 Previous investigations have shown that dichloroace tic acid is formed from trichloroacetic acid by gut microflora isolated in vitro. 4 To determine the impact of gut microflora on dichlor oacetic acid formation from a trichloroethylene dose in vivo, we developed a procedure which reduced gut microflora some 3 orders of magnitude below pub lished levels. 5 The administration of trichloroethylene to control mice and to mice whose gut was practically sterile resulted in equivalent concentrations of dichloroace tic acid and other metabolites in blood and liver, but significantly different content of these metabolites in cecum contents. 6 These data indicate that gut microflora contribute minimally, if at all, to the formation of circulating dichloroacetic acid under these conditions.

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The mediating role of adiposity in the longitudinal association between cardiorespiratory fitness and blood pressure in adolescents: LabMed cohort study

European Journal of Clinical Investigation ◽

10.1111/eci.13430 ◽

2020 ◽

Author(s):

Maria Reyes Beltran‐Valls ◽

Rute Santos ◽

Jorge Mota ◽

Carla Moreira ◽

Luís Lopes ◽

...

Keyword(s):

Blood Pressure ◽

Cohort Study ◽

Cardiorespiratory Fitness ◽

Mediating Role ◽

Longitudinal Association

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Psychosocial Distress and Blood Pressure among Young Adults: Role of Cortisol as Mediator

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v17i1.897 ◽

2018 ◽

Vol 17 (1) ◽

Author(s):

Wan Fatein Wan Omar ◽

Ramli Musa ◽

Jamalludin A. Rahman ◽

Azarisman Shah Mohd Shah ◽

Norlelawati A. Talib ◽

...

Keyword(s):

Blood Pressure ◽

Young Adults ◽

Risk Factor ◽

Stress Test ◽

Fasting Blood Glucose ◽

Serum Cortisol ◽

Psychosocial Distress ◽

The Body ◽

Mediating Role

Introduction: Hypertension is the most prevalent risk factor of cardiovascular diseases in Malaysia. 17.3% of hypertension cases in Malaysia is attributed to adults aged 18 to 39 years. Psychosocial distress is a possible risk factor for elevated blood pressure in young adults, and cortisol could be the mediating factor. The aim of this study is to evaluate the mediating role of cortisol in hypertension and psychosocial distress in young adults. Materials and Methods: A comparative crosssectional study was conducted in 240 young adults aged 45 years or less. The body mass index, waist circumference and blood pressure parameters were recorded. Serum cortisol, creatinine, fasting blood glucose and lipid profile were measured following acute mental stress test. Psychosocial distress was assessed using the DASS-21 questionnaire. Results: Mean (standard deviation) values for SBP, DBP and MAP were 126.0 (16.3), 84.1 (12.2) and 98.1 (13.1) mmHg respectively. Anxiety was significantly associated with systolic blood pressure (β = 0.644), diastolic blood pressure (β = 0.454) and mean arterial pressure (β = 0.516) after adjusting to sex, age and cortisol. However, it was not mediated by cortisol. Depression and stress were not found to have any effect on blood pressure of the young adults studied. Conclusion: The data suggest that there is no elevated risk for psychosocial distress and hypertension that cortisol poses in young adults.

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